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  1. Article ; Online: Non-24-hour Sleep-Wake Rhythm Disorder.

    Abbott, Sabra M

    Neurologic clinics

    2019  Volume 37, Issue 3, Page(s) 545–552

    Abstract: Non-24-hour sleep-wake rhythm disorder is a circadian rhythm sleep-wake disorder characterized by an inability to entrain to the 24-hour environment. Patients present with complaints of insomnia or hypersomnia, with progressive daily shifts of sleep-wake ...

    Abstract Non-24-hour sleep-wake rhythm disorder is a circadian rhythm sleep-wake disorder characterized by an inability to entrain to the 24-hour environment. Patients present with complaints of insomnia or hypersomnia, with progressive daily shifts of sleep-wake activity on actigraphy or sleep logs. Although first recognized in blind individuals without light perception, it also can be seen in individuals with intact vision. Treatment focuses on timed melatonin in blind individuals, whereas it is more complex in sighted individuals, using multiple time cues, such as light, melatonin, social interactions, feeding, and activity.
    MeSH term(s) Humans ; Sleep Disorders, Circadian Rhythm/diagnosis ; Sleep Disorders, Circadian Rhythm/physiopathology ; Sleep Disorders, Circadian Rhythm/therapy
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2019.03.002
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  2. Article ; Online: What's in a name? delayed by any other name is still a circadian disorder: a call for improved nomenclature for delayed sleep-wake phase disorder subtypes.

    Abbott, Sabra M / Phillips, Andrew J / Reid, Kathryn J / Cain, Sean W / Zee, Phyllis C

    Sleep

    2023  Volume 46, Issue 11

    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad222
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    Zs.A 1475: Show issues Location:
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  3. Article ; Online: Circadian Rhythm Sleep-Wake Disorders.

    Zee, Phyllis C / Abbott, Sabra M

    Continuum (Minneapolis, Minn.)

    2020  Volume 26, Issue 4, Page(s) 988–1002

    Abstract: Purpose of review: This article provides an overview of circadian physiology and discusses common presentations and treatment strategies for the circadian rhythm sleep-wake disorders.: Recent findings: Circadian rhythms are present throughout the ... ...

    Abstract Purpose of review: This article provides an overview of circadian physiology and discusses common presentations and treatment strategies for the circadian rhythm sleep-wake disorders.
    Recent findings: Circadian rhythms are present throughout the body, and appreciation for the role that circadian dysregulation plays in overall health is increasing, with mounting associations between circadian disruption and cardiometabolic disease risk.
    Summary: It is important to recognize the ubiquitous role that circadian rhythms play throughout the brain and body. An understanding of circadian neurophysiology will provide insight into the means by which patients with a variety of neuropathologies at the level of the retina, optic nerve, or hypothalamus may also be at risk for circadian dysfunction.
    MeSH term(s) Chronobiology Disorders/pathology ; Chronobiology Disorders/physiopathology ; Circadian Rhythm/physiology ; Humans ; Sleep Disorders, Circadian Rhythm/pathology ; Sleep Disorders, Circadian Rhythm/physiopathology
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000000884
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  4. Article ; Online: Circadian Rhythms: Implications for Health and Disease.

    Abbott, Sabra M / Zee, Phyllis C

    Neurologic clinics

    2019  Volume 37, Issue 3, Page(s) 601–613

    Abstract: Circadian rhythms are present in nearly all organisms studied, and are present throughout the human body. The proper coordination of these rhythms, both within the body, and with respect to the environment appears to be important for overall health. This ...

    Abstract Circadian rhythms are present in nearly all organisms studied, and are present throughout the human body. The proper coordination of these rhythms, both within the body, and with respect to the environment appears to be important for overall health. This article reviews the available data looking at the association between circadian dysregulation and cardiometabolic, neurologic, and neurodegenerative disease risk. In addition we discuss the limited but growing evidence supporting the use of circadian-based interventions to improve overall health.
    MeSH term(s) Animals ; Circadian Rhythm/physiology ; Humans
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2019.04.004
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  5. Article ; Online: Assessment and Management of Sleep Disturbances in Atopic Dermatitis: A Review.

