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Article ; Online: Dyslipidemia and thrombosis: causal relationship or epiphenomenon of sedentary lifestyle?

Sturm, Wolfgang / Sandhofer, Anton

Arteriosclerosis, thrombosis, and vascular biology

2005 Volume 25, Issue 3, Page(s) e19

MeSH term(s)	Humans ; Hyperlipidemias/epidemiology ; Hyperlipidemias/etiology ; Life Style ; Physical Fitness ; Risk Factors ; Thrombosis/epidemiology ; Thrombosis/etiology
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/01.ATV.0000157142.64490.e9
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Zs.A 1705: Show issues

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Article ; Online: Body adiposity index and other indexes of body composition in the SAPHIR study: association with cardiovascular risk factors.

Melmer, Andreas / Lamina, Claudia / Tschoner, Alexander / Ress, Claudia / Kaser, Susanne / Laimer, Markus / Sandhofer, Anton / Paulweber, Bernhard / Ebenbichler, Christoph F

Obesity (Silver Spring, Md.)

2013 Volume 21, Issue 4, Page(s) 775–781

Abstract: Objective: The accuracy of anthropometric surrogate markers such as the body adiposity index (BAI) and other common indexes like the body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) to predict metabolic sequelae is ... ...

Abstract	Objective: The accuracy of anthropometric surrogate markers such as the body adiposity index (BAI) and other common indexes like the body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) to predict metabolic sequelae is essential for its use in clinical practice. Design and methods: Thus, we evaluated the strength of BAI and other indexes to relate with anthropometric parameters, adipocytokines, blood lipids, parameters of glucose-homeostasis and blood pressure in 1,770 patients from the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) study in a crosssectional design. Measurements were BAI, BMI, WHR, WHtR, abdominal subcutaneous and visceral adipose tissue (aSAT and VAT), total body adipose tissue mass, body weight, waist- and hip circumference (WC and HC), leptin, adiponectin, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), fasting plasma glucose, fasting plasma insulin, the homeostasis model assessment of insulin resistance (HOMAIR), systolic and diastolic blood pressure. Results and conclusions: BAI was significantly associated with leptin and HC. We conclude that BAI was the best calculator for leptin. BAI was inferior to BMI to predict anthropometric parameters other than HC, adiponectin, blood lipids, parameters of glucose homeostasis, and blood pressure in this cross-sectional study.
MeSH term(s)	Adiponectin/blood ; Adipose Tissue ; Adiposity ; Adult ; Aged ; Austria ; Blood Glucose/analysis ; Blood Pressure ; Body Mass Index ; Body Weight ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Fasting ; Female ; Homeostasis ; Humans ; Insulin/blood ; Insulin Resistance ; Leptin/blood ; Male ; Middle Aged ; Obesity/complications ; Obesity/physiopathology ; Prospective Studies ; Risk Factors ; Triglycerides/blood ; Waist Circumference ; Waist-Hip Ratio
Chemical Substances	Adiponectin ; Blood Glucose ; Cholesterol, HDL ; Cholesterol, LDL ; Insulin ; Leptin ; Triglycerides
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.20289
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Article ; Online: The influence of two variants in the adenosine triphosphate-binding cassette transporter 1 gene on plasma lipids and carotid atherosclerosis.

Sandhofer, Anton / Iglseder, Bernhard / Kaser, Susanne / Morè, Elena / Paulweber, Bernhard / Patsch, Josef R

Metabolism: clinical and experimental

2008 Volume 57, Issue 10, Page(s) 1398–1404

Abstract: Variants in the adenosine triphosphate-binding-cassette transporter 1 (ABCA1) gene are known to affect high-density lipoprotein cholesterol and plasma triglycerides and the development of atherosclerosis. We investigated the influence of the R219K and ... ...

