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  1. Article ; Online: Medical knowledge about COVID-19 is travelling at the speed of mistrust: why this is relevant to primary care.

    Tharmaratnam, Tharmegan / D'Urzo, Anthony / Cazzola, Mario

    Family practice

    2022  Volume 39, Issue 5, Page(s) 988–991

    MeSH term(s) African Americans ; COVID-19 ; Humans ; Primary Health Care ; Trust
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605939-9
    ISSN 1460-2229 ; 0263-2136
    ISSN (online) 1460-2229
    ISSN 0263-2136
    DOI 10.1093/fampra/cmac001
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  2. Article ; Online: Sleep deprivation-induced oculomotor dysfunction: implications for surgical and medical performance.

    Ghanem, Mohannad / Mallah, Saad Imad / Iskandar, Mina Amin / Tharmaratnam, Tharmegan

    The Journal of physiology

    2020  Volume 598, Issue 8, Page(s) 1437–1439

    MeSH term(s) Circadian Rhythm ; Eye Movements ; Humans ; Sleep ; Sleep Deprivation
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP279357
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  3. Article ; Online: Chronic aerobic exercise reduces the aortic age of an elderly cohort.

    Iskandar, Mina Amin / Tharmaratnam, Tharmegan / Ahmad, Zunair

    The Journal of physiology

    2018  Volume 596, Issue 20, Page(s) 4811–4812

    MeSH term(s) Aorta ; Exercise ; Vascular Stiffness
    Language English
    Publishing date 2018-09-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP276961
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  4. Article ; Online: Synergistic effects of brain-derived neurotrophic factor (BDNF) and exercise intensity on memory in the adolescent brain: a commentary.

    Tharmaratnam, Tharmegan / Tabobondung, Tyler / Tabobondung, Taylor / Doherty, Sally

    Environmental health and preventive medicine

    2018  Volume 23, Issue 1, Page(s) 12

    Abstract: This commentary highlights the recently published study by Jeon and Ha (Environ Health Prev Med 22:27, 2017) examining the effects of exercise intensity and brain-derived neurotrophic factor (BDNF) on memory in adolescents. This 12-week training study ... ...

    Abstract This commentary highlights the recently published study by Jeon and Ha (Environ Health Prev Med 22:27, 2017) examining the effects of exercise intensity and brain-derived neurotrophic factor (BDNF) on memory in adolescents. This 12-week training study elicited increases in BDNF and improvements in working memory during moderate- and high-intensity exercise, which may have been achieved through improved brain tissue oxygenation, nutrient delivery, and BDNF mRNA expression. These improvements highlight the positive neuroendocrinological effects of BDNF and its role as a potential candidate molecule, as a mediator of synaptic plasticity. In this commentary, we aim to highlight the strengths and potential areas of consideration of Jeon and Ha (Environ Health Prev Med 22:27, 2017). We also offer insight into the clinical implications of this study, such as advocating for exercise in healthy children and as adjunctive therapy in pathological states. This study is promising and further highlights the importance of cardiorespiratory exercise in improving physiological health and cognitive functioning in youth through the phenomenon of neuroplasticity.
    MeSH term(s) Adolescent ; Brain-Derived Neurotrophic Factor/metabolism ; Exercise/physiology ; Humans ; Memory/physiology
    Chemical Substances Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2018-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2018758-0
    ISSN 1347-4715 ; 1342-078X
    ISSN (online) 1347-4715
    ISSN 1342-078X
    DOI 10.1186/s12199-018-0701-8
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  5. Article ; Online: Synergistic effects of brain-derived neurotrophic factor (BDNF) and exercise intensity on memory in the adolescent brain

    Tharmegan Tharmaratnam / Tyler Tabobondung / Taylor Tabobondung / Sally Doherty

    Environmental Health and Preventive Medicine, Vol 23, Iss 1, Pp 1-

    a commentary

    2018  Volume 4

    Abstract: Abstract This commentary highlights the recently published study by Jeon and Ha (Environ Health Prev Med 22:27, 2017) examining the effects of exercise intensity and brain-derived neurotrophic factor (BDNF) on memory in adolescents. This 12-week training ...

