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Article: The Sigma-1 Receptor in Cellular Stress Signaling.

Hayashi, Teruo

2019 Volume 13, Page(s) 733

Abstract: After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs. It ... ...

Abstract	After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs. It forms a complex with the ER chaperone BiP that controls specific signaling molecules' stability and function at the ER to regulate Ca
Language	English
Publishing date	2019-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.00733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Elderly Patient Developed Ulcerative Colitis after SARS-CoV-2 mRNA Vaccination: A Case Report and Review of the Literature.

Shimada, Takahito / Takada, Jun / Baba, Atsushi / Iwashita, Masahide / Hayashi, Takao / Maeda, Teruo / Shimizu, Masahito

Internal medicine (Tokyo, Japan)

2024 Volume 63, Issue 6, Page(s) 809–814

Abstract: An 86-year-old man presented to our hospital with symptoms of diarrhea and bloody stool, which had manifested two weeks after receiving his third severe acute respiratory syndrome coronavirus 2 mRNA vaccination. Colonoscopy revealed diffuse, rough- ... ...

Abstract	An 86-year-old man presented to our hospital with symptoms of diarrhea and bloody stool, which had manifested two weeks after receiving his third severe acute respiratory syndrome coronavirus 2 mRNA vaccination. Colonoscopy revealed diffuse, rough-surfaced mucosa extending from the ascending colon to the rectum. Despite attempting probiotic treatment, the patient's condition did not improve, leading to admission. Endoscopic findings at admission worsened. Based on endoscopic and histopathological findings, the patient was diagnosed with ulcerative colitis. Corticosteroids and 5-aminosalicylic acid were administered, and the clinical symptoms improved. Subsequently, the disease worsened during steroid tapering, and filgotinib was added, leading to steroid-free remission.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Colitis, Ulcerative/diagnosis ; SARS-CoV-2 ; COVID-19/complications ; COVID-19/diagnosis ; Vaccination ; RNA, Messenger
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2024-01-02
Publishing country	Japan
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2891-23
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Article ; Online: Conversion of psychological stress into cellular stress response: roles of the sigma-1 receptor in the process.

Hayashi, Teruo

Psychiatry and clinical neurosciences

2015 Volume 69, Issue 4, Page(s) 179–191

Abstract: Psychiatrists empirically recognize that excessive or chronic psychological stress can result in long-lasting impairments of brain functions that partly involve neuronal cell damage. Recent studies begin to elucidate the molecular pathways activated/ ... ...

Abstract	Psychiatrists empirically recognize that excessive or chronic psychological stress can result in long-lasting impairments of brain functions that partly involve neuronal cell damage. Recent studies begin to elucidate the molecular pathways activated/inhibited by psychological stress. Activation of the hypothalamic-pituitary-adrenal axis under psychological stress causes inflammatory oxidative stresses in the brain, in part due to elevation of cytokines. Psychological stress or neuropathological conditions (e.g., accumulation of β-amyloids) trigger 'cellular stress responses', which promote upregulation of molecular chaperones to protect macromolecules from degradation. The unfolded protein response, the endoplasmic reticulum (ER)-specific cellular stress response, has been recently implicated in the pathophysiology of neuropsychiatric disorders and the pharmacology of certain clinically used drugs. The sigma-1 receptor is an ER protein whose ligands are shown to exert antidepressant-like and neuroprotective actions. Recent studies found that the sigma-1 receptor is a novel ligand-operated ER chaperone that regulates bioenergetics, free radical generation, oxidative stress, unfolded protein response and cytokine signaling. The sigma-1 receptor also regulates morphogenesis of neuronal cells, such as neurite outgrowth, synaptogenesis, and myelination, which can be perturbed by cellular stress. The sigma-1 receptor may thus contribute to a cellular defense system that protects nervous systems against chronic psychological stress. Findings from sigma receptor research imply that not only cell surface monoamine effectors but also intracellular molecules, especially those at the ER, may provide novel therapeutic targets for future drug developments.
MeSH term(s)	Animals ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Molecular Sequence Data ; Oxidative Stress/physiology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology ; Receptors, sigma/metabolism ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology ; Sigma-1 Receptor
Chemical Substances	Receptors, sigma
Language	English
Publishing date	2015-02-16
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.12262
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Article ; Online: Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs.

Hayashi, Teruo

Journal of pharmacological sciences

2014 Volume 127, Issue 1, Page(s) 2–5

Abstract: Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer. Recent research exploring the molecular function of the sigma-1 ... ...

