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  1. Book ; Online: Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity

    Yoneshiro, Takeshi / Johannes Betz, Matthias / Rensen, Patrick C. N. / Rodriguez-Rodriguez, Rosalia

    2020  

    Keywords Medicine ; Endocrinology ; brown adipose tissue ; beige adipocytes ; energy metabolism ; thermogenesis ; obesity ; type 2 diabetes
    Size 1 electronic resource (187 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230639
    ISBN 9782889662821 ; 2889662829
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Atherosclerosis: an overview of mouse models and a detailed methodology to quantify lesions in the aortic root.

    van der Vaart, Jamie I / van Eenige, Robin / Rensen, Patrick C N / Kooijman, Sander

    Vascular biology (Bristol, England)

    2024  Volume 6, Issue 1

    Abstract: Cardiovascular disease, the primary cause of human mortality globally, is predominantly caused by a progressive disorder known as atherosclerosis. Atherosclerosis refers to the process of accumulation of cholesterol-enriched lipoproteins and the ... ...

    Abstract Cardiovascular disease, the primary cause of human mortality globally, is predominantly caused by a progressive disorder known as atherosclerosis. Atherosclerosis refers to the process of accumulation of cholesterol-enriched lipoproteins and the concomitant initiation of inflammatory processes in the arterial wall, including the recruitment of immune cells. This leads to the formation of atherosclerotic plaques, initially causing a thickening of the arterial wall and narrowing of arteries. However, as plaque formation progresses, atherosclerotic plaques may become unstable and rupture, leading to a blood clot that blocks the affected artery or travels through the blood to block blood flow elsewhere. In the early 1990s, emerging gene editing methods enabled the development of apolipoprotein E knockout (Apoe-/- ) and low-density lipoprotein receptor knockout (Ldlr-/- ) mice. These mice have been instrumental in unraveling the complex pathogenesis of atherosclerosis. Around the same time, human APOE*3-Leiden transgenic mice were generated, which were more recently cross-bred with human cholesteryl ester transfer protein (CETP) transgenic mice to generate APOE*3-Leiden.CETP mice. This model appears to closely mimic human lipoprotein metabolism and responds to classic lipid-lowering interventions due to an intact ApoE-LDLR pathway of lipoprotein remnant clearance. In this review, we describe the role of lipid metabolism and inflammation in atherosclerosis development and highlight the characteristics of the frequently used animal models to study atherosclerosis, with a focus on mouse models, discussing their advantages and limitations. Moreover, we present a detailed methodology to quantify atherosclerotic lesion area within the aortic root region of the murine heart, as well as details required for scoring atherosclerotic lesion severity based on guidelines of the American Heart Association adapted for mice.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2516-5658
    ISSN (online) 2516-5658
    DOI 10.1530/VB-23-0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early but Not Late Exercise Training in Mice Exacerbates Hepatic Inflammation in Developing Nonalcoholic Fatty Liver Disease.

    Kovynev, Artemiy / Ying, Zhixiong / Lambooij, Joost M / van der Zande, Hendrik J P / Guigas, Bruno / Rensen, Patrick C N / Schönke, Milena

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 5, Page(s) 1282–1285

    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2023.00094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Response by Brunham et al to Letter Regarding Article, "Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis".

    Brunham, Liam R / Trinder, Mark / Rensen, Patrick C N / Boyd, John

    Circulation

    2021  Volume 144, Issue 6, Page(s) e122

    MeSH term(s) Cholesterol Ester Transfer Proteins ; Cholesterol, HDL ; Humans ; Lipoproteins, HDL/metabolism ; Sepsis/diagnosis ; Sepsis/drug therapy ; Triglycerides
    Chemical Substances Cholesterol Ester Transfer Proteins ; Cholesterol, HDL ; Lipoproteins, HDL ; Triglycerides
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.055698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Role of homeostatic iron regulator protein in hepatic cholesterol metabolism: interaction between Kupffer cells and hepatocytes?

    Blauw, Lisanne L / Rensen, Patrick C N

    European heart journal

    2020  Volume 41, Issue 40, Page(s) 3960–3962

    MeSH term(s) Atherosclerosis ; Cholesterol ; Cholesterol, LDL ; Hemochromatosis ; Hemochromatosis Protein ; Hepatocytes ; Homeostasis ; Humans ; Iron ; Kupffer Cells ; Liver
    Chemical Substances Cholesterol, LDL ; HFE protein, human ; Hemochromatosis Protein ; Cholesterol (97C5T2UQ7J) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  6. Article: Ethnic Disparities in Lipid Metabolism and Clinical Outcomes between Dutch South Asians and Dutch White Caucasians with Type 2 Diabetes Mellitus.

