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Article: A Clinical Perspective on Advanced Developments in Bone Biopsy Assessment in Rare Bone Disorders.

Treurniet, Sanne / Eekhoff, Elisabeth M W / Schmidt, Felix N / Micha, Dimitra / Busse, Björn / Bravenboer, Nathalie

2020 Volume 11, Page(s) 399

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Biopsy/methods ; Bone Diseases/diagnosis ; Fibrous Dysplasia of Bone/diagnosis ; Humans ; Loeys-Dietz Syndrome/diagnosis ; Myositis Ossificans/diagnosis ; Osteitis Deformans/diagnosis ; Osteogenesis Imperfecta/diagnosis ; Osteopetrosis/diagnosis ; Osteoporosis/diagnosis ; Rare Diseases/diagnosis
Language	English
Publishing date	2020-06-23
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2020.00399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Warning messages in crisis communication

Rahn, Maxi / Tomczyk, Samuel / Schopp, Nathalie / Schmidt, Silke

Frontiers in Psychology

Risk appraisal and warning compliance in severe weather, violent acts, and the COVID-19 pandemic

2021

Abstract: ... A cross-sectional survey examined 403 German participants from 18 to 89 years (M = 29.24; 72% female). Participants were ...

Title translation	Warnmeldungen in der Krisenkommunikation: Risikobewertung und Warnbefolgung bei Unwettern, Gewalttaten und der COVID-19-Pandemie (DeepL)
Abstract	Background: In crisis communication, warning messages are key to informing and galvanizing the public to prevent or mitigate damage. Therefore, this study examines how risk appraisal and individual characteristics influence the intention to comply with behavioral recommendations of a warning message regarding three hazard types: the COVID-19 pandemic, violent acts, and severe weather. Methods: A cross-sectional survey examined 403 German participants from 18 to 89 years (M = 29.24; 72% female). Participants were allocated to one of three hazard types (COVID-19 pandemic, violent acts, severe weather) and presented with warning messages that were previously issued via an official warning app. Four components of risk appraisal-perceived severity (PS), anticipated negative emotions (AE), anticipatory worry (AW), and risk perception (RP)-were assessed before and after presenting the warning message. Path models were calculated to predict the intention to comply with the warning message, controlling for age, gender, and previous hazard experience. Results: For the COVID-19 pandemic, higher age (beta = 0.18) predicted warning compliance (R-2 = 0.05). AE (beta = 0.20) predicted compliance in the case of violent acts (R-2 = 0.09). For severe weather, PS (beta = 0.28), age (beta = 0.29), and female gender (beta = 0.34) lead to higher compliance (R-2 = 0.27). Changes across risk appraisal components were not consistent, as some facets decreased after the receipt of a warning message. Discussion: Risk appraisal has shown a marginal yet differential influence on warning message compliance in different types of hazards. Regarding the COVID-19 pandemic, the impact of sociodemographic factors on compliance should be studied more intensively. Moreover, integrating intermediary variables, such as self-efficacy, is necessary.
Keywords	Behavioral Intention ; Bereitwilligkeit ; COVID-19 ; Cognitive Appraisal ; Compliance ; Extreme Weather ; Extremwetter ; Gewalt ; Kognitive Bewertung (Emotionspsychologie) ; Kommunikationsinhalte ; Messages ; Risikowahrnehmung ; Risk Perception ; Verhaltensabsicht ; Violence ; Warnings ; Warnungen
Language	English
Document type	Article
DOI	10.3389/fpsyg.2021.557178
Database	PSYNDEX

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Article ; Online: Cholesterol-modifying drugs in COVID-19.

Schmidt, Nathalie M / Wing, Peter A C / McKeating, Jane A / Maini, Mala K

Oxford open immunology

2020 Volume 1, Issue 1, Page(s) iqaa001

Abstract: Infection with severe acute respiratory syndrom coronavirus 2 (SARS-CoV-2) is more likely to lead to poor outcomes in the elderly and those with cardiovascular disease, obesity or metabolic syndrome. Here, we consider mechanisms by which dyslipidaemia ... ...

