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Article: Chronic renal pain: An approach to investigation and management.

Dewar, Malcolm J / Chin, Joseph L

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2018 Volume 12, Issue 6 Suppl 3, Page(s) S167–S170

Language	English
Publishing date	2018-05-31
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.5327
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Article: Comparison of salvage radical prostatectomy vs. salvage ablation therapy for biopsy-proven radio-recurrent localized prostate cancer.

McPherson, Victor / Nair, Shiva M / Tin, Amy L / Dewar, Malcolm / Siddiqui, Khurram / Sjoberg, Daniel D / Vickers, Andrew J / Eastham, James / Chin, Joseph L

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2023 Volume 18, Issue 2, Page(s) 41–46

Abstract: Introduction: Radiation therapy for prostate cancer is associated with a 15-20% five-year recurrence rate. Patients with recurrence in the prostate only are candidates for salvage local therapies; however, there is no consensus on modality. This study ... ...

Abstract	Introduction: Radiation therapy for prostate cancer is associated with a 15-20% five-year recurrence rate. Patients with recurrence in the prostate only are candidates for salvage local therapies; however, there is no consensus on modality. This study uses registries at Memorial Sloan Kettering Cancer Center (MSKCC) and University of Western Ontario (UWO) to compare the oncologic outcomes of salvage radical prostatectomy (SRP) and salvage ablation (SA). Methods: A total of 444 patients were available for analysis. Due to intergroup differences, propensity score methodology was used and identified 378 patients with more comparable pre-salvage prostate-specific antigen (PSA), Gleason score, and primary radiation treatment. Patients underwent SRP at MSKCC and SA at UWO. Results: Of the 378 patients, 48 died of disease, with a 6.0-year median (interquartile range [IQR] 3.0, 9.7) followup among survivors; 88 developed metastases, with a median 4.6-year (IQR 2.3, 7.9) followup among metastasis-free survivors. There was a non-significantly higher rate of cancer-specific (hazard ratio [HR ] 1.02, 95% confidence interval [CI] 0.51, 2.06, p=0.9) and improved metastasis-free survival (HR 0.71, 95% CI 0.44, 1.13, p=0.15) among patients undergoing SA compared to patients undergoing SRP. There were 143 patients who received hormonal therapy, with higher rates of androgen deprivation therapy (ADT) in SA (HR 1.42, 95% CI 0.97, 2.08, p=0.068), although this did not meet conventional levels of significance. Conclusions: This propensity score analysis of salvage therapy for radio-recurrent prostate cancer identified no statistically significant differences in oncologic outcome between SRP and SA; however, there was evidence of a lower risk of ADT in the cohort undergoing SRP. Given they are both potentially curative therapies, these treatments are viable options for men with clinically localized, radio-recurrent prostate cancer rather than ADT alone. Future research may further elucidate subpopulations that may be more amenable to either SRP or SA.
Language	English
Publishing date	2023-11-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.8373
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Article ; Online: Long-Term Outcomes of Whole Gland Salvage Cryotherapy for Locally Recurrent Prostate Cancer following Radiation Therapy: A Combined Analysis of Two Centers.

Chin, Joseph L / Lavi, Arnon / Metcalfe, Michael J / Siddiqui, Khuram / Dewar, Malcolm / Petros, Firas G / Li, Roger / Nogueras González, Graciela M / Wang, Xuemei / Nair, Shiva M / Ward, John F / Pisters, Louis

The Journal of urology

2021 Volume 206, Issue 3, Page(s) 646–654

Abstract: Purpose: Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose of this study is to determine long-term outcomes ...

