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  1. Book ; Thesis: Retrospektive Evaluation der ersten Kurzzeitergebnisse nach Verwendung eines neuen Pfannenimplantates zur acetabulären Defektrekonstruktion

    Wacker, Miriam / Rößler, Philip P.

    2021  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Miriam Wacker ; 1. Gutachter: PD Dr. med. Philip P. Rößler
    Language German
    Size 114 Seiten, Illustrationen, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
    HBZ-ID HT020879026
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Longitudinal Radiographic Bone Density Measurement in Revision Hip Arthroplasty and Its Correlation with Clinical Outcome.

    Roessler, Philip P / Eich, Jakob / Wirtz, Dieter C / Schildberg, Frank A

    Journal of clinical medicine

    2023  Volume 12, Issue 8

    Abstract: The subjective analysis of conventional radiography represents the principal method for bone diagnostics in endoprosthetics. Alternative objective quantitative methods are described but not commonly used. Therefore, semi-quantitative methods are tested ... ...

    Abstract The subjective analysis of conventional radiography represents the principal method for bone diagnostics in endoprosthetics. Alternative objective quantitative methods are described but not commonly used. Therefore, semi-quantitative methods are tested using digital computation and artificial intelligence to standardize, simplify, and ultimately improve the assessment. This study aimed to evaluate the correlation between relative density progressions and clinical outcomes. Radiographs and clinical examinations before and 24 and 48 weeks after surgery were obtained from sixty-eight patients with a modular hip stem. For the calculation of the relative bone density, the modal gray values of the Gruen zones were measured using ImageJ and were normalized by gray values of the highest and lowest ROI. The clinical outcomes were measured according to the Harris hip score before evaluating them for correlations. Analyses were performed separately for subgroups and bone regions. The Harris hip score increased from 44.15 ± 15.00 pre-operatively to 66.20 ± 13.87 at the latest follow-up. The relative bone density adjustment of Gruen zone 7 showed a significant correlation to its clinical outcome. Other bone adaptations could be realistically reproduced and differences by regional zones and patients' histories visualized. Next to the simplicity and that no additional examination is required, the method provides good semi-quantitative results and visualizes adaptations, which make it suitable for use.
    Language English
    Publishing date 2023-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12082795
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  3. Article ; Online: Females show worse functional outcome and quality of life compared to males 2 years after meniscus surgery: Data analysis from the German Arthroscopy Registry.

    Mai, Celine / Mai, Patrick / Hinz, Maximilian / Saenger, Rebecca / Seil, Romain / Tischer, Thomas / Roessler, Philip P

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2024  

    Abstract: Purpose: The purpose of this study was to investigate the impact of sex on knee function, activity and quality of life following meniscus surgery using data from the German Arthroscopy Registry.: Methods: This is a retrospective cohort study with ... ...

    Abstract Purpose: The purpose of this study was to investigate the impact of sex on knee function, activity and quality of life following meniscus surgery using data from the German Arthroscopy Registry.
    Methods: This is a retrospective cohort study with data collected between 2017 and 2022. Patient-reported outcome measures (PROMs), namely Knee Injury and Osteoarthritis Outcome Score (KOOS), EuroQol Visual Analogue Scale (EQ Scale), and Marx Activity Rating Scale (MARS), were collected preoperatively and at 6, 12 and 24 months postoperatively. Data were analysed to examine differences between male and female patients regarding PROMs, pre-existing conditions, meniscus lesion types and surgical treatments.
    Results: A total of 1106 female (36.6%) and 1945 male patients (63.7%) were included. Males were significantly younger than females and had a higher body mass index. Overall, there were four times more medial meniscus lesions (MMLs) (77.5%) than lateral meniscus lesions (LMLs) (27.9%). Degenerative LMLs were more frequent in females, while traumatic LMLs were more common in males. Frequencies of traumatic and degenerative MMLs were similar among males and females. Males had higher absolute KOOS irrespective of treatment or meniscus lesion type. Meniscus repair resulted in similar improvements in ΔKOOS for both sexes, while meniscus resection exhibited higher absolute KOOS for males at each time point. Males generally had higher EQ Scale and MARS than females.
    Conclusion: Greater improvements in knee function, activity and quality of life were observed in males. While MMLs appear to be comparable among sexes, the nature of LML differed significantly. These results may help surgeons to refine patient selection for specific treatments to improve overall clinical outcomes.
    Level of evidence: Level III.
    Language English
    Publishing date 2024-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1002/ksa.12131
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  4. Article ; Online: The Role of Osteotomy in Chronic Valgus Instability and Hyperextension Valgus Thrust (Medial Closing Wedge Distal Femoral Varus Osteotomy and Lateral Opening Wedge High Tibial Osteotomy).

