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Article ; Online: Trastorno cognitivo: una realidad en el síndrome de fatiga crónica.

Fernández, Alfredo Avellaneda / Martínez, Maravillas Izquierdo

2011 Volume 136, Issue 6, Page(s) 248–249

Title translation	Cognitive impairment: a reality in chronic fatigue syndrome.
MeSH term(s)	Cognition Disorders/etiology ; Fatigue Syndrome, Chronic/complications ; Humans
Language	Spanish
Publishing date	2011-03-12
Publishing country	Spain
Document type	Editorial
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2010.10.002
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Book: El Quijote apócrifo

Fernández de Avellaneda, Alonso / Rodríguez López-Vázquez, Alfredo

(Letras Hispánicas ; 685)

2011

Author's details	Alonso Fernández de Avellaneda. Ed. de Alfredo Rodríguez López-Vázquez
Series title	Letras Hispánicas ; 685
Language	Spanish
Size	569 S., 18 cm
Edition	1. ed.
Publisher	Catedra
Publishing place	Madrid
Document type	Book
Note	Critical ed
ISBN	9788437628523 ; 8437628520
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Síndrome de fatiga crónica. Documento de consenso.

Fernández, Alfredo Avellaneda / Martín, Alvaro Pérez / Martínez, Maravillas Izquierdo

Atencion primaria

2009 Volume 41, Issue 10, Page(s) 529–531

Title translation	Chronic fatigue syndrome. Consensus document.
MeSH term(s)	Clinical Protocols ; Consensus Development Conferences as Topic ; Decision Trees ; Fatigue Syndrome, Chronic/diagnosis ; Fatigue Syndrome, Chronic/therapy ; Humans
Language	Spanish
Publishing date	2009-09-09
Publishing country	Spain
Document type	Editorial
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1016/j.aprim.2009.06.013
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Article: Enfoque interdisciplinario de las enfermedades raras: un nuevo reto para un nuevo siglo.

Izquierdo Martínez, Maravillas / Avellaneda Fernández, Alfredo

Medicina clinica

2003 Volume 121, Issue 8, Page(s) 299–303

Title translation	Interdisciplinary approach of rare diseases: a new challenge for a new century.
MeSH term(s)	Health Services Administration ; Humans ; Patient Care Team ; Rare Diseases ; Spain
Language	Spanish
Publishing date	2003-09-13
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/s0025-7753(03)73924-4
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Article ; Online: Second trimester amniotic fluid adiponectin level is affected by maternal tobacco exposure, insulin, and PAPP-A level.

De Leon-Luis, Juan / Perez, Ricardo / Pintado Recarte, Pilar / Avellaneda Fernandez, Alfredo / Romero Roman, Carlos / Antolin Alvarado, Eugenia / Ortiz-Quintana, Luis / Izquierdo Martinez, Maravillas

European journal of obstetrics, gynecology, and reproductive biology

2012 Volume 165, Issue 2, Page(s) 189–193

Abstract: Objectives: Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The objectives of the present study were to determine the amniotic fluid (AF) concentration of adiponectin during the second ... ...

