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  1. Book: RAT HEPATIC NEOPLASIA. EDITED BY PAUL M. NEWBERNE, W.H. BUTLER

    Newberne, Paul M.

    1978  

    Title variant RAT HEPATIC NEOPLASIA
    Keywords LIVER NEOPLASMS / CONGRESSES ; NEOPLASMS, EXPERIMENTAL / CONGRESSES ; RATS / PATHOLOGY / CONGRESSES
    Size XIII,288 S.
    Publisher M.I.T. PRESS
    Publishing place CAMBRIDGE, MASS.; LONDON
    Document type Book
    Note 'UPDATED WORKING PAPERS DERIVED FROM ... A WORKSHOP ON RAT LIVER NEOPLASIA AT WOODS HOLE, MASSACHUSETTS, IN OCTOBER 1974' - PREFACE
    HBZ-ID HT000326462
    ISBN 0-262-14029-2 ; 978-0-262-14029-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1981 A 850 order for loan Magazin

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  2. Book: Trace substances and health / 2

    Newberne, Paul M.

    a handbook

    1982  

    Author's details ed. by Paul M. Newberne
    Collection Trace substances and health
    Language English
    Size VIII, 175 S. : Ill., graph. Darst.
    Edition 1. [Dr.]
    Publisher Dekker
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT002320865
    ISBN 0-8247-1850-X ; 978-0-8247-1850-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 4064 order for loan Magazin

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  3. Book: Trace substances and health / 1

    Newberne, Paul M.

    a handbook

    1976  

    Author's details ed. by Paul M. Newberne
    Collection Trace substances and health
    Language English
    Size IX, 398 S. : graph. Darst.
    Edition 1. print.
    Publisher Dekker
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT005004233
    ISBN 0-8247-6341-6 ; 978-0-8247-6341-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1977 A 750 -1- order for loan Magazin
    1977 A 750a -1- order for loan Magazin

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  4. Book ; Collection: Trace substances and health

    Newberne, Paul M.

    a handbook

    1976  

    Author's details ed. by Paul M. Newberne
    Keywords ENVIRONMENTAL POLLUTANTS / TOXICITY ; Spurenelement ; Gesundheitsgefährdung ; Pestizid ; Umweltbelastung
    Subject Gesundheitsgefahr ; Gesundheitsrisiko ; Gesundheitsbelastung ; Gesundheitliches Risiko ; Ökologische Belastung ; Umweltbeeinträchtigung ; Umweltproblem ; Umwelt ; Biozid ; Mikroelement
    Language English
    Dates of publication 1976-9999
    Publisher Dekker
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT002210400
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Choline deficiency associated with diethanolamine carcinogenicity.

    Newberne, Paul M

    Toxicological sciences : an official journal of the Society of Toxicology

    2002  Volume 67, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Carcinogens/toxicity ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Choline Deficiency/complications ; Choline Deficiency/metabolism ; Choline Deficiency/pathology ; Ethanolamines/toxicity ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Neoplasms/etiology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred Strains
    Chemical Substances Carcinogens ; Ethanolamines ; diethanolamine (AZE05TDV2V)
    Language English
    Publishing date 2002-05
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/67.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Book: Nutrition, immunity and infection

    Chandra, Ranjit Kumar / Newberne, Paul M.

    mechanisms of interactions

    1977  

    Author's details by R. K. Chandra, P. M. Newberne
    Keywords DISEASE / ETIOLOGY ; IMMUNITY ; INFECTION / COMPLICATIONS ; NUTRITION DISORDERS / COMPLICATIONS
    Size XV, 246 S.
    Publisher Plenum Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT000065764
    ISBN 0-306-31058-9 ; 978-0-306-31058-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1979 A 716 order for loan Magazin

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  7. Article: Effects of Bowman-Birk inhibitor on rat colon carcinogenesis.

