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  1. Article ; Online: von Willebrand disease: A guide for the internist.

    Kaur, Varinder / Elghawy, Omar / Deshpande, Saarang / Riley, David

    Cleveland Clinic journal of medicine

    2024  Volume 91, Issue 2, Page(s) 119–127

    Abstract: von Willebrand disease (VWD), the most common inherited bleeding disorder, results when patients either do not make enough von Willebrand factor (VWF) or make defective VWF. The pathophysiology of this disorder is complex but needs to be understood to ... ...

    Abstract von Willebrand disease (VWD), the most common inherited bleeding disorder, results when patients either do not make enough von Willebrand factor (VWF) or make defective VWF. The pathophysiology of this disorder is complex but needs to be understood to interpret the diagnostic tests. Most patients have mild to moderate symptoms and can be adequately counseled and managed by a general internist, but some need to consult a hematologist. We review the pathophysiology of VWD, its subtypes, common presentations of each subtype, diagnostic testing, and management of mild as well as severe clinical manifestations of VWD.
    MeSH term(s) Humans ; von Willebrand Diseases/diagnosis ; von Willebrand Diseases/therapy ; von Willebrand Factor ; Physicians
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.91a.22033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Genetic evaluation of crossbred Bos indicus cow temperament at parturition.

    Munguía Vásquez, María F / Gill, Clare A / Riggs, Penny K / Herring, Andy D / Sanders, James O / Riley, David G

    Journal of animal science

    2024  Volume 102

    Abstract: Cow temperament at parturition may be mostly a measure of aggressiveness. The heritability of cow temperament at parturition in Bos taurus cows has been reported to be low. The objectives of this study were to estimate the heritability of cow temperament ...

    Abstract Cow temperament at parturition may be mostly a measure of aggressiveness. The heritability of cow temperament at parturition in Bos taurus cows has been reported to be low. The objectives of this study were to estimate the heritability of cow temperament at parturition, conduct a genome-wide association analysis of cow temperament at the time of parturition, and estimate the correspondence of cow temperament at the time of parturition with cow productive performance and early-life temperament traits in Bos indicus crossbreds. Cow temperament was assessed from 1 to 5 indicating increasing levels of aggressiveness of cows (937 cows and 4,337 parturitions) from 2005 to 2022. Estimates of heritability and repeatability were 0.12 ± 0.024 and 0.24 ± 0.018. The estimates of proportion of phenotypic variance were 0.13 ± 0.019 and 0.02 ± 0.011 for permanent and maternal permanent environmental components, respectively. Estimates of heritability for maximum lifetime temperament score and proportions of temperament scores >1 were 0.18 ± 0.07 and 0.13 ± 0.072. Within cycles (generations), 2-yr-old cows had lower temperament score means than cows in most other age categories. There were low to moderate positive estimates of unadjusted correlation coefficients (r = 0.22 to 0.29; P < 0.05) of unadjusted temperament score with temperament measured on the same females when they were 8 mo old. There were low to moderate positive estimates of correlation coefficients (r = 0.09 to 0.37; P < 0.05) of unadjusted temperament score with calving rate, weaning rate, weaning weight per cow exposed, and weaning weight per 454 kg cow weight at weaning. Cows with the lowest temperament score had lower (P < 0.05) calving and weaning rate than cows in other temperament categories. Within 3 of 5 cycles, cows with the lowest temperament score (totally docile) had lower (P < 0.05) weaning weight per cow exposed than cows in other temperament categories. There were 2 SNP on BTA 4 associated with maximum lifetime temperament score (FDR < 0.05). The non-genetic influence of a cow's mother was documented in her own temperament measured at the time of calving; this may be a consequence of learned behavior. Less aggressiveness displayed by cows at the time of calving may be accompanied by lower reproductive and maternal performance.
    MeSH term(s) Pregnancy ; Female ; Cattle/genetics ; Animals ; Temperament ; Genome-Wide Association Study/veterinary ; Parturition/genetics ; Reproduction/genetics ; Weaning
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/skae022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1312: Show issues Location:
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  3. Article ; Online: Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy.

    Gentzler, Ryan D / Riley, David O / Martin, Linda W

    Current oncology reports

    2020  Volume 22, Issue 11, Page(s) 109

    Abstract: Purpose of review: Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the ... ...

