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Article: Soluble HLA-G in rheumatoid arthritis.

Verbruggen, Leon A / Rebmann, Vera / Demanet, Christian / De Cock, Seija / Grosse-Wilde, Hans

2006 Volume 67, Issue 8, Page(s) 561–567

Abstract: We investigated potential correlations between soluble HLA-G (sHLA-G) and soluble HLA class I (sHLA ... HLA-DQB1 in patients with rheumatoid arthritis (RA). SHLA-G plasma concentrations from 106 RA patients ... The mean sHLA-G levels were lower and sHLA-I levels higher in the RA patients than in healthy controls ...

Abstract	We investigated potential correlations between soluble HLA-G (sHLA-G) and soluble HLA class I (sHLA-I) levels, respectively, and parameters of disease activity or genetic factors determined by HLA-DRB1 and HLA-DQB1 in patients with rheumatoid arthritis (RA). SHLA-G plasma concentrations from 106 RA patients (mean age 59.8 years, 80 women) were assessed by a sensitive enzyme-linked immunosorbent assay format. The mean sHLA-G levels were lower and sHLA-I levels higher in the RA patients than in healthy controls. Correlation coefficients of 0.248 to 0.344 (p < 0.01) between sHLA-G and rheumatoid factor, CRP, and EULAR joint swelling score were found. Patients with disease-associated HLA epitopes had higher sHLA-G levels than those without. Significantly lower sHLA-G was observed in groups of patients having HLA-DRB103 or HLA-DQB102 compared to groups without these genotypes. In contrast, HLA-DQB103 or disease-associated epitopes combined with HLA-DQB103 were associated with higher sHLA-G levels, whereas the inverse was observed in the combined presence of HLA-DRB103 and HLA-DQB102. SHLA-G as a percentage of sHLA-I was lower in patients positive for HLA-DQB102 and higher in patients positive for HLA-DQB103 and in its combined presence with disease-associated epitopes or with HLA-DRB1*07. As especially sHLA-G strongly inhibits T and natural killer (NK) cell functions, low sHLA-G suggests that T and NK cell activities are not efficiently restricted by sHLA-G molecules in rheumatoid arthritis. The sHLA-G levels, however, increase in correlation with parameters of disease activity and appear to be affected by the presence of disease-predisposing epitopes and other HLA-DRB1, DQB1 genotypes.
MeSH term(s)	Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/immunology ; Epitopes/immunology ; Female ; Genetic Predisposition to Disease ; HLA Antigens/blood ; HLA-DQ Antigens/blood ; HLA-DQ beta-Chains ; HLA-DR Antigens/blood ; HLA-DRB1 Chains ; HLA-G Antigens ; Histocompatibility Antigens Class I/blood ; Humans ; Male ; Membrane Glycoproteins/blood ; Middle Aged
Chemical Substances	Epitopes ; HLA Antigens ; HLA-DQ Antigens ; HLA-DQ beta-Chains ; HLA-DQB1 antigen ; HLA-DR Antigens ; HLA-DRB1 Chains ; HLA-G Antigens ; Histocompatibility Antigens Class I ; Membrane Glycoproteins
Language	English
Publishing date	2006-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2006.03.023
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Zs.A 1597: Show issues

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Article: 99mTc-MAMA-chrysamine G, a probe for beta-amyloid protein of Alzheimer's disease.

Dezutter, N A / Dom, R J / de Groot, T J / Bormans, G M / Verbruggen, A M

European journal of nuclear medicine

1999 Volume 26, Issue 11, Page(s) 1392–1399

Abstract: Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein ...

