Result 1 - 10 of total 6423
1998
| Author's details | [Potpourri-Bearb.: G. Grabowski ; E. Simons ; W.-E. Stein] |
|---|---|
| Language | German |
| Size | 4 Bl |
| Publisher | Intersong Musikverl |
| Publishing place | Hamburg |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2020
| Institution | Universitätsklinikum Köln / Klinik und Poliklinik für Orthopädie und Unfallchirurgie |
|---|---|
| Author's details | vorgelegt von Tobias Seidel ; 1. Gutachter: Professor Dr. med. G. Stein, 2. Gutachterin: Universitätsprofessorin Dr. med. S. Stock ; aus der Klinik und Poliklinik für Orthopädie und Unfallchirurgie der Universität zu Köln |
| Subject code | 610 |
| Language | German |
| Size | 75 Blätter, Illustrationen, Diagramme |
| Publishing place | Köln |
| Publishing country | Germany |
| Document type | Book ; Thesis |
| Thesis / German Habilitation thesis | Dissertation, Universität zu Köln, 2020 |
| HBZ-ID | HT020706405 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2021 D 91 | order for loan | Magazin |
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2000 Volume 74, Issue 11, Page(s) 5040–5052
Abstract: ... that upon gamma irradiation, HIV-1-infected cells lose their G(1)/S checkpoints, enter the S phase inappropriately, and ... eventually apoptose. The loss of the G(1)/S checkpoint is associated with a loss of p21/Waf1 protein and ... increased activity of a major G(1)/S kinase, namely, cyclin E/cdk2. The p21/Waf1 protein, a known ...
| Abstract | Productive high-titer infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile reverse transcripts and lack of viral progeny formation. An interplay between Tat and p53 has previously been reported, where Tat inhibited the transcription of the p53 gene, which may aid in the development of AIDS-related malignancies, and p53 expression inhibited HIV-1 long terminal repeat transcription. Here, by using a well-defined and -characterized stress signal, gamma irradiation, we find that upon gamma irradiation, HIV-1-infected cells lose their G(1)/S checkpoints, enter the S phase inappropriately, and eventually apoptose. The loss of the G(1)/S checkpoint is associated with a loss of p21/Waf1 protein and increased activity of a major G(1)/S kinase, namely, cyclin E/cdk2. The p21/Waf1 protein, a known cyclin-dependent kinase inhibitor, interacts with the cdk2/cyclin E complex and inhibits progression of cells into S phase. We find that loss of the G(1)/S checkpoint in HIV-1-infected cells may in part be due to Tat's ability to bind p53 (a known activator of the p21/Waf1 promoter) and sequester its transactivation activity, as seen in both in vivo and in vitro transcription assays. The loss of p21/Waf1 in HIV-1-infected cells was specific to p21/Waf1 and did not occur with other KIP family members, such as p27 (KIP1) and p57 (KIP2). Finally, the advantage of a loss of the G(1)/S checkpoint for HIV-1 per se may be that it pushes the host cell into the S phase, which may then allow subsequent virus-associated processes, such as RNA splicing, transport, translation, and packaging of virion-specific genes, to occur. |
|---|---|
| MeSH term(s) | CDC2-CDC28 Kinases ; Cell Cycle Proteins ; Cell Line ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinase Inhibitor p57 ; Cyclin-Dependent Kinases/metabolism ; Cyclins/metabolism ; G1 Phase ; Gamma Rays ; Gene Products, tat/metabolism ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Microtubule-Associated Proteins/metabolism ; Nuclear Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; S Phase ; Signal Transduction ; T-Lymphocytes/cytology ; Tumor Suppressor Proteins ; tat Gene Products, Human Immunodeficiency Virus |
| Chemical Substances | CDKN1A protein, human ; CDKN1C protein, human ; Cell Cycle Proteins ; Cyclin E ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p57 ; Cyclins ; Gene Products, tat ; Microtubule-Associated Proteins ; Nuclear Proteins ; Tumor Suppressor Proteins ; tat Gene Products, Human Immunodeficiency Virus ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; CDC2-CDC28 Kinases (EC 2.7.11.22) ; CDK2 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 2 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) |
| Language | English |
| Publishing date | 2000-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. |
| ZDB-ID | 80174-4 |
| ISSN | 1098-5514 ; 0022-538X |
| ISSN (online) | 1098-5514 |
| ISSN | 0022-538X |
| DOI | 10.1128/jvi.74.11.5040-5052.2000 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 609: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of affective disorders
2024 Volume 356, Page(s) 122–136
Abstract: ... s) (aRR = 1.27-1.94), and antenatal anxiety (aRR = 1.97-2.22) were associated with increased risk ...