    Abstract Purpose of review: Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer.
    Recent findings: Several small studies support the safety and feasibility of neoadjuvant immunotherapy, noting similar perioperative rates of morbidity and mortality compared with historical controls. Data from several phase II trials have shown high rates of major pathologic response (MPR), though it is unclear if this will correlate with a survival benefit. Phase III trials of neoadjuvant immunotherapy alone or in combination with chemotherapy are ongoing. Neoadjuvant immunotherapy offers a promising treatment modality in earlier stage NSCLC patients. Results of ongoing phase II and phase III trials will be essential in determining how to best integrate this treatment modality in the future.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/therapy ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Humans ; Immunotherapy ; Lung Neoplasms/surgery ; Lung Neoplasms/therapy ; Neoadjuvant Therapy
    Language English
    Publishing date 2020-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-020-00969-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5521: Show issues Location:
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  4. Article ; Online: A Review of Successes and Impeding Challenges of IoT-Based Insect Pest Detection Systems for Estimating Agroecosystem Health and Productivity of Cotton.

    Kiobia, Denis O / Mwitta, Canicius J / Fue, Kadeghe G / Schmidt, Jason M / Riley, David G / Rains, Glen C

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 8

    Abstract: Using artificial intelligence (AI) and the IoT (Internet of Things) is a primary focus of applied engineering research to improve agricultural efficiency. This review paper summarizes the engagement of artificial intelligence models and IoT techniques in ...

    Abstract Using artificial intelligence (AI) and the IoT (Internet of Things) is a primary focus of applied engineering research to improve agricultural efficiency. This review paper summarizes the engagement of artificial intelligence models and IoT techniques in detecting, classifying, and counting cotton insect pests and corresponding beneficial insects. The effectiveness and limitations of AI and IoT techniques in various cotton agricultural settings were comprehensively reviewed. This review indicates that insects can be detected with an accuracy of between 70 and 98% using camera/microphone sensors and enhanced deep learning algorithms. However, despite the numerous pests and beneficial insects, only a few species were targeted for detection and classification by AI and IoT systems. Not surprisingly, due to the challenges of identifying immature and predatory insects, few studies have designed systems to detect and characterize them. The location of the insects, sufficient data size, concentrated insects on the image, and similarity in species appearance are major obstacles when implementing AI. Similarly, IoT is constrained by a lack of effective field distance between sensors when targeting insects according to their estimated population size. Based on this study, the number of pest species monitored by AI and IoT technologies should be increased while improving the system's detection accuracy.
    MeSH term(s) Animals ; Artificial Intelligence ; Gossypium ; Insecta ; Agriculture ; Algorithms
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23084127
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  5. Article: Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice.

    Bottom, Riley T / Kozanian, Olga O / Rohac, David J / Erickson, Michael A / Huffman, Kelly J

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 812429

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.812429
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  6. Article: The Acceptability of a Community-Based Perturbation-Based Balance Training to Older Adults and Healthcare Professionals.

    Whitten, Justin / O'Leary, Bryant / Graham, David / Grocke-Dewey, Michelle / Riley, Julie / Harper, Danielle / Tarabochia, Dawn

    Gerontology & geriatric medicine

    2024  Volume 10, Page(s) 23337214241246843

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844974-5
    ISSN 2333-7214 ; 2333-7214
    ISSN (online) 2333-7214
    ISSN 2333-7214
    DOI 10.1177/23337214241246843
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  7. Article ; Online: Pathology in Practice.

    Aronson, Riley K / Conway, David S / Pumphrey, Stephanie A / Almela, Ramón M / Powers, Adam / Burnum, Annabelle / Conrado, Francisco O

    Journal of the American Veterinary Medical Association

    2022  Volume 261, Issue 1, Page(s) 1–4

    MeSH term(s) Animals ; Animal Diseases/diagnosis
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.22.06.0269
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 423: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Pathogenic Leptospira are widespread in the urban wildlife of southern California.

    Helman, Sarah K / Tokuyama, Amanda F N / Mummah, Riley O / Stone, Nathan E / Gamble, Mason W / Snedden, Celine E / Borremans, Benny / Gomez, Ana C R / Cox, Caitlin / Nussbaum, Julianne / Tweedt, Isobel / Haake, David A / Galloway, Renee L / Monzón, Javier / Riley, Seth P D / Sikich, Jeff A / Brown, Justin / Friscia, Anthony / Sahl, Jason W /
    Wagner, David M / Lynch, Jessica W / Prager, Katherine C / Lloyd-Smith, James O

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14368

    Abstract: Leptospirosis, the most widespread zoonotic disease in the world, is broadly understudied in multi-host wildlife systems. Knowledge gaps regarding Leptospira circulation in wildlife, particularly in densely populated areas, contribute to frequent ... ...

