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  1. Article ; Online: Syphilitic gastritis resembling gastric cancer.

    Liu, Guohong / Zhuang, Xiaohui / Chen, Chen / Li, Lei / Qiao, Zhenguo

    Gastrointestinal endoscopy

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 519: Show issues

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  2. Article: Inhibition of Ca2+ induced Macrophage Oxidative Stress Cascade in Mice With Ulcerative Colitis.

    Yan, Hao / Li, Guohong

    Alternative therapies in health and medicine

    2024  

    Abstract: Context: In the context of ulcerative coloproctitis (UC), a chronic and non-specific inflammatory condition of the colon and rectum with an elusive etiology, the therapeutic potential of G protein-coupled receptor 109a (GPR109a) has gained prominence. ... ...

    Abstract Context: In the context of ulcerative coloproctitis (UC), a chronic and non-specific inflammatory condition of the colon and rectum with an elusive etiology, the therapeutic potential of G protein-coupled receptor 109a (GPR109a) has gained prominence. GPR109a is expressed in various cell types including colonic epithelium, adipocytes, neutrophils, and macrophages, positioning it as a promising candidate for pharmacological intervention in colitis.
    Objective: the mechanistic role of GPR109a in a mouse model of UC and to assess its capacity to mitigate the disease's progression.
    Design: The research team performed an animal study.
    Setting: Conducted by a research team in the biomedical setting of the People's Hospital of Dongxihu District in Wuhan, Hubei province of China.
    Animals: This animal study engaged 16 specific pathogen-free (SPF) male BALB/c mice, aged between 4 to 6 weeks and weighing 20-24 grams each.
    Outcome measures: (1) analysis of rectal lesions via hematoxylin-eosin (HE) staining, (2) the use of transmission electron microscopy to examine suborganelle spatial relationships, (3) Western blot analysis to evaluate a spectrum of protein expressions such as phosphorylated IP3R, p-PERK, p-IRE-1α, mitofusins, NADPH oxidases, TNF-α, and IL-1β, and (4) determination of intracellular calcium concentrations to gauge intestinal barrier function impairment involving specific calcium pathway signals.
    Results: Results from the study painted a picture of significant infiltration by inflammatory cells within the mucosal and submucosal layers, compounded by pronounced endoplasmic reticulum expansion. Abundant interfaces between the ER and the mitochondria formed multiple structures known as mitochondria-associated membranes or MAMs. When evaluated under calcium-rich conditions, the protein levels mentioned earlier were notably elevated in the GPR109a knockdown (KD) group versus the infection control (NC) counterparts. However, this differential expression disappeared under calcium-depleted conditions or when treated with 2-aminoethyl diphenyl borinate (2-APB). Additionally, fluorescence intensity assays showed marked suppression in the GPR109a-KD plus lipopolysaccharide (LPS) group compared to the control.
    Conclusions: Drawing these observations to a close, the study concluded that GPR109a has an inhibitory effect on the advancement of ulcerative coloproctitis in mice. This is mediated through the activation of a calcium-induced oxidative stress cascade within macrophages, delineating a promising therapeutic pathway for the management of this inflammatory disease.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4504: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome.

    Li, Guohong

    Science China. Life sciences

    2020  Volume 63, Issue 6, Page(s) 791–794

    MeSH term(s) Base Sequence ; Chromatin/genetics ; Chromatin/metabolism ; Gene Regulatory Networks ; Genome, Human/genetics ; Humans ; Nucleic Acid Conformation
    Chemical Substances Chromatin
    Language English
    Publishing date 2020-05-09
    Publishing country China
    Document type Editorial
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-020-1723-y
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  4. Article: Secondary Metabolites from the Nematode-Trapping Fungus

    Lei, Hongmei / Zhang, Guangke / Zhao, Peiji / Li, Guohong

    Microorganisms

    2023  Volume 11, Issue 11

    Abstract: As a representative nematode-trapping fungus, ...

    Abstract As a representative nematode-trapping fungus,
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11112693
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  5. Article: Volatile Metabolites from

    Sun, Yongxiang / Ran, Yuan / Yang, Hanbo / Mo, Minghe / Li, Guohong

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: Brevundimonas ... ...

    Abstract Brevundimonas diminuta
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11040966
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  6. Article ; Online: Nucleosome Dynamics Derived at the Single-Molecule Level Bridges Its Structures and Functions.

    Chen, Ping / Li, Guohong / Li, Wei

    JACS Au

    2024  Volume 4, Issue 3, Page(s) 866–876

    Abstract: Nucleosome, the building block of chromatin, plays pivotal roles in all DNA-related processes. While cryogenic-electron microscopy (cryo-EM) has significantly advanced our understanding of nucleosome structures, the emerging field of single-molecule ... ...

    Abstract Nucleosome, the building block of chromatin, plays pivotal roles in all DNA-related processes. While cryogenic-electron microscopy (cryo-EM) has significantly advanced our understanding of nucleosome structures, the emerging field of single-molecule force spectroscopy is illuminating their dynamic properties. This technique is crucial for revealing how nucleosome behavior is influenced by chaperones, remodelers, histone variants, and post-translational modifications, particularly in their folding and unfolding mechanisms under tension. Such insights are vital for deciphering the complex interplay in nucleosome assembly and structural regulation, highlighting the nucleosome's versatility in response to DNA activities. In this Perspective, we aim to consolidate the latest advancements in nucleosome dynamics, with a special focus on the revelations brought forth by single-molecule manipulation. Our objective is to highlight the insights gained from studying nucleosome dynamics through this innovative approach, emphasizing the transformative impact of single-molecule manipulation techniques in the field of chromatin research.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Secondary Metabolites from the Endoparasitic Nematophagous Fungus

    Dai, Zebao / Gan, Yang / Zhao, Peiji / Li, Guohong

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: Harposporium ... ...

    Abstract Harposporium anguillulae
    Language English
    Publishing date 2022-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081553
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  8. Article ; Online: Earthquake potential across the North-South seismic belt of China.

    Li, Yanchuan / Shan, Xinjian / Qu, Chunyan / Zhang, Guohong / Song, Xiaogang

    Science bulletin

    2023  Volume 69, Issue 2, Page(s) 179–182

    Language English
    Publishing date 2023-09-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.09.043
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  9. Article ; Online: Investigation of

    Chen, Jie / Hu, Xiuxiu / Li, Guohong / Wan, Pingmin / Shao, Zhiyong / Jin, Erguang / Liu, Xiaohua / Yang, Qian / Long, Anying / Qian, Yunguo

    Veterinary sciences

    2024  Volume 11, Issue 1

    Abstract: Prototheca ... ...

    Abstract Prototheca bovis
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci11010037
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  10. Article ; Online: Multiple Functions of l-Thioproline in the Synthesis of Chiral Metal Bromides Showing Second-Harmonic-Generation Responses.

    Qian, Peiqi / Li, Ying / Cheng, Juan / Li, Jing / Zeng, Hongmei / Huang, Ling / Zou, Guohong / Lin, Zhien

    Inorganic chemistry

    2024  

    Abstract: Three new homochiral metal bromides, namely, (l-Htp) ...

    Abstract Three new homochiral metal bromides, namely, (l-Htp)
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c01397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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