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  1. Article: Ethical considerations underpinning the donation of live, non-regenerative organs.

    Olbourne, N A

    Journal of law and medicine

    2001  Volume 9, Issue 1, Page(s) 76–79

    Abstract: The recent donation of a kidney to one of Australia's most prominent citizens by a long-time friend and employee has brought to attention the problems of access facing patients who require renal transplantation as a life-saving measure. The lack of ... ...

    Abstract The recent donation of a kidney to one of Australia's most prominent citizens by a long-time friend and employee has brought to attention the problems of access facing patients who require renal transplantation as a life-saving measure. The lack of availability of cadaver organs, the improved techniques available to minimise tissue rejection and the potential to genetically engineer tissue-compatible individuals for future organ donation have generated an interest in the ethical and legal considerations that underlie live organ donation.
    MeSH term(s) Australia ; Ethics, Medical ; Humans ; Kidney Transplantation ; Living Donors
    Language English
    Publishing date 2001-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1236328-5
    ISSN 1320-159X
    ISSN 1320-159X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4288: Show issues Location:
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  2. Article: Re: Factors affecting the rupture of silicone-gel breast implants.

    Olbourne, N A

    Annals of plastic surgery

    1994  Volume 33, Issue 4, Page(s) 462–463

    MeSH term(s) Breast Implants/adverse effects ; Female ; Humans ; Prosthesis Failure ; Silicones
    Chemical Substances Silicones
    Language English
    Publishing date 1994-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/00000637-199410000-00023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes.

    Botting, Rachel A / Bertram, Kirstie M / Baharlou, Heeva / Sandgren, Kerrie J / Fletcher, James / Rhodes, Jake W / Rana, Hafsa / Plasto, Toby M / Wang, Xin Maggie / Lim, Jake J K / Barnouti, Laith / Kohout, Mark P / Papadopoulos, Tim / Merten, Steve / Olbourne, Norman / Cunningham, Anthony L / Haniffa, Muzlifah / Harman, Andrew N

    Journal of leukocyte biology

    2017  Volume 101, Issue 6, Page(s) 1393–1403

    Abstract: Mononuclear phagocytes are present in skin and mucosa and represent one of the first lines of defense against invading pathogens, which they detect via an array of pathogen-binding receptors expressed on their surface. However, their extraction from ... ...

    Abstract Mononuclear phagocytes are present in skin and mucosa and represent one of the first lines of defense against invading pathogens, which they detect via an array of pathogen-binding receptors expressed on their surface. However, their extraction from tissue is difficult, and the isolation technique used has functional consequences on the cells obtained. Here, we compare mononuclear phagocytes isolated from human skin using either enzymatic digestion or spontaneous migration. Cells isolated via enzymatic digestion are in an immature state, and all subsets are easily defined. However, cells isolated by spontaneous migration are in a mature state, and CD141 cross-presenting DCs (cDC1) are more difficult to define. Different pathogen-binding receptors are susceptible to cleavage by blends of collagenase, demonstrating that great care must be taken in choosing the correct enzyme blend to digest tissue if carrying out pathogen-interaction assays. Finally, we have optimized mononuclear phagocyte culture conditions to enhance their survival after liberation from the tissue.
    MeSH term(s) Cell Movement ; Cell Separation/methods ; Enzymes/metabolism ; Humans ; Monocytes/cytology ; Monocytes/immunology ; Monocytes/metabolism ; Phagocytes/cytology ; Phagocytes/immunology ; Phagocytes/metabolism ; Phenotype ; Skin/cytology ; Skin/immunology ; Skin/metabolism
    Chemical Substances Enzymes
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.4A1116-496R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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  4. Article ; Online: Inhibition of two temporal phases of HIV-1 transfer from primary Langerhans cells to T cells: the role of langerin.

    Nasr, Najla / Lai, Joey / Botting, Rachel A / Mercier, Sarah K / Harman, Andrew N / Kim, Min / Turville, Stuart / Center, Rob J / Domagala, Teresa / Gorry, Paul R / Olbourne, Norman / Cunningham, Anthony L

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 193, Issue 5, Page(s) 2554–2564

    Abstract: Epidermal Langerhans cells (eLCs) uniquely express the C-type lectin receptor langerin in addition to the HIV entry receptors CD4 and CCR5. They are among the first target cells to encounter HIV in the anogenital stratified squamous mucosa during sexual ... ...

