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Article: [Comparative study on the academic thought of bloodletting for expelling pathogens between Jin-Yuan Dynasties and Ming-Qing Dynasties].

Chen, Hao / She, Yan-Fen / Gao, Ya-Yu / Song, Xiao-Dan / Fan, Xi-Sheng / Shi, Xu-Liang / Dong, Shang-Pu / Lv, Jing

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2021 Volume 41, Issue 7, Page(s) 813–817

Abstract: ... of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct ... the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using ... that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing ...

Abstract	The relevant provisions of bloodletting for expelling pathogens are collected from the works of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using frequency analysis, the bloodletting device, bloodletting location, bloodletting volume, the related pathogens and indications are compared between these two times so that the evidences could be provided for the inheritance and development of the academic thought of bloodletting for expelling pathogens. It is found that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing Dynasties and
MeSH term(s)	Acupuncture Points ; Bloodletting ; China ; Medicine, Chinese Traditional ; Meridians ; Needles
Language	Chinese
Publishing date	2021-07-14
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20200609-k0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Chu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 1478–1490

Abstract: Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss ...

Abstract	Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. Objective: To explore the mechanism of YQCM decoction in the treatment of ARHL. Materials and methods: The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an Results: The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H Conclusions: Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
MeSH term(s)	Aged ; Caspase 3 ; Drugs, Chinese Herbal/therapeutic use ; Hearing Loss/drug therapy ; Humans ; Hydrogen Peroxide/toxicity ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology ; Neurodegenerative Diseases/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
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Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss

Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Zhu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1478-1490

2022

Abstract: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL ...

Abstract	Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. To explore the mechanism of YQCM decoction in the treatment of ARHL. The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 μM H₂O₂ for 3 h were applied. Cell viability and mitochondrial membrane potential (ΔΨM) were detected by CCK-8 and high-content analysis. γH2AX and cleaved caspase-3 were detected by Western blot. The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H₂O₂ treatment could reduce the cell viability by 68% and impaired ΔΨM, while 90 μg/mL YQCM pre-treatment could restore the cell viability by 97.45% and increase ΔΨM (2-fold higher). YQCM pre-treatment also reduced γH2AX and cleaved caspase-3 protein levels. Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
Keywords	Oriental traditional medicine ; Western blotting ; apoptosis ; bioinformatics ; caspase-3 ; cell viability ; databases ; elderly ; membrane potential ; mitochondrial membrane ; models ; neurodegenerative diseases ; pharmacology ; Molecular docking ; molecular dynamics simulation ; HEI-OC1 ; mitochondrial membrane potential ; AKT1
Language	English
Dates of publication	2022-1231
Size	p. 1478-1490.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2101671
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nimodipine attenuates dibutyl phthalate-induced learning and memory impairment in kun ming mice: An in vivo study based on bioinformatics analysis.

Yan, Biao / Ma, Ping / Chen, Shaohui / Cheng, Hongguo / Tang, Min / Sun, Yanling / Yang, Xu / Wu, Yang / Cheng, Menglin

Environmental toxicology

2020 Volume 36, Issue 5, Page(s) 821–830

Abstract: Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that ... ...

Abstract	Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that nimodipine (Nim) palys a neuropharmacological and psychopharmacological role in neurons, the attenuating effects of Nim on learning and memory impairment induced by DBP exposure remain unknown. Based on bioinformatics analysis we found that the biological processes affected by both DBP and Nim may involve the calcium signaling pathway, the MAPK signaling pathway and the apoptosis pathway. The results of an in vivo study confirmed that DBP affects the levels of Ca
MeSH term(s)	Animals ; Computational Biology ; Dibutyl Phthalate/toxicity ; Memory Disorders/chemically induced ; Mice ; Nimodipine/toxicity ; Plasticizers
Chemical Substances	Plasticizers ; Dibutyl Phthalate (2286E5R2KE) ; Nimodipine (57WA9QZ5WH)
Language	English
Publishing date	2020-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23084
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Book ; Conference proceedings: Yan Pei-Ming

Hegyi, Lóránd / Yan, Pei-Ming

exécution ; [exposition au Musée d'Art Moderne de Saint-Etienne Métropole, 3 mars - 30 avril 2006]

2006

Institution	Musée d'Art Moderne Saint-Etienne
Event/congress	Exposition (2006.03.03-04.30, Saint-Etienne)
Author's details	[commisaire: Lóránd Hegyi. Yan Pei-Ming]
Language	French ; English
Size	363 S
Publisher	Presse du Réel
Publishing place	Dijon
Document type	Book ; Conference proceedings
Note	Text franz. und engl. ; Enth. Texte über und Interviews mit Yan Pei-Ming
Accompanying material	Liste des œuvres
ISBN	2840661616 ; 9782840661610
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury.

Lan, Rui / Zhang, Yong / Wu, Tao / Ma, Yun-Zhi / Wang, Bao-Qi / Zheng, Hai-Zhong / Li, Ya-Na / Wang, Yan / Gu, Chun-Qing / Wu, Ji-Tao

Behavioural neurology

2018 Volume 2018, Page(s) 4147502

Abstract: We investigated whether Xiao-Xu-Ming decoction reduced mitophagy activation and kept mitochondrial ...