    Abstract Abstract This commentary highlights the recently published study by Jeon and Ha (Environ Health Prev Med 22:27, 2017) examining the effects of exercise intensity and brain-derived neurotrophic factor (BDNF) on memory in adolescents. This 12-week training study elicited increases in BDNF and improvements in working memory during moderate- and high-intensity exercise, which may have been achieved through improved brain tissue oxygenation, nutrient delivery, and BDNF mRNA expression. These improvements highlight the positive neuroendocrinological effects of BDNF and its role as a potential candidate molecule, as a mediator of synaptic plasticity. In this commentary, we aim to highlight the strengths and potential areas of consideration of Jeon and Ha (Environ Health Prev Med 22:27, 2017). We also offer insight into the clinical implications of this study, such as advocating for exercise in healthy children and as adjunctive therapy in pathological states. This study is promising and further highlights the importance of cardiorespiratory exercise in improving physiological health and cognitive functioning in youth through the phenomenon of neuroplasticity.
    Keywords Brain-derived neurotrophic factor ; Memory ; Aerobic exercise ; Neurogenesis ; Exercise intensity ; Cognition ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Komiyama Printing Co. Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Exercise becomes brain: sustained aerobic exercise enhances hippocampal neurogenesis.

    Tharmaratnam, Tharmegan / Civitarese, Robert A / Tabobondung, Tyler / Tabobondung, Taylor A

    The Journal of physiology

    2016  Volume 595, Issue 1, Page(s) 7–8

    MeSH term(s) Brain ; Exercise ; Hippocampus ; Neurogenesis ; Physical Conditioning, Animal
    Language English
    Publishing date 2016-10-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP272761
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  7. Article: Entamoeba histolytica

    Tharmaratnam, Tharmegan / Kumanan, Thirunavukarasu / Iskandar, Mina Amin / D'Urzo, Katrina / Gopee-Ramanan, Prasaanthan / Loganathan, Mayura / Tabobondung, Tyler / Tabobondung, Taylor Anthony / Sivagurunathan, Seyon / Patel, Mitul / Tobbia, Iqdam

    Tropical medicine and health

    2020  Volume 48, Page(s) 2

    Abstract: Entamoeba ... ...

    Abstract Entamoeba histolytica
    Language English
    Publishing date 2020-01-22
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2209835-5
    ISSN 1349-4147 ; 1348-8945
    ISSN (online) 1349-4147
    ISSN 1348-8945
    DOI 10.1186/s41182-020-0193-2
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  8. Article ; Online: Exercise and oestrogens: aerobic high-intensity exercise promotes leg vascular and skeletal muscle mitochondrial adaptations in early postmenopause.

    Tharmaratnam, Tharmegan / Tabobondung, Tyler / Tabobondung, Taylor / Sivagurunathan, Seyon / Iskandar, Mina Amin

    The Journal of physiology

    2017  Volume 595, Issue 20, Page(s) 6379–6380

    MeSH term(s) Estrogens ; Exercise ; Female ; Humans ; Mitochondria ; Muscle, Skeletal ; Postmenopause
    Chemical Substances Estrogens
    Language English
    Publishing date 2017-09-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP275063
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  9. Article ; Online: An Association Between Cardiologist Billing Patterns, Health Care Use, and Outcomes in Cardiac Patients.

    Bhatia, Rajan Sacha / Ko, Dennis T / Chu, Cherry / Croxford, Ruth / Bouck, Zachary / Tharmaratnam, Tharmegan / Dorian, Paul / Ross, Heather / Austin, Peter C / Shojania, Kaveh / Goodman, Shaun G

    CJC open

    2021  Volume 3, Issue 6, Page(s) 758–768

    Abstract: Background: Whether individual cardiologist billings are associated with differences in ambulatory care management and clinical outcomes in patients with coronary artery disease (CAD) and heart failure (HF) remains poorly understood.: Methods: We ... ...