    Roessler, Philip P / Getgood, Alan

    Clinics in sports medicine

    2019  Volume 38, Issue 3, Page(s) 435–449

    Abstract: Chronic valgus instability with concomitant valgus malalignment is a challenging diagnosis that cannot be successfully treated with ligament surgery alone. Hyperextension valgus thrust may be a symptom of this configuration, expressing the need for ... ...

    Abstract Chronic valgus instability with concomitant valgus malalignment is a challenging diagnosis that cannot be successfully treated with ligament surgery alone. Hyperextension valgus thrust may be a symptom of this configuration, expressing the need for thorough diagnosis and treatment. The present article will help to understand pathoanatomy and mechanisms of chronic valgus instability in combination with malalignment and provide a description of treatment techniques, in particular medial closing wedge distal femoral varus osteotomy (MCWDFVO) and lateral opening wedge high tibial osteotomy (LOWHTO), and their indications to deal with both issues simultaneously.
    MeSH term(s) Bone Malalignment/surgery ; Humans ; Joint Instability/surgery ; Knee Joint/surgery ; Osteotomy/methods ; Physical Examination ; Preoperative Period ; Radiography ; Tibia/surgery
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 779944-5
    ISSN 1556-228X ; 0278-5919
    ISSN (online) 1556-228X
    ISSN 0278-5919
    DOI 10.1016/j.csm.2019.02.012
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  5. Article ; Online: Infiltration therapy in the context of cartilage surgery.

    Steens, Wolfram / Zinser, Wolfgang / Rößler, Philip / Heyse, Thomas

    Archives of orthopaedic and trauma surgery

    2023  

    Abstract: Guideline-based surgical cartilage therapy for focal cartilage damage offers highly effective possibilities to sustainably reduce patients' complaints and to prevent or at least delay the development of early osteoarthritis. In the knee joint, it has the ...

    Abstract Guideline-based surgical cartilage therapy for focal cartilage damage offers highly effective possibilities to sustainably reduce patients' complaints and to prevent or at least delay the development of early osteoarthritis. In the knee joint, it has the potential to reduce almost a quarter of the arthroses requiring joint replacement caused by cartilage damage. Biologically effective injection therapies could further improve these results. Based on the currently available literature and preclinical studies, intra- and postoperative injectables may have a positive effect of platelet-rich plasma/fibrin (PRP/PRF) and hyaluronic acid (HA) on cartilage regeneration and, in the case of HA injections, also on the clinical outcome can be assumed. The role of a combination therapy with use of intra-articular corticosteroids is lacking in the absence of adequate study data and cannot be defined yet. With regard to adipose tissue-based cell therapy, the current scientific data do not yet justify any recommendation for its use. Further studies also regarding application intervals, timing and differences in different joints are required.
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-023-04964-1
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  6. Article ; Online: Systematic review on groove pancreatitis: management of a rare disease.

    Ukegjini, Kristjan / Steffen, Thomas / Tarantino, Ignazio / Jonas, Jan P / Rössler, Fabian / Petrowsky, Henrik / Gubler, Christoph / Müller, Philip C / Oberkofler, Christian E

    BJS open

    2023  Volume 7, Issue 5

    Abstract: Background: Groove pancreatitis is a focal form of chronic pancreatitis affecting the area of the paraduodenal groove. The aim of this systematic review was to assess the clinical presentation, diagnosis and treatment of patients with groove ... ...

