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  1. Article: Thousands introduced annually: the aquarium pathway for non‐indigenous plants to the St Lawrence Seaway

    Cohen, Jill / Nicholas Mirotchnick / Brian Leung

    Frontiers in ecology and the environment. 2007 Dec., v. 5, no. 10

    2007  

    Abstract: ... system and found that thousands of non‐indigenous plant propagules are introduced to the St Lawrence ...

    Abstract Non‐indigenous species are both economically and ecologically costly. Invasions are occurring at an accelerating rate worldwide and therefore present a critical challenge to natural resource managers. The aquarium trade is commonly recognized as a pathway for non‐indigenous plants, but few regulations exist to curb such introductions. In addition, very few studies have attempted to quantify the number of propagules introduced through the aquarium trade each year, probably because it is difficult to directly measure the number of propagules introduced. Here, we use a novel approach to quantify propagule numbers by analyzing each step in the path to introduction and synthesizing this information to calculate propagule pressure for each species. We used the aquarium plant trade in Montreal, Quebec, Canada, as our study system and found that thousands of non‐indigenous plant propagules are introduced to the St Lawrence Seaway each year, through the Montreal aquarium trade alone. Two known invaders are among those species with the highest measured propagule pressure.
    Keywords aquarium plants ; introduced plants ; managers ; trade ; Quebec
    Language English
    Dates of publication 2007-12
    Size p. 528-532.
    Publishing place Ecological Society of America
    Document type Article
    ZDB-ID 2110853-5
    ISSN 1540-9309 ; 1540-9295
    ISSN (online) 1540-9309
    ISSN 1540-9295
    DOI 10.1890/060137
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: EUS-Guided Cholecystoduodenostomy for a Poor Surgical Candidate With Chronic Octreotide-Associated Gallstones From Metastatic Neuroendocrine Tumor.

    Leung, Lawrence Jun / Hamerski, Christopher / Karia, Kunal / Gupta, Suraj

    ACG case reports journal

    2024  Volume 11, Issue 3, Page(s) e01306

    Abstract: Chronic octreotide use has been associated with gallstone formation. Historically, cholecystectomy has been the defining treatment for those who have gallstone-related disease. For those who are poor surgical candidates, percutaneous and endoscopic ... ...

    Abstract Chronic octreotide use has been associated with gallstone formation. Historically, cholecystectomy has been the defining treatment for those who have gallstone-related disease. For those who are poor surgical candidates, percutaneous and endoscopic approaches have been used. We describe the endoscopic management of a 74-year-old man with significant gallstone burden and associated sequelae because of chronic octreotide for metastatic neuroendocrine tumor through endoscopic ultrasound-guided cholecystoduodenostomy with gallstone extraction using lumen-apposing metal stents.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000001306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chemerin Forms: Their Generation and Activity.

    Zhao, Lei / Leung, Lawrence L / Morser, John

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: Chemerin is the product of ... ...

    Abstract Chemerin is the product of the
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10082018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Methods to Investigate Thrombin Cleavage of Osteopontin (OPN).

    Zhao, Lei / Leung, Lawrence L / Morser, John

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2747, Page(s) 95–117

    Abstract: Osteopontin (OPN) is a matricellular protein containing binding sites for a variety of ligands including an RGD sequence for binding to ... ...

    Abstract Osteopontin (OPN) is a matricellular protein containing binding sites for a variety of ligands including an RGD sequence for binding to α
    MeSH term(s) Mice ; Animals ; Osteopontin/genetics ; Osteopontin/metabolism ; Thrombin/metabolism ; Cell Adhesion/physiology ; Amino Acid Sequence ; Integrins/metabolism ; Peptide Hydrolases/metabolism ; Carboxypeptidases/metabolism
    Chemical Substances Osteopontin (106441-73-0) ; Thrombin (EC 3.4.21.5) ; Integrins ; Peptide Hydrolases (EC 3.4.-) ; Carboxypeptidases (EC 3.4.-)
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3589-6_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Thrombin Cleavage of Osteopontin and the Host Anti-Tumor Immune Response.

    Leung, Lawrence L / Myles, Timothy / Morser, John

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Osteopontin (OPN) is a multi-functional protein that is involved in various cellular processes such as cell adhesion, migration, and signaling. There is a single conserved thrombin cleavage site in OPN that, when cleaved, yields two fragments with ... ...

    Abstract Osteopontin (OPN) is a multi-functional protein that is involved in various cellular processes such as cell adhesion, migration, and signaling. There is a single conserved thrombin cleavage site in OPN that, when cleaved, yields two fragments with different properties from full-length OPN. In cancer, OPN has tumor-promoting activity and plays a role in tumor growth and metastasis. High levels of OPN expression in cancer cells and tumor tissue are found in various types of cancer, including breast, lung, prostate, ovarian, colorectal, and pancreatic cancer, and are associated with poor prognosis and decreased survival rates. OPN promotes tumor progression and invasion by stimulating cell proliferation and angiogenesis and also facilitates the metastasis of cancer cells to other parts of the body by promoting cell adhesion and migration. Furthermore, OPN contributes to immune evasion by inhibiting the activity of immune cells. Thrombin cleavage of OPN initiates OPN's tumor-promoting activity, and thrombin cleavage fragments of OPN down-regulate the host immune anti-tumor response.
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Where Is My Future?