Abstract	Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer. Recent research exploring the molecular function of the sigma-1 receptor started unveiling underlying mechanisms of the therapeutic activity of those ligands. Via the molecular chaperone activity, the sigma-1 receptor regulates protein folding/degradation, ER/oxidative stress, and cell survival. The chaperone activity is activated or inhibited by synthetic sigma-1 receptor ligands in an agonist-antagonist manner. Sigma-1 receptors are localized at the endoplasmic reticulum (ER) membranes that are physically associated with the mitochondria (MAM: mitochondria-associated ER membrane). In specific types of neurons (e.g., those at the spinal cord), sigma-1 receptors are also clustered at ER membranes that juxtapose postsynaptic plasma membranes. Recent studies indicate that sigma-1 receptors, partly in sake of its unique subcellular localization, regulate the mitochondria function that involves bioenergetics and free radical generation. The sigma-1 receptor may thus provide an intracellular drug target that enables controlling ER stress and free radical generation under pathological conditions.
MeSH term(s)	Animals ; Endoplasmic Reticulum/metabolism ; Humans ; Mitochondria/metabolism ; Models, Biological ; Molecular Chaperones/agonists ; Molecular Chaperones/antagonists & inhibitors ; Molecular Chaperones/metabolism ; Molecular Chaperones/physiology ; Psychotropic Drugs/pharmacology ; Receptors, sigma/agonists ; Receptors, sigma/antagonists & inhibitors ; Receptors, sigma/metabolism ; Signal Transduction/physiology ; Sigma-1 Receptor
Chemical Substances	Molecular Chaperones ; Psychotropic Drugs ; Receptors, sigma
Language	English
Publishing date	2014-12-09
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2014.07.001
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Article ; Online: Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant

Motoyama, Takayuki / Kondoh, Yasumitsu / Shimizu, Takeshi / Hayashi, Teruo / Honda, Kaori / Uchida, Motoko / Osada, Hiroyuki

Journal of agricultural and food chemistry

2022 Volume 70, Issue 10, Page(s) 3109–3116

Abstract: Melanin is a secondary metabolite required for the infection of the rice blast ... ...

Abstract	Melanin is a secondary metabolite required for the infection of the rice blast fungus
MeSH term(s)	Ascomycota ; Hydro-Lyases/metabolism ; Magnaporthe ; Melanins ; Oryza/metabolism ; Plant Diseases/microbiology
Chemical Substances	Melanins ; Hydro-Lyases (EC 4.2.1.-) ; scytalone dehydratase (EC 4.2.1.94)
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.1c04984
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Article ; Online: A case of congenital single testis with testicular cancer patient and azoospermia who was able to collect spermatozoa with ipsilateral Onco‐TESE

Kazumasa Hayashi / Teruo Inamoto / Haruhito Azuma / Hiroshi Masuda / Hirotsugu Oku

Clinical Case Reports, Vol 9, Iss 1, Pp 535-

2021 Volume 539

Abstract: Abstract Onco‐TESE is a useful strategy for cancer patients with a congenital single testis who wish to preserve their fertility. ...

Abstract	Abstract Onco‐TESE is a useful strategy for cancer patients with a congenital single testis who wish to preserve their fertility.
Keywords	cancer patient ; congenital single testis ; Onco‐TESE ; testicular cancer ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A case of congenital single testis with testicular cancer patient and azoospermia who was able to collect spermatozoa with ipsilateral Onco-TESE.

Hayashi, Kazumasa / Inamoto, Teruo / Azuma, Haruhito / Masuda, Hiroshi / Oku, Hirotsugu

Clinical case reports

2020 Volume 9, Issue 1, Page(s) 535–539

Abstract: Onco-TESE is a useful strategy for cancer patients with a congenital single testis who wish to preserve their fertility. ...

Abstract	Onco-TESE is a useful strategy for cancer patients with a congenital single testis who wish to preserve their fertility.
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3576
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Article: Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae

Motoyama, Takayuki / Kondoh, Yasumitsu / Shimizu, Takeshi / Hayashi, Teruo / Honda, Kaori / Uchida, Motoko / Osada, Hiroyuki

Journal of agricultural and food chemistry. 2022 Mar. 02, v. 70, no. 10

2022

Abstract: Melanin is a secondary metabolite required for the infection of the rice blast fungus Pyricularia oryzae. Melanin biosynthesis enzymes are targets for controlling rice blast disease, and three types of commercial melanin biosynthesis inhibitors (MBIs) ... ...