Abstract	Purpose: Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose of this study is to determine long-term outcomes following salvage cryotherapy for RRPca. Materials and methods: Patients undergoing salvage cryotherapy for biopsy-proven, localized RRPCa from 1992 through 2004 were prospectively accrued at two centers. Preoperative characteristics, perioperative morbidity and postoperative data were reviewed from our database. The primary outcomes were overall survival (OS) and disease-specific survival (DSS). The secondary outcomes were freedom from castration-resistant prostate cancer (CRPC) and freedom from androgen deprivation therapy (ADT). Results: A total of 268 patients were identified with a median followup of 10.3 years. A total of 223 complication events were recorded; of them, 168 were Clavien I-II events and 55 Clavien III events. At 10 years, 69% had freedom from ADT and 76% had freedom from CRPC. The 10-year DSS rate was 81%, and the 10-year OS rate was 77%. A pre-salvage prostate specific antigen level of >10 ng/ml was associated with an increased risk of developing CRPC and initiation of ADT but was not associated with DSS or OS. The use of neoadjuvant ADT was associated with improved OS and DSS but did not affect freedom from CRPC or adjuvant ADT. Conclusions: Salvage cryotherapy for RRPCa provides excellent long-term freedom from ADT, CRPC and DSS with acceptable morbidity. OS at 10 years was 77%. Prospective trials are required for validation.
MeSH term(s)	Aged ; Androgen Antagonists/pharmacology ; Androgen Antagonists/therapeutic use ; Chemotherapy, Adjuvant/statistics & numerical data ; Cryosurgery/adverse effects ; Follow-Up Studies ; Humans ; Kallikreins/blood ; Male ; Neoadjuvant Therapy/methods ; Neoadjuvant Therapy/statistics & numerical data ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/therapy ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Prostate/pathology ; Prostate/radiation effects ; Prostate/surgery ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms, Castration-Resistant/blood ; Prostatic Neoplasms, Castration-Resistant/diagnosis ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/therapy ; Radiation Tolerance ; Radiotherapy, Adjuvant/statistics & numerical data ; Retrospective Studies ; Salvage Therapy/adverse effects ; Salvage Therapy/methods ; Survival Rate ; Treatment Outcome
Chemical Substances	Androgen Antagonists ; KLK3 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2021-04-18
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000001831
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Article: Time-dependent rheology of starch thickeners and the clinical implications for dysphagia therapy.

Dewar, Richard J / Joyce, Malcolm J

Dysphagia

2006 Volume 21, Issue 4, Page(s) 264–269

Abstract: The viscosity of nonsolid foods and the stability of their viscosity over time is critical in managing dysphagia. The time-dependent viscosity of liquids thickened with starch-based thickeners was measured at constant temperature and shear rate. ... ...

Abstract	The viscosity of nonsolid foods and the stability of their viscosity over time is critical in managing dysphagia. The time-dependent viscosity of liquids thickened with starch-based thickeners was measured at constant temperature and shear rate. Viscosity was measured between 30-min intervals of rest (zero shear) over a period of 17 h at 20.0 degrees C. Two common types of thickeners were evaluated: maize-based and maltodextrin-based (the latter commonly used in pediatrics). The maize-based thickeners undergo a significant decrease in viscosity over the initial 1-4 h following preparation. The maltodextrin-based thickener's viscosity increases significantly 30 min following preparation and is then more stable over time than its maize-based equivalent. These findings suggest that the success of current dysphagia therapies that use thickeners could be influenced by the time-dependent nature of thickened fluid viscosity. Acknowledgment and appropriate selection of the thickener type is shown to be of great importance.
MeSH term(s)	Deglutition Disorders/therapy ; Humans ; Rheology/methods ; Starch/administration & dosage ; Time Factors ; Treatment Outcome ; Viscosity
Chemical Substances	Starch (9005-25-8)
Language	English
Publishing date	2006-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632764-3
ISSN	1432-0460 ; 0179-051X
ISSN (online)	1432-0460
ISSN	0179-051X
DOI	10.1007/s00455-006-9050-7
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Article ; Online: Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.

Riek, Heidi C / Brien, Donald C / Coe, Brian C / Huang, Jeff / Perkins, Julia E / Yep, Rachel / McLaughlin, Paula M / Orange, Joseph B / Peltsch, Alicia J / Roberts, Angela C / Binns, Malcolm A / Lou, Wendy / Abrahao, Agessandro / Arnott, Stephen R / Beaton, Derek / Black, Sandra E / Dowlatshahi, Dar / Finger, Elizabeth / Fischer, Corinne E /

Frank, Andrew R / Grimes, David A / Kumar, Sanjeev / Lang, Anthony E / Lawrence-Dewar, Jane M / Mandzia, Jennifer L / Marras, Connie / Masellis, Mario / Pasternak, Stephen H / Pollock, Bruce G / Rajji, Tarek K / Sahlas, Demetrios J / Saposnik, Gustavo / Seitz, Dallas P / Shoesmith, Christen / Steeves, Thomas D L / Strother, Stephen C / Sunderland, Kelly M / Swartz, Richard H / Tan, Brian / Tang-Wai, David F / Tartaglia, Maria Carmela / Turnbull, John / Zinman, Lorne / Munoz, Douglas P

Brain communications

2023 Volume 5, Issue 2, Page(s) fcad049

Abstract: Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters measured from ... ...