Abstract	Infection with severe acute respiratory syndrom coronavirus 2 (SARS-CoV-2) is more likely to lead to poor outcomes in the elderly and those with cardiovascular disease, obesity or metabolic syndrome. Here, we consider mechanisms by which dyslipidaemia and the use of cholesterol-modifying drugs could influence the virus-host relationship. Cholesterol is essential for the assembly, replication and infectivity of enveloped virus particles; we highlight several cholesterol-modifying drugs with the potential to alter the SARS-CoV-2 life cycle that could be tested in
Keywords	covid19
Language	English
Publishing date	2020-06-18
Publishing country	England
Document type	Journal Article
ISSN	2633-6960
ISSN (online)	2633-6960
DOI	10.1093/oxfimm/iqaa001
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Article ; Online: Patient-reported outcome measures for emotional functioning in cancer patients: Content comparison of the EORTC CAT Core, FACT-G, HADS, SF-36, PRO-CTCAE, and PROMIS instruments.

Rothmund, Maria / Pilz, Micha J / Egeter, Nathalie / Lidington, Emma / Piccinin, Claire / Arraras, Juan I / Grønvold, Mogens / Holzner, Bernhard / van Leeuwen, Marieke / Petersen, Morten Aa / Schmidt, Heike / Young, Teresa / Giesinger, Johannes M

Psycho-oncology

2023 Volume 32, Issue 4, Page(s) 628–639

Abstract: Background: Cancer and its treatment can have substantial impact on patients' emotional functioning. Several patient-reported outcome measures (PROMs) assessing emotional functioning are available, but differences in content limit the comparability of ... ...

Abstract	Background: Cancer and its treatment can have substantial impact on patients' emotional functioning. Several patient-reported outcome measures (PROMs) assessing emotional functioning are available, but differences in content limit the comparability of results. To better understand conceptual (dis)similarities, we conducted a content comparison of commonly used PROMs. Methods: We included emotional functioning items, scales, and item banks from the EORTC CAT Core, EORTC QLQ-C30, FACT-G, Hospital anxiety and depression scale (HADS), SF-36, PRO-CTCAE, and PROMIS (item banks for anxiety, depression, and anger). Item content was linked to the International Classification of Functioning, Disability, and Health (ICF) and a hierarchical framework established for PROMIS. Single items could be coded with more than one ICF category but were solely assigned to one facet within the PROMIS framework. Results: The measures comprise 132 unique items covering the ICF components 'Body functions' (136/153 codings, 88.9%) and 'Activities and participation' (15/153, 9.8%). Most ICF codings (112/153, 73.2%) referred to the third-level category 'b1528 Emotional functions, other specified'. According to the PROMIS framework 48.5% of the items assessed depression (64/132 items), followed by anxiety (41/132, 31.1%) and anger (26/132, 19.7%). The EORTC measures covered depression, anxiety, and anger in a single measure, while the PROMIS inventory provides separate item banks for these concepts. The FACT-G, SF-36, PRO-CTCAE and HADS covered depression and anxiety, but not anger. Conclusion: Our results provide an in-depth conceptual understanding of selected PROMs and important qualitative information going beyond psychometric evidence. Such information supports the identification of PROMs for which scores can be meaningfully linked with quantitative methods.
MeSH term(s)	Humans ; Quality of Life/psychology ; Emotions ; Anxiety ; Patient Reported Outcome Measures ; Neoplasms/therapy ; Neoplasms/psychology ; Psychometrics ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.6109
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Article ; Online: Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma.

Zakeri, Nekisa / Hall, Andrew / Swadling, Leo / Pallett, Laura J / Schmidt, Nathalie M / Diniz, Mariana O / Kucykowicz, Stephanie / Amin, Oliver E / Gander, Amir / Pinzani, Massimo / Davidson, Brian R / Quaglia, Alberto / Maini, Mala K

Nature communications

2022 Volume 13, Issue 1, Page(s) 1372

Abstract: Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident ... ...