Abstract	Variants in the adenosine triphosphate-binding-cassette transporter 1 (ABCA1) gene are known to affect high-density lipoprotein cholesterol and plasma triglycerides and the development of atherosclerosis. We investigated the influence of the R219K and I883M variants in the ABCA1 gene on plasma lipids and carotid intima media thickness and plaque extent in 688 healthy men (40-60 years old). The R219K variant showed no effect on plasma lipids, but carriers of the K allele displayed a lower intima media thickness (P = .001) and a reduced risk of advanced plaque extent (odds ratio [OR], 0.59; 0.39-0.88; P = .009) compared with noncarriers. However, this risk reduction was observed in nonsmokers only (OR, 0.47; 0.27-0.80; P < .001), but not in smokers (OR, 0.75; 0.41-1.39; P = .2). The I883M variant showed no effect on plasma lipids or carotid atherosclerosis. Risk of advanced plaque extent was reduced in subjects carrying the R219K variant alone (OR, 0.59; 0.38-0.94; P = .025), but not in subjects carrying both variants. Haplotype distribution did not differ between subjects with and without advanced atherosclerosis irrespective of smoking history. We conclude that smoking abrogates the protective effect of the R219K.
MeSH term(s)	ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Adult ; Blood Pressure ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/genetics ; Carotid Artery Diseases/metabolism ; DNA/chemistry ; DNA/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Haplotypes ; Humans ; Linkage Disequilibrium ; Lipids/blood ; Male ; Middle Aged ; Particle Size ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; Smoking/adverse effects ; Smoking/blood ; Tunica Intima/diagnostic imaging ; Ultrasonography
Chemical Substances	ABCA1 protein, human ; ATP Binding Cassette Transporter 1 ; Lipids ; DNA (9007-49-2)
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80230-x
ISSN	1532-8600 ; 0026-0495
ISSN (online)	1532-8600
ISSN	0026-0495
DOI	10.1016/j.metabol.2008.05.009
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Uc I Zs.316: Show issues

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Article: Valvular disease and myocardial infarctions in a patient with Behçet disease.

Schirmer, Michael / Weidinger, Franz / Sandhofer, Anton / Gschwendtner, Andreas / Wiedermann, Christian

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2003 Volume 9, Issue 5, Page(s) 316–320

Abstract: Cardiac involvement occurs in less than 5% of Behçet patients, and coincidence of regurgitation of the aortic and mitral valves and myocardial infarctions is rare. This report describes a 49-year-old Turkish man with Behçet disease (BD) of 6 years' ... ...

Abstract	Cardiac involvement occurs in less than 5% of Behçet patients, and coincidence of regurgitation of the aortic and mitral valves and myocardial infarctions is rare. This report describes a 49-year-old Turkish man with Behçet disease (BD) of 6 years' duration who presented with reduced left ventricular function. Both aortic and mitral valves had to be replaced. Five months later, the patient presented with non-ST segment elevation myocardial infarction. Only 1 month later, the patient was successfully resuscitated after an acute ST segment elevation inferior myocardial infarction. Coronary arteries were normal in appearance at angiography before valvular replacement and at autopsy 2 years later. This report should increase awareness of cardiac involvement in BD and its potential danger. Even in BD patients without atherothrombotic plaques, myocardial infarctions can happen. Early and adequate immunosuppressive treatment might have reduced cardiac morbidity in this patient.
Language	English
Publishing date	2003-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1283266-2
ISSN	1076-1608
ISSN	1076-1608
DOI	10.1097/01.rhu.0000089787.12268.d6
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Zs.A 4815: Show issues

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Article: The Taq1B-variant in the cholesteryl ester-transfer protein gene and the risk of metabolic syndrome.

Sandhofer, Anton / Tatarczyk, Tobias / Laimer, Markus / Ritsch, Andreas / Kaser, Susanne / Paulweber, Bernhard / Ebenbichler, Christoph F / Patsch, Josef R

Obesity (Silver Spring, Md.)

2008 Volume 16, Issue 4, Page(s) 919–922

Abstract: The metabolic syndrome is associated with low high-density lipoprotein-cholesterol (HDL-C) and decreased low-density lipoprotein (LDL) particle size. The Taq1B-polymorphism in the cholesteryl ester-transfer protein (CETP)-gene influences HDL-C, CETP ... ...

