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  1. Article: Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002.

    Goldstein, Joseph L / Brown, Michael S

    The Journal of clinical investigation

    2002  Volume 110, Issue 12, Page(s) S11–3

    MeSH term(s) Animals ; Awards and Prizes ; Biomedical Research ; Cholesterol/metabolism ; Education, Medical ; Humans ; Societies, Scientific ; United States
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2002-12-19
    Publishing country United States
    Document type Address
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/jci120038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Michael S. Brown, MD and Joseph L. Goldstein, MD. 1985 Nobel laureates in medicine.

    Brown, M S / Goldstein, J L

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    1996  Volume 44, Issue 2, Page(s) 14–23

    Abstract: When Michael S. Brown, MD and Joseph L. Goldstein, MD first met as interns at the Massachusetts ... with myocardial infarction, Brown and Goldstein, who relocated to the University of Texas Southwestern Medical Center in 1972 ... the Nobel Prize in Medicine in 1985. Today, as Regental Professors of the University of Texas, Brown and Goldstein ...

    Abstract When Michael S. Brown, MD and Joseph L. Goldstein, MD first met as interns at the Massachusetts General Hospital in 1966, they could hardly have imagined that their careers would continue to be intertwined some 30 years later. It was shortly following their arrival as clinical associates at the National Institutes of Health in 1968 that the pair developed an interest in abnormalities of cholesterol metabolism. Bolstered by epidemiologic data that showed elevated cholesterol levels in many patients with myocardial infarction, Brown and Goldstein, who relocated to the University of Texas Southwestern Medical Center in 1972, began a search for receptors important in cholesterol homeostasis. These studies, performed in their early stages while juggling clinical duties at Parkland Hospital, culminated in a series of scientific achievements which merited among other honors the Hazen Award in 1982, the Lasker Award in 1985, and the Nobel Prize in Medicine in 1985. Today, as Regental Professors of the University of Texas, Brown and Goldstein head a laboratory group which continues to test the cutting edge of medical research. Although impressed with the pace of technological advances in biology, the declining role of clinically oriented physicians in biomedical research troubles the pair. Interviewed in their library in Dallas, Brown and Goldstein spoke about the complicated balance of science, medicine, and education necessary to produce another generation of successful investigators.
    MeSH term(s) Cholesterol/metabolism ; Education, Medical ; Homeostasis ; Humans ; Nobel Prize ; Research Support as Topic ; Science
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 1996-02
    Publishing country England
    Document type Interview
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 1081-5589 ; 0009-9279
    ISSN (online) 1708-8267
    ISSN 1081-5589 ; 0009-9279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman.

    Lefkowitz, Robert / Goldstein, Joseph / Brown, Michael

    The Journal of clinical investigation

    2012  Volume 122, Issue 5, Page(s) 1586–1587

    MeSH term(s) Clinical Medicine/history ; History, 20th Century ; Lipid Metabolism ; Nobel Prize ; Physiology/history ; United States
    Language English
    Publishing date 2012-06-01
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Interview ; Portrait
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/jci64244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How the JCI's most-cited paper sparked the field of lipoprotein research.

    Brown, Michael S / Goldstein, Joseph L

    The Journal of clinical investigation

    2024  Volume 134, Issue 4

    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI177475
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  5. Book ; Online ; E-Book: Standards for ocular toxicology and inflammation

    Gilger, Brian C. / Cook, Cynthia S. / Brown, Michael H.

    2018  

    Author's details Brian C. Gilger, Cynthia S. Cook, Michael H. Brown editors
    Keywords Medicine ; Pharmacology ; Ophthalmology
    Language English
    Size 1 Online-Ressource (ix, 212 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019828183
    ISBN 978-3-319-78364-2 ; 9783319783635 ; 3-319-78364-5 ; 3319783637
    DOI 10.1007/978-3-319-78364-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Online ; E-Book: Ballweg's physician assistant

    Ritsema, Tamara S. / Brown, Darwin / Vetrosky, Daniel T. / Coplan, Bettie / MacLean, Michael J. / Zaweski, Joseph / Ballweg, Ruth

    a guide to clinical practice

    (ClinicalKey)

    2021  

    Abstract: Designed as a highly visual and practical resource to be used across the spectrum of lifelong learning, Ballweg's Physician Assistant, 7th Edition, helps you master all the core competencies needed for physician assistant certification, recertification, ...

