LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 697

Search options

  1. Article: Metastatic Melanoma Treatment with Pembrolizumab after Hypersensitivity Reaction to Nivolumab: A Case Report.

    Cruse, Alyssa R / Basilio, Alexa J / Lawson, David H

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1232–1236

    Abstract: Programmed death protein-1 (PD-1) checkpoint inhibitors such as pembrolizumab and nivolumab are cornerstones to metastatic melanoma treatment, and they are often considered to be pharmacologically similar and interchangeable when it comes to designing ... ...

    Abstract Programmed death protein-1 (PD-1) checkpoint inhibitors such as pembrolizumab and nivolumab are cornerstones to metastatic melanoma treatment, and they are often considered to be pharmacologically similar and interchangeable when it comes to designing chemotherapy regimens. In this case report, we describe a patient who had consistent immune reactions to nivolumab infusion but was able to tolerate pembrolizumab, without any reactions, when given hydrocortisone premedication. This case demonstrates a successful transition from one PD-1 checkpoint inhibitor to another with resolution of infusion-related reactions in a patient undergoing treatment for metastatic melanoma.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000534023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Evolution of endosymbiosis-mediated nuclear calcium signaling in land plants.

    Lam, Anson H C / Cooke, Aisling / Wright, Hannah / Lawson, David M / Charpentier, Myriam

    Current biology : CB

    2024  

    Abstract: The ability of fungi to establish mycorrhizal associations with plants and enhance the acquisition of mineral nutrients stands out as a key feature of terrestrial life. Evidence indicates that arbuscular mycorrhizal (AM) association is a trait present in ...

    Abstract The ability of fungi to establish mycorrhizal associations with plants and enhance the acquisition of mineral nutrients stands out as a key feature of terrestrial life. Evidence indicates that arbuscular mycorrhizal (AM) association is a trait present in the common ancestor of land plants,
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.03.063
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Insights into the Psychology of Trauma Should Inform the Practice of Oncology.

    Lawson, Kathryn C / Lawson, David H

    The oncologist

    2018  Volume 23, Issue 7, Page(s) 750–751

    MeSH term(s) Humans ; Medical Oncology ; Neoplasms ; Physicians
    Language English
    Publishing date 2018-03-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1634/theoncologist.2018-0091
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 494: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: 20/20 in 2020: seeking clarity on the management of stage III melanoma in a rapidly changing treatment environment.

    Chandrasekaran, Sanjay / Lawson, David H

    Annals of translational medicine

    2020  Volume 8, Issue 12, Page(s) 776

    Language English
    Publishing date 2020-07-10
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.02.69
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Acute effects of low load blood flow restricted and non restricted exercise on muscle excitation, neuromuscular efficiency, and average torque.

    Hill, Ethan C / Rivera, Paola M / Proppe, Chris E / Gonzalez Rojas, David H / Lawson, John E

    Journal of musculoskeletal & neuronal interactions

    2023  Volume 23, Issue 2, Page(s) 165–174

    Abstract: Objectives: The purpose of this investigation was to examine the acute effects of low-load blood flow restriction (LLBFR) and low-load (LL) resistance exercise on muscle excitation, neuromuscular efficiency, and average torque.: Methods: Eleven men ( ... ...

    Abstract Objectives: The purpose of this investigation was to examine the acute effects of low-load blood flow restriction (LLBFR) and low-load (LL) resistance exercise on muscle excitation, neuromuscular efficiency, and average torque.
    Methods: Eleven men (age±SD=22±3yrs) randomly performed LLBFR and LL that consisted of 30 unilateral leg extensions at 30% of one-repetition maximum while surface electromyography (sEMG) and torque were simultaneously assessed. Polynomial regression analyses and slope comparisons were performed to examine patterns of responses and rates of change.
    Results: sEMG amplitude increased for LLBFR (9 of 11) and LL (8 of 11) and between composite responses (R
    Conclusion: LLBFR elicited greater fatigue-induced increases in muscle excitation and decreases in neuromuscular efficiency than LL, but neither LLBFR nor LL affected average submaximal concentric torque.
    MeSH term(s) Humans ; Male ; Electromyography ; Exercise/physiology ; Muscle, Skeletal/physiology ; Resistance Training ; Torque ; Young Adult ; Adult
    Language English
    Publishing date 2023-06-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2041366-X
    ISSN 1108-7161
    ISSN 1108-7161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5401: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Blood flow restriction attenuates surface mechanomyography lateral and longitudinal, but not transverse oscillations during fatiguing exercise.