Abstract	Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters measured from eye movement tasks such as prosaccade and antisaccade. Existing studies typically examine few saccade parameters in single diseases, using multiple separate neuropsychological test scores to relate oculomotor behaviour to cognition; however, this approach produces inconsistent, ungeneralizable results and fails to consider the cognitive heterogeneity of these diseases. Comprehensive cognitive assessment and direct inter-disease comparison are crucial to accurately reveal potential saccade biomarkers. We remediate these issues by characterizing 12 behavioural parameters, selected to robustly describe saccade behaviour, derived from an interleaved prosaccade and antisaccade task in a large cross-sectional data set comprising five disease cohorts (Alzheimer's disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and cerebrovascular disease;
Language	English
Publishing date	2023-03-02
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcad049
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Article ; Online: Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke.

Yu, Di / Liang, Nuanyi / Zebarth, Julia / Shen, Qing / Ozzoude, Miracle / Goubran, Maged / Rabin, Jennifer S / Ramirez, Joel / Scott, Christopher J M / Gao, Fuqiang / Bartha, Robert / Symons, Sean / Haddad, Seyyed Mohammad Hassan / Berezuk, Courtney / Tan, Brian / Kwan, Donna / Hegele, Robert A / Dilliott, Allison A / Nanayakkara, Nuwan D /

Binns, Malcolm A / Beaton, Derek / Arnott, Stephen R / Lawrence-Dewar, Jane M / Hassan, Ayman / Dowlatshahi, Dar / Mandzia, Jennifer / Sahlas, Demetrios / Casaubon, Leanne / Saposnik, Gustavo / Otoki, Yurika / Lanctôt, Krista L / Masellis, Mario / Black, Sandra E / Swartz, Richard H / Taha, Ameer Y / Swardfager, Walter

Journal of the American Heart Association

2022 Volume 12, Issue 1, Page(s) e026901

Abstract: Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] ...

Abstract	Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] and 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods and Results Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging criteria. Metabolites were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13-DiHOME/12(13)-EpOME ratio (β=0.251,
MeSH term(s)	Humans ; Linoleic Acid ; Oxylipins ; Epoxide Hydrolases ; Stroke/diagnostic imaging ; Stroke/pathology ; Cerebral Small Vessel Diseases/diagnostic imaging ; Magnetic Resonance Imaging ; Atrophy ; Water
Chemical Substances	Linoleic Acid (9KJL21T0QJ) ; Oxylipins ; Epoxide Hydrolases (EC 3.3.2.-) ; Water (059QF0KO0R)
Language	English
Publishing date	2022-12-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.026901
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Article ; Online: Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.

Sunderland, Kelly M / Beaton, Derek / Arnott, Stephen R / Kleinstiver, Peter / Kwan, Donna / Lawrence-Dewar, Jane M / Ramirez, Joel / Tan, Brian / Bartha, Robert / Black, Sandra E / Borrie, Michael / Brien, Donald / Casaubon, Leanne K / Coe, Brian C / Cornish, Benjamin / Dilliott, Allison A / Dowlatshahi, Dar / Finger, Elizabeth / Fischer, Corinne /

Frank, Andrew / Fraser, Julia / Freedman, Morris / Greenberg, Barry / Grimes, David A / Hassan, Ayman / Hatch, Wendy / Hegele, Robert A / Hudson, Christopher / Jog, Mandar / Kumar, Sanjeev / Lang, Anthony / Levine, Brian / Lou, Wendy / Mandzia, Jennifer / Marras, Connie / McIlroy, William / Montero-Odasso, Manuel / Munoz, David G / Munoz, Douglas P / Orange, Joseph B / Park, David S / Pasternak, Stephen H / Pieruccini-Faria, Frederico / Rajji, Tarek K / Roberts, Angela C / Robinson, John F / Rogaeva, Ekaterina / Sahlas, Demetrios J / Saposnik, Gustavo / Scott, Christopher J M / Seitz, Dallas / Shoesmith, Christen / Steeves, Thomas D L / Strong, Michael J / Strother, Stephen C / Swartz, Richard H / Symons, Sean / Tang-Wai, David F / Tartaglia, Maria Carmela / Troyer, Angela K / Turnbull, John / Zinman, Lorne / McLaughlin, Paula M / Masellis, Mario / Binns, Malcolm A

Alzheimer's & dementia : the journal of the Alzheimer's Association

2022 Volume 19, Issue 1, Page(s) 226–243

Abstract: Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap.: Methods: This multi-site, longitudinal, observational cohort study recruited ... ...

Abstract	Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods: This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results: We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion: Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.
MeSH term(s)	Humans ; Male ; Aged ; Neurodegenerative Diseases/epidemiology ; Activities of Daily Living ; Ontario ; Cohort Studies ; Longitudinal Studies ; Alzheimer Disease ; Cognitive Dysfunction
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.12632
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Article ; Online: Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients.