    Abstract Background: Whether individual cardiologist billings are associated with differences in ambulatory care management and clinical outcomes in patients with coronary artery disease (CAD) and heart failure (HF) remains poorly understood.
    Methods: We conducted a population-based, retrospective cohort study of cardiologists who treat patients with CAD or HF using administrative claims data in Ontario, Canada. The primary exposure was cardiologist billing quintile. We then stratified median billing amounts into quintiles, from lowest (quintile 1) to highest billing physicians (quintile 5).
    Results: The main outcomes of interest were cardiac diagnostic and therapeutic procedures that occurred within 365 days of the index visit. Our 2 cohorts respectively consisted of 170,959 patients with CAD seen by 1 of 423 cardiologists and 56,262 HF patients seen by 1 of 413 cardiologists. CAD patients of higher-billing cardiologists had higher rates of echocardiograms (adjusted odds ratio [aOR], 1.65; 95% confidence interval [CI], 1.39 to 1.94 for quintile 5 vs quintile 2) and stress tests (aOR, 1.50; 95% CI, 1.28-1.75) at 1 year, with a similar pattern for HF patients of echocardiogram (aOR, 1.40; 95% CI, 1.23-1.59;
    Conclusions: Cardiac patients seen by the highest-billing cardiologists received more noninvasive cardiac testing compared with lower-billing cardiologists.
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2021.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: COVID-19: breaking down a global health crisis.

    Mallah, Saad I / Ghorab, Omar K / Al-Salmi, Sabrina / Abdellatif, Omar S / Tharmaratnam, Tharmegan / Iskandar, Mina Amin / Sefen, Jessica Atef Nassef / Sidhu, Pardeep / Atallah, Bassam / El-Lababidi, Rania / Al-Qahtani, Manaf

    Annals of clinical microbiology and antimicrobials

    2021  Volume 20, Issue 1, Page(s) 35

    Abstract: Coronavirus disease 2019 (COVID-19) is the second pandemic of the twenty-first century, with over one-hundred million infections and over two million deaths to date. It is a novel strain from the Coronaviridae family, named Severe Acute Respiratory ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is the second pandemic of the twenty-first century, with over one-hundred million infections and over two million deaths to date. It is a novel strain from the Coronaviridae family, named Severe Acute Respiratory Distress Syndrome Coronavirus-2 (SARS-CoV-2); the 7th known member of the coronavirus family to cause disease in humans, notably following the Middle East Respiratory syndrome (MERS), and Severe Acute Respiratory Distress Syndrome (SARS). The most characteristic feature of this single-stranded RNA molecule includes the spike glycoprotein on its surface. Most patients with COVID-19, of which the elderly and immunocompromised are most at risk, complain of flu-like symptoms, including dry cough and headache. The most common complications include pneumonia, acute respiratory distress syndrome, septic shock, and cardiovascular manifestations. Transmission of SARS-CoV-2 is mainly via respiratory droplets, either directly from the air when an infected patient coughs or sneezes, or in the form of fomites on surfaces. Maintaining hand-hygiene, social distancing, and personal protective equipment (i.e., masks) remain the most effective precautions. Patient management includes supportive care and anticoagulative measures, with a focus on maintaining respiratory function. Therapy with dexamethasone, remdesivir, and tocilizumab appear to be most promising to date, with hydroxychloroquine, lopinavir, ritonavir, and interferons falling out of favour. Additionally, accelerated vaccination efforts have taken place internationally, with several promising vaccinations being mass deployed. In response to the COVID-19 pandemic, countries and stakeholders have taken varying precautions to combat and contain the spread of the virus and dampen its collateral economic damage. This review paper aims to synthesize the impact of the virus on a global, micro to macro scale.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19/transmission ; COVID-19 Vaccines/immunology ; Global Health ; Humans ; Risk Factors ; SARS-CoV-2/pathogenicity ; Virulence
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2097873-X
    ISSN 1476-0711 ; 1476-0711
    ISSN (online) 1476-0711
    ISSN 1476-0711
    DOI 10.1186/s12941-021-00438-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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