    Author's details senior editors, Tamara S. Ritsema, Darwin L. Brown, Daniel T. Vetrosky; associate editors, Bettie Coplan, Michael J. MacLean, Joseph Zaweski; editor emeritus, Ruth Ballweg
    Series title ClinicalKey
    Abstract "Designed as a highly visual and practical resource to be used across the spectrum of lifelong learning, Ballweg's Physician Assistant, 7th Edition, helps you master all the core competencies needed for physician assistant certification, recertification, and clinical practice. It remains the only textbook that covers all aspects of the physician assistant profession, the PA curriculum, and the PA's role in clinical practice. Ideal for both students and practicing PAs, it features a succinct, bulleted writing style, convenient tables, practical case studies, and clinical application questions that enable you to master key concepts and clinical applications" --Provided by publisher.
    MeSH term(s) Physician Assistants. ; Clinical Competence. ; Professional Role. ; Delivery of Health Care/methods.
    Keywords Physicians' assistants ; Clinical competence
    Subject code 610.6953
    Language English
    Dates of publication 2021-2022
    Size 1 online resource (606 pages) :, illustrations (some color)
    Edition Seventh edition.
    Publisher Elsevier
    Publishing place St. Louis, Missouri
    Document type Book ; Online ; E-Book
    Note Previous edition: Physician assistant : a guide to clinical practice / [edited by] Ruth Ballweg, Darwin Brown, Daniel T. Vetrosky, Tamara S. Ritsema. Sixth edition. 2018.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-69581-7 ; 0-323-65416-9 ; 978-0-323-69581-7 ; 978-0-323-65416-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Politics and the Public Health Workforce: Lessons Suggested from a Five-State Study.

    Sparer, Michael S / Brown, Lawrence D

    The Milbank quarterly

    2023  Volume 101, Issue 3, Page(s) 815–840

    Abstract: Policy Points The United States public health system relies on an inadequate and inefficient mix of federal, state, and local funding. Various state-based initiatives suggest that a promising path to bipartisan support for increased public health funding ...

    Abstract Policy Points The United States public health system relies on an inadequate and inefficient mix of federal, state, and local funding. Various state-based initiatives suggest that a promising path to bipartisan support for increased public health funding is to gain the support of local elected officials by providing state (and federal) funding directly to local health departments, albeit with performance strings attached. Even with more funding, we will not solve the nation's public health workforce crisis until we make public health a more attractive career path with fewer bureaucratic barriers to entry.
    Context: The COVID-19 pandemic exposed the shortcomings of the United States public health system. High on the list is a public health workforce that is understaffed, underpaid, and undervalued. To rebuild that workforce, the American Rescue Plan (ARP) appropriated $7.66 billion to help create 100,000 new public health jobs. As part of this initiative, the Centers for Disease Control and Prevention (CDC) distributed roughly $2 billion to state, local, tribal, and territorial health agencies for use between July 1, 2021, and June 30, 2023. At the same time, several states have enacted (or are considering enacting) initiatives to increase state funding for their local health departments with the goal of ensuring that these departments can deliver a core set of services to all residents. The differences in approach between this first round of ARP funding and theseparate state initiatives offer an opportunity to compare, contrast, and suggest lessons learned.
    Methods: After interviewing leaders at the CDC and other experts on the nation's public health workforce, we visited five states (Kentucky, Indiana, Mississippi, New York, and Washington) to examine, by means of interviews and documents, the implementation and impact of both the ARP workforce funds as well as the state-based initiatives.
    Findings: Three themes emerged. First, states are not spending the CDC workforce funding in a timely fashion; although the specifics vary, there are several organizational, political, and bureaucratic obstacles. Second, the state-based initiatives follow different political paths but rely on the same overarching strategy: gain the support of local elected officials by providing funding directly to local health departments, albeit with performance strings attached. These state initiatives offer their federal counterparts a political roadmap toward a more robust model of public health funding. Third, even with increased funding, we will not meet the nation's public health workforce challenges until we make public health a more attractive career path (with higher pay, improved working conditions, and more training and promotion opportunities) with fewer bureaucratic barriers to entry (most importantly, with less reliance on outdated civil service rules).
    Conclusion: The politics of public health requires a closer look at the role played by county commissioners, mayors, and other local elected officials. We need a political strategy to persuade these officials that their constituents will benefit from a better public health system.
    MeSH term(s) Humans ; United States ; Public Health ; Health Workforce ; Pandemics ; COVID-19/epidemiology ; COVID-19/prevention & control ; Workforce ; Politics
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632829-5
    ISSN 1468-0009 ; 0887-378X
    ISSN (online) 1468-0009
    ISSN 0887-378X
    DOI 10.1111/1468-0009.12657
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  8. Article ; Online: Court Intrusion Into Science and Medicine-The Mifepristone Decisions.