Abstract	The metabolic syndrome is associated with low high-density lipoprotein-cholesterol (HDL-C) and decreased low-density lipoprotein (LDL) particle size. The Taq1B-polymorphism in the cholesteryl ester-transfer protein (CETP)-gene influences HDL-C, CETP concentration, and LDL-size. We investigated the effect of the Taq1B-polymorphism on the risk of the metabolic syndrome in 1,503 participants (973 men, 530 women) of the Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk study. CETP concentration was determined in a subgroup (n = 486) by an enzyme-linked immunosorbent assay. Prevalence of the metabolic syndrome was 16.7% (18.5% in men, 13.5% in women). The Taq1B-polymorphism influenced significantly CETP concentrations, HDL-C levels, and LDL-size (P < 0.001 for all). The relative risk of the metabolic syndrome was reduced by 32% (odds ratio (OR) 0.68 (95% CI: 0.51-0.89), P = 0.005) in carriers of the B2 variant. This risk reduction persisted after adjustment for age and sex (OR 0.69 (0.53-0.92), P = 0.01) and after further adjustment for body mass index, waist-to-hip ratio, blood pressure, insulin resistance (IR), HDL-C, and triglycerides (TGs) (OR 0.43 (0.26-0.72), P = 0.001). Furthermore, the risk reduction was more pronounced in men than in women. We conclude that CETP plays an important role in the metabolic syndrome, possibly involving novel functions of CETP.
MeSH term(s)	Adult ; Aged ; Cholesterol Ester Transfer Proteins/genetics ; Deoxyribonucleases, Type II Site-Specific ; Female ; Genetic Predisposition to Disease/epidemiology ; Genetic Variation ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics ; Middle Aged ; Obesity/epidemiology ; Obesity/genetics ; Prevalence ; Risk Factors ; Sex Distribution
Chemical Substances	CETP protein, human ; Cholesterol Ester Transfer Proteins ; Deoxyribonucleases, Type II Site-Specific (EC 3.1.21.4) ; TCGA-specific type II deoxyribonucleases (EC 3.1.21.4)
Language	English
Publishing date	2008-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1930-7381 ; 1071-7323
ISSN (online)	1930-739X
ISSN	1930-7381 ; 1071-7323
DOI	10.1038/oby.2007.130
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Cholesteryl Ester Transfer Protein in Metabolic Syndrome

Sandhofer, Anton / Kaser, Susanne / Ritsch, Andreas / Laimer, Markus / Engl, Julia / Paulweber, Bernhard / Patsch, Josef R / Ebenbichler, Christoph F

Obesity research. 2006 May, v. 14, no. 5

2006

Abstract: OBJECTIVE: Low high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and small dense-low density lipoprotein (LDL) are key components of metabolic syndrome (MS). Cholesteryl ester transfer protein (CETP) mediates the transfer of ... ...

Abstract	OBJECTIVE: Low high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and small dense-low density lipoprotein (LDL) are key components of metabolic syndrome (MS). Cholesteryl ester transfer protein (CETP) mediates the transfer of triglycerides (TGs) from TG-rich lipoproteins to HDL and LDL particles in exchange for cholesteryl esters, leading to low HDL-C and small dense-LDL. The aim of this study was to investigate the role of CETP in subjects with MS. RESEARCH METHODS AND PROCEDURES: In a cross-sectional cohort of 234 middle-aged men and 252 women randomly selected from the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) study, MS was diagnosed according to the National Cholesterol Education Program guidelines. CETP mass was determined by enzyme-linked immunosorbent assay and LDL size-by-gradient polyacrylamide gel electrophoresis. RESULTS: Men and women with MS had lower HDL-C (45 ± 7 vs. 58 ± 13 and 48 ± 10 vs. 71 ± 14 mg/dL for men and women, respectively; p < 0.001 for all) and higher TG levels (222 ± 71 vs. 98 ± 54 and 167 ± 67 vs. 90 ± 35 mg/dL for men and women, respectively; p < 0.001 for all) than healthy subjects. LDL size was lower in subjects with MS (256 ± 11 A vs. 267 ± 11 A and 262 ± 10 A vs. 273 ± 8 Å for men and women, respectively; p < 0.001 for all). CETP mass was higher in men with MS (1.87 ± 0.78 vs. 1.40 ± 0.65 μg/mL; p < 0.001) but not in women (1.74 ± 0.79 vs. 1.62 ± 0.62 μg/mL). CETP mass correlated inversely with LDL size in both men and women (r = -0.19, p < 0.01 and r = -0.13, p < 0.05 in men and women, respectively). DISCUSSION: MS is associated with increased CETP mass in men. Increased CETP mass may be responsible for reduced HDL-C and reduced LDL particle diameter in MS.
Keywords	men ; women ; adults ; high density lipoprotein ; low density lipoprotein ; blood lipids ; triacylglycerols ; hypertriglyceridemia ; metabolic syndrome ; animal proteins ; blood proteins ; atherosclerosis ; enzyme-linked immunosorbent assay ; particle size ; diameter ; cholesteryl ester transfer protein
Language	English
Dates of publication	2006-05
Size	p. 812-818.
Publishing place	The North American Association for the Study of Obesity
Document type	Article
ZDB-ID	1201744-9
ISSN	1550-8528 ; 1071-7323
ISSN (online)	1550-8528
ISSN	1071-7323
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 4061: Show issues

