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  1. Article ; Online: Sociophonetics: The Role of Words, the Role of Context, and the Role of Words in Context.

    Hay, Jennifer

    Topics in cognitive science

    2018  Volume 10, Issue 4, Page(s) 696–706

    Abstract: This paper synthesizes a wide range of literature from sociolinguistics and cognitive psychology, to argue for a central role for the "word" as a vehicle of language variation and change. Three crucially interlinked strands of research are reviewed-the ... ...

    Abstract This paper synthesizes a wide range of literature from sociolinguistics and cognitive psychology, to argue for a central role for the "word" as a vehicle of language variation and change. Three crucially interlinked strands of research are reviewed-the role of context in associative learning, the word-level storage of phonetic and contextual detail, and the phonetic consequences of skewed distributions of words across different contexts. I argue that the human capacity for associative learning, combined with attention to fine-phonetic detail at the level of the word, plays a significant role in predicting a range of subtle but systematically robust observed socioindexical patterns in speech production and perception.
    MeSH term(s) Cognitive Science ; Humans ; Phonetics ; Psycholinguistics ; Social Perception ; Social Sciences ; Speech ; Speech Perception
    Language English
    Publishing date 2018-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2482883-X
    ISSN 1756-8765 ; 1756-8757
    ISSN (online) 1756-8765
    ISSN 1756-8757
    DOI 10.1111/tops.12326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Moving beyond the "Health Halo" of Alcohol: What Will it Take to Achieve Population Awareness of the Cancer Risks of Alcohol?

    Hay, Jennifer L / Kiviniemi, Marc T / Orom, Heather / Waters, Erika A

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2023  Volume 32, Issue 1, Page(s) 9–11

    Abstract: We discuss the implications of Seidenberg and colleagues' report confirming low levels of accurate awareness of the cancer harms associated with alcohol use, including wine, beer, and liquor consumption. The authors propose that academic and lay ... ...

    Abstract We discuss the implications of Seidenberg and colleagues' report confirming low levels of accurate awareness of the cancer harms associated with alcohol use, including wine, beer, and liquor consumption. The authors propose that academic and lay messaging describing consumption of wine and other forms of alcohol as reducing heart disease risk has created generalized beliefs about the health benefits of drinking alcohol. This "health halo" surrounding alcohol consumption leads the public to overgeneralize alcohol health benefits to other diseases, including cancer. We discuss the need to address high levels of perceived risk uncertainty to help the public distinguish between the impact of alcohol on heart disease versus cancer, and to overcome other barriers to including alcohol use reduction as a cancer prevention strategy. Given recent increases in U.S. population drinking rates, as well as morbidity and mortality associated with alcohol use, the time is right to marshal multilevel efforts to educate the public regarding the fact that alcohol is carcinogenic. If successful, these efforts will have multiple downstream benefits, including the ability of the lay public to use the most up-to-date scientific evidence to make informed decisions about whether, and how much, to engage in a risky behavior. See related article by Seidenberg et al., p. 46.
    MeSH term(s) Humans ; Alcohol Drinking/adverse effects ; Alcohol Drinking/epidemiology ; Alcoholic Beverages ; Wine ; Ethanol ; Neoplasms/epidemiology ; Neoplasms/etiology ; Neoplasms/prevention & control ; Heart Diseases
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-01-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-22-1102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Restricted and repetitive behaviors and their developmental and demographic correlates in 4-8-year-old children: A transdiagnostic approach.

    Keating, Jennifer / Van Goozen, Stephanie / Uljarevic, Mirko / Hay, Dale / Leekam, Susan R

    Frontiers in behavioral neuroscience

    2023  Volume 17, Page(s) 1085404

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1085404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Consent and Identifiability for Patient Images in Research, Education, and Image-Based Artificial Intelligence.

    Salvador, Trina / Gu, Lilly / Hay, Jennifer L / Kurtansky, Nicholas R / Masterson-Creber, Ruth / Halpern, Allan C / Rotemberg, Veronica

    JAMA dermatology

    2024  Volume 160, Issue 4, Page(s) 470–472

    MeSH term(s) Humans ; Artificial Intelligence ; Educational Status ; Informed Consent
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2024.0084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Influence of anosognosia on patient-reported outcomes for psychiatric symptoms and quality of life in Huntington's disease.

    Isaacs, David A / Hay, Kaitlyn R / Hoadley, Jennifer / McDonell, Katherine E / Brown, Amy E / Wynn, Amy / Claassen, Daniel O / Gibson, Jessie

    Parkinsonism & related disorders

    2024  Volume 123, Page(s) 106969

    Abstract: Introduction: Anosognosia, defined as reduced awareness of one's deficit or symptom, is common in Huntington's disease (HD) and detectable at each disease stage. The impact of anosognosia on self-reporting in HD populations is critical to understand ... ...