| Abstract | Background: Few studies have evaluated postnatal anxiety and posttraumatic stress (PTS) before and during the Covid-19 pandemic using comparable data across time. We used data from two national maternity surveys in England to explore the impact of the pandemic on prevalence and risk factors for postnatal anxiety and PTS. Methods: Analysis was conducted using population-based surveys carried out in 2018 (n = 4509) and 2020 (n = 4611). Weighted prevalence estimates for postnatal anxiety and PTS were compared across surveys. Adjusted risk ratios (aRR) were estimated for the association between risk factors and postnatal anxiety and PTS. Findings: Prevalence of postnatal anxiety increased from 13.7 % in 2018 to 15.1 % in 2020 (+1.4 %(95%CI:-0.4-3.1)). Prevalence of postnatal PTS increased from 9.7 % in 2018 to 11.5 % in 2020 (+1.8 %(95%CI:0.3-3.4)), due to an increase in PTS related to birth trauma from 2.5 % to 4.3 % (+1.8 %(95%CI:0.9-2.6); there was no increase in PTS related to non-birth trauma. Younger age (aRR = 1.31-1.51), being born in the UK (aRR = 1.29-1.59), long-term physical or mental health problem(s) (aRR = 1.27-1.94), and antenatal anxiety (aRR = 1.97-2.22) were associated with increased risk of postnatal anxiety and PTS before and during the pandemic, whereas higher satisfaction with birth (aRR = 0.92-0.94) and social support (aRR = 0.81-0.82) were associated with decreased risk. Interpretation: Prevalence of postnatal PTS was significantly higher during the pandemic, compared to before the pandemic, due to an increase in PTS related to birth trauma. Prevalence of postnatal anxiety was not significantly higher during the pandemic. Risk factors for postnatal anxiety and PTS were similar before and during the pandemic. |
|---|---|
| Language | English |
| Publishing date | 2024-04-03 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 135449-8 |
| ISSN | 1573-2517 ; 0165-0327 |
| ISSN (online) | 1573-2517 |
| ISSN | 0165-0327 |
| DOI | 10.1016/j.jad.2024.04.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1485: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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The Science of the total environment
2024 Volume 924, Page(s) 171484
Abstract: This study explores the greenhouse gas (GHG) fluxes of nitrous oxide ( ... ...
| Abstract | This study explores the greenhouse gas (GHG) fluxes of nitrous oxide (N |
|---|---|
| MeSH term(s) | Greenhouse Gases/analysis ; Wetlands ; Carbon Dioxide/analysis ; Greenhouse Effect ; Wastewater ; Environmental Monitoring ; Nitrogen ; Methane/analysis ; Nitrous Oxide/analysis ; Water Purification |
| Chemical Substances | Greenhouse Gases ; Carbon Dioxide (142M471B3J) ; Wastewater ; Nitrogen (N762921K75) ; Methane (OP0UW79H66) ; Nitrous Oxide (K50XQU1029) |
| Language | English |
| Publishing date | 2024-03-09 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 121506-1 |
| ISSN | 1879-1026 ; 0048-9697 |
| ISSN (online) | 1879-1026 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2024.171484 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 949: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Endocrine oncology (Bristol, England)
2024 Volume 4, Issue 1, Page(s) e230015
Abstract: Objectives: The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce : Materials and methods: Men with mCRPC, with more than one prostate-specific membrane ... ...
| Abstract | Objectives: The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce Materials and methods: Men with mCRPC, with more than one prostate-specific membrane antigen (PSMA)-avid lesion on PET/CT scanning (pathognomic in that setting for prostate cancer lesions), were approached to undergo PET/CT with gallium Results: Out of the 24 men referred, three did not meet the inclusion criteria. Seventeen declined, largely because the study offered them no therapeutic benefit. Among the four men imaged, three had no exendin-avid lesions, while one had six osseous PSMA-avid lesions, three of which were also exendin avid. Conclusions: We demonstrated |
|---|---|
| Language | English |
| Publishing date | 2024-01-22 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2634-4793 |
| ISSN (online) | 2634-4793 |
| DOI | 10.1530/EO-23-0015 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2015
| Institution | Universitätsklinikum Köln / Klinik und Poliklinik für Orthopädie und Unfallchirurgie |
|---|---|
| Author's details | vorgelegt von Sophie Goldmann ; 1. Berichterstatterin/Berichterstatter: Privatdozent Dr. med. G. Stein, 2. Berichterstatterin/Berichterstatter: Universitätsprofessor Dr. med. R. Goldbrunner ; aus der Klinik und Poliklinik für Orthopädie und Unfallchirurgie der Universität zu Köln |
| Subject code | 610 |
| Language | German |
| Size | 60 Seiten, Illustrationen |
| Publishing place | Köln |
| Publishing country | Germany |
| Document type | Book ; Thesis |
| Thesis / German Habilitation thesis | Dissertation, Medizinische Fakultät der Universität zu Köln, 2015 |
| HBZ-ID | HT018865003 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2016 D 81 | order for loan | Magazin |
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2015
| Institution | Universitätsklinikum Köln / Klinik und Poliklinik für Orthopädie und Unfallchirurgie |
|---|---|
| Author's details | vorgelegt von Sophie Goldmann ; 1. Berichterstatterin/Berichterstatter: Privatdozent Dr. med. G. Stein, 2. Berichterstatterin/Berichterstatter: Universitätsprofessor Dr. med. R. Goldbrunner ; aus der Klinik und Poliklinik für Orthopädie und Unfallchirurgie der Universität zu Köln |
| Subject code | 610 |
| Language | German |
| Size | 60 S. : Ill., graph. Darst. |
| Publishing country | Germany |
| Document type | Book ; Online ; Thesis |
| Thesis / German Habilitation thesis | Köln, Univ., Diss., 2015 |
| HBZ-ID | HT018727793 |
| DOI | 10.4126/38m-006371328 |
| Database | Repository for Life Sciences |
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Journal of medical case reports
2024 Volume 18, Issue 1, Page(s) 127
Abstract: Background: Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents ... ...