    Aaron, Daniel G / Brown, Teneille R / Sinha, Michael S

    JAMA

    2023  Volume 329, Issue 20, Page(s) 1735–1737

    MeSH term(s) Female ; Humans ; Pregnancy ; Abortion, Induced/legislation & jurisprudence ; Medicine ; Mifepristone/therapeutic use ; Supreme Court Decisions ; United States ; Science/legislation & jurisprudence ; Legislation, Medical
    Chemical Substances Mifepristone (320T6RNW1F)
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.7790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Little Bit More: Bitplane-Wise Bit-Depth Recovery.

    Punnappurath, Abhijith / Brown, Michael S

    IEEE transactions on pattern analysis and machine intelligence

    2022  Volume 44, Issue 12, Page(s) 9718–9724

    Abstract: Imaging sensors digitize incoming scene light at a dynamic range of 10-12 bits (i.e., 1024-4096 tonal values). The sensor image is then processed onboard the camera and finally quantized to only 8 bits (i.e., 256 tonal values) to conform to prevailing ... ...

    Abstract Imaging sensors digitize incoming scene light at a dynamic range of 10-12 bits (i.e., 1024-4096 tonal values). The sensor image is then processed onboard the camera and finally quantized to only 8 bits (i.e., 256 tonal values) to conform to prevailing encoding standards. There are a number of important applications, such as high-bit-depth displays and photo editing, where it is beneficial to recover the lost bit depth. Deep neural networks are effective at this bit-depth reconstruction task. Given the quantized low-bit-depth image as input, existing deep learning methods employ a single-shot approach that attempts to either (1) directly estimate the high-bit-depth image, or (2) directly estimate the residual between the high- and low-bit-depth images. In contrast, we propose a training and inference strategy that recovers the residual image bitplane-by-bitplane. Our bitplane-wise learning framework has the advantage of allowing for multiple levels of supervision during training and is able to obtain state-of-the-art results using a simple network architecture. We test our proposed method extensively on several image datasets and demonstrate an improvement from 0.5dB to 2.3dB PSNR over prior methods depending on the quantization level.
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2021.3125692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dirty bomb source term characterization and downwind dispersion: Review of experimental evidence.

    Brambilla, Sara / Nelson, Matthew A / Brown, Michael J

    Journal of environmental radioactivity

    2023  Volume 263, Page(s) 107166

    Abstract: ... One U.S. Government official has even described a dirty bomb attack as "all but inevitable ...

    Abstract Dirty bombs are considered one of the easiest forms of radiological terrorism, a form of terrorism based on the deliberate use of radiological material to cause adverse effects in a target population. One U.S. Government official has even described a dirty bomb attack as "all but inevitable". While people in the vicinity of the blast may experience acute radiation effects, people downwind may unknowingly be contaminated by the radioactive airborne particulate and face increased long-term cancer risk. The likelihood of increased cancer risk depends on the radionuclide used and its specific activity, its aerosolization potential, the particle sizes generated in the blast, and where a person is with respect to the detonation. Different studies have reported that plausible radionuclides for dirty bomb include
    MeSH term(s) Humans ; Nuclear Weapons ; Radiation Monitoring/methods ; Radiation Injuries ; Terrorism ; Neoplasms/complications
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1483112-0
    ISSN 1879-1700 ; 0265-931X
    ISSN (online) 1879-1700
    ISSN 0265-931X
    DOI 10.1016/j.jenvrad.2023.107166
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