Abstract	Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident memory T-cells (T
MeSH term(s)	Carcinoma, Hepatocellular/drug therapy ; Humans ; Liver Neoplasms ; Lymphocyte Activation ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocyte Subsets
Chemical Substances	Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-29012-1
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Article ; Online: Erratum for Brahimi-Horn et al., "Local Mitochondrial-Endolysosomal Microfusion Cleaves the Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia".

Brahimi-Horn, M Christiane / Lacas-Gervais, Sandra / Adaixo, Ricardo / Ilc, Karine / Rouleau, Matthieu / Notte, Annick / Dieu, Marc / Michiels, Carine / Voeltzel, Thibault / Maguer-Satta, Véronique / Pelletier, Joffrey / Ilie, Marius / Hofman, Paul / Manoury, Bénédicte / Schmidt, Alexander / Hiller, Sebastian / Pouysségur, Jacques / Mazure, Nathalie M

Molecular and cellular biology

2022 Volume 42, Issue 1, Page(s) e0051521

Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00515-21
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Article ; Online: An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity.

Wing, Peter A C / Schmidt, Nathalie M / Peters, Rory / Erdmann, Maximilian / Brown, Rachel / Wang, Hao / Swadling, Leo / Newman, Joseph / Thakur, Nazia / Shionoya, Kaho / Morgan, Sophie B / Hinks, Timothy Sc / Watashi, Koichi / Bailey, Dalan / Hansen, Scott B / Davidson, Andrew D / Maini, Mala K / McKeating, Jane A

PLoS pathogens

2023 Volume 19, Issue 5, Page(s) e1011323

Abstract: The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for ... ...

Abstract	The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle and in T cell function. Here we show that blockade of the enzyme Acyl-CoA:cholesterol acyltransferase (ACAT) with Avasimibe inhibits SARS-CoV-2 pseudoparticle infection and disrupts the association of ACE2 and GM1 lipid rafts on the cell membrane, perturbing viral attachment. Imaging SARS-CoV-2 RNAs at the single cell level using a viral replicon model identifies the capacity of Avasimibe to limit the establishment of replication complexes required for RNA replication. Genetic studies to transiently silence or overexpress ACAT isoforms confirmed a role for ACAT in SARS-CoV-2 infection. Furthermore, Avasimibe boosts the expansion of functional SARS-CoV-2-specific T cells from the blood of patients sampled during the acute phase of infection. Thus, re-purposing of ACAT inhibitors provides a compelling therapeutic strategy for the treatment of COVID-19 to achieve both antiviral and immunomodulatory effects. Trial registration: NCT04318314.
MeSH term(s)	Humans ; Acyltransferases/antagonists & inhibitors ; Antiviral Agents/pharmacology ; COVID-19 ; SARS-CoV-2 ; T-Lymphocytes
Chemical Substances	Acyltransferases (EC 2.3.-) ; Antiviral Agents ; avasimibe (28LQ20T5RC)
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011323
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Isolation of human intrahepatic leukocytes for phenotypic and functional characterization by flow cytometry.

Kucykowicz, Stephanie / Amin, Oliver E / Burton, Alice R / Swadling, Leo / Schmidt, Nathalie M / Zakeri, Nekisa / Davies, Jessica / Aidoo-Micah, Gloryanne / Stegmann, Kerstin A / Easom, Nicholas J / Jeffery-Smith, Anna / Maini, Mala K / Pallett, Laura J

STAR protocols

2022 Volume 3, Issue 2, Page(s) 101356

Abstract: With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative. Here, we provide a protocol for the isolation of human intrahepatic leukocytes (IHL) maximizing ... ...