    Abstract Epidermal Langerhans cells (eLCs) uniquely express the C-type lectin receptor langerin in addition to the HIV entry receptors CD4 and CCR5. They are among the first target cells to encounter HIV in the anogenital stratified squamous mucosa during sexual transmission. Previous reports on the mechanism of HIV transfer to T cells and the role of langerin have been contradictory. In this study, we examined HIV replication and langerin-mediated viral transfer by authentic immature eLCs and model Mutz-3 LCs. eLCs were productively infected with HIV, whereas Mutz-3 LCs were not susceptible because of a lack of CCR5 expression. Two successive phases of HIV viral transfer to T cells via cave/vesicular trafficking and de novo replication were observed with eLCs as previously described in monocyte-derived or blood dendritic cells, but only first phase transfer was observed with Mutz-3 LCs. Langerin was expressed as trimers after cross-linking on the cell surface of Mutz-3 LCs and in this form preferentially bound HIV envelope protein gp140 and whole HIV particles via the carbohydrate recognition domain (CRD). Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog. However, the langerin homolog did not inhibit direct HIV infection of T cells. These two novel soluble langerin inhibitors could be developed to prevent HIV uptake, infection, and subsequent transfer to T cells during early stages of infection.
    MeSH term(s) Antigens, CD/immunology ; Biological Transport/immunology ; HIV Infections/immunology ; HIV Infections/pathology ; HIV-1/physiology ; Humans ; Langerhans Cells/immunology ; Langerhans Cells/pathology ; Langerhans Cells/virology ; Lectins, C-Type/antagonists & inhibitors ; Lectins, C-Type/immunology ; Mannose-Binding Lectins/antagonists & inhibitors ; Mannose-Binding Lectins/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes/virology ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/immunology
    Chemical Substances Antigens, CD ; CD207 protein, human ; Lectins, C-Type ; Mannose-Binding Lectins ; env Gene Products, Human Immunodeficiency Virus ; gp140 envelope protein, Human immunodeficiency virus 1
    Language English
    Publishing date 2014-09-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1400630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  5. Article: Congenital urethral fistula. Case reports.

    Olbourne, N A

    Plastic and reconstructive surgery

    1976  Volume 57, Issue 2, Page(s) 237–239

    Abstract: Two new cases of congenital urethral fistula are reported, and the literature on the subject is reviewed. The embryology is discussed and applied to the recorded examples of the abnormality in an attempt to understand the mechanism of their formation. ...

    Abstract Two new cases of congenital urethral fistula are reported, and the literature on the subject is reviewed. The embryology is discussed and applied to the recorded examples of the abnormality in an attempt to understand the mechanism of their formation.
    MeSH term(s) Humans ; Infant ; Male ; Urethral Diseases/congenital ; Urethral Diseases/surgery ; Urinary Fistula/congenital ; Urinary Fistula/surgery
    Language English
    Publishing date 1976-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/00006534-197602000-00027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 293: Show issues

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  6. Article ; Online: Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin.

    Kim, Min / Truong, Naomi R / James, Virginia / Bosnjak, Lidija / Sandgren, Kerrie J / Harman, Andrew N / Nasr, Najla / Bertram, Kirstie M / Olbourne, Norman / Sawleshwarkar, Shailandra / McKinnon, Kaylene / Cohen, Ralph C / Cunningham, Anthony L

    PLoS pathogens

    2015  Volume 11, Issue 4, Page(s) e1004812

    Abstract: The mechanism by which immunity to Herpes Simplex Virus (HSV) is initiated is not completely defined. HSV initially infects mucosal epidermis prior to entering nerve endings. In mice, epidermal Langerhans cells (LCs) are the first dendritic cells (DCs) ... ...