    Abstract Background: Groove pancreatitis is a focal form of chronic pancreatitis affecting the area of the paraduodenal groove. The aim of this systematic review was to assess the clinical presentation, diagnosis and treatment of patients with groove pancreatitis.
    Methods: Medical literature databases (Embase, Medline via PubMed and Cochrane Central Register of Controlled Trials) were systematically searched for data recorded between 1 January 1990 and 31 August 2022 regarding patient characteristics, diagnosis, surgical treatment and outcomes. The following inclusion criteria were applied: RCTs, observational studies (cohort and case-control studies) and case studies with >3 cases including patients with groove pancreatitis undergoing medical, endoscopic or surgical treatment with available clinical and diagnostic data. Fisher's exact test for binary data and Mann-Whitney U test or Student t-test for continuous data were adopted for statistical analysis.
    Results: Of 649 studies, 44 were included, involving reports on 1404 patients with a mean age of 49 years. In 41 of the 44 studies in which patient gender was described, 86 per cent (N = 1023) of patients were male. Information on the risk factors of alcohol and nicotine was available in 37 and 23 studies, respectively. Seventy-nine per cent (N = 886) of patients had a history of excessive alcohol consumption and 83 per cent (N = 595) were smokers. Information on clinical symptoms was available in 37 of the 44 included studies and 78.5 per cent (N = 870) presented with abdominal pain. Some 27 studies comprising 920 groove pancreatitis patients were treatment oriented. Seventy-four per cent (N = 682) of patients were treated conservatively, 26.4 per cent (N = 134) underwent endoscopic treatment and 54.7 per cent (N = 503) required surgery. There was complete relief of symptoms in 35.6 per cent (N = 243) after conservative treatment, 55.2 per cent (N = 74) after endoscopic treatment and 69.6 per cent (N = 350) after surgical treatment. The median follow-up time was 42 months (range, 1-161 months).
    Conclusion: Groove pancreatitis shows on imaging a typical triad: cystic lesions in the pancreatic duct or duodenal wall, calcifications, and thickenings of the duodenal wall. Surgery appears to be the most effective treatment modality.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Rare Diseases ; Abdominal Pain/etiology ; Case-Control Studies ; Conservative Treatment ; Pancreatitis/diagnostic imaging ; Pancreatitis/therapy
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Systematic Review ; Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad094
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  7. Article ; Online: Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them.

    Dalvit, Claudio / Gmür, Isabel / Rößler, Philip / Gossert, Alvar D

    Progress in nuclear magnetic resonance spectroscopy

    2023  Volume 138-139, Page(s) 52–69

    Abstract: NMR spectroscopy is currently extensively used in binding assays for hit identification, but its use in dissociation constant determination is more limited when compared to other biophysical techniques, in particular for tight binders. Although NMR is ... ...

    Abstract NMR spectroscopy is currently extensively used in binding assays for hit identification, but its use in dissociation constant determination is more limited when compared to other biophysical techniques, in particular for tight binders. Although NMR is quite suitable for measuring the binding strength of weak to medium affinity ligands with dissociation constant K
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 209325-x
    ISSN 1873-3301 ; 0079-6565
    ISSN (online) 1873-3301
    ISSN 0079-6565
    DOI 10.1016/j.pnmrs.2023.07.001
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  8. Article ; Online: Comment on Roessler et al.: Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.

    Roessler, Philip P / Efe, Turgay

    International orthopaedics

    2016  Volume 40, Issue 3, Page(s) 645–646

    MeSH term(s) Cartilage ; Cartilage Diseases ; Cartilage, Articular ; Chondrocytes ; Collagen Type I ; Follow-Up Studies ; Humans ; Knee Joint ; Transplantation, Autologous
    Chemical Substances Collagen Type I
    Language English
    Publishing date 2016-03
    Publishing country Germany
    Document type Comment ; Letter
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-015-3056-4
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    Zs.A 1324: Show issues Location:
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  9. Article ; Online: Suture Tape Reduces Quadriceps Tendon Repair Gap Formation Compared With High-Strength Suture: A Cadaveric Biomechanical Analysis.

    Roessler, Philip P / Burkhart, Timothy A / Getgood, Alan / Degen, Ryan M

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2020  Volume 36, Issue 8, Page(s) 2260–2267

    Abstract: ... cycles (P = .021). There were no significant difference with respect to the number of suture or tape ...