| Abstract | Background: Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16 months. Currently no standardized treatment protocol exists for this condition. Case presentation: We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel. She was treated with local radiation with 2300 cGy to the right breast with a complete response. She then had a subsequent recurrence in the ipsilateral breast 8 months after completion of post treatment imaging. She remains alive to date approximately 2 years after her initial diagnosis of breast metastasis on seventh line treatment. Conclusions: Breast metastasis from primary ovarian cancer is rare and represents advanced disease characterized by multi-drug chemoresistance and a poor prognosis. This case describes radiation therapy as a safe, effective treatment option to improve local control and quality of life in these patients, but with limited durability of response. |
|---|---|
| MeSH term(s) | Female ; Humans ; Middle Aged ; Quality of Life ; Breast Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Ovarian Neoplasms/pathology ; Paclitaxel/therapeutic use ; Cystadenocarcinoma, Serous/therapy ; Cystadenocarcinoma, Serous/secondary |
| Chemical Substances | Paclitaxel (P88XT4IS4D) |
| Language | English |
| Publishing date | 2024-03-26 |
| Publishing country | England |
| Document type | Review ; Case Reports ; Journal Article |
| ZDB-ID | 2269805-X |
| ISSN | 1752-1947 ; 1752-1947 |
| ISSN (online) | 1752-1947 |
| ISSN | 1752-1947 |
| DOI | 10.1186/s13256-024-04445-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Globalization and Health, Vol 17, Iss 1, Pp 1-
COVAX and the financialization of global vaccine equity
2021 Volume 11
Abstract: ... the world’s most prominent effort to ensure equitable access to SARS-CoV-2 vaccines. Launched as part ... that future iterations of it will improve pandemic preparedness. So far COVAX’s role in the ongoing ... not been analyzed. Methods This article describes and critically assesses COVAX’s financial logics ...
| Abstract | Abstract Background During the first year and a half of the COVID-19 pandemic, COVAX has been the world’s most prominent effort to ensure equitable access to SARS-CoV-2 vaccines. Launched as part of the Access to COVID-19 Tools Accelerator (Act-A) in June 2020, COVAX suggested to serve as a vaccine buyers’ and distribution club for countries around the world. It also aimed to support the pharmaceutical industry in speeding up and broadening vaccine development. While COVAX has recently come under critique for failing to bring about global vaccine equity, influential politicians and public health advocates insist that future iterations of it will improve pandemic preparedness. So far COVAX’s role in the ongoing financialization of global health, i.e. in the rise of financial concepts, motives, practices and institutions has not been analyzed. Methods This article describes and critically assesses COVAX’s financial logics, i.e. the concepts, arguments and financing flows on which COVAX relies. It is based on a review of over 109 COVAX related reports, ten in-depth interviews with global health experts working either in or with COVAX, as well as participant observation in 18 webinars and online meetings concerned with global pandemic financing, between September 2020 and August 2021. Results The article finds that COVAX expands the scale and scope of financial instruments in global health governance, and that this is done by conflating different understandings of risk. Specifically, COVAX conflates public health risk and corporate financial risk, leading it to privilege concerns of pharmaceutical companies over those of most participating countries – especially low and lower-middle income countries (LICs and LMICs). COVAX thus drives the financialization of global health and ends up constituting a risk itself - that of perpetuating the downsides of financialization (e.g. heightened inequality, secrecy, complexity in governance, an ineffective and slow use of aid), whilst insufficiently realising its potential ... |
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| Keywords | COVAX ; COVID-19 ; Risk ; Finance ; Financialization ; Vaccines ; Public aspects of medicine ; RA1-1270 |
| Subject code | 910 |
| Language | English |
| Publishing date | 2021-09-01T00:00:00Z |
| Publisher | BMC |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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