Abstract	We investigated whether Xiao-Xu-Ming decoction reduced mitophagy activation and kept mitochondrial function in cerebral ischemia-reperfusion injury. Rats were randomly divided into 5 groups: sham, ischemia and reperfusion (IR), IR plus XXMD (60 g/kg/day) (XXMD60), IR plus cyclosporin A (10 mg/kg/day) (CsA), and IR plus vehicle (Vehicle). Focal cerebral ischemia and reperfusion models were induced by middle cerebral artery occlusion (MCAO). Cerebral infarct areas were measured by triphenyl tetrazolium chloride staining. Cerebral ischemic injury was evaluated by hematoxylin and eosin staining (HE) and Nissl staining. Ultrastructural features of mitochondria and mitophagy in the penumbra of the ischemic cortex were observed by transmission electron microscopy. Mitophagy was detected by immunofluorescence labeled with LC3B and VDAC1. Autophagy lysosome formation was observed by immunofluorescence labeled with LC3B and Lamp1. The expression of LC3B, Beclin1, and Lamp1 was analyzed by Western blot. The rats subjected to MCAO showed worsened neurological score and cell ischemic damage. These were all significantly reversed by XXMD or CsA. Moreover, XXMD/CsA notably downregulated mitophagy and reduced the increase in LC3, Beclin1, and Lamp1 expression induced by cerebral ischemia and reperfusion. The findings demonstrated that XXMD exerted neuroprotective effect via downregulating LC3, Beclin1, Lamp1, and mitochondrial p62 expression level, thus leading to the inhibition of mitophagy.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Brain Ischemia/drug therapy ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Male ; Medicine, Chinese Traditional ; Mitochondria/drug effects ; Mitochondrial Degradation/drug effects ; Neuroprotective Agents/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Neuroprotective Agents ; xiao-xu-ming
Language	English
Publishing date	2018-06-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1001896-7
ISSN	1875-8584 ; 0953-4180
ISSN (online)	1875-8584
ISSN	0953-4180
DOI	10.1155/2018/4147502
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Zs.A 2574: Show issues

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Article ; Online: Dr. Chi-Ming Chu: Respected founder of molecular virology and pioneer of biologicals in China.

Yan, Weizheng / Huang, Baoying / Ruan, Li / Tan, Wenjie

Protein & cell

2017 Volume 8, Issue 9, Page(s) 629–633

MeSH term(s)	China ; Hepatitis B virus/immunology ; History, 20th Century ; Humans ; Molecular Biology/history ; Orthomyxoviridae/immunology ; Viral Vaccines/immunology ; Virology/history
Chemical Substances	Viral Vaccines
Language	English
Publishing date	2017-07-26
Publishing country	Germany
Document type	Biography ; Historical Article ; Journal Article ; Portrait ; Research Support, Non-U.S. Gov't
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-8018
ISSN (online)	1674-8018
ISSN	1674-8018
DOI	10.1007/s13238-017-0445-z
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Article: [Effects of pri ming different low-dose rocurium on pharmacodynamics of mivacurium].

Xin, Yan / Guo, Ying / Jiang, Yuge / Zhang, Hong

Zhonghua yi xue za zhi

2014 Volume 94, Issue 21, Page(s) 1647–1650

Abstract: Objective: To explore the effects of pri ming rocuronium on neuromuscular blockade produced ... they received a saline placebo injection (GroupI) and a pri ming dose of rocuronium 0.06 mg/kg (GroupII ... became progressively shorter with the growing pri ming dose of rocurium among three experiment groups ...

Abstract	Objective: To explore the effects of pri ming rocuronium on neuromuscular blockade produced by mivacurium. Methods: Ethical approval was granted by the medical ethics committee of our hospital with a reference number of C-2013-018-01. A total of 120 ASA physical status I and II patients undergoing selective otorhinolaryngologic surgery under general anesthesia signed the form of informed consent. And they were randomly divided by a random number table into 4 groups. After a standardized imidazole-propofol-fentanyl induction, they received a saline placebo injection (GroupI) and a pri ming dose of rocuronium 0.06 mg/kg (GroupII) , rocuronium 0.075 mg/kg (Group III) and rocuronium 0.1 mg/kg (Group IV). An intubating dose of mivacurium 0.15 mg/kg was offered 3 minutes later. Anesthesia was maintained with propofol and remifentanyl continuous infusion. Neuromuscular block was monitored with train of four (TOF) stimulation. The onset time, reappearance of T1 (DUR TOFc 1), times of T1 25% and 75% recovery, recovery index and times of TOF25%, 75% and 90% recovery were recorded. Results: The onset time of mivacurium was significantly shorter and the times of T1 25% and 75% recovery were significantly longer in groups of II, III and IV than those in groupI. No significant difference existed in recovery index among 4 groups. The onset time of mivacurium became progressively shorter with the growing pri ming dose of rocurium among three experiment groups. And it was not statistically significant. Conclusions: Pri ming rocuronium decreases the onset and intubating times of mivacurium without effect on recovery index. No significant difference exists in drug effect among 3 experiment groups.
MeSH term(s)	Androstanols ; Anesthesia, General ; Fentanyl ; Humans ; Isoquinolines/pharmacokinetics ; Neuromuscular Nondepolarizing Agents/pharmacokinetics ; Propofol
Chemical Substances	Androstanols ; Isoquinolines ; Neuromuscular Nondepolarizing Agents ; mivacurium (77D66S9Q93) ; Fentanyl (UF599785JZ) ; rocuronium (WRE554RFEZ) ; Propofol (YI7VU623SF)
Language	Chinese
Publishing date	2014-06-03
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
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Article ; Online: Treatment effect of Qi ming granule in preventing macular edema after phacoemulsification in diabetes