Abstract	Chrysamine G (CG), an analogue of Congo red, is known to bind in vitro to the beta-amyloid protein (Abeta 10-43) and to homogenates of several regions of the brain of Alzheimer's disease (AD) patients. We synthesised a conjugate of 2-(acetamido)-CG with a bis-S-trityl protected monoamide-monoaminedithiol (MAMA-Tr(2)) tetraligand, which was efficiently deprotected and labelled with a 75% yield with technetium-99m, to obtain (99m)Tc-MAMA-CG. In mice, (99m)Tc-MAMA-CG was cleared mainly by the hepatobiliary system, resulting in a fast blood clearance. Brain uptake of (99m)Tc-MAMA-CG was low. Co-injection with the blood pool tracer iodine-125 human serum albumin ((125)I-HSA) demonstrated a brain/blood activity ratio for (99m)Tc-MAMA-CG that was significantly higher than that for (125)I-HSA (t test for dependent samples, P<0.02), indicating the ability of (99m)Tc-MAMA-CG to cross the blood-brain barrier. In vitro autoradiography demonstrated pronounced binding of (99m)Tc-MAMA-CG to beta-amyloid deposits in autopsy sections of the parietal and occipital cortex of an AD patient as compared with controls. Adding 10 microM Congo red during incubation displaced the binding of (99m)Tc-MAMA-CG. Congo red staining and autoradiography identified the same lesions. (99m)Tc-MAMA-CG seems to bind selectively to beta-amyloid deposition in human brain parenchyma and blood vessels in vitro and thus might be a lead compound for further development of a useful tracer agent for the in vivo diagnosis of Alzheimer's disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/analysis ; Animals ; Benzoates ; Biphenyl Compounds ; Brain/diagnostic imaging ; Brain/metabolism ; Coloring Agents ; Female ; Humans ; Isotope Labeling ; Male ; Mice ; Mice, Inbred Strains ; Middle Aged ; Organotechnetium Compounds ; Radionuclide Imaging ; Radiopharmaceuticals ; Technetium ; Tissue Distribution
Chemical Substances	99mTc-MAMA-chrysamine G ; Amyloid beta-Peptides ; Benzoates ; Biphenyl Compounds ; Coloring Agents ; Organotechnetium Compounds ; Radiopharmaceuticals ; chrysamine G (6472-91-9) ; Technetium (7440-26-8)
Language	English
Publishing date	1999-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s002590050470
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Zs.A 1227: Show issues

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Article: In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis.

Dezutter, N A / Sciot, R M / de Groot, T J / Bormans, G M / Verbruggen, A M

Nuclear medicine communications

2001 Volume 22, Issue 5, Page(s) 553–558

Abstract: ... of chrysamine G (CG), a lipophilic analogue of Congo red, were synthesized as potential tracer agents for direct ...

Abstract	To date, systemic amyloidosis is diagnosed histologically in vitro using Congo red staining or in vivo using iodine-123 serum amyloid P component (123I-SAP) scintigraphy. 99Tcm-labelled derivatives of chrysamine G (CG), a lipophilic analogue of Congo red, were synthesized as potential tracer agents for direct and quantitative scintigraphic evaluation of amyloid deposits. To determine the affinity of 99Tcm-MAMA-CG, 99Tcm-Me4MAMA-CG and 99Tcm-MAMA-CG diethyl ester for amyloid, in vitro autoradiography was performed on sections of human kidney biopsy cylinders from kidneys with amyloid deposits (types AA, Alambda and Akappa) or control kidney tissue after incubation with the respective tracer agents. The binding of 99Tcm-MAMA-CG and its tetramethyl derivative was higher to kidney biopsy material with amyloid deposits of the AA, Alambda or Akappa type compared with control kidney tissue. This higher binding was prevented by the presence of 10 microM Congo red in the incubation medium. The diethyl ester of 9Tcm-MAMA-CG did not demonstrate increased binding to Congo red-positive kidney tissue. In conclusion, 99Tcm-MAMA-CG and 99Tcm-Me4MAMA-CG localize specifically to amyloid deposits in human kidney tissue, suggesting that these tracer agents may be applicable as specific targeting agents for diagnostic purposes in clinical amyloidosis.
MeSH term(s)	Adult ; Aged ; Amyloid/analysis ; Amyloidosis/diagnostic imaging ; Autoradiography ; Benzoates ; Child ; Female ; Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Diseases/diagnostic imaging ; Male ; Middle Aged ; Organotechnetium Compounds ; Radionuclide Imaging ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics ; Reference Values ; Technetium/pharmacokinetics
Chemical Substances	99mTc-MAMA-chrysamine G ; Amyloid ; Benzoates ; Organotechnetium Compounds ; Radiopharmaceuticals ; Technetium (7440-26-8)
Language	English
Publishing date	2001-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/00006231-200105000-00014
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Zs.A 1577: Show issues

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Article: Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis.