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Article: Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome.

Sandhofer, Anton / Laimer, Markus / Ebenbichler, Christoph F / Kaser, Susanne / Paulweber, Bernhard / Patsch, Josef R

Obesity research

2003 Volume 11, Issue 6, Page(s) 760–768

Abstract: Objective: In obesity, plasma leptin is high and soluble leptin receptor (sOb-R) levels are low, resulting in a low fraction of bound leptin. The aim of this study was to investigate the influence of insulin resistance (IR) and the metabolic syndrome ( ... ...

Abstract	Objective: In obesity, plasma leptin is high and soluble leptin receptor (sOb-R) levels are low, resulting in a low fraction of bound leptin. The aim of this study was to investigate the influence of insulin resistance (IR) and the metabolic syndrome (MS) on sOb-R concentration and the bound-free ratio of leptin. Research methods and procedures: sOb-R, leptin levels, and homeostasis model assessment (HOMA) index for IR were determined in 76 middle-aged obese or overweight men. Results: Concentration of sOb-R and soluble receptor-bound fraction of leptin were lowest in the highest tertile of HOMA-IR. sOb-R and the bound-free ratio of leptin correlated with HOMA-IR, leptin concentration, and waist-to-hip ratio independently of age, BMI, and fat mass. Leptin and waist-to-hip ratio were the sole independent determinants of sOb-R concentration, and BMI, HOMA-IR, and visceral adipose tissue were independent determinants of the bound fractin of leptin. sOb-R concentration and the bound fraction of leptin decreased with increasing numbers of components of the MS, resulting in lower sOb-R concentration and a lower fraction of bound leptin in men with the MS. Discussion: IR and abdominal obesity are associated with low sOb-R concentration and low bound-free ratio of leptin independent of fat mass. Low sOb-R concentration and low bound-free ratio of leptin segregate with components of the MS. We suggest that low sOb-R levels and a low fraction of specifically bound leptin are markers of leptin resistance, which is independently associated with IR and abdominal obesity and may constitute an additional component of the MS.
MeSH term(s)	Adipose Tissue ; Adult ; Blood Pressure ; Body Composition ; Body Constitution ; Body Mass Index ; Fasting ; Homeostasis ; Humans ; Insulin/blood ; Insulin Resistance ; Leptin/blood ; Linear Models ; Male ; Metabolic Syndrome/blood ; Middle Aged ; Protein Binding ; Receptors, Cell Surface/blood ; Receptors, Leptin
Chemical Substances	Insulin ; LEPR protein, human ; Leptin ; Receptors, Cell Surface ; Receptors, Leptin
Language	English
Publishing date	2003-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1201744-9
ISSN	1550-8528 ; 1071-7323
ISSN (online)	1550-8528
ISSN	1071-7323
DOI	10.1038/oby.2003.106
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Zs.A 4061: Show issues

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Article ; Online: Cholesteryl ester transfer protein and hepatic lipase gene polymorphisms: effects on hepatic mRNA levels, plasma lipids and carotid atherosclerosis.

Soyal, Selma M / Sandhofer, Anton / Hahne, Penelope / Oberkofler, Hannes / Felder, Thomas / Iglseder, Bernhard / Miller, Karl / Krempler, Franz / Patsch, Josef R / Paulweber, Bernhard / Patsch, Wolfgang

Atherosclerosis

2011 Volume 216, Issue 2, Page(s) 374–380

Abstract: Objective: HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other. We studied associations of CETP-Taq1B and -514C>T-LIPC polymorphisms with hepatic mRNA levels, and their combined ... ...