Jun Li / Song-Ping Yu / Tian-Yan Shi / Xiu-Zhen Zhang

Guoji Yanke Zazhi, Vol 15, Iss 8, Pp 1444-

2015 Volume 1446

Abstract: AIM: To evaluate the clinical therapeutic efficacy of the Qi ming granule for macular edema ... given oral administration Qi ming granule(4.5g, tid)and vitamin C(0.1g, tid)for 6mo postoperatively, while vitamin C(0.1g ... CONCLUSION:Qi ming granule can significantly reduce the incidences of macular edema and suppresses increasing ...

Abstract	AIM: To evaluate the clinical therapeutic efficacy of the Qi ming granule for macular edema(ME)in diabetic patients after phacoemulsification. METHODS:In this was a prospective clinical comparison study, 57 diabetic patients(76 eyes)who underwent phacoemulsification were recruited and divided into two groups: treatment group(34 eyes)and control group(42 eyes). All the patients in treatment group were given oral administration Qi ming granule(4.5g, tid)and vitamin C(0.1g, tid)for 6mo postoperatively, while vitamin C(0.1g, tid)for the controls. General clinical examinations, including blood glucose and glycated hemoglobin, as well as comprehensive standardized ophthalmic examinations were performed. Optical coherence tomography(OCT)were used to detect macular edema incidence and measure central field retinal thickness. RESULTS: No significant difference was found in the levels of blood glucose,glycated hemoglobin, course of disease, and macular thickness between the two groups during the initial visits. At the 6 th month, 2 eyes(6%)eyes had clinically apparent macular edema in treatment group, while 6(14%)eyes had clinically apparent macular edema in control group( P= 0.285). The central subfield retinal thickness values were significantly lower in the treatment group(211.76±41.21μm)than those in control group(278.36±48.94μm)( P <0.01). CONCLUSION:Qi ming granule can significantly reduce the incidences of macular edema and suppresses increasing retinal thickening after phacoemulsification in patients with diabetes mellitus.
Keywords	Qi ming granule ; phacoemulsification ; macular edema ; diabetes mellitus ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2015-08-01T00:00:00Z
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of bacterial community inhabiting the surfaces of weathered bricks of Nanjing Ming city walls.

Qi-Wang / Ma, Guang-You / He, Lin-Yan / Sheng, Xia-Fang

The Science of the total environment

2011 Volume 409, Issue 4, Page(s) 756–762

Abstract: Nanjing Ming city wall, one of the important historic heritages in China, has greatly suffered ...

Abstract	Nanjing Ming city wall, one of the important historic heritages in China, has greatly suffered weathering. Microbes play an important role in the weathering of historic buildings. However, little is known about the microbial community inhabiting naturally weathered brick minerals and their roles in the mineral weathering. To examine the associations between microorganisms and brick weathering process, we compare the phylogenetic diversity, abundance, community structure, and specific functional groups of bacteria existing in weathered bricks by using a coupled approach involving cultivation-independent analysis of denaturing gradient gel electrophoresis (DGGE) as well as cultivation-based analysis of Si-releasing bacteria. DGGE and sequence analyses show that the bacterial communities were different along a weathering gradient and the abundance of bacterial communities positively and significantly correlates with the extent of brick weathering. Laboratory brick mineral dissolution experiments indicate that bacteria isolated from the surfaces of weathered brick were very effective in enhancing brick dissolution. Phylogenetic analyses show that the weathered bricks were inhabited by specific functional groups of bacteria (Bacillus, Massillia, Brevibacillus, Glacialice, Acinetobacter, Brachysporum, and Achromobacter) that contribute to the brick weathering.
MeSH term(s)	Achromobacter/classification ; Achromobacter/genetics ; Achromobacter/metabolism ; Acinetobacter/classification ; Acinetobacter/genetics ; Acinetobacter/metabolism ; Bacillus/classification ; Bacillus/genetics ; Bacillus/metabolism ; Bacteria/classification ; Bacteria/genetics ; Bacteria/metabolism ; Base Sequence ; Biodiversity ; Biomass ; Brevibacillus/classification ; Brevibacillus/genetics ; Brevibacillus/metabolism ; China ; Construction Materials/microbiology ; DNA, Bacterial ; Denaturing Gradient Gel Electrophoresis ; Molecular Sequence Data ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Silicon/metabolism ; Weather
Chemical Substances	DNA, Bacterial ; RNA, Ribosomal, 16S ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2011-01-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2010.11.001
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