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Article ; Online: MRE-based NASH score for diagnosis of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease.

Lee, Young-Sun / Lee, Ji Eun / Yi, Hyon-Seung / Jung, Young Kul / Jun, Dae Won / Kim, Ji Hoon / Seo, Yeon Seok / Yim, Hyung Joon / Kim, Baek-Hui / Kim, Jeong Woo / Lee, Chang Hee / Yeon, Jong Eun / Lee, Juneyoung / Um, Soon Ho / Byun, Kwan Soo

Hepatology international

2022 Volume 16, Issue 2, Page(s) 316–324

Abstract: Background and aims: As the prevalence of nonalcoholic fatty liver disease (NAFLD) is approximately 30% in the general population, it is important to develop a non-invasive biomarker for the diagnosis of nonalcoholic steatohepatitis (NASH). This ... ...

Abstract	Background and aims: As the prevalence of nonalcoholic fatty liver disease (NAFLD) is approximately 30% in the general population, it is important to develop a non-invasive biomarker for the diagnosis of nonalcoholic steatohepatitis (NASH). This prospective cross-sectional study aimed to develop a scoring system for NASH diagnosis through multiparametric magnetic resonance (MR) and clinical indicators. Methods: Medical history, laboratory tests, and MR parameters of patients with NAFLD were assessed. A scoring system was developed using a logistic regression model. In total, 127 patients (58 with nonalcoholic fatty liver [NAFL] and 69 with NASH) were enrolled. After evaluating 23 clinical characteristics of the patients (4 categorical and 19 numeric variables) for the NASH diagnostic model, an equation for MR elastography (MRE)-based NASH score was obtained using 3 demographic factors, 2 laboratory variables, and MRE. Results: The MRE-based NASH score showed a satisfactory accuracy for NASH diagnosis (c-statistics, 0.841; 95% CI 0.772-0.910). At a cut-off MRE-based NASH score of 0.68 for NASH diagnosis, its sensitivity was 0.68 and specificity was 0.91. When an MRE-based NASH score of 0.37 was used as a cut-off for NASH exclusion, the sensitivity was 0.91 and specificity was 0.55. Overall, 35% (44/127) of patients were in the gray zone (between 0.37 and 0.68). Internal validation via bootstrapping also indicated the satisfactory accuracy of NASH diagnosis (optimism-corrected statistics, 0.811). Conclusion: MRE-based NASH score is a useful and accurate non-invasive biomarker for diagnosis of NASH in patients with NAFLD.
MeSH term(s)	Biomarkers ; Cross-Sectional Studies ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Prospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2270316-0
ISSN	1936-0541 ; 1936-0533
ISSN (online)	1936-0541
ISSN	1936-0533
DOI	10.1007/s12072-022-10300-3
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Article ; Online: Noninvasive measurement of cerebrospinal fluid flow using an ultrasonic transit time flow sensor: a preliminary study.

Pennell, Thomas / Yi, Juneyoung L / Kaufman, Bruce A / Krishnamurthy, Satish

Journal of neurosurgery. Pediatrics

2016 Volume 17, Issue 3, Page(s) 270–277

Abstract: OBJECT Mechanical failure-which is the primary cause of CSF shunt malfunction-is not readily diagnosed, and the specific reasons for mechanical failure are not easily discerned. Prior attempts to measure CSF flow noninvasively have lacked the ability to ... ...