Dezutter, N A / Landman, W J / Jager, P L / de Groot, T J / Dupont, P J / Tooten, P C / Zekarias, B / Gruys, E / Verbruggen, A M

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2001 Volume 8, Issue 3, Page(s) 202–214

Abstract: ... a 99mTc-labelled derivative of the lipophilic Congo red analogue chrysamine G (CG), as a possible ...

Abstract	To date, systemic amyloidosis is diagnosed histologically using Congo red staining or in vivo using iodine-123 labelled serum amyloid P component (123I-SAP) scintigraphy. We developed 99mTc-MAMA-CG, a 99mTc-labelled derivative of the lipophilic Congo red analogue chrysamine G (CG), as a possible alternative to 123I-SAP. In vivo 99mTc-MAMA-CG scintigraphy, performed in chickens with spontaneous joint amyloidosis, resulted as soon as 10 min after injection in scintigraphic images showing uptake of activity in amyloid-loaded organs (liver, joints). One of these chickens was studied also with 123I-SAP resulting in scintigraphic images revealing 123I-SAP binding to amyloid deposits in the liver. However, up to 11 h after injection no radioactivity was visible in the amyloid positive joints. In vitro autoradiography, performed on sections of chicken joints with Enterococcus faecalis induced amyloid arthropathy (chjAA), demonstrated the failure of 99mTc-MAMA-CG to bind significantly to amyloid deposits in the presence of 10 microM Congo red The specificity of 99mTc-MAMA-CG localisation was also established by the absence of 99mTc-MAMA-CG binding in non-amyloidotic organs in vitro and in vivo. 99mTc-MAMA-CG did not show any sign of acute toxicity. These findings establish the usefulness of 99mTc-MAMA-CG as a non-invasive in vivo diagnostic probe in chickens with amyloid arthropathy and suggest that it may also be applicable to human amyloidosis.
MeSH term(s)	Amyloid/analysis ; Amyloidosis/diagnosis ; Amyloidosis/diagnostic imaging ; Amyloidosis/microbiology ; Animals ; Autoradiography/methods ; Benzoates/chemistry ; Chickens ; Disease Models, Animal ; Enterococcus faecalis/pathogenicity ; Evaluation Studies as Topic ; Female ; Iodine Radioisotopes/chemistry ; Molecular Probes ; Organotechnetium Compounds/chemistry ; Radionuclide Imaging ; Serum Amyloid P-Component
Chemical Substances	99mTc-MAMA-chrysamine G ; Amyloid ; Benzoates ; Iodine Radioisotopes ; Molecular Probes ; Organotechnetium Compounds ; Serum Amyloid P-Component
Language	English
Publishing date	2001-09-27
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205246-2
ISSN	1350-6129
ISSN	1350-6129
DOI	10.3109/13506120109007363
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Zs.A 4114: Show issues

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Article ; Online: RANKL blockade for erosive hand osteoarthritis: a randomized placebo-controlled phase 2a trial.

Wittoek, Ruth / Verbruggen, Gust / Vanhaverbeke, Tine / Colman, Roos / Elewaut, Dirk

Nature medicine

2024 Volume 30, Issue 3, Page(s) 829–836

Abstract: Erosive hand osteoarthritis (OA) is a prevalent and disabling disease with limited treatment options. Here we present the results of a monocentric, placebo-controlled, double-blind, randomized phase 2a clinical trial with denosumab, a receptor activator ... ...