    Kennedy, Ann R / Billings, Paul C / Wan, X Steven / Newberne, Paul M

    Nutrition and cancer

    2002  Volume 43, Issue 2, Page(s) 174–186

    Abstract: The present study was undertaken to determine whether the Bowman-Birk inhibitor (BBI) could prevent colon carcinogenesis in rats treated with dimethylhydrazine (DMH) and whether there were adverse side effects associated with treatment with BBI for ... ...

    Abstract The present study was undertaken to determine whether the Bowman-Birk inhibitor (BBI) could prevent colon carcinogenesis in rats treated with dimethylhydrazine (DMH) and whether there were adverse side effects associated with treatment with BBI for cancer prevention. BBI was evaluated in the forms of purified BBI (PBBI) or an extract of soybeans enriched in BBI, termed BBI concentrate (BBIC). The results demonstrate that PBBI and BBIC reduced the incidence and frequency of tumors in DMH-treated rats compared with animals treated with DMH alone. Autoclaved BBIC, in which the protease inhibitor activity of BBI was destroyed, had a weak and statistically insignificant, suppressive effect on DMH-induced colon carcinogenesis in rats, suggesting that the protease inhibitor activity of BBI is likely to be responsible for the anticarcinogenic activity of BBIC. Soy molasses, which contains soy isoflavones, did not have an effect on colon cancer carcinogenesis in DMH-treated rats. Similar to results from previous studies (Nauss et al. JNCI 73, 915-924, 1984), the most aggressive, malignant colon adenocarcinomas developed within or in association with gut-associated lymphoid tissue aggregates. No adverse side effects on the pancreas or animal growth were observed in rats treated with PBBI or BBIC. These results demonstrate that PBBI and BBIC may be used to prevent colon cancer without significant adverse side effects.
    MeSH term(s) Animals ; Anticarcinogenic Agents/adverse effects ; Anticarcinogenic Agents/pharmacology ; Colonic Neoplasms/chemically induced ; Colonic Neoplasms/epidemiology ; Colonic Neoplasms/pathology ; Colonic Neoplasms/prevention & control ; Dimethylhydrazines ; Incidence ; Male ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Trypsin Inhibitor, Bowman-Birk Soybean/adverse effects ; Trypsin Inhibitor, Bowman-Birk Soybean/pharmacology
    Chemical Substances Anticarcinogenic Agents ; Dimethylhydrazines ; Trypsin Inhibitor, Bowman-Birk Soybean
    Language English
    Publishing date 2002
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 424433-3
    ISSN 0163-5581
    ISSN 0163-5581
    DOI 10.1207/S15327914NC432_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1496: Show issues Location:
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  8. Article ; Online: Effects of selenomethionine in irradiated human thyroid epithelial cells and tumorigenicity studies.

    Ware, Jeffrey H / Zhou, Zhaozong / Romero-Weaver, Ana L / Wan, X Steven / Newberne, Paul M / Kennedy, Ann R

    Nutrition and cancer

    2011  Volume 63, Issue 7, Page(s) 1114–1121

    Abstract: The objectives of the present study were to characterize γ-ray, 1 GeV/n proton, and 1 GeV/n iron ion radiation-induced adverse biological effects in terms of toxicity and transformation of HTori-3 human thyroid epithelial cells; to evaluate the ability ... ...