Abstract	OBJECT Mechanical failure-which is the primary cause of CSF shunt malfunction-is not readily diagnosed, and the specific reasons for mechanical failure are not easily discerned. Prior attempts to measure CSF flow noninvasively have lacked the ability to either quantitatively or qualitatively obtain data. To address these needs, this preliminary study evaluates an ultrasonic transit time flow sensor in pediatric and adult patients with external ventricular drains (EVDs). One goal was to confirm the stated accuracy of the sensor in a clinical setting. A second goal was to observe the sensor's capability to record real-time continuous CSF flow. The final goal was to observe recordings during instances of flow blockage or lack of flow in order to determine the sensor's ability to identify these changes. METHODS A total of 5 pediatric and 11 adult patients who had received EVDs for the treatment of hydrocephalus were studied in a hospital setting. The primary EVD was connected to a secondary study EVD that contained a fluid-filled pressure transducer and an in-line transit time flow sensor. Comparisons were made between the weight of the drainage bag and the flow measured via the sensor in order to confirm its accuracy. Data from the pressure transducer and the flow sensor were recorded continuously at 100 Hz for a period of 24 hours by a data acquisition system, while the hourly CSF flow into the drip chamber was recorded manually. Changes in the patient's neurological status and their time points were noted. RESULTS The flow sensor demonstrated a proven accuracy of ± 15% or ± 2 ml/hr. The flow sensor allowed real-time continuous flow waveform data recordings. Dynamic analysis of CSF flow waveforms allowed the calculation of the pressure-volume index. Lastly, the sensor was able to diagnose a blocked catheter and distinguish between the blockage and lack of flow. CONCLUSIONS The Transonic flow sensor accurately measures CSF output within ± 15% or ± 2 ml/hr, diagnoses the blockage or lack of flow, and records real-time continuous flow data in patients with EVDs. Calculations of a wide variety of diagnostic parameters can be made from the waveform recordings, including resistance and compliance of the ventricular catheters and the compliance of the brain. The sensor's clinical applications may be of particular importance to the noninvasive diagnosis of shunt malfunctions with the development of an implantable device.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cerebrospinal Fluid Shunts/adverse effects ; Child ; Drainage/methods ; Female ; Humans ; Hydrocephalus/surgery ; Intracranial Pressure/physiology ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Treatment Outcome ; Ultrasonography
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2403985-8
ISSN	1933-0715 ; 1933-0707
ISSN (online)	1933-0715
ISSN	1933-0707
DOI	10.3171/2015.7.PEDS1577
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Article ; Online: Perioperative Intravenous Corticosteroids and Radiographic Prevertebral Soft Tissue Swelling in Anterior Cervical Fusion for Degenerative Disease.

Yi, Juneyoung L / Glover, Michael / Charitable, John / Ramcharran, Harry / Kurra, Swamy / Tallarico, Richard A / Sun, Mike H / Lavelle, William F

World neurosurgery

2019 Volume 125, Page(s) e784–e789

Abstract: Objective: Prevertebral soft tissue swelling (PSTS) is a known complication of anterior cervical fusion (ACF). Prior studies have shown that perioperative steroids may reduce PSTS after ACF. We retrospectively evaluated the role of perioperative ... ...

Abstract	Objective: Prevertebral soft tissue swelling (PSTS) is a known complication of anterior cervical fusion (ACF). Prior studies have shown that perioperative steroids may reduce PSTS after ACF. We retrospectively evaluated the role of perioperative intravenous (IV) corticosteroid administration in minimizing radiographic PSTS measurements in patients undergoing ACF for degenerative disease. Methods: Records of 100 consecutive patients undergoing ACF for degenerative disease (Current Procedural Terminology code 63075) from January 2010 through December 2012 by 2 orthopedic spine fellowship-trained surgeons at a single institution were retrospectively reviewed. Patients were included on the basis of specific criteria. They were then separated into comparison and IV steroid groups. Demographic and surgical data were collected. Last, measurements of PSTS, which included PSTS ratio and PSTS index (PSTSI), were obtained from plain radiographs preoperatively and at 3 postoperative time points. Results: Eighty patients were included; 26 received IV steroids at the surgeon's discretion (12 intraoperatively, 11 postoperatively and 3 at both time periods). With the exception of a history of prior anterior cervical spine surgery (3.70% comparison vs. 23.08% IV steroid, P = 0.01), there was no statistically significant demographic characteristic. Furthermore, there was no statistically significant surgical characteristic. Last, there was no statistically significant difference between groups at any time point for either PSTS ratio at any level or PSTSI. Conclusions: There does not appear to be a role for perioperative IV steroid administration in minimizing radiographic PSTS in patients undergoing ACF for degenerative disease. The relationship between perioperative IV steroid administration and PSTS requires further investigation.
MeSH term(s)	Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/pharmacology ; Adult ; Cervical Vertebrae/surgery ; Diskectomy/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Retrospective Studies ; Spinal Diseases/surgery ; Spinal Fusion/adverse effects
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2019-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.01.169
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Zs.A 1159: Show issues

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Article ; Online: Cauda equina repair in the rat: Part 3. Axonal regeneration across Schwann cell-Seeded collagen foam.