Abstract	Objectives: Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The objectives of the present study were to determine the amniotic fluid (AF) concentration of adiponectin during the second trimester of pregnancy and to demonstrate its association with maternal and fetal variables and AF concentrations of insulin, leptin, and pregnancy-associated-plasma-protein A (PAPP-A). Study design: We performed a cross-sectional study of 222 pregnant women who underwent amniocentesis at 15-18 weeks for genetic reasons. No malformation or chromosomal disorder was found in the newborn after birth. AF adiponectin, leptin, PAPP-A, and insulin concentrations were measured using commercially available assays. All maternal, fetal, and biochemical variables were studied using univariate and multivariate linear regression analysis to determine their association with the AF concentration of adiponectin. Results: Adiponectin concentration was negatively correlated with maternal smoking status (β=-5.208; p<0.001) and positively correlated with levels of insulin (β=0.621; p=0.002) and PAPP-A (β=40.150; p<0.001). Non-significant correlations were found between adiponectin concentration and maternal age, maternal body mass index, gestational age at amniocentesis, fetal gender, and AF level of leptin. Conclusion: These findings suggest that the fetus and its membrane adipocytokines, in relationship with maternal and other fetal variables, play a dynamic role in the regulation of energy and oxidative stress homeostasis due to its insulin-sensitizing and antiatherosclerotic effects. The association of these molecules with maternal tobacco consumption during pregnancy could have perinatal implications.
MeSH term(s)	Adiponectin/metabolism ; Adult ; Amniocentesis ; Amniotic Fluid/chemistry ; Cross-Sectional Studies ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Insulin/metabolism ; Leptin/metabolism ; Male ; Maternal Age ; Maternal Exposure ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy-Associated Plasma Protein-A/metabolism ; Smoking/adverse effects
Chemical Substances	Adiponectin ; Insulin ; Leptin ; Pregnancy-Associated Plasma Protein-A (EC 3.4.24.-)
Language	English
Publishing date	2012-12
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2012.07.031
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Article: Impacto sociosanitario en pacientes con enfermedades raras (estudio ERES).

Avellaneda Fernández, Alfredo / Layola, Miquel / Izquierdo Martínez, Maravillas / Guilera, Magda / Badia Llach, Xavier / Ramón, José R

Medicina clinica

2007 Volume 129, Issue 17, Page(s) 646–651

Abstract: Background and objective: The impact and burden of disease of the rare diseases (RD) is not known, also the type of disability that entail. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain.: Patients and method: ... ...

Title translation	Sociosanitary impact on patients with rare diseases (ERES study).
Abstract	Background and objective: The impact and burden of disease of the rare diseases (RD) is not known, also the type of disability that entail. The objective of the work is to analyze the socio-sanitary impact of the RD in Spain. Patients and method: This is a nationwide study. The dimensions used were mobility, personal care and daily activities of the EUROQoL-5D questionnaire to analyze the degree of dependency of the patient with RD. Results: 714 surveys were analyzed. 51.2% were men; 21.1% were children and 78.9% adults. The more frequent laboral status were: retired/pensioner, active and student (35.3%; 29.2%, and 17.1% respectively). In the last quarterly 8.4% of the patients were in situation of transitory labor incapacity: 5.7% men and 11.9% women (p < 0.005). The patients referred disability (slight or moderate degree) in the areas: physical (87.7%), emotional (83.6%), social (75.6%) and sensorial (53%). They presented severe mixed disability (sensorial and physic) in 6.4%. Patient organisations, physicians and Internet (80.1%; 48.2% and 47.3% respectively) were the used sources of information. The patients were more satisfied with doctor's care than social worker's (47% and 2.4% respectively), considering doctors more accessible than social workers (32.4% and 13.1% respectively). Conclusions: RD present a high percentage of disability and dependency, being both more severe in children. The patient organisations are the main source of information. Patients are more satisfied and consider the doctor more accessible than the social worker. This work might serve to make decisions in the socio-sanitary assistance for RD.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Cost of Illness ; Cross-Over Studies ; Data Interpretation, Statistical ; Disabled Persons ; Female ; Humans ; Male ; Marital Status ; Middle Aged ; Patient Education as Topic ; Patient Satisfaction ; Quality of Life ; Rare Diseases/economics ; Rare Diseases/therapy ; Socioeconomic Factors ; Spain ; Surveys and Questionnaires
Language	Spanish
Publishing date	2007-01-11
Publishing country	Spain
Document type	Comparative Study ; English Abstract ; Evaluation Studies ; Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1157/13112096
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Article: Necesidades de formación en enfermedades raras para atención primaria.

