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Article ; Online: Evaluation of clinical effects of a multidisciplinary-collaborated cancer support team for gastrointestinal cancer chemotherapy: prospective observational study protocol of M-CAST study.

Iimura, Yohei / Nakazawa, Mitsuko / Tsuru, Yukari / Togashi, Hitomi / Honda, Tomoe / Baba, Keisuke / Ishibashi, Masaaki / Sasuga, Chieko / Furukawa, Naoki / Sato, Tomoko / Matsubara, Yasuo / Kamisato, Ayako / Yoshii, Eiko / Kuroda, Seiichiro / Boku, Narikazu

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 215

Abstract: Background: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate ... ...

Abstract	Background: Although the multidisciplinary-collaborated team approach in cancer treatment has recently become popular, prospectively evaluated evidence is limited. We started a multidisciplinary-collaborated cancer support team (MCST) to facilitate cooperation across multidisciplinary medical staff in our hospital and established clinical evidence of supportive care. This study aimed to prospectively evaluate the clinical activity and effect of MCST in patients with gastrointestinal cancer receiving chemotherapy. Methods: This is a single-center, single-arm, observational study. Patients with gastrointestinal cancer scheduled to receive chemotherapy are enrolled and supported by the MCST. The primary endpoints are the number of interventions by medical staff and the number of patients who showed improvement in side effects. The secondary endpoints are the severity of side effects, medical expenses, number of consultations, the acceptance rate of prescription recommendations, adjuvant chemotherapy completion rates, dose intensity, and time required for co-medical intervention. In addition, medical staff and attending physicians evaluate all adverse events. Discussion: This study is expected to contribute to establishing new cancer-supportive care teams for patients with gastrointestinal cancer receiving chemotherapy and those with cancer receiving chemotherapy. Trial registration: This trial was registered in the Japan Registry of Clinical Trials (jRCT) as jRCT1030220495. The date of first registration, 29/11/2022, https://jrct.niph.go.jp/search.
MeSH term(s)	Humans ; Gastrointestinal Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Japan ; Prospective Studies ; Observational Studies as Topic
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02849-6
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Article ; Online: Safety and efficacy of S-1 plus oxaliplatin 130 mg/m

Kashiwada, Tomomi / Shinozaki, Katsunori / Ueno, Shohei / Kawanaka, Hirofumi / Uno, Futoshi / Okita, Yoshihiro / Fukahori, Masaru / Matsushita, Hidenobu / Emi, Yasunori / Shimokawa, Mototsugu / Makiyama, Akitaka / Saeki, Hiroshi / Oki, Eiji / Maehara, Yoshihiko / Mori, Masaki / Baba, Eishi

International journal of clinical oncology

2020 Volume 26, Issue 2, Page(s) 345–354

Abstract: Background: In a randomized pivotal global phase III study, S-1 and oxaliplatin 100 mg/m ... Methods: Patients with HER2-negative AGC received 80 mg/m: Results: Seventy-one patients were enrolled ...

Abstract	Background: In a randomized pivotal global phase III study, S-1 and oxaliplatin 100 mg/m Methods: Patients with HER2-negative AGC received 80 mg/m Results: Seventy-one patients were enrolled from June 2015 to November 2016, but eight were excluded for ineligibility. Therefore, all final analyses were conducted with 63 patients. The confirmed RR was 46.0% (90% confidence interval [CI]: 36.1-56.3), and the disease control rate was 77.8% (90% CI: 68.1-85.1). The median PFS and OS were 4.9 (95% CI: 4.2-7.1) and 14.8 (95% CI: 11.1-18.9) months, respectively. Incidences of grade 3-4 AEs > 10% were anorexia (19.0%), peripheral neuropathy (12.7%), nausea (11.1%), and thrombocytopenia (11.1%). Conclusions: This study represents the first evaluation of SOX130 in patients with HER2-negative AGC. SOX130 showed an acceptable safety profile, but the prespecified statistical efficacy targets were not achieved.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Combinations ; Esophagogastric Junction/pathology ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/metabolism ; Oxaliplatin/administration & dosage ; Oxaliplatin/adverse effects ; Oxonic Acid/adverse effects ; Oxonic Acid/therapeutic use ; Receptor, ErbB-2/metabolism ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/metabolism ; Tegafur/adverse effects ; Tegafur/therapeutic use
Chemical Substances	Drug Combinations ; Oxaliplatin (04ZR38536J) ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; Oxonic Acid (5VT6420TIG) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-10-21
Publishing country	Japan
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-020-01803-w
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Article: Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.