Abstract	With the growing appreciation of tissue-resident immunity, studying tissue-specific immune cells contributing to both homeostasis and disease is imperative. Here, we provide a protocol for the isolation of human intrahepatic leukocytes (IHL) maximizing viability, purity, and yield. Our protocol is scalable by tissue weight, allowing for reproducible and efficient IHL liberation suitable for functional characterization, cell isolation, and profiling by flow (or mass) cytometry. Furthermore, we provide a "guide" to determine an expected IHL yield per gram of tissue processed. For complete details on the use and execution of this protocol, please refer to Stegmann et al. (2016), Pallett et al. (2017), Easom et al. (2018), Swadling et al. (2020), Pallett et al. (2020), and Zakeri et al. (2022).
MeSH term(s)	Cell Separation/methods ; Flow Cytometry/methods ; Humans ; Leukocytes ; Lymphocytes
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101356
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain.

Tu, Nguyen Huu / Inoue, Kenji / Lewis, Parker K / Khan, Ammar / Hwang, Jun Hyeong / Chokshi, Varun / Dabovic, Branka Brukner / Selvaraj, Shanmugapriya / Bhattacharya, Aditi / Dubeykovskaya, Zinaida / Pinkerton, Nathalie M / Bunnett, Nigel W / Loomis, Cynthia A / Albertson, Donna G / Schmidt, Brian L

Cells

2023 Volume 12, Issue 13

Abstract: Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and ... ...

Abstract	Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and neurogenic inflammation. The contribution of CGRP to oral cancer pain is investigated in the present study. The findings demonstrate that CGRP-immunoreactive (-ir) neurons and neurites innervate orthotopic oral cancer xenograft tumors in mice. Cancer increases anterograde transport of CGRP in axons innervating the tumor, supporting neurogenic secretion as the source of CGRP in the oral cancer microenvironment. CGRP antagonism reverses oral cancer nociception in preclinical oral cancer pain models. Single-cell RNA-sequencing is used to identify cell types in the cancer microenvironment expressing the CGRP receptor components, receptor activity modifying protein 1
MeSH term(s)	Humans ; Mice ; Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin ; Procalcitonin ; Receptors, Calcitonin Gene-Related Peptide/genetics ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; Cancer Pain/drug therapy ; Endothelial Cells/metabolism ; Peptide Hormones ; Mouth Neoplasms/drug therapy ; Tumor Microenvironment
Chemical Substances	Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Calcitonin (9007-12-9) ; Procalcitonin ; Receptors, Calcitonin Gene-Related Peptide ; Peptide Hormones
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12131675
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Article ; Online: Calcitonin Related Polypeptide Alpha Mediates Oral Cancer Pain

Nguyen Huu Tu / Kenji Inoue / Parker K. Lewis / Ammar Khan / Jun Hyeong Hwang / Varun Chokshi / Branka Brukner Dabovic / Shanmugapriya Selvaraj / Aditi Bhattacharya / Zinaida Dubeykovskaya / Nathalie M. Pinkerton / Nigel W. Bunnett / Cynthia A. Loomis / Donna G. Albertson / Brian L. Schmidt

Cells, Vol 12, Iss 1675, p

2023 Volume 1675

Abstract	Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and neurogenic inflammation. The contribution of CGRP to oral cancer pain is investigated in the present study. The findings demonstrate that CGRP-immunoreactive (-ir) neurons and neurites innervate orthotopic oral cancer xenograft tumors in mice. Cancer increases anterograde transport of CGRP in axons innervating the tumor, supporting neurogenic secretion as the source of CGRP in the oral cancer microenvironment. CGRP antagonism reverses oral cancer nociception in preclinical oral cancer pain models. Single-cell RNA-sequencing is used to identify cell types in the cancer microenvironment expressing the CGRP receptor components, receptor activity modifying protein 1 Ramp1 and calcitonin receptor like receptor (CLR, encoded by Calcrl ). Ramp1 and Calcrl transcripts are detected in cells expressing marker genes for Schwann cells, endothelial cells, fibroblasts and immune cells. Ramp1 and Calcrl transcripts are more frequently detected in cells expressing fibroblast and immune cell markers. This work identifies CGRP as mediator of oral cancer pain and suggests the antagonism of CGRP to alleviate oral cancer pain.
Keywords	oral cancer ; pain ; CGRP ; peptidergic neurons ; CALCRL/RAMP1 ; cancer innervation ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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