    Abstract The objectives of the present study were to characterize γ-ray, 1 GeV/n proton, and 1 GeV/n iron ion radiation-induced adverse biological effects in terms of toxicity and transformation of HTori-3 human thyroid epithelial cells; to evaluate the ability of L-selenomethionine (SeM) to protect against radiation-induced transformation when present at different times during the assay period; and to evaluate the tumorigenicity of HTori-3 cells derived from anchorage-independent colonies following iron ion radiation exposure. Cell survival was determined by a clonogenic assay, transformation was measured by a soft agar colony formation assay, and the tumorigenic potential of the cells was determined by injecting them subcutaneously into athymic nude mice and monitoring tumor formation. The results demonstrate that exposure of HTori-3 cells to γ-ray, proton, or iron ion radiation resulted in decreased clonogenic survival, which persisted for weeks after the radiation exposure. Treatment with SeM initiated up to 7 days after the radiation exposure conferred significant protection against radiation-induced anchorage-independent growth. HTori-3 cells derived from all evaluated anchorage-independent colonies formed tumors when injected into athymic nude mice, indicating that these cells are tumorigenic and that anchorage-independent colony growth is a reliable surrogate endpoint biomarker for the radiation-induced malignant transformation of HTori-3 cells.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Biomarkers ; Cell Line ; Epithelial Cells/drug effects ; Epithelial Cells/radiation effects ; Gamma Rays/adverse effects ; Humans ; Iron/adverse effects ; Mice ; Mice, Nude ; Nonlinear Dynamics ; Protons/adverse effects ; Regression Analysis ; Selenomethionine/pharmacology ; Thyroid Gland/cytology
    Chemical Substances Antioxidants ; Biomarkers ; Protons ; Selenomethionine (964MRK2PEL) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2011-09-14
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2011.605981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1496: Show issues Location:
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  9. Article: Chemical Carcinogenesis: Mycotoxins and Other Chemicals to Which Humans Are Exposed

    Newberne, Paul M.

    Seminars in Liver Disease

    1984  Volume 4, Issue 02, Page(s) 122–135

    Language English
    Publishing date 1984-05-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/s-2008-1040652
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Effects of Selenomethionine in Irradiated Human Thyroid Epithelial Cells and Tumorigenicity Studies

    Ware, Jeffrey H / Zhou, Zhaozong / Romero-Weaver, Ana L / Wan, X. Steven / Newberne, Paul M / Kennedy, Ann R

    Nutrition and cancer. 2011 Oct. 1, v. 63, no. 7

    2011  

    Abstract: The objectives of the present study were to characterize γ-ray, 1 GeV/n proton, and 1 GeV/n iron ion radiation-induced adverse biological effects in terms of toxicity and transformation of HTori-3 human thyroid epithelial cells; to evaluate the ability ... ...

    Abstract The objectives of the present study were to characterize γ-ray, 1 GeV/n proton, and 1 GeV/n iron ion radiation-induced adverse biological effects in terms of toxicity and transformation of HTori-3 human thyroid epithelial cells; to evaluate the ability of L-selenomethionine (SeM) to protect against radiation-induced transformation when present at different times during the assay period; and to evaluate the tumorigenicity of HTori-3 cells derived from anchorage-independent colonies following iron ion radiation exposure. Cell survival was determined by a clonogenic assay, transformation was measured by a soft agar colony formation assay, and the tumorigenic potential of the cells was determined by injecting them subcutaneously into athymic nude mice and monitoring tumor formation. The results demonstrate that exposure of HTori-3 cells to γ-ray, proton, or iron ion radiation resulted in decreased clonogenic survival, which persisted for weeks after the radiation exposure. Treatment with SeM initiated up to 7 days after the radiation exposure conferred significant protection against radiation-induced anchorage-independent growth. HTori-3 cells derived from all evaluated anchorage-independent colonies formed tumors when injected into athymic nude mice, indicating that these cells are tumorigenic and that anchorage-independent colony growth is a reliable surrogate endpoint biomarker for the radiation-induced malignant transformation of HTori-3 cells.
    Keywords agar ; biomarkers ; cell viability ; epithelial cells ; gamma radiation ; humans ; mice ; monitoring ; neoplasms ; selenomethionine ; toxicity
    Language English
    Dates of publication 2011-1001
    Size p. 1114-1121.
    Publishing place Taylor & Francis Group
    Document type Article
    ZDB-ID 2025822-7
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2011.605981
    Database NAL-Catalogue (AGRICOLA)

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