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  1. Book ; Online ; Thesis: Strukturelle Veränderungen der Mikrozirkulation bei experimenteller Urämie - Quantifizierung, Typisierung, Konsequenzen

    Prommer, Hans-Ulrich [Verfasser]

    In-vivo Untersuchungen am M. cremaster bei Mäusen mit chronischer Niereninsuffizienz

    2019  

    Author's details Hans-Ulrich Prommer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis.

    Prommer, Hans-Ulrich / Maurer, Johannes / von Websky, Karoline / Freise, Christian / Sommer, Kerstin / Nasser, Hamoud / Samapati, Rudi / Reglin, Bettina / Guimarães, Pedro / Pries, Axel Radlach / Querfeld, Uwe

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 5317

    Abstract: Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the ... ...

    Abstract Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1α, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis.
    MeSH term(s) Abdominal Muscles/blood supply ; Animals ; Biomarkers ; Blood Flow Velocity ; Blood Pressure ; Coronary Vessels ; Disease Models, Animal ; Hypoxia/etiology ; Hypoxia/metabolism ; Leukocyte Rolling/immunology ; Male ; Mice ; Microcirculation ; Microvascular Rarefaction ; Myocardium ; Neovascularization, Pathologic/etiology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/physiopathology ; Oxygen/metabolism ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/metabolism ; Severity of Illness Index ; Uremia/diagnosis ; Uremia/etiology ; Vascular Diseases/etiology ; Vascular Diseases/metabolism ; Vascular Diseases/physiopathology
    Chemical Substances Biomarkers ; Oxygen (S88TT14065)
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-23663-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis

    Hans-Ulrich Prommer / Johannes Maurer / Karoline von Websky / Christian Freise / Kerstin Sommer / Hamoud Nasser / Rudi Samapati / Bettina Reglin / Pedro Guimarães / Axel Radlach Pries / Uwe Querfeld

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 14

    Abstract: Abstract Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of ... ...

    Abstract Abstract Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1α, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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