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  1. Article ; Online: Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats.

    Firat, Fatih / Erdemir, Fikret / Günaydın, Bilal / Parlaktas, Bekir Süha / Markoç, Fatma / Yaşar, Adem

    Andrologia

    2020  Volume 52, Issue 5, Page(s) e13567

    Abstract: In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III- ...

    Abstract In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was defined as orchiectomy and followed up for 1 month. Measurements of intracavernosal pressure with different electrical stimuli and pathological findings of smooth muscle collagen in cavernosal tissues were examined. While the cavernosal pressure response in all the different electrical stimuli given in the control group and in all other groups was significantly lower than that in the other groups, it was statistically significant at 7.5 and 10 V (p = .005, p < 0001). According to the pathologic evaluation, the density of tissue collagen increased significantly in the other groups according to the control group. In groups 3 and 4, the density of 4+ collagen was found to be increased according to Groups 1 and 2. In the LH-RH alone group, it appears that there are no 4+ colloid density and less damage. According to these findings, the negative effect of LH-RH treatment on cavernosal tissues appears to be less.
    MeSH term(s) Administration, Oral ; Androgen Antagonists/adverse effects ; Anilides/adverse effects ; Animals ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Collagen/analysis ; Disease Models, Animal ; Erectile Dysfunction/etiology ; Erectile Dysfunction/pathology ; Erectile Dysfunction/prevention & control ; Gonadotropin-Releasing Hormone/agonists ; Goserelin/administration & dosage ; Humans ; Male ; Muscle, Smooth/chemistry ; Muscle, Smooth/drug effects ; Muscle, Smooth/pathology ; Nitriles/adverse effects ; Orchiectomy/adverse effects ; Penis/chemistry ; Penis/drug effects ; Penis/pathology ; Prostatic Neoplasms/therapy ; Rats ; Rats, Wistar ; Tosyl Compounds/adverse effects
    Chemical Substances Androgen Antagonists ; Anilides ; Nitriles ; Tosyl Compounds ; Goserelin (0F65R8P09N) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Collagen (9007-34-5) ; bicalutamide (A0Z3NAU9DP)
    Language English
    Publishing date 2020-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/and.13567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: How to manage pseudoangiomatous stromal hyperplasia: our clinical experience

    Kurt, Emine / Turanlı, Sevim / Markoç, Fatma / Berberoğlu, Uğur

    Turkish journal of medical sciences

    2017  Volume 47, Issue 5, Page(s) 1410–1415

    Abstract: Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. ...

    Abstract Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Patients with clinically or radiologically detected mass and patients who underwent biopsy for other indications and were diagnosed incidentally were included in the study. Results: There were 34 female patients and one male patient with gynecomastia. Twenty-three patients had palpable masses, and 16 of them were diagnosed as PASH with a median size of 3.1 cm. PASH did not show any specific features in radiological imaging. Core needle biopsy was performed for 3 patients before surgical excision; however, the lesions had not been diagnosed as PASH. In pathological examination, lesions associated with PASH showed nonproliferative changes in 14 patients, proliferative changes without atypia in 17, one phyllodes tumor, one in situ tumor, and one invasive cancer. Conclusion: Imaging findings of PASH are nonspecific. It is difficult to give a true prognostic diagnosis through pathological evaluation of big masses with core needle biopsy. We recommend surgical excision, especially for big lesions with suspicious features.
    Language English
    Publishing date 2017--13
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-1702-140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: HER-2/Neu and Hormone Receptor Analysis in Breast Carcinomas and Their Association with Clinicopathologic Parameters.

    Köseoğlu, Reşit Doğan / Markoç, Fatma / Müslehiddinoğlu, Ahmet / İleri, Ayşe Burcu / Deresoy, Faik Alev / Etikan, İlker

    European journal of breast health

    2018  Volume 15, Issue 1, Page(s) 43–50

    Abstract: Objective: Invasive breast carcinomas of no special type (IC-NST) are the heterogeneous tumours showing distinct prognostic features even in patients with similar clinicopathological characteristics. To date, many clinicopathological data have been ... ...

    Abstract Objective: Invasive breast carcinomas of no special type (IC-NST) are the heterogeneous tumours showing distinct prognostic features even in patients with similar clinicopathological characteristics. To date, many clinicopathological data have been analyzed to make a guess about prognosis and to determine treatment modality. In this study, HER-2/neu status was analyzed by using both immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) methods, and its correlations with hormone receptor status and clinicopathological parameters were investigated.
    Materials and methods: The study was included 112 female patients with diagnosis of IC-NST. FISH for HER-2/neu was applied in only primary tumour tissues, while IHC analyses for HER-2/neu, estrogen (ER) and progesterone receptors (PR) were applied on both primary and metastatic lymph node foci. The results were compared with appropriate statistical methods.
    Results: Our rates of HER-2/neu overexpression and gene amplification in the overall study group were 22.3 and 25%, respectively. In the metastatic group, these rates were higher than those of the overall study group (34% and 40%, respectively). Gene amplification rate of the axilla positive group was 40%, while this rate in non-metastatic group was 6.7% (p=0.015). Overexpression and amplification results were compliant (χ
    Conclusion: The concordance rates between the results of IHC and FISH in the HER-2 negative and the overexpression categories were compatible with the literature and lower than the literature, respectively. In the case of ER negativity, the patient's age over 50 years was associated with a higher rate of gene amplification.
    Language English
    Publishing date 2018-10-24
    Publishing country Turkey
    Document type Journal Article
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.5152/ejbh.2018.4118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Chondroid Syringoma of the Hypothenar Region.

