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  1. Article: Improving the Polarity of Text through word2vec Embedding for Primary Classical Arabic Sentiment Analysis.

    Aoumeur, Nour Elhouda / Li, Zhiyong / Alshari, Eissa M

    Neural processing letters

    2023  , Page(s) 1–16

    Abstract: Over the past decade, Sentiment analysis has attracted significant researcher attention. Despite a huge number of studies in this field, Sentiment analysis of authors' books (classical Arabic) with extracting the embedding features has not yet been done. ...

    Abstract Over the past decade, Sentiment analysis has attracted significant researcher attention. Despite a huge number of studies in this field, Sentiment analysis of authors' books (classical Arabic) with extracting the embedding features has not yet been done. The recent feature extraction of Arabic text depends on the frequency of the words within the corpus without extracting the relation between these words. This paper aims to create a new classical Arabic dataset CASAD from many art books by collecting sentences from several stories with human-expert labeling. Additionally, the feature extraction of those datasets is created by word embedding techniques equivalent to Word2vec that are able to extract the deep relation which means features of the formal Arabic language. These features are evaluated by several types of machine learning for classical Arabic, for example, support vector machines (SVM), Logistic Regression (LR), Naive Bayes (NB) K-Nearest Neighbors (KNN), Latent Dirichlet Allocation (LDA) and Classification And Regression Trees (CART). Moreover, statistical methods such as validation and reliability are applied to evaluate this dataset's label. Finally, our experiments evaluated the classification rate of the feature-extraction matrices in two and three classes using six machine-learning algorithms for tenfold cross-validation that showed that the Logistic Regression with Word2Vec approach is the most accurate in predicting topic-polarity occurrence.
    Language English
    Publishing date 2023-01-23
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 1478375-7
    ISSN 1573-773X ; 1370-4621
    ISSN (online) 1573-773X
    ISSN 1370-4621
    DOI 10.1007/s11063-022-11111-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Gene Expression Analysis of M1 and M2 Polarized Macrophages.

    Eissa, Nour / Hussein, Hayam / Ghia, Jean-Eric

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2184, Page(s) 131–144

    Abstract: Macrophages are professional innate immune cells that are broadly disseminated throughout the body, shape various innate and adaptive immune responses, and play crucial roles in inflammation, homeostasis, wound healing, and tissue remodelling. According ... ...

    Abstract Macrophages are professional innate immune cells that are broadly disseminated throughout the body, shape various innate and adaptive immune responses, and play crucial roles in inflammation, homeostasis, wound healing, and tissue remodelling. According to their surrounding microenvironments, macrophages can differentiate themselves in different phenotypes. Over the last two decades, gene expression profiling has been used to decipher new transcripts associated with macrophage phenotypes. This chapter outlines protocols used to isolate and culture murine macrophages and how they can be "polarized" to obtain a specific phenotype. Furthermore, we describe a protocol for gene expression profiling using a quantitative real-time polymerase chain reaction (qPCR), a high-standard technology in the field of gene expression.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Polarity/genetics ; Cells, Cultured ; Cellular Microenvironment/genetics ; Gene Expression/genetics ; Gene Expression Profiling/methods ; Inflammation/genetics ; Macrophage Activation/genetics ; Macrophages/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Phenotype ; RAW 264.7 Cells
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0802-9_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions.

    Kapoor, Kunal / Eissa, Nour / Tshikudi, Diane / Bernstein, Charles N / Ghia, Jean-Eric

    World journal of gastroenterology

    2022  Volume 27, Issue 47, Page(s) 8138–8155

    Abstract: Background: Chromofungin (CHR: chromogranin-A 47-66) is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial properties. Ulcerative colitis (UC) is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c!## ...