    Yuan, Lushun / Verhoeven, Aswin / Blomberg, Niek / van Eyk, Huub J / Bizino, Maurice B / Rensen, Patrick C N / Jazet, Ingrid M / Lamb, Hildo J / Rabelink, Ton J / Giera, Martin / van den Berg, Bernard M

    Metabolites

    2024  Volume 14, Issue 1

    Abstract: Type 2 diabetes mellitus (T2DM) poses a higher risk for complications in South Asian individuals compared to other ethnic groups. To shed light on potential mediating factors, we investigated lipidomic changes in plasma of Dutch South Asians (DSA) and ... ...

    Abstract Type 2 diabetes mellitus (T2DM) poses a higher risk for complications in South Asian individuals compared to other ethnic groups. To shed light on potential mediating factors, we investigated lipidomic changes in plasma of Dutch South Asians (DSA) and Dutch white Caucasians (DwC) with and without T2DM and explore their associations with clinical features. Using a targeted quantitative lipidomics platform, monitoring over 1000 lipids across 17 classes, along with
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14010033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome.

    Li, Sheng / Ying, Zhixiong / Gentenaar, Max / Rensen, Patrick C N / Kooijman, Sander / Visser, Jenny A / Meijer, Onno C / Kroon, Jan

    Journal of the Endocrine Society

    2023  Volume 8, Issue 1, Page(s) bvad162

    Abstract: Context: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with obesity, insulin resistance, and dyslipidemia. Hyperandrogenism is a major characteristic of PCOS. Increased androgen exposure is believed to deregulate metabolic ... ...

    Abstract Context: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with obesity, insulin resistance, and dyslipidemia. Hyperandrogenism is a major characteristic of PCOS. Increased androgen exposure is believed to deregulate metabolic processes in various tissues as part of the PCOS pathogenesis, predominantly through the androgen receptor (AR). Notably, various metabolic features in PCOS are similar to those observed after excess glucocorticoid exposure.
    Objective: We hypothesized that glucocorticoid receptor (GR) signaling is involved in the metabolic symptoms of PCOS.
    Methods: In a PCOS model of chronic dihydrotestosterone (DHT) exposure in female mice, we investigated whether GR signaling machinery was (de)regulated, and if treatment with a selective GR antagonist alleviated the metabolic symptoms.
    Results: We observed an upregulation of GR messenger RNA expression in the liver after DHT exposure. In white adipose tissues and liver we found that DHT upregulated
    Conclusion: We conclude that GR activation may play a role in glucose metabolism in DHT-exposed mice.
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvad162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Time for Novel Strategies to Mitigate Cardiometabolic Risk in Shift Workers.

    Schilperoort, Maaike / Rensen, Patrick C N / Kooijman, Sander

    Trends in endocrinology and metabolism: TEM

    2020  Volume 31, Issue 12, Page(s) 952–964

    Abstract: Circadian disruption induced by shift work is robustly associated with obesity, diabetes, and cardiovascular disease in humans. Less well-known are the mechanisms underlying these associations, and the effectiveness of strategies to reduce ... ...

    Abstract Circadian disruption induced by shift work is robustly associated with obesity, diabetes, and cardiovascular disease in humans. Less well-known are the mechanisms underlying these associations, and the effectiveness of strategies to reduce cardiometabolic risk in the shift work population. In this review, the different ways in which shift work can deteriorate cardiometabolic health, and how to use this information to reflect on various risk-mitigating strategies, is discussed. While individual strategies appear promising in animal studies, the multifactorial disease risk in shift workers likely requires a multidisciplinary approach. Therefore, the need for individually-tailored combined lifestyle interventions, that could be essential in reducing cardiometabolic disorders in the large population of shift workers in our 24/7 society, is argued.
    MeSH term(s) Animals ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Circadian Rhythm/physiology ; Humans ; Risk Factors
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2020.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans.

    Ying, Zhixiong / Tramper, Naomi / Zhou, Enchen / Boon, Mariëtte R / Rensen, Patrick C N / Kooijman, Sander

    Cardiovascular research

    2022  Volume 119, Issue 4, Page(s) 905–918

    Abstract: Brown adipocytes within brown adipose tissue (BAT) and beige adipocytes within white adipose tissue dissipate nutritional energy as heat. Studies in mice have shown that activation of thermogenesis in brown and beige adipocytes enhances the lipolytic ... ...

