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  1. Article ; Online: Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation?

    Kriegel, Joshua / Papadopoulos, Zachary / McKee, Ann C

    Cold Spring Harbor perspectives in medicine

    2018  Volume 8, Issue 2

    Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive mild brain trauma. CTE, previously termed "dementia pugilistica," has been identified in American football, ice hockey, baseball, rugby and soccer players, ...

    Abstract Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive mild brain trauma. CTE, previously termed "dementia pugilistica," has been identified in American football, ice hockey, baseball, rugby and soccer players, boxers, wrestlers, and military personnel exposed to blast and other traumatic brain injuries. There is often a long latency period between an individual's exposure to repetitive brain trauma and the clinical symptoms of CTE. The pathology of CTE is characterized by a progression from isolated focal perivascular hyperphosphorylated tau lesions in the cerebral cortex to a widespread tauopathy that involves diffuse cortical and medial temporal lobe regions. We hypothesize that the spread of tau from focal perivascular lesions to a widespread tauopathy occurs as a result of intraneuronal and intrasynaptic prion-like protein templating, as well as tau secretion and propagation along glymphatic and cerebrospinal fluid pathways.
    MeSH term(s) Brain Concussion/complications ; Chronic Traumatic Encephalopathy/diagnosis ; Chronic Traumatic Encephalopathy/etiology ; Chronic Traumatic Encephalopathy/metabolism ; Chronic Traumatic Encephalopathy/pathology ; Disease Progression ; Humans ; Tauopathies/diagnosis ; Tauopathies/etiology ; Tauopathies/metabolism ; Tauopathies/pathology ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a024059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 50 Patients with Malignant Mesothelioma of Both the Pleura and Peritoneum: A Single-Institution Experience.

    Letica-Kriegel, Allison S / Leinwand, Joshua C / Sonett, Joshua R / Gorenstein, Lyall A / Taub, Robert N / Chabot, John A / Kluger, Michael D

    Annals of surgical oncology

    2019  Volume 27, Issue 1, Page(s) 205–213

    Abstract: Background: The most common sites of malignant mesothelioma are the pleura and peritoneum, but little is known about the incidence, prognosis, or treatment of patients with disease in both cavities. Previous series suggest that multimodality treatment ... ...

    Abstract Background: The most common sites of malignant mesothelioma are the pleura and peritoneum, but little is known about the incidence, prognosis, or treatment of patients with disease in both cavities. Previous series suggest that multimodality treatment improves overall survival for pleural or peritoneal disease, but studies typically exclude patients with disease in both cavities. Despite limitations, this investigation is the only study to broadly examine outcomes for patients with malignant mesothelioma in both the pleural and peritoneal cavities.
    Methods: This study retrospectively examined 50 patients with both pleural and peritoneal mesothelioma treated with the intent to prolong survival. The primary end point was overall survival from the initial operative intervention.
    Results: The median overall survival was 33.9 months from the initial intervention. Female gender and intraperitoneal dwell chemotherapy were independent predictors of overall survival. Within 1 year after the initial diagnosis, second-cavity disease was diagnosed in 52% of the patients. The median time to the second-cavity diagnosis for those with a diagnosis 1 year after the initial diagnosis was 30 months.
    Conclusions: Well-selected patients with both pleural and peritoneal mesothelioma have a survival benefit over palliative treatment that is comparable with that seen in single-cavity disease. The presence of disease in both cavities is not a contraindication to multimodality treatment aimed at prolonging survival, whether the disease is diagnosed synchronously or metachronously. Patients with an initial diagnosis of single cavity disease are at the highest risk for identification of second-cavity disease within the first year after diagnosis.
    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Female ; Humans ; Hyperthermia, Induced ; Lung Neoplasms/mortality ; Lung Neoplasms/therapy ; Male ; Mesothelioma/mortality ; Mesothelioma/therapy ; Mesothelioma, Malignant ; Middle Aged ; Peritoneal Neoplasms/mortality ; Peritoneal Neoplasms/therapy ; Pleural Neoplasms/mortality ; Pleural Neoplasms/therapy ; Prognosis ; Retrospective Studies ; Survival Rate
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-019-07409-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  3. Article ; Online: Acclimation to a High-Salt Diet Is Sex Dependent.

