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Article ; Online: Rodent Models of Post-Stroke Dementia.

Kim, Hahn Young / Back, Dong Bin / Choi, Bo-Ryoung / Choi, Dong-Hee / Kwon, Kyoung Ja

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Post-stroke cognitive impairment is one of the most common complications in stroke survivors. Concomitant vascular risk factors, including aging, diabetes mellitus, hypertension, dyslipidemia, or underlying pathologic conditions, such as chronic cerebral ...

Abstract	Post-stroke cognitive impairment is one of the most common complications in stroke survivors. Concomitant vascular risk factors, including aging, diabetes mellitus, hypertension, dyslipidemia, or underlying pathologic conditions, such as chronic cerebral hypoperfusion, white matter hyperintensities, or Alzheimer's disease pathology, can predispose patients to develop post-stroke dementia (PSD). Given the various clinical conditions associated with PSD, a single animal model for PSD is not possible. Animal models of PSD that consider these diverse clinical situations have not been well-studied. In this literature review, diverse rodent models that simulate the various clinical conditions of PSD have been evaluated. Heterogeneous rodent models of PSD are classified into the following categories: surgical technique, special structure, and comorbid condition. The characteristics of individual models and their clinical significance are discussed in detail. Diverse rodent models mimicking the specific pathomechanisms of PSD could provide effective animal platforms for future studies investigating the characteristics and pathophysiology of PSD.
MeSH term(s)	Animals ; Brain Ischemia/complications ; Dementia/pathology ; Risk Factors ; Rodentia ; Stroke/complications ; Stroke/pathology
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810750
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Validating ΔΔG Selectivity Descriptor for Electrosynthesis of H

Mok, Dong Hyeon / Back, Seoin / Siahrostami, Samira

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202404677

Abstract: Understanding selectivity trends is a crucial hurdle in the developing innovative catalysts for generating hydrogen peroxide through the two-electron oxygen reduction reaction (2e-ORR). The identification of selectivity patterns has been made more ... ...

Abstract	Understanding selectivity trends is a crucial hurdle in the developing innovative catalysts for generating hydrogen peroxide through the two-electron oxygen reduction reaction (2e-ORR). The identification of selectivity patterns has been made more accessible through the introduction of a newly developed selectivity descriptor derived from thermodynamics, denoted as ΔΔG introduced in Chem Catal. 2023, 3(3), 100568. To validate the suitability of this parameter as a descriptor for 2e-ORR selectivity, we utilize an extensive library of 155 binary alloys. We validate that ΔΔG reliably depicts the selectivity trends in binary alloys reported for their high activity in the 2e-ORR. This analysis also enables the identification of nine selective 2e-ORR catalysts underscoring the efficacy of ΔΔG as 2e-ORR selectivity descriptor. This work highlights the significance of concurrently considering both selectivity and activity trends. This holistic approach is crucial for obtaining a comprehensive understanding in the identification of high-performance catalyst materials for optimal efficiency in various applications.
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202404677
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Article ; Online: Characterization of Tauopathy in a Rat Model of Post-Stroke Dementia Combining Acute Infarct and Chronic Cerebral Hypoperfusion.

Back, Dong Bin / Choi, Bo-Ryoung / Han, Jung-Soo / Kwon, Kyoung Ja / Choi, Dong-Hee / Shin, Chan Young / Lee, Jongmin / Kim, Hahn Young

International journal of molecular sciences

2020 Volume 21, Issue 18

Abstract: Post-stroke dementia (PSD) is a major neurodegenerative consequence of stroke. Tauopathy has been reported in diverse neurodegenerative diseases. We investigated the cognitive impairment and pathomechanism associated with tauopathy in a rat model of PSD ... ...