Abstract	Objective: HDL modifying effects of cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) depend in part on each other. We studied associations of CETP-Taq1B and -514C>T-LIPC polymorphisms with hepatic mRNA levels, and their combined effects on plasma lipids and carotid atherosclerosis. Methods: We genotyped the CETP-Taq1B and the -514C>T-LIPC polymorphisms in 67 obese women in whom hepatic CETP and LIPC transcript levels were determined as well as in 1549 participants of the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR). Carotid atherosclerosis was assessed by intima-media thickness and extent of plaques (B-score) of the carotid arteries. Results: In obese women, CETP-Taq1B and -514C>T-LIPC variant alleles were associated with reduced hepatic levels of CETP and LIPC mRNA, respectively. The CETP and LIPC polymorphisms accounted for 12.9 and 14.4% of the variability in respective transcripts. In the SAPHIR population, CETP-Taq1B showed independent effects on LDL diameter, HDL and LDL cholesterol, apolipoproteins AI and B and cholesterol/HDL cholesterol, while -514C>T-LIPC revealed independent effects on HDL cholesterol and apolipoprotein AI. The two polymorphisms displayed interactions at the level of HDL cholesterol. Compared to subjects carrying wild-type alleles at both loci, subjects homozygous for the CETP wild-type allele, but heterozygous for the LIPC polymorphism and subjects heterozygous for the CETP polymorphism, but homozygous for the LIPC wild-type allele showed an increased risk of carotid atherosclerosis (both P<0.05). Conclusions: CETP and LIPC polymorphisms influence the respective hepatic transcript levels, demonstrate interactions on HDL cholesterol and suggest that imbalances between CETP and LIPC activities may modulate the risk of carotid atherosclerosis.
MeSH term(s)	Adult ; Aged ; Carotid Artery Diseases/genetics ; Cholesterol Ester Transfer Proteins/genetics ; Female ; Genotype ; Humans ; Lipase/genetics ; Lipids/chemistry ; Lipoproteins, HDL/metabolism ; Liver/metabolism ; Male ; Middle Aged ; Obesity/complications ; Polymorphism, Genetic ; Risk
Chemical Substances	Cholesterol Ester Transfer Proteins ; LIPC protein, human ; Lipids ; Lipoproteins, HDL ; Lipase (EC 3.1.1.3)
Language	English
Publishing date	2011-03-02
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2011.01.052
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Zs.A 226: Show issues

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Article: Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid.

Sandhofer, Anton / Kähler, Chris / Heininger, Doris / Bellmann, Romuald / Wiedermann, Christian J / Joannidis, Michael

Wiener klinische Wochenschrift

2002 Volume 114, Issue 21-22, Page(s) 938–942

Abstract: Unlabelled: Diuretics are among the most frequently prescribed substances in elderly patients, but they are also associated with the highest incidence of adverse effects in this group of patients. Xipamide is a sulfonamide-like diuretic whose action ... ...

Abstract	Unlabelled: Diuretics are among the most frequently prescribed substances in elderly patients, but they are also associated with the highest incidence of adverse effects in this group of patients. Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular secretion. This characteristic makes it suitable for situations in which the kidney is highly sodium avid. Because of the potency of this substance the risk of adverse reactions like electrolyte disorders or hypovolemia is increased as well. We report seven patients (age 65-85) admitted to the emergency room of the University Hospital of Innsbruck between 1998 and 2002 who had developed serious adverse reactions upon initiation of treatment with xipamide as an additional diuretic. Six of these patients had received combinations with loop diuretics. The disturbances observed were hyponatremia (lowest value 108 mmol/l), hypokalemia (lowest value 1.5 mmol/l) and prerenal azotemia (highest serum urea 269 mg/dl, highest serum creatinine 5.13). Conclusion: With the exception of diuretic resistance in severe heart failure or renal insufficiency a combination therapy of xipamide with a second diuretic appears to be associated with an unnecessarily high risk of serious adverse reactions and thus should be avoided. This is especially true for elderly patients.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Diuretics/administration & dosage ; Diuretics/adverse effects ; Drug Therapy, Combination ; Emergencies ; Female ; Furosemide/administration & dosage ; Furosemide/adverse effects ; Humans ; Hydrochlorothiazide/administration & dosage ; Hydrochlorothiazide/adverse effects ; Hypokalemia/chemically induced ; Hyponatremia/chemically induced ; Hypovolemia/chemically induced ; Male ; Risk Factors ; Sodium Chloride Symporter Inhibitors/administration & dosage ; Sodium Chloride Symporter Inhibitors/adverse effects ; Uremia/chemically induced ; Xipamide/administration & dosage ; Xipamide/adverse effects
Chemical Substances	Diuretics ; Sodium Chloride Symporter Inhibitors ; Hydrochlorothiazide (0J48LPH2TH) ; Xipamide (4S9EY0NUEC) ; Furosemide (7LXU5N7ZO5)
Language	English
Publishing date	2002-11-30
Publishing country	Austria
Document type	Case Reports ; Comparative Study ; Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
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Zs.A 902: Show issues

