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  1. Article ; Online: Bridging the equity gap in patient education: the biliary tract cancer BABEL project.

    Casolino, Raffaella / Braconi, Chiara

    The Lancet. Oncology

    2022  Volume 23, Issue 5, Page(s) 568–570

    MeSH term(s) Biliary Tract Neoplasms/therapy ; Humans ; Patient Education as Topic
    Language English
    Publishing date 2022-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00143-7
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  2. Article ; Online: CD40-agonist: A new avenue for immunotherapy combinations in cholangiocarcinoma.

    Casolino, Raffaella / Braconi, Chiara

    Journal of hepatology

    2021  Volume 74, Issue 5, Page(s) 1021–1024

    Language English
    Publishing date 2021-02-19
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.01.030
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  3. Article ; Online: The rapidly evolving landscape of HCC: Selecting the optimal systemic therapy.

    Zanuso, Valentina / Rimassa, Lorenza / Braconi, Chiara

    Hepatology (Baltimore, Md.)

    2023  

    Abstract: Over the past years, there has been a remarkable advance in the systemic treatment options for advanced HCC. The overall survival has gradually increased over time, with larger benefits for patients with sensitive tumors and preserved liver function, the ...

    Abstract Over the past years, there has been a remarkable advance in the systemic treatment options for advanced HCC. The overall survival has gradually increased over time, with larger benefits for patients with sensitive tumors and preserved liver function, the latter being an essential condition for the delivery of sequential lines of treatment and optimization of clinical outcomes. With the approval of new first-line agents and the introduction of immune checkpoint inhibitor-based therapies, the treatment landscape of advanced HCC is becoming wider than ever. Atezolizumab plus bevacizumab and, more recently, durvalumab plus tremelimumab have entered the clinical practice and are the current standard of care for treatment-naïve patients, surpassing sorafenib and lenvatinib monopoly. As no head-to-head comparisons are available among all the first-line treatment options, the recommendation for the most appropriate choice and sequence is patient-driven and integrates efficacy data with clinical comorbidities, background liver disease, and the safety profile of available drugs. In addition, predictive biomarkers for successful patients' stratification are yet to be available and constitute the focus of ongoing research. The treatment algorithm is likely to become even more complex since systemic therapeutic approaches are now being translated into earlier stages of the disease, with an impact on the evolution of the sequential treatment of patients with HCC.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000572
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  4. Article ; Online: Receptor tyrosine kinase co-amplification and benefit from HER2 inhibitors in biliary tract cancers.

    Casolino, Raffaella / Amato, Francesco / Rae, Colin / Puttagunta, Srikanth / Braconi, Chiara

    Journal of hepatology

    2022  Volume 76, Issue 5, Page(s) 1227–1229

    MeSH term(s) Biliary Tract Neoplasms/drug therapy ; Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Receptor, ErbB-2
    Chemical Substances Protein Kinase Inhibitors ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-01-29
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.01.012
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  5. Article ; Online: Patient-Derived Organoids as a Model for Cancer Drug Discovery.

    Rae, Colin / Amato, Francesco / Braconi, Chiara

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: In the search for the ideal model of tumours, the use of three-dimensional in vitro models is advancing rapidly. These are intended to mimic the in vivo properties of the tumours which affect cancer development, progression and drug sensitivity, and take ...