    Markoç, Fatma / Bostan, Bora / Köseoğlu, R Doğan / Arıkan, A Burcu / Aşcı, Murat

    Balkan medical journal

    2016  Volume 33, Issue 2, Page(s) 243–244

    Language English
    Publishing date 2016-03
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3123
    ISSN (online) 2146-3131
    ISSN 2146-3123
    DOI 10.5152/balkanmedj.2015.151027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis.

    Kalkan, Göknur / Markoç, Fatma / Bas, Yalçin

    JPMA. The Journal of the Pakistan Medical Association

    2014  Volume 64, Issue 5, Page(s) 579–582

    Abstract: Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular ... ...

    Abstract Primary localized cutaneous amyloidosis (PLCA) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement. PCLA is classified into lichen, macular,and nodular amyloidosis. Macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. The treatment of this disease is insufficient,even if there are several alternatives for treatment. Here we present a case of biphasic amyloidosis that responded well to topical tacrolimus ointment 0.1% plus narrow band ultraviolet B (NBUVB) treatment treatment to be able to generate a new treatment alternative model. With this case presentation, by reviewing of the treatment modalities of this rarely observed case, will contribute to the solution of the disease.
    MeSH term(s) Adult ; Amyloidosis ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Narrow Band Imaging ; Ointments ; Phototherapy/methods ; Tacrolimus/administration & dosage ; Ultraviolet Rays
    Chemical Substances Immunosuppressive Agents ; Ointments ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2014-05
    Publishing country Pakistan
    Document type Case Reports ; Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Scapular Bone Grafts: Good Options for Craniofacial Defects?

    Turan, Aydin / Kostakoğlu, Naci / Tuncel, Umut / Gökçe, Erkan / Markoç, Fatma

    Annals of plastic surgery

    2016  Volume 76, Issue 5, Page(s) 509–516

    Abstract: Introduction: There is still no consensus on the ideal material to be used in craniofacial defects. Autogenous bone grafts are mostly preferred owing to their use with fewer complications. The aim of this study was to evaluate whether the scapular bone ... ...

    Abstract Introduction: There is still no consensus on the ideal material to be used in craniofacial defects. Autogenous bone grafts are mostly preferred owing to their use with fewer complications. The aim of this study was to evaluate whether the scapular bone graft can be used with equal or more advantages to other bone graft resources in orbital, maxillary sinus front wall, and frontal bone defects.
    Patients and methods: Twenty-four orbital, maxillary sinus front wall, and frontal bone defects were reconstructed with scapular bone grafts. Sixteen patients presented with complicated orbital fractures, 5 patients presented with isolated orbital floor fractures, and 3 patients presented with frontal bone fractures. The grafts were radiologically evaluated 1 day, 6 months, and 12 months postoperatively by 3-dimensional computed tomography scan.
    Results: All orbital, maxillary sinus front wall, and frontal bone defects were reconstructed successfully with scapular bone grafts. Clinical evaluation of the patients at 6 to 24 months of follow-up was considered satisfactory. Minimal donor site morbidity was observed. Scapular bone grafts adapted nicely to the recipient area, and bony union was complete as demonstrated by 3-dimensional computed tomography scans.
    Conclusions: Reconstruction of orbital, maxillary sinus front wall, and frontal bone defects with scapular bone grafts is an easy and safe procedure with minimal donor site morbidity. Scapular bone graft is a good reconstructive option for orbital, maxillary sinus front wall, and frontal bone defects.
    MeSH term(s) Adolescent ; Adult ; Aged ; Bone Transplantation/methods ; Feasibility Studies ; Female ; Follow-Up Studies ; Frontal Bone/diagnostic imaging ; Frontal Bone/injuries ; Frontal Bone/surgery ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Orbital Fractures/diagnostic imaging ; Orbital Fractures/surgery ; Scapula/transplantation ; Skull Fractures/diagnostic imaging ; Skull Fractures/surgery ; Tomography, X-Ray Computed/methods ; Transplantation, Autologous/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000000357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunohistochemical Analysis of the Extrinsic Apoptosis Process in the Non-Neoplastic and Neoplastic Prostate.

    Ileri, Ayşe Burcu / Köseoğlu, Reşit Doğan / Markoç, Fatma / Etikan, İlker / Atilgan, Doğan / Deresoy, Faik Alev

    Turk patoloji dergisi

    2017  Volume 34, Issue 1, Page(s) 19–28

    Abstract: Objective: Deviations in the apoptotic process have been demonstrated in prostate carcinogenesis. We aimed to evaluate especially the process of extrinsic apoptosis in the spectrum of neoplastic lesions of the prostate epithelium so as to reveal the ... ...