    Abstract Introduction: Anosognosia, defined as reduced awareness of one's deficit or symptom, is common in Huntington's disease (HD) and detectable at each disease stage. The impact of anosognosia on self-reporting in HD populations is critical to understand given growing use of patient-reported outcomes in HD clinical care and research. We aimed to determine the influence of anosognosia on patient-reported outcome measures assessing psychiatric symptoms and quality of life in HD.
    Methods: We enrolled HD patients to complete a battery of patient-reported and rater-administered measures, including the Anosognosia Scale, at baseline and 6 months later. Patient-reported outcome measures included NeuroQoL short forms for depression, anxiety, satisfaction with social roles and activities, and positive affect and well-being and Patient-Reported Outcomes Measurement Information System short forms for emotional distress-anger and sleep-related impairment. Anosognosia Scale-Difference Score indexed patient-clinician agreement on patient motor, cognitive, and behavioral abilities. We conducted multivariable linear regression analyses to quantify the association of baseline anosognosia with 6-month patient-reported outcomes.
    Results: Of 79 patients with complete Anosognosia Scale data at baseline, 25 (31.6 %) met the scale's criterion for anosognosia. In the regression analyses, baseline Difference Score improved prediction of 6-month patient-reported outcomes for depression, anxiety, anger, and positive affect and well-being (χ
    Conclusion: Study results suggest that anosognosia influences patient-reported outcomes for psychiatric symptoms and quality of life in HD populations.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Colorectal cancer information avoidance is associated with screening adherence.

    Orom, Heather / Ramer, Nolan E / Allard, Natasha C / McQueen, Amy / Waters, Erika A / Kiviniemi, Marc T / Hay, Jennifer L

    Journal of behavioral medicine

    2024  Volume 47, Issue 3, Page(s) 504–514

    Abstract: Colorectal cancer (CRC) is the fourth most common cancer among U.S. men and women and the second deadliest. Effective screening modalities can either prevent CRC or find it earlier, but fewer than two thirds of U.S. adults are adherent to CRC screening ... ...

    Abstract Colorectal cancer (CRC) is the fourth most common cancer among U.S. men and women and the second deadliest. Effective screening modalities can either prevent CRC or find it earlier, but fewer than two thirds of U.S. adults are adherent to CRC screening guidelines. We tested whether people who defensively avoid CRC information have lower adherence to CRC screening recommendations and weaker intentions for being screened and whether CRC information avoidance adds predictive ability beyond known determinants of screening. Participants, aged 45-75 years, completed a survey about known structural determinants of CRC screening (healthcare coverage, healthcare use, provider recommendation), CRC information avoidance tendencies, and screening behavior (n = 887) and intentions (n = 425). Models were tested with multivariable regression and structural equation modeling (SEM). To the extent that participants avoided CRC information, they had lower odds of being adherent to CRC screening guidelines (OR = 0.55) and if non-adherent, less likely to intend to be screened (b=-0.50). In the SEM model, avoidance was negatively associated with each known structural determinant of screening and with lower screening adherence (ps < 0.01). Fit was significantly worse for nested SEM models when avoidance was not included, (i.e., the paths to avoidance were fixed to zero). Information avoidance was associated with screening behavior and other known structural determinants of screening adherence, potentially compounding its influence. Novel strategies are needed to reach avoiders, including health communication messaging that disrupts avoidance and interventions external to the healthcare system, with which avoiders are less engaged.
    MeSH term(s) Adult ; Male ; Humans ; Female ; Information Avoidance ; Early Detection of Cancer ; Colorectal Neoplasms/diagnosis ; Surveys and Questionnaires ; Health Communication ; Mass Screening
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441827-x
    ISSN 1573-3521 ; 0160-7715
    ISSN (online) 1573-3521
    ISSN 0160-7715
    DOI 10.1007/s10865-024-00482-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Circulating Endocannabinoids in Canine Multicentric Lymphoma Patients.

    Hay, Jennifer K / Hocker, Samuel E / Monteith, Gabrielle / Woods, J Paul

    Frontiers in veterinary science

    2022  Volume 9, Page(s) 828095

    Abstract: The endocannabinoid system is increasingly being implicated in the pathogenesis and progression of various human cancers. Specifically, increased levels of 2-arachidonoylglycerol (2-AG) and oleoythanolamide (OEA) have been demonstrated in human diffuse ... ...

    Abstract The endocannabinoid system is increasingly being implicated in the pathogenesis and progression of various human cancers. Specifically, increased levels of 2-arachidonoylglycerol (2-AG) and oleoythanolamide (OEA) have been demonstrated in human diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) patients, respectively. The objectives of this paper were to compare 2-AG, OEA, N-arachidonoylethanolamine (AEA), and palmitoylethanolamide (PEA) levels between dogs with multicentric lymphoma and healthy control dogs. In addition, evaluate 2-AG, OEA, AEA, and PEA levels as biomarkers for progression free interval (PFI) and overall survival time (OST) in the dogs with lymphoma. The study consisted of 26 dogs with multicentric B cell lymphoma, 14 dogs with multicentric T cell lymphoma, and 12 healthy control dogs. Serum 2-AG, OEA, AEA, and PEA levels were measured using liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) in dogs with lymphoma and in healthy dogs. OEA, AEA, and PEA levels were significantly elevated in dogs with lymphoma compared to healthy controls (
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.828095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lomustine (CCNU) and prednisone chemotherapy for high-grade completely excised canine mast cell tumors.