    Abstract In the search for the ideal model of tumours, the use of three-dimensional in vitro models is advancing rapidly. These are intended to mimic the in vivo properties of the tumours which affect cancer development, progression and drug sensitivity, and take into account cell-cell interactions, adhesion and invasiveness. Importantly, it is hoped that successful recapitulation of the structure and function of the tissue will predict patient response, permitting the development of personalized therapy in a timely manner applicable to the clinic. Furthermore, the use of co-culture systems will allow the role of the tumour microenvironment and tissue-tissue interactions to be taken into account and should lead to more accurate predictions of tumour development and responses to drugs. In this review, the relative merits and limitations of patient-derived organoids will be discussed compared to other in vitro and ex vivo cancer models. We will focus on their use as models for drug testing and personalized therapy and how these may be improved. Developments in technology will also be considered, including the use of microfluidics, 3D bioprinting, cryopreservation and circulating tumour cell-derived organoids. These have the potential to enhance the consistency, accessibility and availability of these models.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Bioprinting ; Cryopreservation ; Disease Progression ; Drug Discovery ; Drug Screening Assays, Antitumor/methods ; Humans ; Lab-On-A-Chip Devices ; Microfluidics ; Neoplasms/drug therapy ; Neoplastic Cells, Circulating ; Organoids/cytology ; Technology, Pharmaceutical/trends ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073483
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  6. Article ; Online: Metabolic reprogramming in cholangiocarcinoma.

    Raggi, Chiara / Taddei, Maria Letizia / Rae, Colin / Braconi, Chiara / Marra, Fabio

    Journal of hepatology

    2022  Volume 77, Issue 3, Page(s) 849–864

    Abstract: Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the increased energy demands required for rapid proliferation, invasion, and metastasis. Indeed, many tumour cells acquire distinctive metabolic and bioenergetic features ... ...

    Abstract Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the increased energy demands required for rapid proliferation, invasion, and metastasis. Indeed, many tumour cells acquire distinctive metabolic and bioenergetic features that enable them to survive in resource-limited conditions, mainly by harnessing alternative nutrients. Several recent studies have explored the metabolic plasticity of cancer cells with the aim of identifying new druggable targets, while therapeutic strategies to limit the access to nutrients have been successfully applied to the treatment of some tumours. Cholangiocarcinoma (CCA), a highly heterogeneous tumour, is the second most common form of primary liver cancer. It is characterised by resistance to chemotherapy and poor prognosis, with 5-year survival rates of below 20%. Deregulation of metabolic pathways have been described during the onset and progression of CCA. Increased aerobic glycolysis and glutamine anaplerosis provide CCA cells with the ability to generate biosynthetic intermediates. Other metabolic alterations involving carbohydrates, amino acids and lipids have been shown to sustain cancer cell growth and dissemination. In this review, we discuss the complex metabolic rewiring that occurs during CCA development and leads to unique nutrient addiction. The possible role of therapeutic interventions based on metabolic changes is also thoroughly discussed.
    MeSH term(s) Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma/pathology ; Energy Metabolism ; Glycolysis ; Humans
    Language English
    Publishing date 2022-05-18
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.04.038
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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  7. Article ; Online: Noncoding RNA in Cholangiocarcinoma.

    Salati, Massimiliano / Braconi, Chiara

    Seminars in liver disease

    2018  Volume 39, Issue 1, Page(s) 13–25

    Abstract: Cholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic ... ...

    Abstract Cholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection and the intrinsic chemoresistance of CCA cells. Noncoding RNAs (ncRNAs) are transcripts that are not translated into proteins but exert their functional role by regulating the transcription and translation of other genes. The discovery of the first ncRNA dates back to 1993 when the microRNA (miRNA)
    MeSH term(s) Bile Duct Neoplasms/genetics ; Carcinogenesis/genetics ; Cholangiocarcinoma/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Tumor Microenvironment/genetics
    Chemical Substances MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-0038-1676097
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  8. Article: Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer.

    Ofoeyeno, Nduka / Ekpenyong, Emmanuel / Braconi, Chiara

    Cancers

    2020  Volume 13, Issue 1

    Abstract: Biliary tract cancer (BTC) is characterised by poor prognosis and low overall survival in patients. This is generally due to minimal understanding of its pathogenesis, late diagnosis and limited therapeutics in preventing or treating BTC patients. Non- ... ...