    Samynathan, Archana / Fishbein, Anna B / Abbott, Sabra M / Booster, Genery D / Zee, Phyllis C / Sheldon, Stephen H / Yosipovitch, Gil / Silverberg, Jonathan I

    Dermatitis : contact, atopic, occupational, drug

    2023  Volume 35, Issue S1, Page(s) S7–S12

    Abstract: Atopic dermatitis (AD) is a chronic burdensome inflammatory skin disease with well-established cutaneous and systemic comorbidities and disease burden. AD particularly has profound impacts on sleep in individuals of all ages. Sleep disturbances (SDs) ... ...

    Abstract Atopic dermatitis (AD) is a chronic burdensome inflammatory skin disease with well-established cutaneous and systemic comorbidities and disease burden. AD particularly has profound impacts on sleep in individuals of all ages. Sleep disturbances (SDs) affect 6.2% of school-age children and 33-87.1% of adults with AD. This narrative review addresses the burden of SD in AD patients, as well as biological mechanisms of SD in AD, including biological clocks influencing sleep, inflammation, and behavior. Approaches for early detection, diagnosis, objective quantification, patient education, and management are reviewed. It is imperative to break the itch-scratch cycle to reduce SDs and improve quality of life in individuals with AD.
    MeSH term(s) Adult ; Child ; Humans ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/diagnosis ; Quality of Life ; Pruritus/drug therapy ; Pruritus/etiology ; Skin ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy ; Severity of Illness Index ; Chronic Disease ; Sleep
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2023.0074
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    Zs.A 3680: Show issues Location:
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  6. Article ; Online: Response to the letter to the editor for "Obstructive Sleep Apnea and Risk of COVID-19 Infection, Hospitalization and Respiratory Failure".

    Maas, Matthew B / Kim, Minjee / Malkani, Roneil G / Abbott, Sabra M / Zee, Phyllis C

    Sleep & breathing = Schlaf & Atmung

    2021  Volume 25, Issue 4, Page(s) 2105–2106

    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Respiratory Insufficiency/therapy ; SARS-CoV-2 ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2021-01-18
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1500381-4
    ISSN 1522-1709 ; 1520-9512
    ISSN (online) 1522-1709
    ISSN 1520-9512
    DOI 10.1007/s11325-020-02272-1
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    Zs.A 5658: Show issues Location:
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  7. Article ; Online: Impact of sleep disruption on cognitive function in patients with postacute sequelae of SARS-CoV-2 infection: initial findings from a Neuro-COVID-19 clinic.

    Reid, Kathryn J / Ingram, Louis T / Jimenez, Millenia / Orban, Zachary S / Abbott, Sabra M / Grimaldi, Daniela / Knutson, Kristen L / Zee, Phyllis C / Koralnik, Igor J / Maas, Mathew B

    Sleep advances : a journal of the Sleep Research Society

    2024  Volume 5, Issue 1, Page(s) zpae002

    Abstract: Introduction: Fatigue, brain fog, and sleep disturbance are among the most common symptoms of postacute sequelae of SARS-CoV-2 infection (PASC). We sought to determine the impact of sleep disruption on cognition and quality of life in patients with ... ...

    Abstract Introduction: Fatigue, brain fog, and sleep disturbance are among the most common symptoms of postacute sequelae of SARS-CoV-2 infection (PASC). We sought to determine the impact of sleep disruption on cognition and quality of life in patients with neurologic manifestations of PASC (Neuro-PASC).
    Methods: Thirty-nine patients were recruited from Neuro-COVID-19 clinic. Mean age was 48.1 years, 71.8% were female, and 82% were never hospitalized for COVID-19. Patients were evaluated via clinical assessment, quality-of-life measures in domains of cognitive function, fatigue, sleep disturbance, anxiety, and depression, NIH Toolbox cognitive tests, and 7 days of wrist actigraphy.
    Results: The median number of neurologic symptoms attributed to PASC was 6, with brain fog being the most common in 89.7%. Regarding non-neurologic symptoms, 94.9% complained of fatigue and 74.4% of insomnia. Patients reported significant impairment in all quality-of-life domains and performed worse in a task of attention compared to a normative US population. Actigraphy showed Neuro-PASC patients had lower sleep efficiency, longer sleep latency (both
    Conclusion: Prospective studies including larger populations of patients are needed to fully determine the interplay of sleep disruption on the cognitive function and quality of life of patients with PASC.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 2632-5012
    ISSN (online) 2632-5012
    DOI 10.1093/sleepadvances/zpae002
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  8. Article ; Online: Adopting the Unentrained Orphan.