Mackenzie, Samuel J / Yi, Juneyoung L / Singla, Amit / Russell, Thomas M / Osterhout, Donna J / Calancie, Blair

Muscle & nerve

2017 Volume 57, Issue 1, Page(s) E78–E84

Abstract: Introduction: Treatments for patients with cauda equina injury are limited.: Methods: In this study, we first used retrograde labeling to determine the relative contributions of cauda equina motor neurons to intrinsic and extrinsic rat tail muscles. ... ...

Abstract	Introduction: Treatments for patients with cauda equina injury are limited. Methods: In this study, we first used retrograde labeling to determine the relative contributions of cauda equina motor neurons to intrinsic and extrinsic rat tail muscles. Next, we transected cauda equina ventral roots and proceeded to bridge the proximal and distal stumps with either a type I collagen scaffold coated in laminin (CL) or a collagen-laminin scaffold that was also seeded with Schwann cells (CLSC). Regeneration was assessed by way of serial retrograde labeling. Results: After accounting for the axonal contributions to intrinsic vs. extrinsic tail muscles, we noted a higher degree of double labeling in the CLSC group (58.0 ± 39.6%) as compared with the CL group (27.8 ± 16.0%; P = 0.02), but not the control group (33.5 ± 18.2%; P = 0.10). Discussion: Our findings demonstrate the feasibility of using CLSCs in cauda equina injury repair. Muscle Nerve 57: E78-E84, 2018.
MeSH term(s)	Animals ; Axons/physiology ; Cauda Equina/injuries ; Cell Count ; Collagen Type I/pharmacology ; Female ; Laminin/pharmacology ; Motor Neurons ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiology ; Nerve Regeneration/physiology ; Rats ; Rats, Inbred F344 ; Schwann Cells/physiology ; Tissue Scaffolds
Chemical Substances	Collagen Type I ; Laminin
Language	English
Publishing date	2017-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.25751
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Zs.A 1449: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Innervation and function of rat tail muscles for modeling cauda equina injury and repair.

MacKenzie, Samuel J / Yi, Juneyoung L / Singla, Amit / Russell, Thomas M / Calancie, Blair

Muscle & nerve

2015 Volume 52, Issue 1, Page(s) 94–102

Abstract: Introduction: The rat tail exhibits functional impairment after cauda equina injury. Our goal was to better understand the innervation and roles of muscles that control the tail.: Methods: Adult rats received either: (1) ventral root injury; (2) ... ...

Abstract	Introduction: The rat tail exhibits functional impairment after cauda equina injury. Our goal was to better understand the innervation and roles of muscles that control the tail. Methods: Adult rats received either: (1) ventral root injury; (2) caudales nerve injury; or (3) mapping of sacrococcygeal myotomes. Activation of small muscles within the tail itself (intrinsics) was compared with that of larger lumbosacral muscles acting on the tail (extrinsics). Behavioral testing of tail movement was done 1 week later. Results: Rats that received ventral root injury exhibited multiple behavioral deficits, whereas rats with injury to caudales nerves maintained more fully preserved tail movement. Mapping studies revealed much broader overlap of myotomes for extrinsic muscles. Conclusions: Extrinsic tail muscles play a greater role in tail movement in the rat than their intrinsic counterparts and are innervated by multiple neurological segments. These findings have major implications for future research on cauda equina injury.
MeSH term(s)	Animals ; Disease Models, Animal ; Electromyography ; Female ; Gait Disorders, Neurologic/etiology ; Movement/physiology ; Muscle, Skeletal/physiopathology ; Polyradiculopathy/complications ; Polyradiculopathy/pathology ; Rats ; Rats, Sprague-Dawley ; Spinal Nerve Roots/physiopathology ; Swimming/physiology ; Tail/innervation ; Tail/physiopathology ; Wound Healing/physiology
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.24498
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Zs.A 1449: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy and safety of oxiracetam in patients with vascular cognitive impairment: A multicenter, randomized, double-blinded, placebo-controlled, phase IV clinical trial.