Abstract	Erosive hand osteoarthritis (OA) is a prevalent and disabling disease with limited treatment options. Here we present the results of a monocentric, placebo-controlled, double-blind, randomized phase 2a clinical trial with denosumab, a receptor activator of nuclear factor-κB ligand inhibitor, evaluating the effects on structure modification in erosive hand OA. Patients were randomized to 48 weeks treatment with denosumab 60 mg every 3 months (n = 51, 41 females) or placebo (n = 49, 37 females). The primary (radiographic) endpoint was the change in the total Ghent University Scoring System (GUSS) at week 24, where positive changes correspond to remodeling and negative changes to erosive progression. Secondary endpoints were the change in the GUSS at week 48 and the number of new erosive joints at week 48 by the anatomical phase scoring system. Baseline mean GUSS (standard deviation) of target joints was 155.9 (69.3) in the denosumab group and 158.7 (46.8) in the placebo group. The primary endpoint was met with an estimated difference between groups of 8.9 (95% confidence interval (CI) 1.0 to 16.9; P = 0.024) at week 24. This effect was confirmed at week 48 (baseline adjusted GUSS (standard error of the mean) denosumab and placebo were 163.5 (2.9) and 149.2 (3.9), respectively; with an estimated difference between groups of 14.3 (95% CI 4.6 to 24.0; P = 0.003)). At patient level, more new erosive joints were developed in the placebo group compared with denosumab at week 48 (odds ratio 0.24 (95% CI 0.08 to 0.72); P = 0.009). More adverse events occurred in the placebo group (125 events in 44 patients (90%)) compared with the denosumab group (97 events in 41 patients (80%)). These results demonstrate that denosumab has structure modifying effects in erosive hand OA by inducing remodeling and preventing new erosive joints. EU Clinical Trials Register identifier 2015-003223-53 .
MeSH term(s)	Female ; Humans ; Denosumab/adverse effects ; Double-Blind Method ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/drug therapy ; RANK Ligand ; Treatment Outcome ; Male
Chemical Substances	Denosumab (4EQZ6YO2HI) ; RANK Ligand
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02822-0
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

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Article ; Conference proceedings: Precision study of a fast and fully automated FVIII functional inhibitor test

Verbruggen, B. / Moore, G. W. / Binder, N. B.

Hämostaseologie

2024 Volume 44, Issue S 01

Event/congress	GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0044-1779217
Database	Thieme publisher's database

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Zs.A 1631: Show issues

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Article: G-CSF in Felty's syndrome: correction of neutropenia and effects on cytokine release.

Schots, R / Verbruggen, L A / Demanet, C

Clinical rheumatology

1995 Volume 14, Issue 1, Page(s) 116–118

MeSH term(s)	Adult ; Cytokines/drug effects ; Felty Syndrome/drug therapy ; Felty Syndrome/immunology ; Female ; Filgrastim ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Neutrophils/drug effects ; Recombinant Proteins/therapeutic use ; Tumor Necrosis Factor-alpha/drug effects
Chemical Substances	Cytokines ; Recombinant Proteins ; Tumor Necrosis Factor-alpha ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Filgrastim (PVI5M0M1GW)
Language	English
Publishing date	1995-01
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	604755-5
ISSN	0770-3198
ISSN	0770-3198
DOI	10.1007/bf02208099
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Zs.A 1740: Show issues

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Article ; Online: Gut microbiota differences in stunted and normal-lenght children aged 36-45 months in East Nusa Tenggara, Indonesia.

Surono, Ingrid S / Popov, Ilia / Verbruggen, Sanne / Verhoeven, Jessica / Kusumo, Pratiwi D / Venema, Koen

PloS one

2024 Volume 19, Issue 3, Page(s) e0299349

Abstract: ... involved in stunting, or are changed due to e.g. differences in diet, hygiene status, or other factors ...