Avellaneda Fernández, Alfredo / Izquierdo Martínez, Maravillas / Luengo Gómez, Santiago / Arenas Martín, Javier / Ramón, José R

Atencion primaria

2006 Volume 38, Issue 6, Page(s) 345–348

Abstract: Objectives: The problem of the need for primary care (PC) training in rare diseases (RD) is approached through a qualitative research study that tries to define its relevance and to identify the need for RD training in PC.: Methods: By means of ... ...

Title translation	Need for primary care training in rare diseases.
Abstract	Objectives: The problem of the need for primary care (PC) training in rare diseases (RD) is approached through a qualitative research study that tries to define its relevance and to identify the need for RD training in PC. Methods: By means of naturalistic research methods (in-depth interviews and group dynamics), we tried to discover the personal and professional connotations of PC training in RD in the rural and urban areas of the Community of Madrid, Spain. The areas explored by means of structured interview were: challenges and RD definition; professional experience with RD; relevance of PC for RD; training and information in RD; needs and demands for RD in PC. Results: We found no differences between the rural and urban groups nor between different professional categories. The RD concept was relatively unknown and difficulties arose in understanding the magnitude and overall importance of these diseases. Nor did the RD concept express the severity or the repercussions of these diseases. RDs awoke little professional interest, in contrast with the human interest aroused. Conclusions: The professionals interviewed thought that undergraduate training was sufficient, and rejected postgraduate training as unnecessary and unfeasible. The search for active information through Internet was the best way to obtain data to optimize criteria for patient referral. As such, the Information System for Rare Diseases in Spanish (Sistema de Información de Enfermedades Raras en Español, SIERE) (http://iier.isciii.es/er) meets the demands for information.
MeSH term(s)	Education, Medical ; Humans ; Physicians, Family/education ; Primary Health Care ; Rare Diseases ; Spain
Language	Spanish
Publishing date	2006-11-06
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1157/13093372
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Article ; Online: Síndrome de fatiga crónica. Resumen del documento de consenso.

Fernández, Alfredo Avellaneda / Martín, Alvaro Pérez / Martínez, Maravillas Izquierdo / Bustillo, Mar Arruti / Hernández, Francisco Javier Barbado / Labrado, Javier de la Cruz / Peñas, Rafael Díaz-Delgado / Rivas, Eduardo Gutiérrez / Delgado, Cecilia Palacín / Giménez, José Ramón Ramón / Redondo, Javier Rivera

Atencion primaria

2009 Volume 41, Issue 10, Page(s) e1–5

Title translation	Chronic fatigue syndrome. Summary of the consensus document.
MeSH term(s)	Consensus Development Conferences as Topic ; Fatigue Syndrome, Chronic/diagnosis ; Fatigue Syndrome, Chronic/therapy ; Humans
Language	Spanish
Publishing date	2009-09-18
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1016/j.aprim.2009.06.016
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Article ; Online: Malformations of the craniocervical junction (Chiari type I and syringomyelia: classification, diagnosis and treatment).

Fernández, Alfredo Avellaneda / Guerrero, Alberto Isla / Martínez, Maravillas Izquierdo / Vázquez, María Eugenia Amado / Fernández, Javier Barrón / Chesa i Octavio, Ester / Labrado, Javier De la Cruz / Silva, Mercedes Escribano / de Araoz, Marta Fernández de Gamboa Fernández / García-Ramos, Rocío / Ribes, Miguel García / Gómez, Carmen / Valdivia, Joaquín Insausti / Valbuena, Ramón Navarro / Ramón, José R

BMC musculoskeletal disorders

2009 Volume 10 Suppl 1, Page(s) S1

Abstract: Chiari disease (or malformation) is in general a congenital condition characterized by an anatomic defect of the base of the skull, in which the cerebellum and brain stem herniate through the foramen magnum into the cervical spinal canal. The onset of ... ...