Lim, Jae-Sung / Lee, Juneyoung / Kang, Yeonwook / Park, Hyun-Tae / Kim, Dong-Eog / Cha, Jae-Kwan / Park, Tai Hwan / Heo, Jae-Hyuk / Lee, Kyung Bok / Park, Jong-Moo / Oh, Mi Sun / Kim, Eung-Gyu / Chang, Dae-Il / Heo, Sung Hyuk / Park, Man-Seok / Park, HyunYoung / Yi, SangHak / Lee, Yeong Bae / Park, Kwang-Yeol /

Contemporary clinical trials

2023 Volume 126, Page(s) 107108

Abstract: Background: Oxiracetam may have a modest effect on preventing cognitive decline. Exercise can also enhance cognitive function. This trial aims to investigate the effect of oxiracetam on post-stroke cognitive impairment and explore whether this effect is ...

Abstract	Background: Oxiracetam may have a modest effect on preventing cognitive decline. Exercise can also enhance cognitive function. This trial aims to investigate the effect of oxiracetam on post-stroke cognitive impairment and explore whether this effect is modified by exercise. Furthermore, the mechanisms that mediate this effect will be investigated through a neural network analysis. Methods: This is a multicenter, randomized, double-blind, placebo-controlled phase IV trial. Patients who complained of cognitive decline 3 months after stroke and had a high risk of cognitive decline were eligible. Patients were randomly assigned to receive either 800 mg of oxiracetam or placebo twice daily for 36 weeks. After randomization, a predetermined exercise protocol was provided to each participant, and the degree of physical activity was assessed using wrist actigraphy at 4, 12, 24, and 36 weeks. Resting-state functional MRI was obtained in baseline and 36-week follow-up. Co-primary endpoints are changes in the Mini-Mental State Examination and Clinical Dementia Rating-Sum of Boxes. Secondary endpoints include changes in the NINDS-CSN VCIHS-Neuropsychology Protocol, Euro QoL, patient's global assessment, and functional network connectivity. If there is a significant difference in physical activity between the two groups, the interaction effect between physical activity and the treatment group will be examined. A total of 500 patients were enrolled from February 2018, and the last patient's final follow-up was completed in September 2022. Conclusion: This trial is meaningful not only to prove the efficacy of oxiracetam, but also evaluate whether exercise can modify the effects of medication and how cognitive function can be restored. Trial registrationhttp://cris.nih.go.kr (KCT0005137).
MeSH term(s)	Humans ; Quality of Life ; Cognitive Dysfunction/drug therapy ; Pyrrolidines/therapeutic use ; Stroke ; Double-Blind Method ; Treatment Outcome
Chemical Substances	oxiracetam (P7U817352G) ; Pyrrolidines
Language	English
Publishing date	2023-01-29
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2182176-8
ISSN	1559-2030 ; 1551-7144
ISSN (online)	1559-2030
ISSN	1551-7144
DOI	10.1016/j.cct.2023.107108
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Zs.A 1581: Show issues

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Article ; Online: Chronic traumatic encephalopathy.

Yi, Juneyoung / Padalino, David J / Chin, Lawrence S / Montenegro, Philip / Cantu, Robert C

Current sports medicine reports

2013 Volume 12, Issue 1, Page(s) 28–32

Abstract: Sports-related concussion has gained increased prominence, in part due to media coverage of several well-known athletes who have died from consequences of chronic traumatic encephalopathy (CTE). CTE was first described by Martland in 1928 as a syndrome ... ...

Abstract	Sports-related concussion has gained increased prominence, in part due to media coverage of several well-known athletes who have died from consequences of chronic traumatic encephalopathy (CTE). CTE was first described by Martland in 1928 as a syndrome seen in boxers who had experienced significant head trauma from repeated blows. The classic symptoms of impaired cognition, mood, behavior, and motor skills also have been reported in professional football players, and in 2005, the histopathological findings of CTE were first reported in a former National Football League (NFL) player. These finding were similar to Alzheimer's disease in some ways but differed in critical areas such as a predominance of tau protein deposition over amyloid. The pathophysiology is still unknown but involves a history of repeated concussive and subconcussive blows and then a lag period before CTE symptoms become evident. The involvement of excitotoxic amino acids and abnormal microglial activation remain speculative. Early identification and prevention of this disease by reducing repeated blows to the head has become a critical focus of current research.
MeSH term(s)	Athletic Injuries/diagnosis ; Athletic Injuries/therapy ; Brain Injury, Chronic/diagnosis ; Brain Injury, Chronic/therapy ; Humans
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2080040-X
ISSN	1537-8918 ; 1537-890X
ISSN (online)	1537-8918
ISSN	1537-890X
DOI	10.1249/JSR.0b013e31827ec9e3
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Zs.A 5922: Show issues

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Article ; Online: The Impact of Preoperative Mindfulness-Based Stress Reduction on Postoperative Patient-Reported Pain, Disability, Quality of Life, and Prescription Opioid Use in Lumbar Spine Degenerative Disease: A Pilot Study.