Nasser, Hesham / Adhikary, Partho / Abdel-Daim, Amira / Noyori, Osamu / Panaampon, Jutatip / Kariya, Ryusho / Okada, Seiji / Ma, Wenjuan / Baba, Masaya / Takizawa, Hitoshi / Yamane, Mariko / Niwa, Hitoshi / Suzu, Shinya

Cell death discovery

2020 Volume 6, Page(s) 63

Abstract: ... term culture of mouse bone marrow cells with macrophage colony-stimulating factor (M-CSF), a key ... cytokine for macrophage development. They were non-tumorigenic and proliferated in the presence of M-CSF ... like factor 2 (KLF2) was strongly upregulated upon M-CSF stimulation in the self-renewing macrophages ...

Abstract	Recent studies have revealed that tissue macrophages are derived from yolk sac precursors or fetal liver monocytes, in addition to bone marrow monocytes. The relative contribution of these cells to the tissue macrophage pool is not fully understood, but embryo-derived cells are supposed to be more important because of their capacity to self-renew. Here, we show the presence of adult bone marrow-derived macrophages that retain self-renewing capacity. The self-renewing macrophages were readily obtained by long-term culture of mouse bone marrow cells with macrophage colony-stimulating factor (M-CSF), a key cytokine for macrophage development. They were non-tumorigenic and proliferated in the presence of M-CSF in unlimited numbers. Despite several differences from non-proliferating macrophages, they retained many features of cells of the monocytic lineage, including the differentiation into dendritic cells or osteoclasts. Among the transcription factors involved in the self-renewal of embryonic stem cells, Krüppel-like factor 2 (KLF2) was strongly upregulated upon M-CSF stimulation in the self-renewing macrophages, which was accompanied by the downregulation of MafB, a transcription factor that suppresses KLF2 expression. Indeed, knockdown of KLF2 led to cell cycle arrest and diminished cell proliferation in the self-renewing macrophages. Our new cell model would be useful to unravel differences in phenotype, function, and molecular mechanism of proliferation among self-renewing macrophages with different origins.
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-020-00300-3
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Article: Self-Reported Maternal Parenting Stress From 9 m Is Longitudinally Associated With Child ADHD Symptoms at Age 12: Findings From a Population-Based Birth Cohort Study.

Endo, Kaori / Stanyon, Daniel / Yamasaki, Syudo / Nakanishi, Miharu / Niimura, Junko / Kanata, Sho / Fujikawa, Shinya / Morimoto, Yuko / Hosozawa, Mariko / Baba, Kaori / Oikawa, Nao / Nakajima, Naomi / Suzuki, Kazuhiro / Miyashita, Mitsuhiro / Ando, Shuntaro / Hiraiwa-Hasegawa, Mariko / Kasai, Kiyoto / Nishida, Atsushi

Frontiers in psychiatry

2022 Volume 13, Page(s) 806669

Abstract: ... of parents reported that they had parenting stress at 36 m after childbirth. 6.2% of children were evaluated ... as above the cut-off for ADHD symptoms at 12 y. Parenting stress at 1 and 3-4 m was not associated ... with parenting stress at 9-10 m (unadjusted OR = 1.42, : Conclusions: We identified associations between ...