Abstract	Chiari disease (or malformation) is in general a congenital condition characterized by an anatomic defect of the base of the skull, in which the cerebellum and brain stem herniate through the foramen magnum into the cervical spinal canal. The onset of Chiari syndrome symptoms usually occurs in the second or third decade (age 25 to 45 years). Symptoms may vary between periods of exacerbation and remission. The diagnosis of Chiari type I malformation in patients with or without symptoms is established with neuroimaging techniques. The most effective therapy for patients with Chiari type I malformation/syringomyelia is surgical decompression of the foramen magnum, however there are non-surgical therapy to relieve neuropathic pain: either pharmacological and non-pharmacological. Pharmacological therapy use drugs that act on different components of pain. Non-pharmacological therapies are primarily based on spinal or peripheral electrical stimulation. It is important to determine the needs of the patients in terms of health-care, social, educational, occupational, and relationship issues, in addition to those derived from information aspects, particularly at onset of symptoms. Currently, there is no consensus among the specialists regarding the etiology of the disease or how to approach, monitor, follow-up, and treat the condition. It is necessary that the physicians involved in the care of people with this condition comprehensively approach the management and follow-up of the patients, and that they organize interdisciplinary teams including all the professionals that can help to increase the quality of life of patients.
MeSH term(s)	Arnold-Chiari Malformation/classification ; Arnold-Chiari Malformation/complications ; Arnold-Chiari Malformation/diagnosis ; Arnold-Chiari Malformation/psychology ; Arnold-Chiari Malformation/therapy ; Humans ; Syringomyelia/etiology
Language	English
Publishing date	2009-12-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/1471-2474-10-S1-S1
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Article ; Online: Malformations of the craniocervical junction (chiari type I and syringomyelia

García-Ramos Rocío / Fernández de Gamboa Fernández de Araoz Marta / Escribano Silva Mercedes / Chesa i Octavio Ester / De la Cruz Labrado Javier / Barrón Fernández Javier / Amado Vázquez María Eugenia / Izquierdo Martínez Maravillas / Isla Guerrero Alberto / Avellaneda Fernández Alfredo / García Ribes Miguel / Gómez Carmen / Insausti Valdivia Joaquín / Navarro Valbuena Ramón / Ramón José R

BMC Musculoskeletal Disorders, Vol 10, Iss Suppl 1, p S

classification, diagnosis and treatment)

2009 Volume 1

Abstract: Abstract Chiari disease (or malformation) is in general a congenital condition characterized by an anatomic defect of the base of the skull, in which the cerebellum and brain stem herniate through the foramen magnum into the cervical spinal canal. The ... ...

Abstract	Abstract Chiari disease (or malformation) is in general a congenital condition characterized by an anatomic defect of the base of the skull, in which the cerebellum and brain stem herniate through the foramen magnum into the cervical spinal canal. The onset of Chiari syndrome symptoms usually occurs in the second or third decade (age 25 to 45 years). Symptoms may vary between periods of exacerbation and remission. The diagnosis of Chiari type I malformation in patients with or without symptoms is established with neuroimaging techniques. The most effective therapy for patients with Chiari type I malformation/syringomyelia is surgical decompression of the foramen magnum, however there are non-surgical therapy to relieve neurophatic pain: either pharmacological and non-pharmacological. Pharmacological therapy use drugs that act on different components of pain. Non-pharmacological therapies are primarly based on spinal or peripheral electrical stimulation. It is important to determine the needs of the patients in terms of health-care, social, educational, occupational, and relationship issues, in addition to those derived from information aspects, particularly at onset of symptoms. Currently, there is no consensus among the specialists regarding the etiology of the disease or how to approach, monitor, follow-up, and treat the condition. It is necessary that the physicians involved in the care of people with this condition comprehensively approach the management and follow-up of the patients, and that they organize interdisciplinary teams including all the professionals that can help to increase the quality of life of patients.
Keywords	Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Diseases of the musculoskeletal system ; RC925-935
Subject code	610
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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