    Leung, Lawrence

    Family medicine

    2016  Volume 48, Issue 4, Page(s) 316–317

    MeSH term(s) Adolescent ; Alcoholic Intoxication/psychology ; Drug Overdose/psychology ; Humans ; Male ; Pessimism
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Personal Narratives
    ZDB-ID 639374-3
    ISSN 1938-3800 ; 0742-3225
    ISSN (online) 1938-3800
    ISSN 0742-3225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Functionalisation of extracellular vesicles with cyclic-RGDyC potentially for glioblastoma targeted intracellular drug delivery.

    Geng, Tianjiao / Leung, Euphemia / Chamley, Lawrence W / Wu, Zimei

    Biomaterials advances

    2023  Volume 149, Page(s) 213388

    Abstract: With the intrinsic ability to cross the blood-brain barrier, small extracellular vesicles (sEVs) hold promise as endogenous brain-targeted drug delivery nano-platforms for glioblastoma (GBM) treatment. To increase GBM targetability, this study aimed to ... ...

    Abstract With the intrinsic ability to cross the blood-brain barrier, small extracellular vesicles (sEVs) hold promise as endogenous brain-targeted drug delivery nano-platforms for glioblastoma (GBM) treatment. To increase GBM targetability, this study aimed to functionalise sEVs with cyclic arginine-glycine-aspartic acid-tyrosine-cysteine (cRGDyC), a ligand for integrin (α
    MeSH term(s) Humans ; Liposomes/therapeutic use ; Glioblastoma/drug therapy ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Extracellular Vesicles ; Integrins/therapeutic use
    Chemical Substances monomethoxypolyethylene glycol (9004-74-4) ; Liposomes ; Doxorubicin (80168379AG) ; Integrins
    Language English
    Publishing date 2023-03-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-9508
    ISSN (online) 2772-9508
    DOI 10.1016/j.bioadv.2023.213388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding How Contingency Staffing Programs Can Support Mental Health Services in the Veterans Health Administration.

    Jaske, Erin / Wheat, Chelle L / Rubenstein, Lisa V / Leung, Lucinda / Curtis, Idamay / Wahlberg, Lawrence / Felker, Bradford

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2024  

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2023.0573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An un-a-"pill"ing lumen-apposing metal stent occlusion.

    Leung, Lawrence Jun / Gupta, Suraj / Jue, Terry L

    Gastrointestinal endoscopy

    2021  Volume 95, Issue 2, Page(s) 384–385

    MeSH term(s) Endosonography ; Humans ; Metals ; Stents
    Chemical Substances Metals
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2021.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Is land use producing robust signals in future projections from Earth system models, all else being equal?

    Claudia Tebaldi / Michael Wehner / Ruby Leung / David Lawrence

    Environmental Research Letters, Vol 18, Iss 8, p

    2023  Volume 084009

    Abstract: We use six Earth system models (ESMs) run under SSP3-7.0, a scenario characterized by a relatively large land use change (LUC) over the 21st century, and under a variant of the same scenario where a significantly different pattern of LUC, taken from SSP1- ...

    Abstract We use six Earth system models (ESMs) run under SSP3-7.0, a scenario characterized by a relatively large land use change (LUC) over the 21st century, and under a variant of the same scenario where a significantly different pattern of LUC, taken from SSP1-2.6, was used, all else being equal. Our goal is to identify changes in climate extremes between the two scenarios that are statistically significant and robust across the ESMs. The motivation for this study is to test a long-held assumption of the shared socio-economic pathway-representative concentration pathway (SSP-RCP) scenario framework: that the signal from LUC can be safely disregarded when pairing different SSPs to the compatible RCPs, where compatibility only considers global radiative forcing, predominantly determined by well-mixed greenhouse gasses emissions. We analyze extremes of daily minimum and maximum temperatures and precipitation, after fitting non-stationary generalized extreme value distributions in a way that borrows strength along the length of the simulation (2015–2100) and across initial condition ensembles. We consider changes in the 20 year return levels (RL20s) of these metrics by 2100, and focus on eight locations where LUC is large within each scenario, and strongly differs between scenarios, averaging the RL20s over a neighborhood characterized by the same LUC to enhance the signal to noise. We find that precipitation extremes do not show significant differences attributable to LUC differences. For temperature extremes (cold and hot) results are mixed, with some location-index combination showing significant results for some of the ESMs but not all, and not many coherent changes appearing for indices across regions, or regions across indices. These ESMs are representative of what is typically adopted as the source of climate information for impact studies, when the SSP-RCP framework is put to use. Overall, our analysis suggests that the hypothesis to pair SSPs to RCPs in a flexible fashion is overall defensible. However, the ...
    Keywords land use change ; extremes ; multimodel ensembles ; shared socioeconomic pathways ; representative concentration pathways ; scenario framework ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
    Subject code 333
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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