Daisley, Brendan A / Chanyi, Ryan M / Abdur-Rashid, Kamilah / Al, Kait F / Gibbons, Shaeley / Chmiel, John A / Wilcox, Hannah / Reid, Gregor / Anderson, Amanda / Dewar, Malcolm / Nair, Shiva M / Chin, Joseph / Burton, Jeremy P

Nature communications

2020 Volume 11, Issue 1, Page(s) 4822

Abstract: Abiraterone acetate (AA) is an inhibitor of androgen biosynthesis, though this cannot fully explain its efficacy against androgen-independent prostate cancer. Here, we demonstrate that androgen deprivation therapy depletes androgen-utilizing ... ...

Abstract	Abiraterone acetate (AA) is an inhibitor of androgen biosynthesis, though this cannot fully explain its efficacy against androgen-independent prostate cancer. Here, we demonstrate that androgen deprivation therapy depletes androgen-utilizing Corynebacterium spp. in prostate cancer patients and that oral AA further enriches for the health-associated commensal, Akkermansia muciniphila. Functional inferencing elucidates a coinciding increase in bacterial biosynthesis of vitamin K2 (an inhibitor of androgen dependent and independent tumor growth). These results are highly reproducible in a host-free gut model, excluding the possibility of immune involvement. Further investigation reveals that AA is metabolized by bacteria in vitro and that breakdown components selectively impact growth. We conclude that A. muciniphila is a key regulator of AA-mediated restructuring of microbial communities, and that this species may affect treatment response in castrate-resistant cohorts. Ongoing initiatives aimed at modulating the colonic microbiota of cancer patients may consider targeted delivery of poorly absorbed selective bacterial growth agents.
MeSH term(s)	Abiraterone Acetate/metabolism ; Abiraterone Acetate/pharmacology ; Abiraterone Acetate/therapeutic use ; Akkermansia ; Androgen Antagonists/pharmacology ; Androgens/metabolism ; Bacteria/metabolism ; Feces/microbiology ; Gastrointestinal Microbiome/drug effects ; Humans ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; RNA, Ribosomal, 16S/genetics ; Verrucomicrobia/drug effects ; Verrucomicrobia/genetics ; Verrucomicrobia/metabolism ; Vitamin K 2/metabolism ; Vitamin K 2/pharmacology
Chemical Substances	Androgen Antagonists ; Androgens ; RNA, Ribosomal, 16S ; Vitamin K 2 (11032-49-8) ; Abiraterone Acetate (EM5OCB9YJ6)
Language	English
Publishing date	2020-09-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-18649-5
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Article ; Online: Author Correction: Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients.

Nature communications

2020 Volume 11, Issue 1, Page(s) 6394

Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-20410-x
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Article ; Online: Future Research Directions on the “Elusive” White Shark

Charlie Huveneers / Kirin Apps / Edgar E. Becerril-García / Barry Bruce / Paul A. Butcher / Aaron B. Carlisle / Taylor K. Chapple / Heather M. Christiansen / Geremy Cliff / Tobey H. Curtis / Toby S. Daly-Engel / Heidi Dewar / Matt L. Dicken / Michael L. Domeier / Clinton A. J. Duffy / Richard Ford / Malcolm P. Francis / Georgia C. A. French / Felipe Galván-Magaña /

Frontiers in Marine Science, Vol

2018 Volume 5

Abstract: White sharks, Carcharodon carcharias, are often described as elusive, with little information available due to the logistical difficulties of studying large marine predators that make long-distance migrations across ocean basins. Increased understanding ... ...

Abstract	White sharks, Carcharodon carcharias, are often described as elusive, with little information available due to the logistical difficulties of studying large marine predators that make long-distance migrations across ocean basins. Increased understanding of aggregation patterns, combined with recent advances in technology have, however, facilitated a new breadth of studies revealing fresh insights into the biology and ecology of white sharks. Although we may no longer be able to refer to the white shark as a little-known, elusive species, there remain numerous key questions that warrant investigation and research focus. Although white sharks have separate populations, they seemingly share similar biological and ecological traits across their global distribution. Yet, white shark’s behavior and migratory patterns can widely differ, which makes formalizing similarities across its distribution challenging. Prioritization of research questions is important to maximize limited resources because white sharks are naturally low in abundance and play important regulatory roles in the ecosystem. Here, we consulted 43 white shark experts to identify these issues. The questions listed and developed here provide a global road map for future research on white sharks to advance progress toward key goals that are informed by the needs of the research community and resource managers.
Keywords	Carcharodon carcharias ; movement ; threats ; threatened species conservation ; TEPS management ; wildlife tourism ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	333
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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