Abstract	Melanin is a secondary metabolite required for the infection of the rice blast fungus Pyricularia oryzae. Melanin biosynthesis enzymes are targets for controlling rice blast disease, and three types of commercial melanin biosynthesis inhibitors (MBIs) including MBI-R, MBI-D, and MBI-P have been developed. However, the occurrence of MBI-D-resistant strains containing scytalone dehydratase (SDH1/RSY1) with V75M mutations has been recently reported. In this study, we aimed to identify inhibitors of SDH1-V75M. We screened the RIKEN Natural Products Depository chemical library using chemical array technology and evaluated the inhibition of SDH1-V75M by candidate compounds. NPD13731 strongly inhibited the activity of wild-type and mutant SDH1. The structure–activity relationship data were used to create a more potent inhibitor 16, which controlled rice blast disease in rice plants infected with MBI-D-resistant P. oryzae. Compound 16, which we named melabiostin, may be used to develop fungicides for controlling rice blast infections.
Keywords	Magnaporthe oryzae ; biosynthesis ; blast disease ; food chemistry ; fungi ; melanin ; mutants ; rice ; secondary metabolites ; structure-activity relationships
Language	English
Dates of publication	2022-0302
Size	p. 3109-3116.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.1c04984
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of a Psychoeducation Program for People with Schizophrenia Aimed at Increasing Subjective Well-Being and the Factors Influencing Those Effects: a Preliminary Study.

Shinozaki, Ayumi / Hayashi, Teruo / Okamura, Hitoshi

The Psychiatric quarterly

2019 Volume 91, Issue 1, Page(s) 45–52

Abstract: There have been no intervention studies of psychoeducation programs for schizophrenia that focus on improving subjective well-being or studies to determine the factors influencing such effects. This study aimed to examine the effects of a psychoeducation ...

Abstract	There have been no intervention studies of psychoeducation programs for schizophrenia that focus on improving subjective well-being or studies to determine the factors influencing such effects. This study aimed to examine the effects of a psychoeducation program combining traditional psychoeducation with a focus on providing knowledge and information and a new intervention to raise patients' subjective well-being and to clarity the factors affecting the program's efficacy. Subjects were 117 patients who participated in a psychoeducation program for schizophrenia between 2012 and 2018. In addition to comparing subjective well-being (Subjective Well-being under Neuroleptic Drug Treatment Short Form, Japanese version, SWNS-J) and attitudes towards drugs (Drug Attitude Inventory-10, DAI-10) before and after the program, basic information such as psychiatric symptoms was surveyed. The factors influencing the effects of the program were assessed with multiple regression analysis. Scores for SWNS-J subscales and total SWNS-J score increased significantly after the program. Higher total scores on subjective well-being after the program were significantly associated with having less severe negative symptoms and higher total subjective well-being before the program, and with more positive attitudes toward drugs after the program. These results suggest that intervention with a focus on improving subjective well-being can be an effective part of psychoeducation programs for patients with schizophrenia. The results also suggest that the level of improvement in subjective well-being gained from the program may be higher in patients with milder negative symptoms and patients with a better understanding of drug treatment.
MeSH term(s)	Adult ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Patient Education as Topic ; Personal Satisfaction ; Psychotherapy ; Schizophrenia/physiopathology ; Schizophrenia/rehabilitation ; Schizophrenic Psychology
Language	English
Publishing date	2019-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	207521-0
ISSN	1573-6709 ; 0033-2720
ISSN (online)	1573-6709
ISSN	0033-2720
DOI	10.1007/s11126-019-09679-4
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Article ; Online: Implementing the individual placement and support model of supported employment in Japan: Barriers and strategies.

Hayashi, Teruo / Yamaguchi, Sosei / Sato, Sayaka

Psychiatric rehabilitation journal

2019 Volume 43, Issue 1, Page(s) 53–59

Abstract: Objective: In spite of the effectiveness of the individual placement and support model of supported employment (IPS) for the recovery of people with mental illness, the implementation and dissemination of IPS in Japan have not been straightforward. This ...

Abstract	Objective: In spite of the effectiveness of the individual placement and support model of supported employment (IPS) for the recovery of people with mental illness, the implementation and dissemination of IPS in Japan have not been straightforward. This paper summarizes barriers against the implementation of IPS in Japan and discusses potential strategies to overcome them. Method: We reviewed IPS research performed in Japan through literature search, and summarized current employment services and policies in Japan along with a practice report of an ongoing IPS program in a local city in Japan. Results: Barriers against the implementation of IPS in Japan included: (a) systems designed mainly for group-based services, (b) weak recognition of IPS, and (c) cultural background. Nevertheless, we identified 4 intervention studies of IPS in Japanese settings, and all found that more than 40% of the participants gained their employment through IPS. By utilizing available services, the IPE program in Hamada City achieved ∼50% employment rate and sufficient fidelity. Conclusions and implications for practice: The present data indicate that, by combining currently available services, IPS can be implemented successfully in Japan. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
MeSH term(s)	Employment, Supported ; Humans ; Japan ; Program Development ; Psychiatric Rehabilitation ; Rehabilitation, Vocational
Language	English
Publishing date	2019-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2070454-9
ISSN	1559-3126 ; 1095-158X
ISSN (online)	1559-3126
ISSN	1095-158X
DOI	10.1037/prj0000394
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