    Abstract Objective: Deviations in the apoptotic process have been demonstrated in prostate carcinogenesis. We aimed to evaluate especially the process of extrinsic apoptosis in the spectrum of neoplastic lesions of the prostate epithelium so as to reveal the variations in the apoptotic process.
    Material and method: The study included 20 benign prostatic hyperplasia, 8 high-grade prostatic intraepithelial neoplasia and 82 prostatic carcinoma patients. Immunohistochemistry was performed on sections obtained from materials of suprapubic prostatectomy, tru-cut biopsy, transurethral resection and radical prostatectomy. While Fas and FasL were evaluated in glandular and stromal areas, DcR1 and FLIP were evaluated in only glandular areas. Intensity and extent of immunostaining for Fas and FasL antibodies were separately scored and both scores were summarized. The total score of ≥ 4 both for Fas and FasL, expressions of FLIP and DcR1determined in more than 5% of glandular areas were accepted as positive.
    Results: Glandular FasL positivity was observed in 63.8 and 20% of the cases with prostatic carcinoma and benign prostatic hyperplasia, respectively (p=0.001). The loss of stromal Fas expression in PCa was obvious (p < 0.001). FLIP positivity was more frequently seen in high-grade prostatic intraepithelial neoplasia and PCa.
    Conclusion: In prostatic carcinoma, decreased stromal Fas expression, contrary to higher glandular FasL positivity, supports the assertion that sensitivity of epithelial and stromal cells to apoptosis and their protective pathways against apoptosis undergo alterations. Increased FLIP expressions in high-grade prostatic intraepithelial neoplasia and prostatic carcinoma can also be interpreted accordingly.
    MeSH term(s) Adenocarcinoma/pathology ; Aged ; Aged, 80 and over ; Apoptosis/physiology ; Fas Ligand Protein/analysis ; Fas Ligand Protein/biosynthesis ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prostatic Hyperplasia/pathology ; Prostatic Intraepithelial Neoplasia/pathology ; Prostatic Neoplasms/pathology ; Retrospective Studies ; fas Receptor/analysis ; fas Receptor/biosynthesis
    Chemical Substances FAS protein, human ; FASLG protein, human ; Fas Ligand Protein ; fas Receptor
    Language English
    Publishing date 2017-10-06
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2515899-5
    ISSN 1309-5730 ; 1018-5615
    ISSN (online) 1309-5730
    ISSN 1018-5615
    DOI 10.5146/tjpath.2017.01409
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  8. Article ; Online: Pyloric gland type adenoma including intramucosal carcinoma focus of gallbladder.

    Köseoğlu, Reşit Doğan / Özkan, Namık / Barut, Şener / Markoç, Fatma

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

    2014  Volume 25 Suppl 1, Page(s) 234–236

    MeSH term(s) Adenoma/pathology ; Adult ; Carcinoma/pathology ; Female ; Gallbladder Neoplasms/pathology ; Gastric Mucosa ; Humans ; Neoplasms, Multiple Primary/pathology ; Stomach Neoplasms/pathology
    Language English
    Publishing date 2014-12
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 1340275-4
    ISSN 2148-5607 ; 1300-4948
    ISSN (online) 2148-5607
    ISSN 1300-4948
    DOI 10.5152/tjg.2014.4249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chondroid Syringoma of the Hypothenar Region

    Fatma Markoç / Bora Bostan / R.Doğan Köseoğlu / A.Burcu Arıkan / Murat Aşçı

    Balkan Medical Journal, Vol 33, Iss 2, Pp 243-

    2016  Volume 244

    Keywords Medicine ; R
    Language English
    Publishing date 2016-04-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: CT and MRI Findings of a Transitional Cell Carcinoma Case Located at Sino-nasopharyngeal Junction

    Erkan Gokce / Ahmet Eyibilen / Fatma Markoc / Zafer Ozmen / Fatma Aktas

    Çağdaş Tıp Dergisi , Vol 5, Iss 3, Pp 199-

    2015  Volume 202

    Abstract: Nonkeratinizing carcinoma (transitional cell carcinoma) accounts for 1 to 20% of carcinomas of the sinonasal tract. Most of transitional cell carcinomas develop de novo, but a few may arise from preexisting inverted papillomas. Although histopathological ...

    Abstract Nonkeratinizing carcinoma (transitional cell carcinoma) accounts for 1 to 20% of carcinomas of the sinonasal tract. Most of transitional cell carcinomas develop de novo, but a few may arise from preexisting inverted papillomas. Although histopathological findings of transitional cell carcinomas are well documented in the literature, detailed information on imaging findings is scarce. In the present study, CT and MRI findings of a de novo developed transitional cell carcinoma located at sino-nasopharyngeal junction are presented. [J Contemp Med 2015; 5(3.000): 199-202]
    Keywords computed tomography ; magnetic resonance imaging ; nonkeratinizing carcinoma ; transitional cell carcinoma ; Medicine ; R
    Language English
    Publishing date 2015-09-01T00:00:00Z
    Publisher Scopemed
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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