Yi, Juneyoung L / Porucznik, Christina A / Gren, Lisa H / Guan, Jian / Joyce, Evan / Brodke, Darrel S / Dailey, Andrew T / Mahan, Mark A / Hood, Robert S / Lawrence, Brandon D / Spiker, William R / Spina, Nicholas T / Bisson, Erica F

World neurosurgery

2018 Volume 121, Page(s) e786–e791

Abstract: Background: Prescription opioid medications negatively affect postoperative outcomes after lumbar spine surgery. Furthermore, opioid-related overdose death rates in the United States increased by 200% between 2000 and 2014. Thus, alternatives are ... ...

Abstract	Background: Prescription opioid medications negatively affect postoperative outcomes after lumbar spine surgery. Furthermore, opioid-related overdose death rates in the United States increased by 200% between 2000 and 2014. Thus, alternatives are imperative. Mindfulness-based stress reduction (MBSR), a mind-body therapy, has been associated with improved activity and mood in opioid-using patients with chronic pain. This study assessed whether preoperative MBSR is an effective adjunct to standard postoperative care in adult patients undergoing lumbar spine surgery for degenerative disease. Methods: The intervention group underwent a preoperative online MBSR course. The comparison group was matched retrospectively in a 1:1 ratio by age, sex, type of surgery, and preoperative opioid use. Prescription opioid use during hospital admission and at 30 days postoperatively were compared with preoperative use. Thirty-day postoperative patient-reported outcomes for pain, disability, and quality of life were compared with preoperative patient-reported outcomes. Dose-response effect of mindfulness courses was assessed using Mindful Attention Awareness Scale scores. Results: In this pilot study, 24 participants were included in each group. Most intervention patients (70.83%) completed 1 session, and the mean Mindful Attention Awareness Scale score was 4.28 ± 0.71 during hospital admission. At 30 days, mean visual analog scale back pain score was lower in the intervention group (P = 0.004) but other patient-reported outcomes did not differ. Conclusions: During hospital admission, no significant dose-response effect of mindfulness techniques was found. At 30 days postoperatively, MBSR use was associated with less back pain. Further research is needed to assess the effectiveness of preoperative MBSR on postoperative outcomes in lumbar spine surgery for degenerative disease.
MeSH term(s)	Aged ; Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use ; Disability Evaluation ; Disabled Persons ; Female ; Humans ; Intervertebral Disc Degeneration/psychology ; Intervertebral Disc Degeneration/surgery ; Lumbar Vertebrae ; Male ; Middle Aged ; Mindfulness/methods ; Pain Measurement ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Pain, Postoperative/psychology ; Pilot Projects ; Preoperative Period ; Quality of Life/psychology ; Retrospective Studies ; Stress, Psychological/etiology ; Stress, Psychological/psychology ; Stress, Psychological/rehabilitation ; Treatment Outcome
Chemical Substances	Analgesics ; Analgesics, Opioid
Language	English
Publishing date	2018-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2018.09.223
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Article ; Online: Coil embolization of an intracranial aneurysm in an infant with tuberous sclerosis complex: A case report and literature review.

Yi, Juneyoung L / Galgano, Michael A / Tovar-Spinoza, Zulma / Deshaies, Eric M

Surgical neurology international

2012 Volume 3, Page(s) 129

Abstract: Background: Tuberous sclerosis (TS) is a multiorgan neurocutaneous syndrome. Vascular manifestations are often extracranial. There is a paucity of cases involving TS combined with intracranial aneurysms reported in the literature. As a result, treatment ...