Abstract	Post-stroke dementia (PSD) is a major neurodegenerative consequence of stroke. Tauopathy has been reported in diverse neurodegenerative diseases. We investigated the cognitive impairment and pathomechanism associated with tauopathy in a rat model of PSD by modeling acute ischemic stroke and underlying chronic cerebral hypoperfusion (CCH). We performed middle cerebral artery occlusion (MCAO) surgery in rats to mimic acute ischemic stroke, followed by bilateral common carotid artery occlusion (BCCAo) surgery to mimic CCH. We performed behavioral tests and focused on the characterization of tauopathy through histology. Parenchymal infiltration of cerebrospinal fluid (CSF) tracers after intracisternal injection was examined to evaluate glymphatic function. In an animal model of PSD, cognitive impairment was aggravated when BCCAo was combined with MCAO. Tauopathy, manifested by tau hyperphosphorylation, was prominent in the peri-infarct area when CCH was combined. Synergistic accentuation of tauopathy was evident in the white matter. Microtubules in the neuronal axon and myelin sheath showed partial colocalization with the hyperphosphorylated tau, whereas oligodendrocytes showed near-complete colocalization. Parenchymal infiltration of CSF tracers was attenuated in the PSD model. Our experimental results suggest a hypothesis that CCH may aggravate cognitive impairment and tau hyperphosphorylation in a rat model of PSD by interfering with tau clearance through the glymphatic system. Therapeutic strategies to improve the clearance of brain metabolic wastes, including tau, may be a promising approach to prevent PSD after stroke.
MeSH term(s)	Animals ; Brain Infarction/complications ; Brain Infarction/metabolism ; Brain Infarction/pathology ; Brain Infarction/physiopathology ; Dementia/etiology ; Dementia/metabolism ; Dementia/pathology ; Dementia/physiopathology ; Disease Models, Animal ; Male ; Maze Learning ; Rats ; Rats, Wistar ; Stroke/complications ; Stroke/metabolism ; Stroke/pathology ; Stroke/physiopathology ; Tauopathies/etiology ; Tauopathies/metabolism ; Tauopathies/pathology ; Tauopathies/physiopathology
Language	English
Publishing date	2020-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21186929
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Atomic Structure-Free Representation of Active Motifs for Expedited Catalyst Discovery.

Mok, Dong Hyeon / Back, Seoin

Journal of chemical information and modeling

2021 Volume 61, Issue 9, Page(s) 4514–4520

Abstract: To discover new catalysts using density functional theory (DFT) calculations, binding energies of reaction intermediates are considered as descriptors to predict catalytic activities. Recently, machine learning methods have been developed to reduce the ... ...

Abstract	To discover new catalysts using density functional theory (DFT) calculations, binding energies of reaction intermediates are considered as descriptors to predict catalytic activities. Recently, machine learning methods have been developed to reduce the number of computationally intensive DFT calculations for a high-throughput screening. These methods require several steps such as bulk structure optimization, surface structure modeling, and active site identification, which could be time-consuming as the number of new candidate materials increases. To bypass these processes, in this work, we report an atomic structure-free representation of active motifs to predict binding energies. We identify binding site atoms and their nearest neighboring atoms positioned in the same layer and the sublayer, and their atomic properties are collected to construct fingerprints. Our method enabled a quicker training (200-400 s using CPU) compared to the previous deep-learning models and predicted CO and H binding energies with mean absolute errors (MAEs) of 0.120 and 0.105 eV, respectively. Our method is also capable of creating all possible active motifs without any DFT calculations and predicting their binding energies using the trained model. The predicted binding energy distributions can suggest promising candidates to accelerate catalyst discovery.
MeSH term(s)	Binding Sites ; Catalysis ; Machine Learning
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.1c00726
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Article ; Online: Accelerating the Search for New Solid Electrolytes: Exploring Vast Chemical Space with Machine Learning-Enabled Computational Calculations.

Kim, Jongseung / Mok, Dong Hyeon / Kim, Heejin / Back, Seoin

ACS applied materials & interfaces

2023

Abstract: Discovering new solid electrolytes (SEs) is essential to achieving higher safety and better energy density for all-solid-state lithium batteries. In this work, we report machine learning (ML)-assisted high-throughput virtual screening (HTVS) results to ... ...

Abstract	Discovering new solid electrolytes (SEs) is essential to achieving higher safety and better energy density for all-solid-state lithium batteries. In this work, we report machine learning (ML)-assisted high-throughput virtual screening (HTVS) results to identify new SE materials. This approach expands the chemical space to explore by substituting elements of prototype structures and accelerates an evaluation of properties by applying various ML models. The screening results in a few candidate materials, which are validated by density functional theory calculations and ab initio molecular dynamics simulations. The shortlisted oxysulfide materials satisfy key properties to be successful SEs. The advanced screening method presented in this work will accelerate the discovery of energy materials for related applications.
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c10798
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Article ; Online: Effect of amyloid toxicity or chronic cerebral hypoperfusion on brain insulin resistance in a rat model with intracerebroventricular streptozotocin.

Choi, Bo-Ryoung / Seo, Ju-Ha / Back, Dong Bin / Han, Jung-Soo / Choi, Dong-Hee / Kwon, Kyoung Ja / Shin, Chan Young / Lee, Jongmin / Kim, Hahn Young

Brain research bulletin

2020 Volume 158, Page(s) 40–50

Abstract: Sporadic Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder affected by amyloid and vascular pathogenesis. Brain insulin resistance (BIR) has been suggested as one of the pathomechanisms of sporadic AD. We investigated how the ... ...