    Abstract Brown adipocytes within brown adipose tissue (BAT) and beige adipocytes within white adipose tissue dissipate nutritional energy as heat. Studies in mice have shown that activation of thermogenesis in brown and beige adipocytes enhances the lipolytic processing of triglyceride-rich lipoproteins (TRLs) in plasma to supply these adipocytes with fatty acids for oxidation. This process results in formation of TRL remnants that are removed from the circulation through binding of apolipoprotein E (ApoE) on their surface to the LDL receptor (LDLR) on hepatocytes, followed by internalization. Concomitantly, lipolytic processing of circulating TRLs leads to generation of excess surface phospholipids that are transferred to nascent HDLs, increasing their capacity for reverse cholesterol transport. Activation of thermogenic adipocytes thus lowers circulating triglycerides and non-HDL-cholesterol, while it increases HDL-cholesterol. The combined effect is protection from atherosclerosis development, which becomes evident in humanized mouse models with an intact ApoE-LDLR clearance pathway only, and is additive to the effects of classical lipid-lowering drugs including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. A large recent study revealed that the presence of metabolically active BAT in humans is associated with lower triglycerides, higher HDL-cholesterol and lower risk of cardiovascular diseases. This narrative review aims to provide leads for further exploration of thermogenic adipose tissue as a therapeutic target. To this end, we describe the latest knowledge on the role of BAT in lipoprotein metabolism and address, for example, the discovery of the β2-adrenergic receptor as the dominant adrenergic receptor in human thermogenic adipocytes.
    MeSH term(s) Humans ; Animals ; Mice ; Lipid Metabolism ; Cardiovascular Diseases/metabolism ; Triglycerides ; Cholesterol/metabolism ; Adipose Tissue, Brown/metabolism ; Atherosclerosis/metabolism ; Cholesterol, HDL ; Apolipoproteins E ; Thermogenesis ; Energy Metabolism
    Chemical Substances Triglycerides ; Cholesterol (97C5T2UQ7J) ; Cholesterol, HDL ; Apolipoproteins E
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
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  10. Article ; Online: The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease.

    Mehta, Nehal / Dangas, Katerina / Ditmarsch, Marc / Rensen, Patrick C N / Dicklin, Mary R / Kastelein, John J P

    Pharmacological research

    2023  Volume 197, Page(s) 106972

    Abstract: The main role of cholesteryl ester transfer protein (CETP) is the transfer of cholesteryl esters and triglycerides between high-density lipoprotein (HDL) particles and triglyceride-rich lipoprotein and low-density lipoprotein (LDL) particles. There is a ... ...

    Abstract The main role of cholesteryl ester transfer protein (CETP) is the transfer of cholesteryl esters and triglycerides between high-density lipoprotein (HDL) particles and triglyceride-rich lipoprotein and low-density lipoprotein (LDL) particles. There is a long history of investigations regarding the inhibition of CETP as a target for reducing major adverse cardiovascular events. Initially, the potential effect on cardiovascular events of CETP inhibitors was hypothesized to be mediated by their ability to increase HDL cholesterol, but, based on evidence from anacetrapib and the newest CETP inhibitor, obicetrapib, it is now understood to be primarily due to reducing LDL cholesterol and apolipoprotein B. Nevertheless, evidence is also mounting that other roles of HDL, including its promotion of cholesterol efflux, as well as its apolipoprotein composition and anti-inflammatory, anti-oxidative, and anti-diabetic properties, may play important roles in several diseases beyond cardiovascular disease, including, but not limited to, Alzheimer's disease, diabetes, and sepsis. Furthermore, although Mendelian randomization analyses suggested that higher HDL cholesterol is associated with increased risk of age-related macular degeneration (AMD), excess risk of AMD was absent in all CETP inhibitor randomized controlled trial data comprising over 70,000 patients. In fact, certain HDL subclasses may, in contrast, be beneficial for treating the retinal cholesterol accumulation that occurs with AMD. This review describes the latest biological evidence regarding the relationship between HDL and CETP inhibition for Alzheimer's disease, type 2 diabetes mellitus, sepsis, and AMD.
    MeSH term(s) Humans ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Cholesterol, HDL ; Cholesterol Ester Transfer Proteins ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Alzheimer Disease/complications ; Cholesterol/metabolism ; Apolipoproteins/metabolism ; Sepsis/complications
    Chemical Substances Cholesterol, HDL ; Cholesterol Ester Transfer Proteins ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins
    Language English
    Publishing date 2023-10-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 721: Show issues Location:
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