Abstract	Background: Tuberous sclerosis (TS) is a multiorgan neurocutaneous syndrome. Vascular manifestations are often extracranial. There is a paucity of cases involving TS combined with intracranial aneurysms reported in the literature. As a result, treatment has not been well described. Case description: We report the case of a 13-month-old female infant with a prior diagnosis of TS that was found to have new onset of left eye ptosis, anisocoria, and papillary mydriasis indicative of left third cranial nerve palsy. A magnetic resonance angiogram (MRA) of the brain revealed a left internal carotid artery (ICA) aneurysm. Endovascular embolization was determined to be the best option for treatment. After a successful balloon test occlusion with neuromonitoring, the left internal carotid artery was sacrificed via coil embolization. Conclusions: This is only the third case report of endovascular coil embolization of an intracranial aneurysm in an infant with TS. We report no complications during the procedure, and the patient was discharged with resolving left third cranial nerve palsy. Neither surgical nor endovascular outcomes have been well described in the literature. Follow-up on this patient will be useful for establishing protocols of treatment.
Language	English
Publishing date	2012-10-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2567759-7
ISSN	2152-7806 ; 2152-7806
ISSN (online)	2152-7806
ISSN	2152-7806
DOI	10.4103/2152-7806.102944
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Article ; Online: Comparisons of Prehospital Delay and Related Factors Between Acute Ischemic Stroke and Acute Myocardial Infarction.

Yoon, Cindy W / Oh, Hoonji / Lee, Juneyoung / Rha, Joung-Ho / Woo, Seong-Ill / Lee, Won Kyung / Jung, Han-Young / Ban, Byeolnim / Kang, Jihoon / Kim, Beom Joon / Kim, Won-Seok / Yoon, Chang-Hwan / Lee, Heeyoung / Kim, Seongheon / Kim, Sung Hun / Kang, Eun Kyoung / Her, Ae-Young / Cha, Jae-Kwan / Kim, Dae-Hyun /

Kim, Moo-Hyun / Lee, Jang Hoon / Park, Hun Sik / Kim, Keonyeop / Kim, Rock Bum / Choi, Nack-Cheon / Hwang, Jinyong / Park, Hyun-Woong / Park, Ki Soo / Yi, SangHak / Cho, Jae Young / Kim, Nam-Ho / Choi, Kang-Ho / Kim, Yongcheol / Kim, Juhan / Han, Jae-Young / Choi, Jay Chol / Kim, Song-Yi / Choi, Joon-Hyouk / Kim, Jei / Jee, Sung Ju / Sohn, Min Kyun / Choi, Si Wan / Shin, Dong-Ick / Lee, Sang Yeub / Bae, Jang-Whan / Lee, Kunsei / Bae, Hee-Joon

Journal of the American Heart Association

2022 Volume 11, Issue 9, Page(s) e023214

Abstract: Background Prehospital delay is an important contributor to poor outcomes in both acute ischemic stroke (AIS) and acute myocardial infarction (AMI). We aimed to compare the prehospital delay and related factors between AIS and AMI. Methods and Results We ...

Abstract	Background Prehospital delay is an important contributor to poor outcomes in both acute ischemic stroke (AIS) and acute myocardial infarction (AMI). We aimed to compare the prehospital delay and related factors between AIS and AMI. Methods and Results We identified patients with AIS and AMI who were admitted to the 11 Korean Regional Cardiocerebrovascular Centers via the emergency room between July 2016 and December 2018. Delayed arrival was defined as a prehospital delay of >3 hours, and the generalized linear mixed-effects model was applied to explore the effects of potential predictors on delayed arrival. This study included 17 895 and 8322 patients with AIS and AMI, respectively. The median value of prehospital delay was 6.05 hours in AIS and 3.00 hours in AMI. The use of emergency medical services was the key determinant of delayed arrival in both groups. Previous history, 1-person household, weekday presentation, and interhospital transfer had higher odds of delayed arrival in both groups. Age and sex had no or minimal effects on delayed arrival in AIS; however, age and female sex were associated with higher odds of delayed arrival in AMI. More severe symptoms had lower odds of delayed arrival in AIS, whereas no significant effect was observed in AMI. Off-hour presentation had higher and prehospital awareness had lower odds of delayed arrival; however, the magnitude of their effects differed quantitatively between AIS and AMI. Conclusions The effects of some nonmodifiable and modifiable factors on prehospital delay differed between AIS and AMI. A differentiated strategy might be required to reduce prehospital delay.
MeSH term(s)	Emergency Medical Services ; Emergency Service, Hospital ; Female ; Hospitalization ; Humans ; Ischemic Stroke ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.023214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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