Abstract	Background: Attention-deficit/hyperactivity disorder (ADHD) develops in early childhood and carries lifelong impact, but early identification and intervention ensure optimal clinical outcomes. Prolonged or excessive parenting stress may be a response to infant behavioral differences antecedent to developmental disorders such as ADHD, and therefore represents a potentially valuable inclusion in routine early-life assessment. To investigate the feasibility of using routinely-collected self-reported maternal parenting stress as a risk marker for child ADHD, this study investigated the longitudinal association between maternal parenting stress from 1 to 36 months after childbirth and child ADHD in early adolescence. Methods: The sample comprised 2,638 children (1,253 girls) from the Tokyo Teen Cohort population-based birth cohort study. Mothers recorded parenting stress five times from 1 to 36 months following childbirth in the Maternal and Child Health Handbook, a tool used for routine early-life assessment in Japan. Nine years later, mothers evaluated their child's ADHD symptoms at 12 y using the hyperactivity/inattention subscale from the Strength and Difficulties Questionnaire. Results: Approximately 7.5% of parents reported that they had parenting stress at 36 m after childbirth. 6.2% of children were evaluated as above the cut-off for ADHD symptoms at 12 y. Parenting stress at 1 and 3-4 m was not associated with child ADHD symptoms at 12 y. However, child ADHD symptoms at 12 y was significantly associated with parenting stress at 9-10 m (unadjusted OR = 1.42, Conclusions: We identified associations between parenting stress at 9-10, 18 and 36 m after childbirth and child ADHD symptoms at 12 years old. Self-reported parenting stress data may have utility as an early indicator for ADHD risk. Participation in early-life health checks, assessment of parenting stress, and tailoring support to family needs should be promoted for early identification and intervention for ADHD.
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.806669
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Article: Dr. M. Ashraf Darzi: A Tribute (1951–2018)

Baba, Peerzada Umar Farooq

Indian Journal of Plastic Surgery

2018 Volume 51, Issue 03, Page(s) 346–347

Language	English
Publishing date	2018-09-01
Publisher	Thieme Medical and Scientific Publishers Private Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2118680-7
ISSN	1998-376X ; 0970-0358
ISSN (online)	1998-376X
ISSN	0970-0358
DOI	10.4103/ijps.IJPS_244_18
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Article ; Online: Hiroshi Tazaki, M.D., Ph.D., FACS.

Baba, Shiro

Journal of endourology

2010 Volume 24, Issue 8, Page(s) 1363–1364

MeSH term(s)	History, 20th Century ; History, 21st Century ; Japan ; United States ; Urology/history
Language	English
Publishing date	2010-08
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2010.1537
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Does installation of the backstroke start device reduce 15-m start time in swimming?

Ikeda, Yusuke / Ichikawa, Hiroshi / Nara, Rio / Baba, Yasuhiro / Shimoyama, Yoshimitsu

Journal of sports sciences

2017 Volume 35, Issue 2, Page(s) 189–195

Abstract: ... 15-m time. Thirteen college swimmers participated in this study. The aerial start and underwater ... of performance, the 5- and 15-m times were measured. The 5- and 15-m times in the backstroke start device ... condition. In addition, the CM horizontal velocities at 5 m in the backstroke start device condition were ...

Abstract	The purpose of this study was to determine the installation of the backstroke start device reduces 15-m time. Thirteen college swimmers participated in this study. The aerial start and underwater motions were recorded with two digital video cameras. The center of mass (CM) of the swimmer, angular displacements and velocities of the shoulder, hip and knee joints were calculated. As an indicator of performance, the 5- and 15-m times were measured. The 5- and 15-m times in the backstroke start device condition were significantly shorter than in the non-backstroke start device condition. The vertical velocities of the CM at hand-off and toe-off in the backstroke start device condition were significantly greater than in the non-backstroke start device condition, while there was no significant difference in the CM horizontal velocity at toe-off. As a result, the height of the great trochanter at entry of the fingertips, with the backstroke start device, was 15 cm higher than in the non-backstroke start device condition. In addition, the CM horizontal velocities at 5 m in the backstroke start device condition were significantly greater than those of the non-backstroke start device. Thus, the use of the backstroke start device may reduce the 15-m time by diminution of the entry area.
MeSH term(s)	Athletic Performance/physiology ; Biomechanical Phenomena ; Female ; Humans ; Male ; Sports Equipment ; Swimming/physiology ; Time Factors ; Video Recording ; Young Adult
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2016.1161204
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Zs.A 2388: Show issues

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Article: CTX-M-15 extended-spectrum beta-lactamases in Enterobacteriaceae in the intensive care unit of Tlemcen Hospital, Algeria.