Abstract	Sporadic Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder affected by amyloid and vascular pathogenesis. Brain insulin resistance (BIR) has been suggested as one of the pathomechanisms of sporadic AD. We investigated how the amyloid and vascular pathogenesis of AD interacts with BIR. We examined experimental groups mimicking amyloid pathogenesis following intracerebroventriculr (icv) injection of amyloid β or vascular pathogenesis following permanent ligation of the bilateral common carotid arteries in Wistar rats that had undergone icv injection of streptozotocin. Behavioral tests and pathologic studies were performed. Cognitive impairments were induced by BIR superimposed by amyloid or vascular pathogenesis. Neuroinflammation in the white matter and hippocampus was aggravated by an interaction between BIR and vascular pathogenesis. Amyloid-associated pathology in the white matter was enhanced by BIR and vascular pathogenesis. Tau-associated pathology in the hippocampus was altered by BIR in a relation with amyloid or vascular pathogenesis. Our study may provide useful experimental insights based on an integrated approach to the influence of amyloid and vascular pathogenesis on BIR, permitting better understanding of the heterogeneous pathogenesis of sporadic AD. Pathologic responses in sporadic AD may differ depending on amyloid and vascular pathogenesis and may sometimes be synergistically aggravated when combined with BIR.
MeSH term(s)	Amyloid beta-Peptides/administration & dosage ; Amyloid beta-Peptides/toxicity ; Animals ; Brain/drug effects ; Brain/metabolism ; Brain/physiopathology ; Cerebrovascular Circulation/drug effects ; Cerebrovascular Circulation/physiology ; Disease Models, Animal ; Injections, Intraventricular ; Insulin Resistance/physiology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Rats ; Rats, Wistar ; Streptozocin/toxicity
Chemical Substances	Amyloid beta-Peptides ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2020-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2020.02.012
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Zs.A 1243: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Data-driven discovery of electrocatalysts for CO

Mok, Dong Hyeon / Li, Hong / Zhang, Guiru / Lee, Chaehyeon / Jiang, Kun / Back, Seoin

Nature communications

2023 Volume 14, Issue 1, Page(s) 7303

Abstract: The electrochemical carbon dioxide reduction reaction ( ... ...

Abstract	The electrochemical carbon dioxide reduction reaction (CO
Language	English
Publishing date	2023-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43118-0
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Article ; Online: Characterization of Tauopathy in a Rat Model of Post-Stroke Dementia Combining Acute Infarct and Chronic Cerebral Hypoperfusion

Dong Bin Back / Bo-Ryoung Choi / Jung-Soo Han / Kyoung Ja Kwon / Dong-Hee Choi / Chan Young Shin / Jongmin Lee / Hahn Young Kim

International Journal of Molecular Sciences, Vol 21, Iss 6929, p

2020 Volume 6929

Abstract	Post-stroke dementia (PSD) is a major neurodegenerative consequence of stroke. Tauopathy has been reported in diverse neurodegenerative diseases. We investigated the cognitive impairment and pathomechanism associated with tauopathy in a rat model of PSD by modeling acute ischemic stroke and underlying chronic cerebral hypoperfusion (CCH). We performed middle cerebral artery occlusion (MCAO) surgery in rats to mimic acute ischemic stroke, followed by bilateral common carotid artery occlusion (BCCAo) surgery to mimic CCH. We performed behavioral tests and focused on the characterization of tauopathy through histology. Parenchymal infiltration of cerebrospinal fluid (CSF) tracers after intracisternal injection was examined to evaluate glymphatic function. In an animal model of PSD, cognitive impairment was aggravated when BCCAo was combined with MCAO. Tauopathy, manifested by tau hyperphosphorylation, was prominent in the peri-infarct area when CCH was combined. Synergistic accentuation of tauopathy was evident in the white matter. Microtubules in the neuronal axon and myelin sheath showed partial colocalization with the hyperphosphorylated tau, whereas oligodendrocytes showed near-complete colocalization. Parenchymal infiltration of CSF tracers was attenuated in the PSD model. Our experimental results suggest a hypothesis that CCH may aggravate cognitive impairment and tau hyperphosphorylation in a rat model of PSD by interfering with tau clearance through the glymphatic system. Therapeutic strategies to improve the clearance of brain metabolic wastes, including tau, may be a promising approach to prevent PSD after stroke.
Keywords	post-stroke dementia ; tauopathy ; animal model ; chronic cerebral hypoperfusion ; glymphatic system ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chronic cerebral hypoperfusion induces post-stroke dementia following acute ischemic stroke in rats.

Back, Dong Bin / Kwon, Kyoung Ja / Choi, Dong-Hee / Shin, Chan Young / Lee, Jongmin / Han, Seol-Heui / Kim, Hahn Young

Journal of neuroinflammation

2017 Volume 14, Issue 1, Page(s) 216

Abstract: Background: Post-stroke dementia (PSD) is one of the major consequences after stroke. Chronic cerebral hypoperfusion (CCH) can induce vascular cognitive impairment and potentiate amyloid pathology. We investigated how CCH contributes to the development ... ...