    Abstract Purpose: To compare the biomechanical differences between quadriceps tendon (QT) repair with high-strength suture (HSS) versus suture tape (ST) with varying number of suture passes.
    Methods: In total, 28 fresh-frozen QTs were randomized into 2 groups: (1) HSS; or (2) ST; specimens were then further randomized into subgroups of either 4 or 6 suture passes. Specimens were secured within a materials testing system and a 150-N preload was applied for 10 seconds followed by a cyclic loading protocol between 50 N and 250 N for 1000 cycles. Video was used to follow tracking markers used to calculate the magnitude of tendon displacement. Two-way univariate analysis of variance was used to determine the effect of suture type and passes on the displacement after preloading and mixed repeated-measures analysis of variance was used to determine the effect of suture type and passes on displacement following cyclic loading.
    Results: There were large increases in displacement following the preload across all conditions (7.82 ± 3.64 mm), with no statistically significant differences between groups. There was a significant difference in the mean (± standard deviation) displacement between the ST (5.24 ± 2.82 mm) and HSS (7.93 ± 2.91 mm) starting at 200 cycles, which became more pronounced with successive testing out to 1000 cycles (P = .021). There were no significant difference with respect to the number of suture or tape passes.
    Conclusions: Following preloading at 150 N, significant displacement occurred in both QT repair groups. ST demonstrated significantly less displacement than HSS under cyclic loading and had greater ultimate failure loads.
    Clinical relevance: When performing QT repair, emphasis should be placed on appropriate pretensioning of sutures to at least 150 N before knot-tying. In addition, where available, ST should be used over HSS to reduce further cyclic elongation and improve ultimate failure loads.
    MeSH term(s) Biomechanical Phenomena ; Cadaver ; Humans ; Pressure ; Quadriceps Muscle/surgery ; Reconstructive Surgical Procedures ; Stress, Mechanical ; Surgical Tape ; Suture Anchors ; Suture Techniques ; Sutures ; Tendons/surgery ; Video Recording
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2020.04.020
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    Zs.A 2046: Show issues Location:
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  10. Article ; Online: Effect of donor pancreas extraction time on pancreas transplantation-a Swiss tertiary center experience.

    Rössler, Fabian / Kümmerli, Christoph / Hügli, Sandro / Jonas, Jan P / Hübel, Kerstin / Oberkofler, Christian E / Müller, Philip C / de Rougemont, Olivier

    Clinical transplantation

    2022  Volume 37, Issue 1, Page(s) e14846

    Abstract: ... In multivariable analysis, ET did not negatively affect major complications (OR 1.41 [95% CI: .59-3.36]; p = .438) and ... insulin-free survival (HR 1.42 [95% CI: .55-3.63]; p = .459). The median CIT was 522 (441-608) min. CIT ... was associated with major complications (OR 2.51 [95% CI: 1.11-5.68]; p = .027), but without impact ...

    Abstract We aimed to assess the effect of donor pancreas extraction time (ET) on postoperative complications and graft function after pancreas transplantation (PT). We analyzed all consecutive donor pancreas procurements for the simultaneous pancreas and kidney transplantation (SPK) and the associated PT in a Swiss transplant center over a 20-year period. Pancreas ET was defined as the time from cold flush to static storage of the pancreas on ice. The primary endpoint was the effect of extraction time on surgical complications. Secondary endpoints comprised the effect of ET on graft function (insulin-free survival) and graft pancreatitis. Of 115 procured pancreas grafts the median donor pancreas ET was 65 min (IQR: 48-78 min). In multivariable analysis, ET did not negatively affect major complications (OR 1.41 [95% CI: .59-3.36]; p = .438) and insulin-free survival (HR 1.42 [95% CI: .55-3.63]; p = .459). The median CIT was 522 (441-608) min. CIT was associated with major complications (OR 2.51 [95% CI: 1.11-5.68]; p = .027), but without impact on insulin-free survival (HR 1.94 [95% CI: .84-4.48]; p = .119). Patients with and without graft pancreatitis had no statistically significant differences in ET and CIT (p = .164 and p = .47, respectively). In multivariable analysis, Amylase levels > 270 U/L on postoperative day 1 were significantly associated with major complications (OR 3.61 [95% CI: 1.06-12.32]; p = .040). Our results suggest that although no effect of ET on complications and graft function after PT was found, shorter CIT and less graft pancreatitis can have a positive impact on surgical complications. Results could possibly be influenced by the exceptional quality of the pancreas donors, with short travel distances and preservation times in Switzerland.
    MeSH term(s) Humans ; Pancreas Transplantation/methods ; Pancreatitis, Graft ; Switzerland ; Pancreas ; Tissue Donors ; Graft Survival
    Language English
    Publishing date 2022-11-23
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14846
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