    Gohar, Eman Y / De Miguel, Carmen / Obi, Ijeoma E / Daugherty, Elizabeth M / Hyndman, Kelly A / Becker, Bryan K / Jin, Chunhua / Sedaka, Randee / Johnston, Jermaine G / Liu, Pengyuan / Speed, Joshua S / Mitchell, Tanecia / Kriegel, Alison J / Pollock, Jennifer S / Pollock, David M

    Journal of the American Heart Association

    2022  Volume 11, Issue 5, Page(s) e020450

    Abstract: Background Premenopausal women are less likely to develop hypertension and salt-related complications than are men, yet the impact of sex on mechanisms regulating ... ...

    Abstract Background Premenopausal women are less likely to develop hypertension and salt-related complications than are men, yet the impact of sex on mechanisms regulating Na
    MeSH term(s) Acclimatization ; Animals ; Blood Pressure ; Diet ; Endothelin-1/metabolism ; Female ; Humans ; Male ; Rats ; Rats, Sprague-Dawley ; Sodium ; Sodium Chloride ; Sodium Chloride, Dietary/metabolism
    Chemical Substances Endothelin-1 ; Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.020450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Light-Driven Permanent Charge Separation across a Hybrid Zero-Dimensional/Two-Dimensional Interface

    Kriegel, Ilka / Ghini, Michele / Bellani, Sebastiano / Zhang, Kehao / Jansons, Adam W / Crockett, Brandon M / Koskela, Kristopher M / Barnard, Edward S / Penzo, Erika / Hutchison, James E / Robinson, Joshua A / Manna, Liberato / Borys, Nicholas J / Schuck, P. James

    Journal of physical chemistry. 2020 Mar. 16, v. 124, no. 14

    2020  

    Abstract: We report the first demonstration of light-driven permanent charge separation across an ultrathin solid-state zero-dimensional (0D)/2D hybrid interface by coupling photoactive Sn-doped In2O3 nanocrystals with monolayer MoS2, the latter serving as a hole ... ...

    Abstract We report the first demonstration of light-driven permanent charge separation across an ultrathin solid-state zero-dimensional (0D)/2D hybrid interface by coupling photoactive Sn-doped In2O3 nanocrystals with monolayer MoS2, the latter serving as a hole collector. We demonstrate that the nanocrystals in this device-ready architecture act as local light-controlled charge sources by quasi-permanently donating ∼5 holes per nanocrystal to the monolayer MoS2. The amount of photoinduced contactless charge transfer to the monolayer MoS2 competes with what is reached in electrostatically gated devices. Thus, we have constructed a hybrid bilayer structure in which the electrons and holes are separated into two different solid-state materials. The temporal evolution of the local doping levels of the monolayer MoS2 follows a capacitive charging model with effective total capacitances in the femtofarad regime and areal capacitances in the μF cm–2 range. This analysis indicates that the 0D/2D hybrid system may be able to store light energy at densities of at least μJ cm–2, presenting new potential foundational building blocks for next-generation nanodevices that can remotely control local charge density, power miniaturized circuitry, and harvest and store optical energy.
    Keywords electrons ; electrostatic interactions ; energy ; models ; molybdenum disulfide ; nanocrystals ; physical chemistry
    Language English
    Dates of publication 2020-0316
    Size p. 8000-8007.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1932-7455
    DOI 10.1021/acs.jpcc.0c01147
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.

    Mez, Jesse / Chung, Jaeyoon / Jun, Gyungah / Kriegel, Joshua / Bourlas, Alexandra P / Sherva, Richard / Logue, Mark W / Barnes, Lisa L / Bennett, David A / Buxbaum, Joseph D / Byrd, Goldie S / Crane, Paul K / Ertekin-Taner, Nilüfer / Evans, Denis / Fallin, M Daniele / Foroud, Tatiana / Goate, Alison / Graff-Radford, Neill R / Hall, Kathleen S /
    Kamboh, M Ilyas / Kukull, Walter A / Larson, Eric B / Manly, Jennifer J / Haines, Jonathan L / Mayeux, Richard / Pericak-Vance, Margaret A / Schellenberg, Gerard D / Lunetta, Kathryn L / Farrer, Lindsay A

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2016  Volume 13, Issue 2, Page(s) 119–129

    Abstract: Introduction: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.: Methods: We ... ...