    Hay, Jennifer K / Larson, Victoria S

    The Canadian veterinary journal = La revue veterinaire canadienne

    2019  Volume 60, Issue 12, Page(s) 1326–1330

    Abstract: The efficacy and toxicity of lomustine and prednisone for treating high-grade completely excised mast cell tumors (MCTs) was evaluated in a retrospective study of 15 dogs. Dogs were treated with lomustine (CCNU) at 70 mg/ ... ...

    Abstract The efficacy and toxicity of lomustine and prednisone for treating high-grade completely excised mast cell tumors (MCTs) was evaluated in a retrospective study of 15 dogs. Dogs were treated with lomustine (CCNU) at 70 mg/m
    MeSH term(s) Animals ; Dog Diseases ; Dogs ; Lomustine ; Mastocytosis ; Neutropenia/veterinary ; Prednisone ; Retrospective Studies
    Chemical Substances Lomustine (7BRF0Z81KG) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-12-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.

    Hay, Quintessa / Grubb, Christopher / Minucci, Sarah / Valentine, Michael S / Van Mullekom, Jennifer / Heise, Rebecca L / Reynolds, Angela M

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1011113

    Abstract: A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased ... ...

    Abstract A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased instance of respiratory distress in older patients and differences in the inflammatory response. To address this, we performed high pressure ventilation on young (2-3 months) and old (20-25 months) mice for 2 hours and collected data for macrophage phenotypes and lung tissue integrity. Large differences in macrophage activation at baseline and airspace enlargement after ventilation were observed in the old mice. The experimental data was used to determine plausible trajectories for a mathematical model of the inflammatory response to lung injury which includes variables for the innate inflammatory cells and mediators, epithelial cells in varying states, and repair mediators. Classification methods were used to identify influential parameters separating the parameter sets associated with the young or old data and separating the response to ventilation, which was measured by changes in the epithelial state variables. Classification methods ranked parameters involved in repair and damage to the epithelial cells and those associated with classically activated macrophages to be influential. Sensitivity results were used to determine candidate in-silico interventions and these interventions were most impact for transients associated with the old data, specifically those with poorer lung health prior to ventilation. Model results identified dynamics involved in M1 macrophages as a focus for further research, potentially driving the age-dependent differences in all macrophage phenotypes. The model also supported the pro-inflammatory response as a potential indicator of age-dependent differences in response to ventilation. This mathematical model can serve as a baseline model for incorporating other pulmonary injuries.
    MeSH term(s) Humans ; Mice ; Animals ; Aged ; Lung ; Ventilator-Induced Lung Injury ; Respiration, Artificial/adverse effects ; Macrophages ; Models, Theoretical
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Assessing pragmatic language difficulties using the Revised Children's Communication Checklist-2. Exploratory structural equation modeling and associations with restricted and repetitive behaviors.

    Keating, Jennifer / Uljarević, Mirko / van Goozen, Stephanie H M / Abbot-Smith, Kirsten / Hay, Dale F / Leekam, Susan R

    Autism research : official journal of the International Society for Autism Research

    2024  Volume 17, Issue 3, Page(s) 584–595

    Abstract: In this paper, we investigated the psychometric properties of the Child Communication Checklist-Revised (CCC-R) for the first time with an English-speaking sample. We used a confirmatory application of exploratory structural equation modeling (ESEM) to ... ...

    Abstract In this paper, we investigated the psychometric properties of the Child Communication Checklist-Revised (CCC-R) for the first time with an English-speaking sample. We used a confirmatory application of exploratory structural equation modeling (ESEM) to re-evaluate the CCC-R's psychometric properties. We found strong support for its use as an assessment for pragmatic and structural language. Our second main aim was to explore associations between pragmatic and structural language and restricted and repetitive behaviors (RRBs), two hallmark characteristics of autism. We used the CCC-R and Repetitive Behavior Questionnaire (RBQ-2) to investigate these associations in a diverse non-clinical sample of children, taking a transdiagnostic approach. We intentionally excluded autism and other neurodevelopmental diagnoses to test, (1) the CCC-R in a broad sample and (2) the association between pragmatic language and RRB in children not already selected for that association. The sample comprised two groups of children, one was community sampled (n = 123) and the other (n = 143) included children with non-specific behavioral, emotional and/or cognitive difficulties referred to an assessment unit by schools. We found clear associations between pragmatic language difficulties and RRBs in both groups. Regression analysis showed that pragmatic language was the only significant contributor to RRBs even after Grammatical-Semantic score, age, sex, and socioeconomic status were controlled. The pattern was the same for both recruitment groups. However, the effects were stronger for the school-referred group which also had more pragmatic difficulties, grammatical-semantic difficulties and RRBs. A robust link between pragmatic language and RRBs, established in autism, has continuity across the broader non-clinical population.
    MeSH term(s) Child ; Humans ; Checklist ; Latent Class Analysis ; Autism Spectrum Disorder ; Communication Disorders ; Communication ; Language ; Cognition
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.3100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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