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  1. Article ; Online: Double the risk of death and other 'inconvenient truths' about oliguria.

    Kellum, John A / Murugan, Raghavan

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1420–1421

    MeSH term(s) Humans ; Oliguria/etiology
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07187-5
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  2. Article ; Online: The aflatoxin B

    Minko, Irina G / Kellum, Andrew H / Stone, Michael P / Lloyd, R Stephen

    Environmental and molecular mutagenesis

    2023  Volume 65 Suppl 1, Page(s) 9–13

    Abstract: Dietary exposure to aflatoxin ... ...

    Abstract Dietary exposure to aflatoxin B
    MeSH term(s) Animals ; Mutagens/toxicity ; Aflatoxin B1/toxicity ; DNA Adducts/genetics ; Guanine ; Mutagenesis ; Liver Neoplasms/pathology ; Imidazoles/adverse effects
    Chemical Substances Mutagens ; Aflatoxin B1 (9N2N2Y55MH) ; DNA Adducts ; Guanine (5Z93L87A1R) ; Imidazoles
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639145-x
    ISSN 1098-2280 ; 0893-6692
    ISSN (online) 1098-2280
    ISSN 0893-6692
    DOI 10.1002/em.22556
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  3. Article ; Online: Risk and Timing of De Novo Sepsis in Critically Ill Children after Acute Kidney Injury.

    Formeck, Cassandra L / Feldman, Robert / Althouse, Andrew D / Kellum, John A

    Kidney360

    2023  Volume 4, Issue 3, Page(s) 308–315

    MeSH term(s) Humans ; Child ; Critical Illness ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Sepsis/diagnosis
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0005082022
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  4. Article ; Online: How renal is the kidney?

    Bellomo, Rinaldo / Ronco, Claudio / Kellum, John / Reis, Thiago / Forni, Lui

    Lancet (London, England)

    2023  Volume 402, Issue 10412, Page(s) 1527

    MeSH term(s) Humans ; Kidney/diagnostic imaging ; Kidney Neoplasms
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01068-1
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  5. Article ; Online: Management of Chronic Pain in Patients with Substance Use Disorders.

    Eagen, Kellene / Rabson, Laurel / Kellum, Rebecca

    Primary care

    2022  Volume 49, Issue 3, Page(s) 455–468

    Abstract: Understanding the risks for substance use disorders (SUDs) and how to diagnose and treat is essential to the safe and effective treatment of patients with chronic noncancer pain (CNCP). Because of the common neurologic pathways underlying addiction and ... ...

    Abstract Understanding the risks for substance use disorders (SUDs) and how to diagnose and treat is essential to the safe and effective treatment of patients with chronic noncancer pain (CNCP). Because of the common neurologic pathways underlying addiction and chronic pain and common comorbid mental health and psychosocial challenges, these conditions should be treated concurrently. Depending on setting and comfort level of the provider, primary care clinicians may have the resources to provide office-based treatment or may consider referral to specialty treatment. An awareness of the stigma facing patients with both CNCP and SUD is important to providing compassionate, patient-centered care.
    MeSH term(s) Analgesics, Opioid/therapeutic use ; Chronic Pain/epidemiology ; Chronic Pain/therapy ; Comorbidity ; Humans ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604005-6
    ISSN 1558-299X ; 0095-4543
    ISSN (online) 1558-299X
    ISSN 0095-4543
    DOI 10.1016/j.pop.2022.01.008
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  6. Article: Contrast-associated acute kidney injury and cardiovascular events: a secondary analysis of the PRESERVE cohort.

    Murugan, Raghavan / Boudreaux-Kelly, Monique Y / Kellum, John A / Palevsky, Paul M / Weisbord, Steven

    Clinical kidney journal

    2023  Volume 16, Issue 12, Page(s) 2626–2638

    Abstract: Background: Contrast-associated acute kidney injury (CA-AKI) has been associated with a higher risk of cardiovascular (CV) events. We studied the risk of CV events in chronic kidney disease (CKD) patients undergoing angiography and whether biomarkers ... ...

    Abstract Background: Contrast-associated acute kidney injury (CA-AKI) has been associated with a higher risk of cardiovascular (CV) events. We studied the risk of CV events in chronic kidney disease (CKD) patients undergoing angiography and whether biomarkers can predict such events. We also explored whether CA-AKI mediates the association of pre-angiography estimated glomerular filtration rate (eGFR) on CV events.
    Methods: We analysed participants from the Prevention of Serious Adverse Events following the Angiography (PRESERVE) trial. Urinary tissue inhibitor of matrix metalloproteinase [TIMP]-2 and insulin growth factor binding protein [IGFBP]-7, plasma brain-type natriuretic peptide (BNP), high sensitivity C-reactive protein (hs-CRP), and serum cardiac troponin-I (Tn-I) were assayed before and after angiography. We assessed the composite risk of CV events by day 90.
    Results: Of the 922 participants, 119 (12.9%) developed CV events, and 73 (7.9%) developed CA-AKI. Most cases of CA-AKI (90%) were stage 1. There were no differences in urinary [TIMP-2]•[IGFBP7] concentrations or the proportion of patients with CA-AKI among those with and without CV events. Higher BNP, Tn-I, and hs-CRP were associated with CV events, but their discriminatory capacity was modest (AUROC <0.7). CA-AKI did not mediate the association of the pre-angiography eGFR on CV events.
    Conclusions: Most episodes of CA-AKI are stage 1 AKI and are not associated with CV events. Less severe CA-AKI episodes also did not mediate the risk of pre-angiography eGFR on CV events. Our findings suggest that most CV events after contrast procedures are due to underlying CKD and CV risk factors rather than less severe CA-AKI episodes and should help enhance the utilization of clinically indicated contrast procedures among high-risk patients with CKD. Further research is required to examine whether moderate-to-severe CA-AKI episodes are associated with CV events.
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad214
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    Zs.A 6587: Show issues Location:
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  7. Article ; Online: Recovery after AKI: Effects on outcomes over 15 years.