    Abstract Introduction: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power.
    Methods: We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs.
    Results: Two SNPs at novel loci, rs112404845 (P = 3.8 × 10
    Discussion: An informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS.
    MeSH term(s) ATP-Binding Cassette Transporters/genetics ; Black or African American/genetics ; Aged ; Aged, 80 and over ; Alzheimer Disease/ethnology ; Alzheimer Disease/genetics ; Apolipoproteins E/genetics ; Diabetes Complications/ethnology ; Diabetes Complications/genetics ; Educational Status ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Microfilament Proteins/genetics ; Organic Anion Transporters, Sodium-Dependent/genetics ; Polymorphism, Single Nucleotide ; Prevalence ; Smoking/ethnology ; Smoking/genetics ; Symporters/genetics
    Chemical Substances ABCA7 protein, human ; ATP-Binding Cassette Transporters ; Apolipoproteins E ; Cobl protein, human ; Microfilament Proteins ; Organic Anion Transporters, Sodium-Dependent ; Symporters ; sodium-bile acid cotransporter (145420-23-1)
    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1016/j.jalz.2016.09.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

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  6. Article: Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.

    Mez, Jesse / Solomon, Todd M / Daneshvar, Daniel H / Murphy, Lauren / Kiernan, Patrick T / Montenigro, Philip H / Kriegel, Joshua / Abdolmohammadi, Bobak / Fry, Brian / Babcock, Katharine J / Adams, Jason W / Bourlas, Alexandra P / Papadopoulos, Zachary / McHale, Lisa / Ardaugh, Brent M / Martin, Brett R / Dixon, Diane / Nowinski, Christopher J / Chaisson, Christine /
    Alvarez, Victor E / Tripodis, Yorghos / Stein, Thor D / Goldstein, Lee E / Katz, Douglas I / Kowall, Neil W / Cantu, Robert C / Stern, Robert A / McKee, Ann C

    Alzheimer's research & therapy

    2015  Volume 7, Issue 1, Page(s) 62

    Abstract: Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National ... ...

    Abstract Introduction: Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) is a U01 project recently funded by the National Institute of Neurological Disorders and Stroke and the National Institute of Biomedical Imaging and Bioengineering. The goal of the UNITE project is to examine the neuropathology and clinical presentation of brain donors designated as "at risk" for the development of CTE based on prior athletic or military exposure. Here, we present the rationale and methodology for UNITE.
    Methods: Over the course of 4 years, we will analyze the brains and spinal cords of 300 deceased subjects who had a history of repetitive head impacts sustained during participation in contact sports at the professional or collegiate level or during military service. Clinical data are collected through medical record review and retrospective structured and unstructured family interviews conducted by a behavioral neurologist or neuropsychologist. Blinded to the clinical data, a neuropathologist conducts a comprehensive assessment for neurodegenerative disease, including CTE, using published criteria. At a clinicopathological conference, a panel of physicians and neuropsychologists, blinded to the neuropathological data, reaches a clinical consensus diagnosis using published criteria, including proposed clinical research criteria for CTE.
    Results: We will investigate the validity of these clinical criteria and sources of error by using recently validated neuropathological criteria as a gold standard for CTE diagnosis. We also will use statistical modeling to identify diagnostic features that best predict CTE pathology.
    Conclusions: The UNITE study is a novel and methodologically rigorous means of assessing clinicopathological correlation in CTE. Our findings will be critical for developing future iterations of CTE clinical diagnostic criteria.
    MeSH term(s) Athletes ; Athletic Injuries/complications ; Brain/pathology ; Brain Injury, Chronic/etiology ; Brain Injury, Chronic/pathology ; Brain Injury, Chronic/physiopathology ; Consensus ; Female ; Humans ; Immunohistochemistry ; Interviews as Topic ; Male ; Military Personnel ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Retrospective Studies ; Spinal Cord/pathology ; War-Related Injuries/complications
    Language English
    Publishing date 2015-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2506521-X
    ISSN 1758-9193
    ISSN 1758-9193
    DOI 10.1186/s13195-015-0148-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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