    Malkani, Roneil G / Abbott, Sabra M / Zee, Phyllis C

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2018  Volume 14, Issue 8, Page(s) 1447

    MeSH term(s) Humans ; Sleep Disorders, Circadian Rhythm
    Language English
    Publishing date 2018-08-15
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.7306
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    Zs.A 6590: Show issues Location:
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  9. Article ; Online: Circadian Disruption Associated with Alzheimer's Disease.

    Saeed, Yumna / Abbott, Sabra M

    Current neurology and neuroscience reports

    2017  Volume 17, Issue 4, Page(s) 29

    Abstract: Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep- ...

    Abstract Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system. One of the many physiologic process affected by AD is the circadian system, with disruption reflected in abnormalities of the sleep-wake cycle. This interaction is bidirectional, with circadian and sleep disruption influencing disease progression. Understanding the bidirectional relationship between AD and circadian disruption may allow for earlier recognition of the potential to develop dementia as well as improved targeted approaches for therapy. Therapies including melatonin and bright light therapy may be advantageous in improving sleep and circadian rhythms and preventing the progression of disease. However, unfortunately, these modalities are not curative, and additional research is needed to improve treatment options for these individuals.
    MeSH term(s) Alzheimer Disease/complications ; Amyloidogenic Proteins/metabolism ; Animals ; Circadian Rhythm/physiology ; Humans ; Melatonin/metabolism ; Phototherapy ; Sleep Disorders, Circadian Rhythm/etiology ; Sleep Disorders, Circadian Rhythm/therapy
    Chemical Substances Amyloidogenic Proteins ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2017-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-017-0745-y
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  10. Article: Clinical neurophysiology of circadian rhythm sleep-wake disorders.

    Saeed, Yumna / Zee, Phyllis C / Abbott, Sabra M

    Handbook of clinical neurology

    2019  Volume 161, Page(s) 369–380

    Abstract: Circadian rhythms are the endogenous near-24-h oscillations in physiologic processes. In mammals the suprachiasmatic nucleus serves as the primary circadian pacemaker, and it maintains rhythmicity at a genetic level through a complex transcription- ... ...

    Abstract Circadian rhythms are the endogenous near-24-h oscillations in physiologic processes. In mammals the suprachiasmatic nucleus serves as the primary circadian pacemaker, and it maintains rhythmicity at a genetic level through a complex transcription-translation feedback loop of core circadian clock genes. The circadian clock is entrained to the environment through daily exposure to light and melatonin. Disruption of these endogenous rhythms or the ability to entrain to the surrounding environment results in the circadian rhythm sleep-wake disorders (CRSWDs). Patients with CRSWDs can present with either late sleep/wake times (delayed sleep-wake phase disorder), early sleep/wake times (advanced sleep-wake phase disorder), inconsistent sleep/wake times (irregular sleep-wake rhythm disorder) or sleep-wake times that move progressively later each day (non-24-h sleep-wake rhythm disorder). Diagnosis of these disorders relies on the use of sleep logs and/or actigraphy to demonstrate the daily patterns of rest and activity. Treatment of the CRSWDs focuses on sleep hygiene and strategically timed light and melatonin.
    MeSH term(s) Humans ; Sleep Disorders, Circadian Rhythm/physiopathology
    Language English
    Publishing date 2019-07-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-64142-7.00061-8
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