    Abstract Leptospirosis, the most widespread zoonotic disease in the world, is broadly understudied in multi-host wildlife systems. Knowledge gaps regarding Leptospira circulation in wildlife, particularly in densely populated areas, contribute to frequent misdiagnoses in humans and domestic animals. We assessed Leptospira prevalence levels and risk factors in five target wildlife species across the greater Los Angeles region: striped skunks (Mephitis mephitis), raccoons (Procyon lotor), coyotes (Canis latrans), Virginia opossums (Didelphis virginiana), and fox squirrels (Sciurus niger). We sampled more than 960 individual animals, including over 700 from target species in the greater Los Angeles region, and an additional 266 sampled opportunistically from other California regions and species. In the five target species seroprevalences ranged from 5 to 60%, and infection prevalences ranged from 0.8 to 15.2% in all except fox squirrels (0%). Leptospira phylogenomics and patterns of serologic reactivity suggest that mainland terrestrial wildlife, particularly mesocarnivores, could be the source of repeated observed introductions of Leptospira into local marine and island ecosystems. Overall, we found evidence of widespread Leptospira exposure in wildlife across Los Angeles and surrounding regions. This indicates exposure risk for humans and domestic animals and highlights that this pathogen can circulate endemically in many wildlife species even in densely populated urban areas.
    MeSH term(s) Animals ; Humans ; Leptospira/genetics ; Animals, Wild ; Ecosystem ; Mephitidae ; Los Angeles ; Animals, Domestic ; Coyotes ; Didelphis ; Geraniaceae ; Raccoons ; Sciuridae
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40322-2
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  9. Article ; Online: Comparison of Telomere Length in Age-Matched Primiparous and Multiparous Brahman Cows

    O’Daniel, Sydney E. / Kochan, Kelli J. / Long, Charles R. / Riley, David G. / Randel, Ronald D. / Welsh, Thomas H.

    Animals. 2023 July 16, v. 13, no. 14

    2023  

    Abstract: Physiological and psychological stressors have been associated with the attrition of telomeres, which are the protective caps of chromosomes. This study compares the telomere length (TL) in 4-year-old Brahman cows grouped by the first parity (n = 8) and ... ...

    Abstract Physiological and psychological stressors have been associated with the attrition of telomeres, which are the protective caps of chromosomes. This study compares the telomere length (TL) in 4-year-old Brahman cows grouped by the first parity (n = 8) and the second parity (n = 11). The cows were bled via jugular venipuncture, weighed, and had their body condition scores recorded at Day −28 prior to calving and at Day + 7 and Day + 28 post-calving. The duration of labor (Dlabor) and parturition ease were recorded. The peripheral leukocytes were isolated, the leukocyte blood count with differential was recorded, and the genomic DNA was extracted. The relative quantity of telomere products, which is proportional to the average TL, was determined via multiplex quantitative PCR using the ratio (T/S ratio) of bovine telomere and β-globulin DNA. Standards of the bovine telomere (10¹²–10⁷ dilution series) and β-globulin (10⁹–10⁴ dilution series) genes were utilized to produce relative copy numbers. The samples were assayed in triplicate and were included if the triplicate Cq difference was less than 0.25 cycles. The parity was the fixed effect, and the random effects included the sire and day repeated with the cow as the subject. Statistical significance was not observed in the leukocyte number or type (p > 0.1). A reduction in the TL of approximately 9225 telomeric copies was found between Parity 1 and Parity 2 (p = 0.02). A trend was found between the TL and Dlabor (p = 0.06). The stress of parturition and raising the first calf of a cow’s life may be responsible for TL attenuation. Parity may be considered a stressor of cow longevity.
    Keywords Brahman ; DNA ; body condition ; calves ; cows ; leukocyte count ; leukocytes ; longevity ; parturition ; quantitative polymerase chain reaction ; sires ; telomeres
    Language English
    Dates of publication 2023-0716
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13142325
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Skeletal Muscle Expression of Actinin-3 (

    Vaughn, Robert N / Kochan, Kelli J / Torres, Aline K / Du, Min / Riley, David G / Gill, Clare A / Herring, Andy D / Sanders, James O / Riggs, Penny K

    Frontiers in genetics

    2022  Volume 13, Page(s) 796038

    Abstract: In this study, actinin-3 ( ...

    Abstract In this study, actinin-3 (
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.796038
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