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Article ; Online: Resurgence increases with repetition.

Redner, Ryan / Lotfizadeh, Amin D / Edwards, Timothy L / Poling, Alan

2022 Volume 197, Page(s) 104620

Abstract: Resurgence refers to a behavioral process in which a recent response is extinguished (or reinforcement conditions worsen) and a previously extinguished response recurs. In previous research, resurgence has been reliably produced when the resurgence ... ...

Abstract	Resurgence refers to a behavioral process in which a recent response is extinguished (or reinforcement conditions worsen) and a previously extinguished response recurs. In previous research, resurgence has been reliably produced when the resurgence procedure is repeated. Changes in the degree of increase of the resurging response across iterations of the procedure have been inconsistent, however, with some studies showing increases and some showing no changes or decreases in resurgence magnitude. The present study examined the nature of resurgence across repeated iterations of the conventional resurgence procedure by exposing four pigeons to the resurgence procedure six times in succession. In the first condition of the resurgence procedure, pecks on one key (e.g., the left) were reinforced under a variable-interval (VI) 30-s schedule. In the second condition pecks on that key were extinguished, and pecks on another key (e.g., the right) were reinforced under the same schedule. In the final condition there were no programmed consequences for either response. Resurgence was observed in 21 of 24 opportunities (87.5%). Iteration-over-iteration increases in resurgence were observed in 15 of 20 opportunities (75.0%), and this increase was found to be statistically significant. These findings demonstrate that, under certain conditions, resurgence generally increases in magnitude with repeated exposure to the procedures that generate it.
MeSH term(s)	Animals ; Columbidae ; Conditioning, Operant/physiology ; Extinction, Psychological/physiology ; Reinforcement Schedule ; Reinforcement, Psychology
Language	English
Publishing date	2022-03-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196999-7
ISSN	1872-8308 ; 0376-6357
ISSN (online)	1872-8308
ISSN	0376-6357
DOI	10.1016/j.beproc.2022.104620
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Article ; Online: Phase 2 study of epigenetic priming with decitabine followed by cytarabine for acute myeloid leukemia in older patients.

Im, Annie / Quann, Kevin / Agha, Mounzer / Raptis, Anastasios / Redner, Robert L / Hou, Jing-Zhou / Farah, Rafic / Dorritie, Kathleen A / Sehgal, Alison R / Normolle, Daniel / Bovbjerg, Dana H / Aggarwal, Nidhi / Herman, James / Lontos, Konstantinos / Boyiadzis, Michael

American journal of hematology

2024 Volume 99, Issue 3, Page(s) 380–386

Abstract: Acute myeloid leukemia (AML) in older patients has a poor prognosis, low complete remission (CR) rates, and poor overall survival (OS). Preclinical studies have shown synergistic effects of epigenetic priming with hypomethylating agents followed by ... ...

Abstract	Acute myeloid leukemia (AML) in older patients has a poor prognosis, low complete remission (CR) rates, and poor overall survival (OS). Preclinical studies have shown synergistic effects of epigenetic priming with hypomethylating agents followed by cytarabine. Based on these data, we hypothesized that an induction regimen using epigenetic priming with decitabine, followed by cytarabine would be effective and safe in older patients with previously untreated AML. Here, we conducted a phase 2 trial in which older patients with previously untreated AML received an induction regimen consisting of 1 or 2 courses of decitabine 20 mg/m
MeSH term(s)	Aged ; Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cytarabine ; Decitabine ; Epigenesis, Genetic ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Remission Induction ; Treatment Outcome
Chemical Substances	Cytarabine (04079A1RDZ) ; Decitabine (776B62CQ27)
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27212
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Article ; Online: Trapping and escape in a turbid medium.

Krapivsky, P L / Redner, S

The Journal of chemical physics

2017 Volume 147, Issue 21, Page(s) 214903

Abstract: ... compared to the beaker radius R, the fraction of molecules E that escape to the beaker wall and ... combination λ = Na/R. We compute E and T as a function of λ for a spherical beaker and for beakers ...

Abstract	We investigate the absorption of diffusing molecules in a fluid-filled spherical beaker that contains many small reactive traps. The molecules are absorbed either by hitting a trap or by escaping via the beaker walls. In the physical situation where the number N of traps is large and their radii a are small compared to the beaker radius R, the fraction of molecules E that escape to the beaker wall and the complementary fraction T that eventually are absorbed by the traps depend only on the dimensionless parameter combination λ = Na/R. We compute E and T as a function of λ for a spherical beaker and for beakers of other three-dimensional shapes. The asymptotic behavior is found to be universal: 1 - E ∼ λ for λ → 0 and E ∼ λ
Language	English
Publishing date	2017-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5009425
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Article ; Online: Prognostic significance of blast immunophenotype on first post-induction bone marrow biopsy.