    Abstract Biliary tract cancer (BTC) is characterised by poor prognosis and low overall survival in patients. This is generally due to minimal understanding of its pathogenesis, late diagnosis and limited therapeutics in preventing or treating BTC patients. Non-coding RNA (ncRNA) are small RNAs (mRNA) that are not translated to proteins. ncRNAs were considered to be of no importance in the genome, but recent studies have shown they play essential roles in biology and oncology such as transcriptional repression and degradation, thus regulating mRNA transcriptomes. This has led to investigations into the role of ncRNAs in the pathogenesis of BTC, and their clinical implications. In this review, the mechanisms of action of ncRNA are discussed and the role of microRNAs in BTC is summarised. The scope of this review will be limited to miRNA as they have been shown to play the most significant roles in BTC progression. There is huge potential in miRNA-based biomarkers and therapeutics in BTC, but more studies, research and technological advancements are required before it can be translated into clinical practice for patients.
    Language English
    Publishing date 2020-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13010012
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  9. Article ; Online: Biology and Clinical Application of Regulatory RNAs in Hepatocellular Carcinoma.

    Pea, Antonio / Jamieson, Nigel B / Braconi, Chiara

    Hepatology (Baltimore, Md.)

    2020  Volume 73 Suppl 1, Page(s) 38–48

    Abstract: Most of the human genome consists of DNA genes that are translated into RNAs but not into proteins. These RNA molecules are named noncoding RNAs (ncRNA). While in the past it was thought that ncRNAs would be redundant without relevant functions, it is ... ...

    Abstract Most of the human genome consists of DNA genes that are translated into RNAs but not into proteins. These RNA molecules are named noncoding RNAs (ncRNA). While in the past it was thought that ncRNAs would be redundant without relevant functions, it is now well established that ncRNAs identify a class of regulatory molecules that finely tune cell homeostasis and are deregulated in disease states, including hepatocellular carcinoma (HCC). Of note, the number of ncRNAs within a cell increases progressively, with the complexity of the species indicating their essential role in the maintenance of regulatory networks that affect the intricacy of the organism. ncRNAs have been demonstrated to mediate HCC development and progression by affecting intrinsic cancer cell signaling and crosstalk between malignant cells and the microenvironment. Moreover, ncRNAs hold promise as clinical biomarkers, but further evidence is warranted before their translation and integration within clinical practice.
    MeSH term(s) Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/genetics ; Humans ; Liver Neoplasms/etiology ; Liver Neoplasms/genetics ; MicroRNAs/physiology ; RNA, Circular/physiology ; RNA, Untranslated/physiology ; Signal Transduction ; Tumor Microenvironment
    Chemical Substances MicroRNAs ; RNA, Circular ; RNA, Untranslated
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31225
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  10. Article ; Online: Patient-Derived Organoids as a Model for Cancer Drug Discovery

    Colin Rae / Francesco Amato / Chiara Braconi

    International Journal of Molecular Sciences, Vol 22, Iss 3483, p

    2021  Volume 3483

    Abstract: In the search for the ideal model of tumours, the use of three-dimensional in vitro models is advancing rapidly. These are intended to mimic the in vivo properties of the tumours which affect cancer development, progression and drug sensitivity, and take ...

    Abstract In the search for the ideal model of tumours, the use of three-dimensional in vitro models is advancing rapidly. These are intended to mimic the in vivo properties of the tumours which affect cancer development, progression and drug sensitivity, and take into account cell–cell interactions, adhesion and invasiveness. Importantly, it is hoped that successful recapitulation of the structure and function of the tissue will predict patient response, permitting the development of personalized therapy in a timely manner applicable to the clinic. Furthermore, the use of co-culture systems will allow the role of the tumour microenvironment and tissue–tissue interactions to be taken into account and should lead to more accurate predictions of tumour development and responses to drugs. In this review, the relative merits and limitations of patient-derived organoids will be discussed compared to other in vitro and ex vivo cancer models. We will focus on their use as models for drug testing and personalized therapy and how these may be improved. Developments in technology will also be considered, including the use of microfluidics, 3D bioprinting, cryopreservation and circulating tumour cell-derived organoids. These have the potential to enhance the consistency, accessibility and availability of these models.
    Keywords organoids ; patient ; tumour ; drug screening ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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