Abstract	Background: Post-stroke dementia (PSD) is one of the major consequences after stroke. Chronic cerebral hypoperfusion (CCH) can induce vascular cognitive impairment and potentiate amyloid pathology. We investigated how CCH contributes to the development of PSD after stroke in the context of neuroinflammation and amyloid pathology. Methods: We designed a unique animal model for PSD. We performed middle cerebral artery occlusion (MCAO) surgery in rats mimicking acute territorial infarct, which was followed by bilateral common carotid artery occlusion (BCCAo) surgery mimicking CCH. We performed behavioral tests including neurologic function test and water maze task and histological investigations including neuroinflammation, neuronal cell death, amyloid pathology, and aquaporin 4 (AQP4) distribution. Results: Spatial memory was synergistically impaired when BCCAo was superimposed on MCAO. Neuroinflammation with astroglial or microglial activation and amyloid pathology were enhanced in the ipsilateral cortex, thalamus, and hippocampus when BCCAo was superimposed on MCAO. Glymphatic pathway-related AQP4 distribution changed from perivascular to parenchymal pattern. Conclusions: Our experimental results suggest that CCH may contribute to the development of PSD by interfering with amyloid clearance through the glymphatic pathway and concomitant neuroinflammation. Therapeutic strategy to clear brain metabolic waste through the glymphatic pathway may be a promising approach to prevent PSD after stroke.
MeSH term(s)	Animals ; Brain Ischemia/complications ; Brain Ischemia/pathology ; Dementia/etiology ; Dementia/pathology ; Disease Models, Animal ; Male ; Rats ; Rats, Wistar ; Stroke/complications ; Stroke/pathology
Language	English
Publishing date	2017-11-09
Publishing country	England
Document type	Journal Article
ISSN	1742-2094
ISSN (online)	1742-2094
DOI	10.1186/s12974-017-0992-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Defect-rich N-doped CeO₂ supported by N-doped graphene as a metal-free plasmonic hydrogen evolution photocatalyst

Van Dao, Dung / Jung, Hyun Dong / Nguyen, Thuy T. D / Ki, Sang-Woo / Son, Hoki / Bae, Kang-Bin / Le, Thanh Duc / Cho, Yeong-Hoon / Yang, Jin-Kyu / Yu, Yeon-Tae / Back, Seoin / Lee, In-Hwan

Journal of materials chemistry A. 2021 Apr. 28, v. 9, no. 16

2021

Abstract: Heteroatom doping into metal oxides advantageously modulates optoelectronic properties and provides promising possibilities for efficient light-to-energy conversion. Herein, nitrogen-doped ceria (N-CeO₂) nanoparticles are prepared and then coupled with ... ...

Abstract	Heteroatom doping into metal oxides advantageously modulates optoelectronic properties and provides promising possibilities for efficient light-to-energy conversion. Herein, nitrogen-doped ceria (N-CeO₂) nanoparticles are prepared and then coupled with nitrogen-doped graphene (N-Gr) to create an active and long-lasting N-CeO₂/N-Gr heterocatalyst. Optoelectronic features of N-doping materials (e.g., plasmon) are significantly improved toward the visible-light region, particularly for 3.9% N-CeO₂/N-Gr nanocomposites. Namely, the 3.9% N-CeO₂ possesses numerous catalytic active defects (N states, oxygen vacancy, and Ce³⁺ species), leading to a narrow bandgap energy and to the improved plasmonic properties of the ceria host, while the N-Gr preferably serves as an electron scavenger to collect plasmon-generated hot electrons migrating from 3.9% N-CeO₂ to drive photocatalytic reactions under the irradiation of visible-light. Resultantly, the 3.9% N-CeO₂/N-Gr photocatalyst delivers an impressive hydrogen evolution reaction (HER) rate of 3.7 μmol mgcₐₜ⁻¹ h⁻¹ under visible-light, which is 2.0- and 8.2-fold greater than those obtained from 3.9% N-CeO₂ and CeO₂ ones, respectively. Additionally, the combination of 3.9% N-CeO₂ and N-Gr synergistically produces a long-lasting plasmonic HER photocatalyst system. Metal-free plasmonic N-doped oxides supported by N-doped graphene pave a promising pathway for efficient light-to-hydrogen fuel production accordingly.
Keywords	energy ; fuel production ; graphene ; hydrogen production ; irradiation ; light ; nanocomposites ; oxygen ; photocatalysis ; photocatalysts
Language	English
Dates of publication	2021-0428
Size	p. 10217-10230.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/d1ta01379c
Database	NAL-Catalogue (AGRICOLA)

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