    Abstract The mechanism by which immunity to Herpes Simplex Virus (HSV) is initiated is not completely defined. HSV initially infects mucosal epidermis prior to entering nerve endings. In mice, epidermal Langerhans cells (LCs) are the first dendritic cells (DCs) to encounter HSV, but it is CD103(+) dermal DCs that carry viral antigen to lymph nodes for antigen presentation, suggesting DC cross-talk in skin. In this study, we compared topically HSV-1 infected human foreskin explants with biopsies of initial human genital herpes lesions to show LCs are initially infected then emigrate into the dermis. Here, LCs bearing markers of maturation and apoptosis formed large cell clusters with BDCA3(+) dermal DCs (thought to be equivalent to murine CD103(+) dermal DCs) and DC-SIGN(+) DCs/macrophages. HSV-expressing LC fragments were observed inside the dermal DCs/macrophages and the BDCA3(+) dermal DCs had up-regulated a damaged cell uptake receptor CLEC9A. No other infected epidermal cells interacted with dermal DCs. Correspondingly, LCs isolated from human skin and infected with HSV-1 in vitro also underwent apoptosis and were taken up by similarly isolated BDCA3(+) dermal DCs and DC-SIGN(+) cells. Thus, we conclude a viral antigen relay takes place where HSV infected LCs undergo apoptosis and are taken up by dermal DCs for subsequent antigen presentation. This provides a rationale for targeting these cells with mucosal or perhaps intradermal HSV immunization.
    MeSH term(s) Cell Movement ; Dendritic Cells/virology ; Flow Cytometry ; Herpesvirus 1, Human/physiology ; Humans ; Langerhans Cells/virology ; Microscopy, Fluorescence ; Simplexvirus/pathogenicity ; Skin/virology
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1004812
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  7. Article: Choledochal cysts. A review of the cystic anomalies of the biliary tree.

    Olbourne, N A

    Annals of the Royal College of Surgeons of England

    1975  Volume 56, Issue 1, Page(s) 26–32

    Abstract: Congenital cysts of the biliary tree, although uncommon, are being reported in increasing numbers. The widely accepted classification would seem to warrant modification in the light of recent observations. The clinical spectrum of the condition is ... ...

    Abstract Congenital cysts of the biliary tree, although uncommon, are being reported in increasing numbers. The widely accepted classification would seem to warrant modification in the light of recent observations. The clinical spectrum of the condition is reviewed, together with the surgical approach to treatment and its indications and complications.
    MeSH term(s) Adolescent ; Aged ; Biliary Tract Diseases/classification ; Biliary Tract Diseases/diagnosis ; Biliary Tract Diseases/surgery ; Common Bile Duct ; Cysts/classification ; Cysts/diagnosis ; Cysts/surgery ; Drainage ; Female ; Humans ; Male ; Pregnancy ; Sex Factors
    Language English
    Publishing date 1975-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
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  8. Article: Rotation flap for distal nasal defects.

    Olbourne, N A / Kraaijenhagen, J H

    British journal of plastic surgery

    1975  Volume 28, Issue 1, Page(s) 64–66

    MeSH term(s) Female ; Humans ; Male ; Nose/surgery ; Nose Neoplasms/surgery ; Rotation ; Skin Transplantation ; Transplantation, Autologous/methods
    Language English
    Publishing date 1975-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 218112-5
    ISSN 0007-1226
    ISSN 0007-1226
    DOI 10.1016/s0007-1226(75)90154-x
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  9. Article: Percutaneous antegrade urography--a valuable aid in the diagnosis of renal tract pathology.

    Butcher, C / Olbourne, N A

    Australasian radiology

    1974  Volume 18, Issue 3, Page(s) 308–313

    MeSH term(s) Aged ; Carcinoma, Transitional Cell/diagnostic imaging ; Carcinoma, Transitional Cell/pathology ; Humans ; Male ; Ureter/pathology ; Ureteral Neoplasms/diagnostic imaging ; Ureteral Neoplasms/pathology ; Urography/methods ; Urologic Diseases/diagnostic imaging
    Language English
    Publishing date 1974-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 603966-2
    ISSN 0004-8461
    ISSN 0004-8461
    DOI 10.1111/j.1440-1673.1974.tb01880.x
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    Zs.B 66: Show issues Location:
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  10. Article: Malignant melanoma in childhood.

    Olbourne, N A / Harrison, S H

    British journal of plastic surgery

    1974  Volume 27, Issue 4, Page(s) 305–307

    MeSH term(s) Biopsy ; Child, Preschool ; Female ; Humans ; Lung Neoplasms ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Lymphocytes/metabolism ; Melanoma/radiotherapy ; Melanoma/surgery ; Melanoma/therapy ; Neoplasm Metastasis ; Nevus/pathology ; Skin Neoplasms ; Skull ; Skull Neoplasms
    Language English
    Publishing date 1974-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 218112-5
    ISSN 0007-1226
    ISSN 0007-1226
    DOI 10.1016/0007-1226(74)90026-5
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