Article ; Online: Bilateral oblique facial clefts and extremity anomaly in an infant after intrauterine efavirenz exposure and review of its teratogenic risk.
2012 Volume 26, Issue 14, Page(s) 1775–1779
Abstract: Objective: Congenital anomalies may be caused by genetic or environmental factors or a combination of both. Oblique facial clefts are very rare congenital deformities. The occurrence of facial clefts and an extremity anomaly suggests a common underlying ...
| Abstract | Objective: Congenital anomalies may be caused by genetic or environmental factors or a combination of both. Oblique facial clefts are very rare congenital deformities. The occurrence of facial clefts and an extremity anomaly suggests a common underlying cause. Lateral oro-ocular clefts do not occur along normal developmental planes and may be part of the amnion disruption complex sequence. Our objective was to report a case of this very event, which also followed an unusual intrauterine exposure and review the literature on the teratogenic risk of efavirenz. Study design: We report a case of amniotic rupture sequence after fetal HIV and antiretroviral exposure. Result: Teratogenic exposure has been rarely reported and never after antiretroviral exposure. Conclusion: By reporting and registering more cases, we will be able to better assess the risks such medications pose to the developing fetus. The publication of a single case report has the potential to contribute to our knowledge of the significance of prenatal exposure to antiretrovirals and other medications for common HIV-associated disorders. It also generates a hypothesis that can be tested with further clinical data, animal models and epidemiologic studies. |
|---|---|
| MeSH term(s) | Abnormalities, Drug-Induced/diagnostic imaging ; Abnormalities, Drug-Induced/etiology ; Abnormalities, Drug-Induced/surgery ; Acquired Immunodeficiency Syndrome/drug therapy ; Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Benzoxazines/administration & dosage ; Benzoxazines/adverse effects ; Child of Impaired Parents ; Cleft Palate/chemically induced ; Cleft Palate/diagnostic imaging ; Cleft Palate/surgery ; Craniofacial Dysostosis/chemically induced ; Craniofacial Dysostosis/diagnostic imaging ; Craniofacial Dysostosis/surgery ; Eye Abnormalities/chemically induced ; Eye Abnormalities/diagnostic imaging ; Eye Abnormalities/surgery ; Female ; Humans ; Imaging, Three-Dimensional ; Infant ; Infant, Newborn ; Maxillofacial Abnormalities/chemically induced ; Maxillofacial Abnormalities/diagnostic imaging ; Maxillofacial Abnormalities/surgery ; Pregnancy ; Prenatal Exposure Delayed Effects ; Radiography ; Teratogens |
| Chemical Substances | Anti-HIV Agents ; Benzoxazines ; Teratogens ; efavirenz (JE6H2O27P8) |
| Language | English |
| Publishing date | 2012-09-10 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article ; Review |
| ZDB-ID | 639076-6 |
| ISSN | 1473-5571 ; 0269-9370 ; 1350-2840 |
| ISSN (online) | 1473-5571 |
| ISSN | 0269-9370 ; 1350-2840 |
| DOI | 10.1097/QAD.0b013e328356467a |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2228: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.