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  1. Article ; Online: Pleiotropic effects of CD5L in hepatic inflammation and fibrosis.

    Zhou, Tianhao / Glaser, Shannon S

    EBioMedicine

    2019  Volume 44, Page(s) 22–23

    MeSH term(s) Humans ; Inflammation ; Liver Cirrhosis ; Liver Diseases ; Macrophages
    Language English
    Publishing date 2019-05-28
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.05.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  2. Article ; Online: Novel β-catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis.

    Ehrlich, Laurent / Glaser, Shannon S

    Hepatology (Baltimore, Md.)

    2018  Volume 67, Issue 3, Page(s) 829–832

    MeSH term(s) Bile Acids and Salts ; Cholestasis ; Humans ; Liver ; Receptors, Cytoplasmic and Nuclear ; beta Catenin
    Chemical Substances Bile Acids and Salts ; Receptors, Cytoplasmic and Nuclear ; beta Catenin
    Language English
    Publishing date 2018-01-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Author Correction: Complex bile duct network formation within liver decellularized extracellular matrix hydrogels.

    Lewis, Phillip L / Su, Jimmy / Yan, Ming / Meng, Fanyin / Glaser, Shannon S / Alpini, Gianfranco D / Green, Richard M / Sosa-Pineda, Beatriz / Shah, Ramille N

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 923

    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26508-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lipid nanoparticles for oral delivery of nucleic acids for treating inflammatory bowel disease.

    Yang, Chunhua / Alpini, Gianfranco / Glaser, Shannon / Merlin, Didier

    Nanomedicine (London, England)

    2022  Volume 17, Issue 21, Page(s) 1501–1504

    MeSH term(s) Humans ; Nucleic Acids/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Colitis, Ulcerative ; Nanoparticles
    Chemical Substances Lipid Nanoparticles ; Nucleic Acids
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm-2022-0222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6617: Show issues Location:
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  5. Article ; Online: Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease.

    Martínez, Allyson K / Glaser, Shannon S

    Hepatology (Baltimore, Md.)

    2014  Volume 60, Issue 6, Page(s) 1809–1811

    MeSH term(s) Apoptosis ; Bile Ducts, Intrahepatic/enzymology ; Fatty Acids, Nonesterified/adverse effects ; Fatty Liver/etiology ; Humans ; Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Fatty Acids, Nonesterified ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2014-10-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.27341
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    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer.

    Roy, Sukanya / Banerjee, Priyanka / Ekser, Burcin / Bayless, Kayla / Zawieja, David / Alpini, Gianfranco / Glaser, Shannon S / Chakraborty, Sanjukta

    The American journal of pathology

    2021  Volume 191, Issue 12, Page(s) 2052–2063

    Abstract: Increased lymphangiogenesis and lymph node metastasis, the important prognostic indicators of aggressive hepatobiliary malignancies such as hepatocellular cancer and cholangiocarcinoma, are associated with poor patient outcome. The liver produces 25% to ... ...

    Abstract Increased lymphangiogenesis and lymph node metastasis, the important prognostic indicators of aggressive hepatobiliary malignancies such as hepatocellular cancer and cholangiocarcinoma, are associated with poor patient outcome. The liver produces 25% to 50% of total lymphatic fluid in the body and has a dense network of lymphatic vessels. The lymphatic system plays critical roles in fluid homeostasis and inflammation and immune response. Yet, lymphatic vessel alterations and function are grossly understudied in the context of liver pathology. Expansion of the lymphatic network has been documented in clinical samples of liver cancer; and although largely overlooked in the liver, tumor-induced lymphangiogenesis is an important player, increasing tumor metastasis in several cancers. This review aims to provide a detailed perspective on the current knowledge of alterations in the hepatic lymphatic system during liver malignancies, as well as various molecular signaling mechanisms and growth factors that may provide future targets for therapeutic intervention. In addition, the review also addresses current mechanisms and bottlenecks for effective therapeutic targeting of tumor-associated lymphangiogenesis.
    MeSH term(s) Animals ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/therapy ; Bile Ducts, Intrahepatic/pathology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/therapy ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Lymphangiogenesis/genetics ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology ; Lymphatic Metastasis/therapy ; Lymphatic Vessels/pathology ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Signal Transduction/genetics ; Signal Transduction/physiology
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2021.08.011
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    Ud II Zs.76: Show issues Location:
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  7. Article ; Online: Biliary atresia: is lack of innate immune response tolerance key to pathogenesis?

    Glaser, Shannon S

    Liver international : official journal of the International Association for the Study of the Liver

    2008  Volume 28, Issue 5, Page(s) 587–588

    MeSH term(s) Bile Ducts, Intrahepatic/immunology ; Biliary Atresia/immunology ; Biliary Atresia/virology ; Humans ; Immune Tolerance ; Immunity, Innate ; Poly I-C ; RNA, Double-Stranded/immunology
    Chemical Substances RNA, Double-Stranded ; Poly I-C (O84C90HH2L)
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/j.1478-3231.2008.01752.x
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    Zs.A 1632: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.

    Medford, Abigail / Childs, Jonathan / Little, Ashleigh / Chakraborty, Sanjukta / Baiocchi, Leonardo / Alpini, Gianfranco / Glaser, Shannon

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 4, Page(s) 949–957

    Abstract: The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated ... ...

    Abstract The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis.

    Sato, Keisaku / Pham, Linh / Glaser, Shannon / Francis, Heather / Alpini, Gianfranco

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 15, Issue 3, Page(s) 803–805

    MeSH term(s) Humans ; Hepatocytes ; Hepatitis ; Inflammation
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Preparation and Characterization of IL-22 mRNA-loaded Lipid Nanoparticles.

    Alghoul, Zahra / Sung, Junsik / Wu, Kenji / Alpini, Gianfranco / Glaser, Shannon / Yang, Chunhua / Merlin, Didier

    Bio-protocol

    2023  Volume 13, Issue 7, Page(s) e4647

    Abstract: Interleukin-22 (IL-22) has been demonstrated as a critical regulator of epithelial homeostasis and repair; it showed an anti-inflammatory effect against ulcerative colitis. Local microinjection of IL-22 cDNA vector has been shown to be effective in ... ...

    Abstract Interleukin-22 (IL-22) has been demonstrated as a critical regulator of epithelial homeostasis and repair; it showed an anti-inflammatory effect against ulcerative colitis. Local microinjection of IL-22 cDNA vector has been shown to be effective in treating ulcerative colitis in mouse models. However, microinjection comes with multiple technical challenges for routine colon-targeted drug delivery. In contrast, oral administration can get around these challenges and provide comparable efficacy. We showed in previous studies that oral administration of new lipid nanoparticles (nLNP)-encapsulated IL-22 mRNA targets the colon region and efficiently ameliorates colitis. This protocol describes the details of preparing and characterizing the nLNP-encapsulated IL-22 mRNA using three major lipids that mimic the natural ginger-derived nanoparticles. It provides an nLNP platform that can be used to orally deliver other types of nucleic acids to the colon.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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