    Hill, Ethan C / Proppe, Chris E / Rivera, Paola M / Lubiak, Sean M / Gonzalez Rojas, David H / Lawson, John E / Choi, Hwan / Mansy, Hansen / Keller, Joshua L

    Physiological measurement

    2024  Volume 45, Issue 4

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Female ; Muscle Fatigue/physiology ; Exercise/physiology ; Isometric Contraction/physiology ; Regional Blood Flow ; Physical Therapy Modalities ; Muscle, Skeletal/physiology ; Electromyography ; Resistance Training/methods
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1149545-5
    ISSN 1361-6579 ; 0967-3334
    ISSN (online) 1361-6579
    ISSN 0967-3334
    DOI 10.1088/1361-6579/ad360b
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1559: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK.

    Thompson, Catriona M A / Little, Richard H / Stevenson, Clare E M / Lawson, David M / Malone, Jacob G

    Proteins

    2022  Volume 91, Issue 3, Page(s) 300–314

    Abstract: Bacteria are equipped with a diverse set of regulatory tools that allow them to quickly adapt to their environment. The RimK system allows for Pseudomonas spp. to adapt through post-transcriptional regulation by altering the ribosomal subunit RpsF. RimK ... ...

    Abstract Bacteria are equipped with a diverse set of regulatory tools that allow them to quickly adapt to their environment. The RimK system allows for Pseudomonas spp. to adapt through post-transcriptional regulation by altering the ribosomal subunit RpsF. RimK is found in a wide range of bacteria with a conserved amino acid sequence, however, the genetic context and the role of this protein is highly diverse. By solving and comparing the structures of RimK homologs from two related but functionally divergent systems, we uncovered key structural differences that likely contribute to the different activity levels of each of these homologs. Moreover, we were able to clearly resolve the active site of this protein for the first time, resolving binding of the glutamate substrate. This work advances our understanding of how subtle differences in protein sequence and structure can have profound effects on protein activity, which can in turn result in widespread mechanistic changes.
    MeSH term(s) Pseudomonas ; Ribosomes/metabolism ; Amino Acid Sequence ; Glutamic Acid/metabolism
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806683-8
    ISSN 1097-0134 ; 0887-3585
    ISSN (online) 1097-0134
    ISSN 0887-3585
    DOI 10.1002/prot.26429
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2291: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Minimal Intraspecific Aggression among Tawny Crazy Ants (Hymenoptera: Formicidae) in Florida

    Lawson, Katy J / Oi, David H

    Florida entomologist. 2020 July 10, v. 103, no. 2

    2020  

    Abstract: Tawny crazy ants, Nylanderia fulva (Mayr) (Hymenoptera: Formicidae), are an invasive species found in states along the Gulf Coast of the USA. Their large populations are aggressive and can displace ant species already present in the area. Because tawny ... ...

    Abstract Tawny crazy ants, Nylanderia fulva (Mayr) (Hymenoptera: Formicidae), are an invasive species found in states along the Gulf Coast of the USA. Their large populations are aggressive and can displace ant species already present in the area. Because tawny crazy ants are not territorial toward their own species within a locality, it was hypothesized that they may exhibit unicoloniality in their invasive range. To test this hypothesis, tawny crazy ants from separate locations in Florida were confined in small, enclosed arenas, and their interactions were observed and documented using a rating scale of aggression behaviors. Carbohydrate consumption also can affect aggression in ants, so starved and non-starved ants were tested separately. For non-starved ants, the level of aggression between worker ants increased if they were from different locations, but this interaction rarely escalated to fighting. When starved ants from different locations were given access to sucrose solution, the ants would exhibit trophallaxis rather than fighting over the food source. Queens from different colonies would quickly nest together. Thus, intraspecific aggression was not evident among tawny crazy ants collected from widely separated locations in Florida.
    Keywords Nylanderia fulva ; aggression ; coasts ; entomologists ; invasive species ; sucrose ; trophallaxis ; Florida
    Language English
    Dates of publication 2020-0710
    Size p. 247-252.
    Publishing place Florida Entomological Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1938-5102
    DOI 10.1653/024.103.0215
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Acute Effects of Sprint Interval Training and Blood Flow Restriction on Neuromuscular and Muscle Function.