    Abstract Background: Chromofungin (CHR: chromogranin-A 47-66) is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial properties. Ulcerative colitis (UC) is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c
    Aim: To investigate the association between CHR treatment and dendritic cells (DCs)-related markers in different immune compartments in colitis.
    Methods: A model of acute UC-like colitis using dextran sulphate sodium (DSS) was used in addition to biopsies collected from UC patients.
    Results: Intrarectal CHR treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the expression of CD11c, CD40, CD80, CD86 and interleukin (IL)-12p40 in the inflamed colonic mucosa and CD11c, CD80, CD86 IL-6 and IL-12p40 within the mesenteric lymph nodes and the spleen. Furthermore, CHR treatment decreased CD80 and CD86 expression markers of splenic CD11c
    Conclusion: CHR has protective properties against intestinal inflammation
    MeSH term(s) Chromogranin A ; Colitis, Ulcerative/drug therapy ; Colon ; Dendritic Cells ; Dextran Sulfate ; Humans ; Peptide Fragments
    Chemical Substances Chromogranin A ; Peptide Fragments ; chromofungin ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i47.8138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis.

    Eissa, Nour / Elgazzar, Omar / Hussein, Hayam / Hendy, Geoffrey N / Bernstein, Charles N / Ghia, Jean-Eric

    Biomedicines

    2021  Volume 9, Issue 2

    Abstract: Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CHGA ... ...

    Abstract Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CHGA can be cleaved into several derived peptides, including pancreastatin (PST), which is involved in proinflammatory mechanisms. Previously, we showed that the deletion of
    Language English
    Publishing date 2021-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9020134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The immune-sleep crosstalk in inflammatory bowel disease.

    Eissa, Nour / Mujawar, Quais / Alabdoulsalam, Tareq / Zohni, Sahar / El-Matary, Wael

    Sleep medicine

    2020  Volume 73, Page(s) 38–46

    Abstract: Sleep disorders are progressively common and sometimes are associated with aberrant regulation of the adaptive and innate immune responses. Sleep interruption can increase the inflammatory burden by enhancing the pro-inflammatory cytokines particularly ... ...

    Abstract Sleep disorders are progressively common and sometimes are associated with aberrant regulation of the adaptive and innate immune responses. Sleep interruption can increase the inflammatory burden by enhancing the pro-inflammatory cytokines particularly in patients with chronic diseases such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease characterized by immune dysregulation, dysbiosis of gut microbiome, and poor-quality life. Therefore, this review highlights the crosstalk between sleep and immune responses during the progression of IBD.
    MeSH term(s) Cytokines ; Dysbiosis/complications ; Gastrointestinal Microbiome ; Humans ; Inflammatory Bowel Diseases/complications ; Sleep
    Chemical Substances Cytokines
    Language English
    Publishing date 2020-04-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2020.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interdependence between Chromogranin-A, Alternatively Activated Macrophages, Tight Junction Proteins and the Epithelial Functions. A Human and In-Vivo/In-Vitro Descriptive Study.

    Eissa, Nour / Hussein, Hayam / Tshikudi, Diane M / Hendy, Geoffrey N / Bernstein, Charles N / Ghia, Jean-Eric

    International journal of molecular sciences

    2020  Volume 21, Issue 21

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Caco-2 Cells ; Case-Control Studies ; Cells, Cultured ; Chromogranin A/genetics ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Cytokines/genetics ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Gene Knockout Techniques ; Humans ; Interleukin-18/genetics ; Interleukin-8/genetics ; Macrophage Activation ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Tight Junction Proteins/genetics
    Chemical Substances CHGA protein, human ; CXCL8 protein, human ; Chromogranin A ; Cytokines ; IL18 protein, human ; Interleukin-18 ; Interleukin-8 ; Tight Junction Proteins ; chromogranin A, mouse ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21217976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mucosal immunity and gut microbiota in dogs with chronic enteropathy.

    Eissa, Nour / Kittana, Hatem / Gomes-Neto, João Carlos / Hussein, Hayam

    Research in veterinary science

    2018  Volume 122, Page(s) 156–164

    Abstract: Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune ... ...