Abstract	The role of the gut microbiota in energy metabolism of the host has been established, both in overweight/obesity, as well as in undernutrition/stunting. Dysbiosis of the gut microbiota may predispose to stunting. The aim of this study was to compare the gut microbiota composition of stunted Indonesian children and non-stunted children between 36 and 45 months from two sites on the East Nusa Tenggara (ENT) islands. Fecal samples were collected from 100 stunted children and 100 non-stunted children in Kupang and North Kodi. The gut microbiota composition was determined by sequencing amplicons of the V3-V4 region of the 16S rRNA gene. Moreover, fecal SCFA concentrations were analyzed. The microbiota composition was correlated to anthropometric parameters and fecal metabolites. The phyla Bacteroidetes (Bacteroidota; q = 0.014) and Cyanobacteria (q = 0.049) were significantly higher in stunted children. Three taxa at genus levels were consistently significantly higher in stunted children at both sampling sites, namely Lachnoclostridium, Faecalibacterium and Veillonella (q < 7 * 10-4). These and 9 other taxa positively correlated to the z-score length-for-age (zlen), while 11 taxa negatively correlated with zlen. Several taxa also correlated with sanitary parameters, some of which were also significantly different between the two groups. All three fecal SCFA concentrations (acetate, propionate and butyrate) and their total were lower in stunted children compared to non-stunted children, although not significant for butyrate, indicating lower energy-extraction by the gut microbiota. Also, since SCFA have been shown to be involved in gut barrier function, barrier integrity may be affected in the stunted children. It remains to be seen if the three taxa are involved in stunting, or are changed due to e.g. differences in diet, hygiene status, or other factors. The observed differences in this study do not agree with our previous observations in children on Java, Indonesia. There are differences in infrastructure facilities such as clean water and sanitation on ENT and Java, which may contribute to the differences observed. The role of the gut microbiota in stunting therefore requires more in depth studies. Trial registration: the trial was registered at ClinicalTrials.gov with identifier number NCT05119218.
MeSH term(s)	Child ; Humans ; Indonesia/epidemiology ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/analysis ; Growth Disorders/microbiology ; Bacteroidetes/genetics ; Butyrates ; Feces/microbiology
Chemical Substances	RNA, Ribosomal, 16S ; Butyrates
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299349
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Article: Post-error Slowing Reflects the Joint Impact of Adaptive and Maladaptive Processes During Decision Making.

Fievez, Fanny / Derosiere, Gerard / Verbruggen, Frederick / Duque, Julie

Frontiers in human neuroscience

2022 Volume 16, Page(s) 864590

Abstract: Errors and their consequences are typically studied by investigating changes in decision speed and accuracy in trials that follow an error, commonly referred to as "post-error adjustments". Many studies have reported that subjects slow down following an ... ...

Abstract	Errors and their consequences are typically studied by investigating changes in decision speed and accuracy in trials that follow an error, commonly referred to as "post-error adjustments". Many studies have reported that subjects slow down following an error, a phenomenon called "post-error slowing" (PES). However, the functional significance of PES is still a matter of debate as it is not always adaptive. That is, it is not always associated with a gain in performance and can even occur with a decline in accuracy. Here, we hypothesized that the nature of PES is influenced by one's speed-accuracy tradeoff policy, which determines the overall level of choice accuracy in the task at hand. To test this hypothesis, we had subjects performing a task in two distinct contexts (separate days), which either promoted speed (hasty context) or cautiousness (cautious context), allowing us to consider post-error adjustments according to whether subjects performed choices with a low or high accuracy level, respectively. Accordingly, our data indicate that post-error adjustments varied according to the context in which subjects performed the task, with PES being solely significant in the hasty context (low accuracy). In addition, we only observed a gain in performance after errors in a specific trial type, suggesting that post-error adjustments depend on a complex combination of processes that affect the speed of ensuing actions as well as the degree to which such PES comes with a gain in performance.
Language	English
Publishing date	2022-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2022.864590
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Article: Recording ten-fold larger I

Bloothooft, Meye / Verbruggen, Bente / Seibertz, Fitzwilliam / van der Heyden, Marcel A G / Voigt, Niels / de Boer, Teun P

Frontiers in physiology

2024 Volume 15, Page(s) 1298340

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2024.1298340
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