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  1. Article ; Online: Classifications and misclassification in cholangiocarcinoma.

    Cardinale, Vincenzo

    Liver international : official journal of the International Association for the Study of the Liver

    2019  Volume 39, Issue 2, Page(s) 260–262

    MeSH term(s) Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma ; Germany ; Humans
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13998
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Biliary stem cells in health and cholangiopathies and cholangiocarcinoma.

    Cardinale, Vincenzo / Paradiso, Savino / Alvaro, Domenico

    Current opinion in gastroenterology

    2024  Volume 40, Issue 2, Page(s) 92–98

    Abstract: Purpose of review: This review discusses evidence regarding progenitor populations of the biliary tree in the tissue regeneration and homeostasis, and the pathobiology of cholangiopathies and malignancies.: Recent findings: In embryogenesis biliary ... ...

    Abstract Purpose of review: This review discusses evidence regarding progenitor populations of the biliary tree in the tissue regeneration and homeostasis, and the pathobiology of cholangiopathies and malignancies.
    Recent findings: In embryogenesis biliary multipotent progenitor subpopulation contributes cells not only to the pancreas and gall bladder but also to the liver. Cells equipped with a constellation of markers suggestive of the primitive endodermal phenotype exist in the peribiliary glands, the bile duct glands, of the intra- and extrahepatic bile ducts. These cells are able to be isolated and cultured easily, which demonstrates the persistence of a stable phenotype during in vitro expansion, the ability to self-renew in vitro, and the ability to differentiate between hepatocyte and biliary and pancreatic islet fates.
    Summary: In normal human livers, stem/progenitors cells are mostly restricted in two distinct niches, which are the bile ductules/canals of Hering and the peribiliary glands (PBGs) present inside the wall of large intrahepatic bile ducts. The existence of a network of stem/progenitor cell niches within the liver and along the entire biliary tree inform a patho-biological-based translational approach to biliary diseases and cholangiocarcinoma since it poses the basis to understand biliary regeneration after extensive or chronic injuries and progression to fibrosis and cancer.
    MeSH term(s) Humans ; Biliary Tract ; Stem Cells ; Cholangiocarcinoma ; Bile Ducts, Intrahepatic ; Bile Duct Neoplasms
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000001005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2072: Show issues Location:
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  3. Article ; Online: The potential role of endoscopic ultrasound in primary sclerosing cholangitis.

    Lattanzi, Barbara / Covotta, Francesco / Cardinale, Vincenzo

    Journal of hepatology

    2023  Volume 79, Issue 5, Page(s) e199–e200

    Language English
    Publishing date 2023-06-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.05.030
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    Zs.A 2027: Show issues Location:
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  4. Article ; Online: Reply to: "Ductular reaction is a prognostic factor in primary biliary cholangitis".

    Carpino, Guido / Cardinale, Vincenzo / Carbone, Marco

    JHEP reports : innovation in hepatology

    2023  Volume 5, Issue 8, Page(s) 100786

    Language English
    Publishing date 2023-05-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100786
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  5. Article ; Online: ABCB4-alteration screening in adult-onset cholestasis.

    Carbone, Marco / Cardinale, Vincenzo

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 53, Issue 3, Page(s) 261–262

    MeSH term(s) Adult ; Cholestasis/diagnosis ; Humans
    Language English
    Publishing date 2021-01-15
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.12.121
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    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Laparoscopic dissection of a lateral pelvic Schwannoma-a video vignette.

    Papagni, Vincenzo / Picciariello, Arcangelo / Cardinale, Pierantonio / Vincenti, Leonardo

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 23, Issue 11, Page(s) 3035–3036

    MeSH term(s) Dissection ; Humans ; Laparoscopy ; Lymph Node Excision ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/surgery ; Pelvis/surgery ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15876
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    Zs.A 5799: Show issues Location:
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  7. Article ; Online: Role of the Gut-Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence.

    Bragazzi, Maria Consiglia / Venere, Rosanna / Vignone, Anthony / Alvaro, Domenico / Cardinale, Vincenzo

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The "Gut-Liver Axis" refers to the physiological bidirectional interplay between the gut and its microbiota and the liver which, in health, occurs thanks to a condition of immune tolerance. In recent years, several studies have shown that, in case of a ... ...