Lontos, Konstantinos / Tsagianni, Anastasia / Agha, Mounzer / Raptis, Anastasios / Hou, Jing-Zhou / Farah, Rafic / Redner, Robert L / Im, Annie / Dorritie, Kathleen A / Sehgal, Alison / Rossetti, James / Aggarwal, Nidhi / Saul, Melissa / Boyiadzis, Michael / Bailey, Nathanael G

Leukemia & lymphoma

2023 Volume 64, Issue 3, Page(s) 750–752

MeSH term(s)	Humans ; Bone Marrow/pathology ; Prognosis ; Remission Induction ; Bone Marrow Cells/pathology ; Biopsy
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2023.2172981
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Article ; Online: Densification and structural transitions in networks that grow by node copying.

Bhat, U / Krapivsky, P L / Lambiotte, R / Redner, S

Physical review. E

2016 Volume 94, Issue 6-1, Page(s) 62302

Abstract: We introduce a growing network model, the copying model, in which a new node attaches to a randomly selected target node and, in addition, independently to each of the neighbors of the target with copying probability p. When p<1/2, this algorithm ... ...

Abstract	We introduce a growing network model, the copying model, in which a new node attaches to a randomly selected target node and, in addition, independently to each of the neighbors of the target with copying probability p. When p<1/2, this algorithm generates sparse networks, in which the average node degree is finite. A power-law degree distribution also arises, with a nonuniversal exponent whose value is determined by a transcendental equation in p. In the sparse regime, the network is "normal," e.g., the relative fluctuations in the number of links are asymptotically negligible. For p≥1/2, the emergent networks are dense (the average degree increases with the number of nodes N), and they exhibit intriguing structural behaviors. In particular, the N dependence of the number of m cliques (complete subgraphs of m nodes) undergoes m-1 transitions from normal to progressively more anomalous behavior at an m-dependent critical values of p. Different realizations of the network, which start from the same initial state, exhibit macroscopic fluctuations in the thermodynamic limit: absence of self-averaging. When linking to second neighbors of the target node can occur, the number of links asymptotically grows as N^{2} as N→∞, so that the network is effectively complete as N→∞.
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.94.062302
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Article ; Online: Structural Transitions in Densifying Networks.

Lambiotte, R / Krapivsky, P L / Bhat, U / Redner, S

Physical review letters

2016 Volume 117, Issue 21, Page(s) 218301

Abstract: We introduce a minimal generative model for densifying networks in which a new node attaches to a randomly selected target node and also to each of its neighbors with probability p. The networks that emerge from this copying mechanism are sparse for p<1/ ... ...

Abstract	We introduce a minimal generative model for densifying networks in which a new node attaches to a randomly selected target node and also to each of its neighbors with probability p. The networks that emerge from this copying mechanism are sparse for p<1/2 and dense (average degree increasing with number of nodes N) for p≥1/2. The behavior in the dense regime is especially rich; for example, individual network realizations that are built by copying are disparate and not self-averaging. Further, there is an infinite sequence of structural anomalies at p=2/3, 3/4, 4/5, etc., where the N dependences of the number of triangles (3-cliques), 4-cliques, undergo phase transitions. When linking to second neighbors of the target can occur, the probability that the resulting graph is complete-all nodes are connected-is nonzero as N→∞.
Language	English
Publishing date	2016-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.117.218301
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Article ; Online: A nomogram using cytogenetics, TP53, and NPM1 mutational status can predict responses to induction chemotherapy in AML.

Leukemia & lymphoma

2022 Volume 63, Issue 13, Page(s) 3257–3260

MeSH term(s)	Humans ; Induction Chemotherapy ; Nomograms ; Cytogenetics ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Nuclear Proteins/genetics ; Cytogenetic Analysis ; Mutation ; Prognosis ; fms-Like Tyrosine Kinase 3 ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Nuclear Proteins ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2022.2118532
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Zs.A 2997: Show issues

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Article: Variations on a theme: the alternate translocations in APL.

Redner, R L

Leukemia

2002 Volume 16, Issue 10, Page(s) 1927–1932

Abstract: The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent ... ...