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Article: Cholesteryl ester transfer protein in metabolic syndrome.

Sandhofer, Anton / Kaser, Susanne / Ritsch, Andreas / Laimer, Markus / Engl, Julia / Paulweber, Bernhard / Patsch, Josef R / Ebenbichler, Christoph F

Obesity (Silver Spring, Md.)

2006 Volume 14, Issue 5, Page(s) 812–818

Abstract: Objective: Low high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and small dense-low density lipoprotein (LDL) are key components of metabolic syndrome (MS). Cholesteryl ester transfer protein (CETP) mediates the transfer of ... ...

Abstract	Objective: Low high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and small dense-low density lipoprotein (LDL) are key components of metabolic syndrome (MS). Cholesteryl ester transfer protein (CETP) mediates the transfer of triglycerides (TGs) from TG-rich lipoproteins to HDL and LDL particles in exchange for cholesteryl esters, leading to low HDL-C and small dense-LDL. The aim of this study was to investigate the role of CETP in subjects with MS. Research methods and procedures: In a cross-sectional cohort of 234 middle-aged men and 252 women randomly selected from the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) study, MS was diagnosed according to the National Cholesterol Education Program guidelines. CETP mass was determined by enzyme-linked immunosorbent assay and LDL size-by-gradient polyacrylamide gel electrophoresis. Results: Men and women with MS had lower HDL-C (45 +/- 7 vs. 58 +/- 13 and 48 +/- 10 vs. 71 +/- 14 mg/dL for men and women, respectively; p < 0.001 for all) and higher TG levels (222 +/- 71 vs. 98 +/- 54 and 167 +/- 67 vs. 90 +/- 35 mg/dL for men and women, respectively; p < 0.001 for all) than healthy subjects. LDL size was lower in subjects with MS (256 +/- 11 A vs. 267 +/- 11 A and 262 +/- 10 A vs. 273 +/- 8 A for men and women, respectively; p < 0.001 for all). CETP mass was higher in men with MS (1.87 +/- 0.78 vs. 1.40 +/- 0.65 mug/mL; p < 0.001) but not in women (1.74 +/- 0.79 vs. 1.62 +/- 0.62 mug/mL). CETP mass correlated inversely with LDL size in both men and women (r = -0.19, p < 0.01 and r = -0.13, p < 0.05 in men and women, respectively). Discussion: MS is associated with increased CETP mass in men. Increased CETP mass may be responsible for reduced HDL-C and reduced LDL particle diameter in MS.
MeSH term(s)	Adult ; Aged ; Blood Pressure/physiology ; Body Mass Index ; Cholesterol Ester Transfer Proteins/blood ; Cholesterol Ester Transfer Proteins/physiology ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Female ; Humans ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/chemistry ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/pathology ; Metabolic Syndrome/physiopathology ; Middle Aged ; Particle Size ; Sex Factors ; Triglycerides/blood ; Waist-Hip Ratio
Chemical Substances	Cholesterol Ester Transfer Proteins ; Cholesterol, HDL ; Cholesterol, LDL ; Lipoproteins, LDL ; Triglycerides
Language	English
Publishing date	2006-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1930-7381 ; 1071-7323
ISSN (online)	1930-739X
ISSN	1930-7381 ; 1071-7323
DOI	10.1038/oby.2006.94
Database	MEDical Literature Analysis and Retrieval System OnLINE

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