    Abstract The "Gut-Liver Axis" refers to the physiological bidirectional interplay between the gut and its microbiota and the liver which, in health, occurs thanks to a condition of immune tolerance. In recent years, several studies have shown that, in case of a change in gut bacterial homeostasis or impairment of intestinal barrier functions, cholangiocytes, which are the epithelial cells lining the bile ducts, activate innate immune responses against gut-derived microorganisms or bacterial products that reach the liver via enterohepatic circulation. Intestinal dysbiosis or impaired intestinal barrier functions cause cholangiocytes to be exposed to an increasing amount of microorganisms that can reactivate inflammatory responses, thus inducing the onset of liver fibrosis. The present review focuses on the role of the gut-liver axis in the pathogenesis of cholangiopathies.
    MeSH term(s) Humans ; Liver/pathology ; Liver Cirrhosis/pathology ; Bile Ducts/pathology ; Immunity, Innate ; Epithelial Cells/pathology ; Dysbiosis/complications ; Dysbiosis/pathology
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076660
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  8. Article ; Online: Intrahepatic cholangiocarcinoma: Evolving strategies in management and treatment.

    Bragazzi, Maria Consiglia / Venere, Rosanna / Ribichini, Emanuela / Covotta, Francesco / Cardinale, Vincenzo / Alvaro, Domenico

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 56, Issue 3, Page(s) 383–393

    Abstract: Intrahepatic cholangiocarcinoma is the second most frequent primary liver cancer after hepatocellular carcinoma. According to International Classification of Diseases-11 (ICD-11), intrahepatic cholangiocarcinoma is identified by a specific diagnostic ... ...

    Abstract Intrahepatic cholangiocarcinoma is the second most frequent primary liver cancer after hepatocellular carcinoma. According to International Classification of Diseases-11 (ICD-11), intrahepatic cholangiocarcinoma is identified by a specific diagnostic code, different with respect to perihilar-CCA or distal-CCA. Intrahepatic cholangiocarcinoma originates from intrahepatic small or large bile ducts including the second-order bile ducts and has a silent presentation that combined with the highly aggressive nature and refractoriness to chemotherapy contributes to the alarming increasing incidence and mortality. Indeed, at the moment of the diagnosis, less than 40% of intrahepatic cholangiocarcinoma are suitable of curative surgical therapy, that is so far the only effective treatment. The main goals of clinicians and researchers are to make an early diagnosis, and to carry out molecular characterization to provide the patient with personalized treatment. Unfortunately, these goals are not easily achievable because of the heterogeneity of this tumor from anatomical, molecular, biological, and clinical perspectives. However, recent progress has been made in molecular characterization, surgical treatment, and management of intrahepatic cholangiocarcinoma and, this article deals with these advances.
    MeSH term(s) Humans ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma ; Liver/pathology ; Liver Transplantation ; Bile Duct Neoplasms/diagnosis ; Bile Duct Neoplasms/therapy
    Language English
    Publishing date 2023-09-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.08.052
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Assessing Risk Acceptability and Tolerability in Italian Tunnels with the Quantum Gu@larp Model.

    Guarascio, Massimo / Alakbarli, Emin / Despabeladera, Carlota / Cardinale, Vincenzo / Ghasemichamazkoti, Azadeh / Darabi, Nima

    Entropy (Basel, Switzerland)

    2023  Volume 26, Issue 1

    Abstract: Road tunnels are associated with numerous risks including traffic accidents and fires, posing threats to individual or group users. Key risk indicators such as Risk Quantum, Individual Risk, Societal Risk, and Expected Number of Fatalities are ... ...

    Abstract Road tunnels are associated with numerous risks including traffic accidents and fires, posing threats to individual or group users. Key risk indicators such as Risk Quantum, Individual Risk, Societal Risk, and Expected Number of Fatalities are instrumental in evaluating the level of risk exposure. These indicators empower Rights-Holders and Duty-Holders to report hazards, prevent disasters, and implement timely remedial measures. A crucial indicator, the Scenario Risk Quantum, has its roots in the forensic evaluation of responsibility in a fatal tunnel accident in the UK since 1949. The Quantum of Risk of each design scenario, reasonably selected among rational and practicable possibilities, has both a deterministic and probabilistic character. The Risk Tolerability and Acceptability criteria are modelled according to risk indicators by selecting the parameters according to ethical principles and societal policy. Scenarios are meticulously identified, described, probabilised and assigned probabilities prior to the quantitative risk analysis. These risk indicators are integral to the risk assessment process. This article delves into the understanding of these indicators within the context of Italian road tunnels, employing the Quantum Gu@larp Model to analyse Risk Acceptability and Tolerability.
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e26010040
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  10. Article ; Online: Periostin and mesothelin: Potential predictors of malignant progression in intrahepatic cholangiocarcinoma.

    Mandrekar, Pranoti / Cardinale, Vincenzo

    Hepatology communications

    2018  Volume 2, Issue 5, Page(s) 481–483

    Language English
    Publishing date 2018-04-25
    Publishing country United States
    Document type Editorial
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1189
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