    Abstract Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune responses and the gut microbiota composition are thought to play an essential role in CE. Similar to humans, it is hypothesized that the breakdown in mucosal tolerance leads to aberrant and pathological immune responses toward the gut microbiota, that in turn, may contribute to the severity of disease, at least for certain CE subsets. Therefore, in this review, we discuss some of the most relevant and recent insights microbiological and immunological aspects characterizing CE in dogs.
    MeSH term(s) Animals ; Dog Diseases/immunology ; Dog Diseases/microbiology ; Dogs ; Gastrointestinal Microbiome ; Immunity, Mucosal ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology
    Language English
    Publishing date 2018-11-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2018.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Retinoic acid-mediated anti-inflammatory responses in equine immune cells stimulated by LPS and allogeneic mesenchymal stem cells.

    Abdelhamid, Leila / Hussein, Hayam / Ghanem, Mostafa / Eissa, Nour

    Research in veterinary science

    2017  Volume 114, Page(s) 225–232

    Abstract: Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic immunomodulatory properties. Allogeneic mesenchymal stem cells (MSCs)-based therapy is an effective approach to induce tissue healing and regeneration in many equine ... ...

    Abstract Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic immunomodulatory properties. Allogeneic mesenchymal stem cells (MSCs)-based therapy is an effective approach to induce tissue healing and regeneration in many equine orthopedic conditions. However, MSCs-based therapies induced inflammatory responses in vivo. This study aimed to: 1. Determine the effect of RA cell culture treatment on inflammatory responses of lipopolysaccharides (LPS)- and allogeneic MSCs-stimulated peripheral blood mononuclear cells (PBMCs). 2. Determine the effect of RA on stimulated MSCs viability and morphology. Allogeneic MSCs-stimulated PBMCs had significant decreases in the anti-inflammatory cytokines (IL-10, IL-1ra, TGF-β1), increases in the pro-inflammatory mediators (IL-1β, IL-6, TNF-α, SAA), and increases of CD14 and MHC II percent positive cells compared to LPS- and non-stimulated PBMCs. Retinoic acid treatment of LPS- and allogeneic MSCs-stimulated PBMCs counterbalanced the induced inflammatory responses. Moreover, RA significantly improved the viability and morphology of stimulated MSCs. These findings highlighted the potential complications of equine allogeneic MSCs-based therapies and the immuno-modulatory effect of RA on equine stimulated cells. In conclusion, the use of RA to ameliorate allogeneic MSCs therapy associated inflammation may offer advantages that would require further investigations.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2017.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mucosal immunity and gut microbiota in dogs with chronic enteropathy

    Eissa, Nour / Hatem Kittana / Hayam Hussein / João Carlos Gomes-Neto

    Research in veterinary science. 2019 Feb., v. 122

    2019  

    Abstract: Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune ... ...

    Abstract Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune responses and the gut microbiota composition are thought to play an essential role in CE. Similar to humans, it is hypothesized that the breakdown in mucosal tolerance leads to aberrant and pathological immune responses toward the gut microbiota, that in turn, may contribute to the severity of disease, at least for certain CE subsets. Therefore, in this review, we discuss some of the most relevant and recent insights microbiological and immunological aspects characterizing CE in dogs.
    Keywords digestive system diseases ; dogs ; etiology ; humans ; immune response ; immunopathology ; intestinal microorganisms ; mucosal immunity ; pathogenesis ; signs and symptoms (animals and humans)
    Language English
    Dates of publication 2019-02
    Size p. 156-164.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2018.11.019
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Effects of Temperature on the Expression of Two Ovarian Differentiation-Related Genes

    Shen, Zhi-Gang / Eissa, Nour / Yao, Hong / Xie, Zhi-Gang / Wang, Han-Ping

    Frontiers in physiology

    2018  Volume 9, Page(s) 1208

    Abstract: Exposure to stress induces a series of responses and influences a wide range of biological processes including sex differentiation in fish. The present work investigated the molecular and physiological response to thermal stress throughout the early ... ...

    Abstract Exposure to stress induces a series of responses and influences a wide range of biological processes including sex differentiation in fish. The present work investigated the molecular and physiological response to thermal stress throughout the early development stage covering the whole period of sex differentiation of bluegill,
    Language English
    Publishing date 2018-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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