    Peerapornratana, Sadudee / Fiorentino, Marco / Priyanka, Priyanka / Murugan, Raghavan / Kellum, John A

    Journal of critical care

    2023  Volume 76, Page(s) 154280

    Abstract: Purpose: To examine the effect of kidney recovery on mortality, dialysis and kidney transplantation up to 15 years after AKI.: Materials and methods: We studied 29,726 survivors of critical illness and compared these outcomes stratified by AKI and ... ...

    Abstract Purpose: To examine the effect of kidney recovery on mortality, dialysis and kidney transplantation up to 15 years after AKI.
    Materials and methods: We studied 29,726 survivors of critical illness and compared these outcomes stratified by AKI and recovery status at hospital discharge. Kidney recovery was defined as a return of serum creatinine to ≤150% of baseline without dialysis prior to hospital discharge.
    Results: Overall AKI occurred in 59.2% in which two thirds developed stage 2-3 AKI. Recovery rate of AKI at hospital discharge was 80.8%. Patients who did not recover experienced the worst 15-year mortality compared to those who recovered and those without AKI (57.8% vs 45.2% vs 30.3%, p < 0.001). This pattern was also found in subgroups of patients with suspected sepsis-associated (57.1% vs 47.9% vs 36.5%, p < 0.001) and cardiac surgery-associated AKI (60.1% vs 41.8% vs 25.9%, p < 0.001). The rates of dialysis and transplantation at 15 years were low and not associated with recovery status.
    Conclusions: Recovery of AKI in critically ill patients at hospital discharge had an effect on long-term mortality for up to 15 years. These results have implications for acute care, follow-up and choice of endpoints for clinical trials.
    MeSH term(s) Humans ; Renal Dialysis ; Patient Discharge ; Sepsis ; Critical Care ; Acute Kidney Injury/therapy ; Risk Factors ; Retrospective Studies
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154280
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  8. Article ; Online: Author Correction: Conceptual advances and evolving terminology in acute kidney disease.

    Kellum, John A / Ronco, Claudio / Bellomo, Rinaldo

    Nature reviews. Nephrology

    2021  Volume 17, Issue 7, Page(s) 503

    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00426-2
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  9. Article ; Online: Conceptual advances and evolving terminology in acute kidney disease.

    Kellum, John A / Ronco, Claudio / Bellomo, Rinaldo

    Nature reviews. Nephrology

    2021  Volume 17, Issue 7, Page(s) 493–502

    Abstract: Over the past decade, new insights into epidemiology, pathophysiology and biomarkers have modified our understanding of acute kidney dysfunction and damage, and their association with subsequent chronic kidney disease. The concept of acute kidney injury ( ...

    Abstract Over the past decade, new insights into epidemiology, pathophysiology and biomarkers have modified our understanding of acute kidney dysfunction and damage, and their association with subsequent chronic kidney disease. The concept of acute kidney injury (AKI), which has relied on established but nonetheless flawed biomarkers of solute clearance (serum creatinine levels and urinary output), has been challenged by the identification of novel biomarkers of tubular stress and/or damage. The expression of some of these novel biomarkers precedes changes in conventional biomarkers or can increase their predictive power, and might therefore enhance the clinical accuracy of the definition of AKI. In addition, the need to consider AKI recurrence, duration and progression to chronic kidney disease within the clinical and epidemiological framework of AKI led to the emergence of the concept of acute kidney disease. New definitions of acute syndromes of kidney impairment and injury are needed.
    MeSH term(s) Acute Kidney Injury/classification ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/physiopathology ; Biomarkers/analysis ; Creatinine/blood ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Terminology as Topic ; Urination
    Chemical Substances Biomarkers ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00410-w
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  10. Article ; Online: Paradigms of acute kidney injury in the intensive care setting.

    Kellum, John A / Prowle, John R

    Nature reviews. Nephrology

    2018  Volume 14, Issue 4, Page(s) 217–230

    Abstract: Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies, variable pathogenesis and diverse outcomes. However, these heterogeneities are not reflected in current approaches to the diagnosis and, to some degree, ... ...

    Abstract Acute kidney injury (AKI) is a heterogeneous clinical syndrome that has multiple aetiologies, variable pathogenesis and diverse outcomes. However, these heterogeneities are not reflected in current approaches to the diagnosis and, to some degree, treatment of AKI. For example, congestive heart failure and dehydration can produce identical changes in serum creatinine level and urine output (parameters that are used to define AKI); however, they differ vastly in their physiological contexts and demand completely opposite treatments. AKI is often still considered to be a homogeneous clinical entity, which implies a uniform pathogenesis and a well-defined prognosis. As a consequence, efforts to find effective AKI treatments have been hampered by a lack of clear clinical classifications for various types of AKI. In addition, subclassification of AKI into subclinical phenotypes - for example, on the basis of protein biomarkers and other in vitro diagnostics that take into account disease aetiology and underlying pathogenesis - might be necessary to develop therapeutic approaches that effectively target the widely differing pathomechanisms of AKI. In this Review, we discuss the major subtypes of AKI that are associated with sepsis, major surgery, renal hypoperfusion and nephrotoxin exposure -situations that are typically seen in the intensive care setting. We consider differences and similarities in their phenotype, pathogenesis and outcomes and how this information might be used to guide treatment.
    MeSH term(s) Acute Kidney Injury/classification ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/therapy ; Biomarkers/blood ; Humans ; Intensive Care Units ; Phenotype ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2017.184
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