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  1. Article ; Online: Long COVID: which symptoms can be attributed to SARS-CoV-2 infection?

    Brightling, Christopher E / Evans, Rachael A

    Lancet (London, England)

    2022  Volume 400, Issue 10350, Page(s) 411–413

    MeSH term(s) COVID-19/complications ; Humans ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01385-X
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  2. Article ; Online: Airway remodelling in asthma and the epithelium: on the edge of a new era.

    Varricchi, Gilda / Brightling, Christopher E / Grainge, Christopher / Lambrecht, Bart N / Chanez, Pascal

    The European respiratory journal

    2024  Volume 63, Issue 4

    Abstract: Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can ... ...

    Abstract Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can initiate remodelling
    MeSH term(s) Humans ; Airway Remodeling ; Asthma ; Cytokines ; Thymic Stromal Lymphopoietin ; Epithelium
    Chemical Substances Cytokines ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01619-2023
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  3. Article ; Online: Asthma exacerbations during pregnancy: A need for precision medicine.

    Brightling, Christopher E

    Respirology (Carlton, Vic.)

    2019  Volume 25, Issue 7, Page(s) 670–671

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Biomarkers ; Female ; Humans ; Precision Medicine ; Pregnancy
    Chemical Substances Anti-Asthmatic Agents ; Biomarkers
    Language English
    Publishing date 2019-12-16
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13761
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    Zs.A 4957: Show issues Location:
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  4. Article ; Online: Bronchial thermoplasty: what we know, what we don't know, and what we need to know.

    Russell, Richard J / Brightling, Christopher E

    The European respiratory journal

    2021  Volume 59, Issue 1

    MeSH term(s) Bronchial Thermoplasty ; Humans
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02018-2021
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  5. Article ; Online: Pathological disease in the lung periphery after acute COVID-19.

    Siddiqui, Salman / Brightling, Christopher E

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 10, Page(s) 1089–1090

    MeSH term(s) COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Humans ; Lung/pathology ; Lung/virology ; SARS-CoV-2
    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00378-7
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    Zs.A 7041: Show issues Location:
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  6. Article ; Online: Airway hyperresponsiveness in asthma: The role of the epithelium.

    Bradding, Peter / Porsbjerg, Celeste / Côté, Andréanne / Dahlén, Sven-Erik / Hallstrand, Teal S / Brightling, Christopher E

    The Journal of allergy and clinical immunology

    2024  Volume 153, Issue 5, Page(s) 1181–1193

    Abstract: Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR in people with asthma provides the substrate for bronchoconstriction in response to numerous diverse stimuli, contributing to airflow limitation and symptoms ... ...

    Abstract Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR in people with asthma provides the substrate for bronchoconstriction in response to numerous diverse stimuli, contributing to airflow limitation and symptoms including breathlessness, wheeze, and chest tightness. Dysfunctional airway smooth muscle significantly contributes to AHR and is displayed as increased sensitivity to direct pharmacologic bronchoconstrictor stimuli, such as inhaled histamine and methacholine (direct AHR), or to endogenous mediators released by activated airway cells such as mast cells (indirect AHR). Research in in vivo human models has shown that the disrupted airway epithelium plays an important role in driving inflammation that mediates indirect AHR in asthma through the release of cytokines such as thymic stromal lymphopoietin and IL-33. These cytokines upregulate type 2 cytokines promoting airway eosinophilia and induce the release of bronchoconstrictor mediators from mast cells such as histamine, prostaglandin D
    MeSH term(s) Humans ; Asthma/immunology ; Asthma/physiopathology ; Animals ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Cytokines/metabolism ; Cytokines/immunology ; Respiratory Hypersensitivity/immunology ; Respiratory Hypersensitivity/physiopathology ; Bronchial Hyperreactivity/immunology ; Bronchial Hyperreactivity/physiopathology ; Mast Cells/immunology ; Bronchoconstriction
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.02.011
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  7. Article ; Online: Clinical trial research in focus: do trials prepare us to deliver precision medicine in those with severe asthma?

    Brightling, Christopher E

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 2, Page(s) 92–95

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Clinical Trials as Topic ; Humans ; Precision Medicine/methods
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2017-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(17)30011-5
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  8. Article ; Online: Long COVID research: an update from the PHOSP-COVID Scientific Summit.

    Brightling, Christopher E / Evans, Rachael A / Singapuri, Amisha / Smith, Nikki / Wain, Louise V

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 11, Page(s) e93–e94

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00341-7
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  9. Article ; Online: Dupilumab in type 2 airway inflammation-a step forward in targeted therapy for COPD.

    Tan, Ronnie Voon Shiong / Aung, Hnin Wint Wint / Flynn, Cara / Greening, Neil J / Brightling, Christopher E

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 2, Page(s) 404–406

    MeSH term(s) Humans ; Inflammation/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.10.022
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  10. Article ; Online: Chronic obstructive pulmonary disease phenotypes, biomarkers, and prognostic indicators.

    Brightling, Christopher E

    Allergy and asthma proceedings

    2016  Volume 37, Issue 6, Page(s) 432–438

    Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria are based on lung function impairment, symptoms, and exacerbation frequency but do not capture the ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria are based on lung function impairment, symptoms, and exacerbation frequency but do not capture the heterogeneity of the disease in terms of the complex pathologic changes that occur within lung, the different airway inflammatory patterns, or the airway microbial ecology. Recognition of the importance of defining the heterogeneity of COPD has led to the identification of important phenotypes with specific biomarkers, treatment responses, and underlying pathophysiologic mechanisms. This review summarized the presentation at the Eastern Allergy Conference 2016, which considered how multidimensional phenotyping provides important clinical insights that enable the clinician to move toward a precision medicine approach for COPD.
    MeSH term(s) Airway Remodeling ; Biomarkers ; Emphysema/complications ; Emphysema/pathology ; Humans ; Infection/complications ; Infection/microbiology ; Infection/pathology ; Infection/virology ; Inflammation/complications ; Inflammation/pathology ; Phenotype ; Prognosis ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/etiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-12-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1312445-6
    ISSN 1539-6304 ; 1088-5412
    ISSN (online) 1539-6304
    ISSN 1088-5412
    DOI 10.2500/aap.2016.37.3996
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