Ahmed, Z Baba / Ayad, A / Mesli, E / Messai, Y / Bakour, R / Drissi, M

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

2012 Volume 18, Issue 4, Page(s) 382–386

Abstract: ... M-15 type. Molecular typing of the isolates showed the clonal nature of 4 K. pneumoniae isolates ...

Abstract	The aim of this study was to detect extended-spectrum beta-lactamases (ESBL) in Enterobacteriaceae isolates in the intensive care unit (ICU) of Tlemcen hospital in north-western Algeria. Antimicrobial susceptibility testing, molecular typing, characterization of ESBL-encoding genes and the genetic environment, conjugation experiments and plasmid analysis were carried out. In all, 28 Enterobacteriaceae isolates were isolated from specimens recovered from patients in the ICU and 2 from surfaces of the unit. Of these, 11 isolates (4 Escherichia coli, 5 Klebsiella pneumoniae and 2 Enterobacter cloacae) produced ESBL of the CT-X-M-15 type. Molecular typing of the isolates showed the clonal nature of 4 K. pneumoniae isolates. The bla(CTXM-15) gene was genetically linked to insertion sequence lSEcp1B and was transferable by conjugation from 3 isolates. Regular monitoring of resistance mechanisms, the establishment of a prevention strategy, and more rational and appropriate use of antibiotics are needed.
MeSH term(s)	Algeria ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Bacterial Typing Techniques ; Cluster Analysis ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/microbiology ; DNA Fingerprinting ; Drug Resistance, Bacterial ; Electrophoresis, Gel, Pulsed-Field ; Enterobacteriaceae/classification ; Enterobacteriaceae/isolation & purification ; Enterobacteriaceae Infections/drug therapy ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Humans ; Intensive Care Units ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; beta-Lactamases/drug effects ; beta-Lactamases/metabolism
Chemical Substances	Anti-Infective Agents ; beta-lactamase CTX-M-15 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2012-07-05
Publishing country	Egypt
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1291071-5
ISSN	1687-1634 ; 1020-3397
ISSN (online)	1687-1634
ISSN	1020-3397
DOI	10.26719/2012.18.4.382
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Zs.A 4388: Show issues

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Article: Electrotransformation of Clostridium paraputrificum M-21 with some plasmids.

Sakka, Kazuo / Kawase, Mamiko / Baba, Daisuke / Morimoto, Kenji / Karita, Shuichi / Kimura, Tetsuya / Ohmiya, Kunio

Journal of bioscience and bioengineering

2003 Volume 96, Issue 3, Page(s) 304–306

Abstract: Clostridium paraputrificum M-21 was transformed with several shuttle plasmids constructed ... stercorarium xylanase gene xyn10B was successfully expressed in C. paraputrificum M-21 and the expressed ...

Abstract	Clostridium paraputrificum M-21 was transformed with several shuttle plasmids constructed for Clostridium acetobutylicum-Escherichia coli and Clostridium perfringens-E. coli by electroporation. The Clostridium stercorarium xylanase gene xyn10B was successfully expressed in C. paraputrificum M-21 and the expressed protein did not suffer from proteolysis by host protease(s). This system will provide us with a genetic tool for genetic and metabolic engineering of this bacterium.
Language	English
Publishing date	2003
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1465387-4
ISSN	1347-4421 ; 1389-1723
ISSN (online)	1347-4421
ISSN	1389-1723
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Z 4728: Show issues

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Article ; Online: Synthesis and theoretical studies of gallium complexes back-shielded by a cage-shaped framework of tris(m-oxybenzyl)arene.

Nakajima, Hideto / Yasuda, Makoto / Chiba, Kouji / Baba, Akio

Chemical communications (Cambridge, England)

2010 Volume 46, Issue 26, Page(s) 4794–4796

Abstract: Cage-shaped gallium complexes with a back-shielding framework of tris(m-oxybenzyl)arene were ...

Abstract	Cage-shaped gallium complexes with a back-shielding framework of tris(m-oxybenzyl)arene were synthesized, their bottom arene rings tuned their characteristic Lewis acidity, which was supported by theoretical calculation as well as catalytic application in a hetero Diels-Alder reaction.
Language	English
Publishing date	2010-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c0cc00253d
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