    Gonzalez Rojas, David H / Wizenberg, Aaron M / Rivera, Paola M / Proppe, Christopher E / Lawson, John E / Stock, Matt S / Stout, Jeffrey R / Billaut, François / Hill, Ethan C

    Journal of musculoskeletal & neuronal interactions

    2024  Volume 24, Issue 1, Page(s) 38–46

    Abstract: BFR) applied during sprint interval training (SIT) on performance and neuromuscular function.: Methods: Fifteen men completed a randomized bout of SIT with CBFR, IBFR, and without BFR (No-BFR), consisting of 2, 30-s maximal sprints on a cycle ... ...

    Abstract BFR) applied during sprint interval training (SIT) on performance and neuromuscular function.
    Methods: Fifteen men completed a randomized bout of SIT with CBFR, IBFR, and without BFR (No-BFR), consisting of 2, 30-s maximal sprints on a cycle ergometer with a resistance of 7.5% of body mass. Concentric peak torque (CPT), maximal voluntary isometric contraction (MVIC) torque, and muscle thickness (MT) were measured before and after SIT, including surface electromyography (sEMG) recorded during the strength assessments. Peak and mean revolutions per minute (RPM) were measured during SIT and power output was examined relative to physical working capacity at the fatigue threshold (PWC
    Results: CPT and MVIC torque decreased from pre-SIT (220.3±47.6 Nm and 355.1±72.5 Nm, respectively) to post-SIT (147.9±27.7 Nm and 252.2±45.5 Nm, respectively, all P<0.05), while MT increased (1.77±0.31 cm to 1.96±0.30 cm). sEMG mean power frequency decreased during CPT (-12.8±10.5%) and MVIC (-8.7±10.2%) muscle actions. %PWC
    Conclusion: SIT with or without BFR induced comparable alterations in neuromuscular fatigue and sprint performance across all conditions, without affecting neuromuscular function.
    MeSH term(s) Humans ; Male ; Electromyography ; High-Intensity Interval Training ; Isometric Contraction/physiology ; Muscle Fatigue ; Muscle, Skeletal/physiology ; Regional Blood Flow/physiology ; Torque
    Language English
    Publishing date 2024-03-04
    Publishing country Greece
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2041366-X
    ISSN 1108-7161
    ISSN 1108-7161
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5401: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Identification of individual root-knot nematodes using low coverage long-read sequencing.

    Sellers, Graham S / Jeffares, Daniel C / Lawson, Bex / Prior, Tom / Lunt, David H

    PloS one

    2021  Volume 16, Issue 12, Page(s) e0253248

    Abstract: Root-knot nematodes (RKN; genus Meloidogyne) are polyphagous plant pathogens of great economic importance to agriculturalists globally. These species are small, diverse, and can be challenging for accurate taxonomic identification. Many of the most ... ...

    Abstract Root-knot nematodes (RKN; genus Meloidogyne) are polyphagous plant pathogens of great economic importance to agriculturalists globally. These species are small, diverse, and can be challenging for accurate taxonomic identification. Many of the most important crop pests confound analysis with simple genetic marker loci as they are polyploids of likely hybrid origin. Here we take a low-coverage, long-read genome sequencing approach to characterisation of individual root-knot nematodes. We demonstrate library preparation for Oxford Nanopore Technologies Flongle sequencing of low input DNA from individual juveniles and immature females, multiplexing up to twelve samples per flow cell. Taxonomic identification with Kraken 2 (a k-mer-based taxonomic assignment tool) is shown to reliably identify individual nematodes to species level, even within the very closely related Meloidogyne incognita group. Our approach forms a robust, low-cost, and scalable method for accurate RKN species diagnostics.
    MeSH term(s) Animals ; DNA, Helminth/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Plant Diseases/genetics ; Plant Diseases/parasitology ; Tylenchoidea/classification ; Tylenchoidea/genetics
    Chemical Substances DNA, Helminth
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0253248
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top