Abstract	The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR. In this review we will discuss these variant translocations, and discuss the insights that we have gained from their study.
MeSH term(s)	Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 15 ; Chromosomes, Human, Pair 17 ; Humans ; Leukemia, Promyelocytic, Acute/genetics ; Translocation, Genetic
Language	English
Publishing date	2002-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/sj.leu.2402720
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Article ; Online: NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK.

Chattopadhyay, Anuja / Abecassis, Irina / Redner, Robert L

Leukemia & lymphoma

2015 Volume 56, Issue 12, Page(s) 3401–3406

Abstract: ... R, induces recruitment of TRADD, and subsequent recruitment of a cascade of proteins that ultimate ...

Abstract	The t(5;17) variant of acute promeylocytic leukemia (APL) expresses a fusion of nucleophosmin (NPM) with the retinoic acid receptor alpha (RARA). We have previously shown that NPM-RAR is a binding partner of the tumor necrosis factor (TNF) receptor type-I-associated DEATH domain protein, TRADD. Binding of TNF to its receptor, TNF-R, induces recruitment of TRADD, and subsequent recruitment of a cascade of proteins that ultimate activate caspase 3, nuclear factor κB (NFκB) and c-Jun N-terminal kinase (JNK). We have previously shown that NPM-RAR interaction with TRADD blocks TNF activation of caspase 3, caspase 8, poly(ADP-ribose) polymerase (PARP) cleavage and, ultimately, apoptosis. We now report that NPM-RAR expression is permissive for TNF activation of NFκB and JNK. We propose that inhibition of TNF activation of apoptosis, while preserving TNF activation of NFκB and JNK pathways that stimulate cell growth and survival, represents a novel mechanism through which NPM-RAR contributes to development of the leukemic phenotype.
MeSH term(s)	Caspases/metabolism ; Cell Line ; Enzyme Activation/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Oncogene Proteins, Fusion/metabolism ; Protein Binding ; Protein Transport ; TNF Receptor-Associated Death Domain Protein/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	NF-kappa B ; NPM-RARalpha protein, human ; Oncogene Proteins, Fusion ; TNF Receptor-Associated Death Domain Protein ; Tumor Necrosis Factor-alpha ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2015-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2015.1023799
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Article ; Online: Pulmonary Granuloma Is Not Always the Tuberculosis Hallmark: Pathology of Tuberculosis Stages in New World and Old World Monkeys Naturally Infected with the Mycobacterium tuberculosis Complex.

Pereira, Asheley H B / Lopes, Claudia A A / Pissinatti, Thalita A / Pinto, Ana C A / Oliveira, Daniel R A / Leal, Gabriel M / Oliveira, Luís C M / Redner, Paulo / Barbosa, Bruna E P / Moreira, Silvia B / Pissinatti, Alcides / Maruyama, Fernanda H / Nakazato, Luciano / Dutra, Valéria / Ubiali, Daniel G

Journal of comparative pathology

2022 Volume 199, Page(s) 55–74

Abstract: We present the pathology of monkeys naturally infected with Mycobacterium tuberculosis complex from five different colonies in Rio de Janeiro, Brazil. On the basis of gross and histopathological findings, the lesions were classified into chronic-active, ... ...

Abstract	We present the pathology of monkeys naturally infected with Mycobacterium tuberculosis complex from five different colonies in Rio de Janeiro, Brazil. On the basis of gross and histopathological findings, the lesions were classified into chronic-active, extrapulmonary, early-activation or latent-reactivation stages. Typical granulomatous pneumonia was seen in 46.6% of cases (six rhesus monkeys [Macaca mulatta] and one Uta Hick's bearded saki [Chiropotes utahickae]). The absence of pulmonary granulomas did not preclude a diagnosis of tuberculosis (TB): classical granulomatous pneumonia was observed in the chronic-active and latent-reactivation stages but not in the extrapulmonary and early-activation stages. The early-activation stage was characterized by interstitial pneumonia with a predominance of foamy macrophages and molecular and immunohistochemical evidence of M. tuberculosis complex infection. TB should be considered as a cause of interstitial pneumonia in New World Monkeys. We recommend the use of immunohistochemistry and molecular analysis for diagnosis of TB, even when typical macroscopic or histological changes are not observed.
MeSH term(s)	Animals ; Mycobacterium tuberculosis ; Cercopithecidae ; Brazil ; Tuberculosis/veterinary ; Granuloma/veterinary ; Granuloma/pathology ; Pneumonia/veterinary ; Macaca mulatta
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2022.09.011
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