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Book ; Online: Childhood Obesity

Androutsos, Odysseas / Charmandari, Evangelia

Nutrition and Lifestyle Determinants, Prevention and Management

2022

Keywords	Research & information: general ; Biology, life sciences ; Food & society ; adipose tissue ; obesity ; children ; adolescence ; development ; eating disorders ; adolescents ; prevention programs ; systematic review ; adolescent ; adiposity indicators ; discriminatory capability ; metabolic syndrome ; principal component analysis ; risk screening tool ; Taiwan ; COVID-19 ; lifestyle ; determinants ; diet ; physical activity ; sedentary behavior ; COV-EAT ; parents ; dietary intake ; feeding practices ; family meals ; breakfast ; snacking habits ; gestational diabetes mellitus ; pregnancy ; study protocol ; randomised controlled trial ; large for gestational age ; complex intervention ; calorie restriction ; maternal weight gain ; childhood obesity ; adiposity ; type 2 diabetes ; prevention ; complementary feeding ; solid food ; breastfeeding ; overweight ; weight management ; body composition ; resting energy expenditure ; age ; leptin ; pandemic ; lockdown ; exercise ; sport ; mood ; quality of life ; parental feeding practices ; genetic susceptibility to obesity ; eating behavior ; birth cohort ; sugar-sweetened beverage ; school-based ; intervention ; ecological model ; difference in difference approach ; preschoolers ; nutrition literacy ; nutrition education ; self-efficacy ; teachers ; vascular function ; aerobic training ; L-Citrulline ; L-Arginine ; nitric oxide
Language	0\|e
Size	1 electronic resource (308 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021621609
ISBN	9783036550930 ; 3036550933
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Determinants, Screening, Prevention and Management of Obesity in Youth: New Evidence and Horizons.

Androutsos, Odysseas / Charmandari, Evangelia

Nutrients

2022 Volume 14, Issue 16

Abstract: The prevalence of obesity has significantly increased over the last four decades worldwide [ ... ]. ...

Abstract	The prevalence of obesity has significantly increased over the last four decades worldwide [...].
MeSH term(s)	Adolescent ; Humans ; Mass Screening ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/prevention & control ; Prevalence ; Risk Factors
Language	English
Publishing date	2022-08-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14163280
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Indications of younger age at menarche in Greek adolescents but with no relation to body mass index.

Papageorgiou, Anastasia / Charmandari, Evangelia / Efthymiou, Vasiliki / Vlachakis, Dimitrios / Bacopoulou, Flora

Hormones (Athens, Greece)

2024

Abstract: Purpose: This study aimed to present recent trends in the pubertal timing of a Greek female sample.: Methods: Data were collected retrospectively from medical records of healthy females aged 6-18 years who attended a tertiary Adolescent Friendly ... ...

Abstract	Purpose: This study aimed to present recent trends in the pubertal timing of a Greek female sample. Methods: Data were collected retrospectively from medical records of healthy females aged 6-18 years who attended a tertiary Adolescent Friendly Health Center over a 5-year period (2016-2020) and included gestational age, birth anthropometrics, and age of thelarche and/or pubarche and/or menarche, along with corresponding anthropometric, hormonal, and biochemical measurements. Results: Data from 298 girls' medical records were included in the analysis. Median age at menarche, thelarche, and pubarche was 12, 9, and 9 years, respectively. The mean interval between pubertal onset and menarche was 1.99 years. The mean body mass index (BMI) at menarche and thelarche was 20.99 kg/m Conclusion: The timing of pubertal stages in the Greek female sample studied followed the recent international downward trends. Younger age at menarche was not related to BMI.
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2075912-5
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.1007/s42000-024-00557-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Genetic Basis of Childhood Obesity: A Systematic Review.

Vourdoumpa, Aikaterini / Paltoglou, George / Charmandari, Evangelia

Nutrients

2023 Volume 15, Issue 6

Abstract: Overweight and obesity in childhood and adolescence represents one of the most challenging public health problems of our century owing to its epidemic proportions and the associated significant morbidity, mortality, and increase in public health costs. ... ...

Abstract	Overweight and obesity in childhood and adolescence represents one of the most challenging public health problems of our century owing to its epidemic proportions and the associated significant morbidity, mortality, and increase in public health costs. The pathogenesis of polygenic obesity is multifactorial and is due to the interaction among genetic, epigenetic, and environmental factors. More than 1100 independent genetic loci associated with obesity traits have been currently identified, and there is great interest in the decoding of their biological functions and the gene-environment interaction. The present study aimed to systematically review the scientific evidence and to explore the relation of single-nucleotide polymorphisms (SNPs) and copy number variants (CNVs) with changes in body mass index (BMI) and other measures of body composition in children and adolescents with obesity, as well as their response to lifestyle interventions. Twenty-seven studies were included in the qualitative synthesis, which consisted of 7928 overweight/obese children and adolescents at different stages of pubertal development who underwent multidisciplinary management. The effect of polymorphisms in 92 different genes was assessed and revealed SNPs in 24 genetic loci significantly associated with BMI and/or body composition change, which contribute to the complex metabolic imbalance of obesity, including the regulation of appetite and energy balance, the homeostasis of glucose, lipid, and adipose tissue, as well as their interactions. The decoding of the genetic and molecular/cellular pathophysiology of obesity and the gene-environment interactions, alongside with the individual genotype, will enable us to design targeted and personalized preventive and management interventions for obesity early in life.
MeSH term(s)	Adolescent ; Child ; Humans ; Pediatric Obesity/genetics ; Overweight ; Body Mass Index ; Genotype ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15061416
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 Update.

Nicolaides, Nicolas C / Charmandari, Evangelia

International journal of molecular sciences

2021 Volume 22, Issue 19

Abstract: Glucocorticoids are the final products of the neuroendocrine hypothalamic-pituitary-adrenal axis, and play an important role in the stress response to re-establish homeostasis when it is threatened, or perceived as threatened. These steroid hormones have ...

Abstract	Glucocorticoids are the final products of the neuroendocrine hypothalamic-pituitary-adrenal axis, and play an important role in the stress response to re-establish homeostasis when it is threatened, or perceived as threatened. These steroid hormones have pleiotropic actions through binding to their cognate receptor, the human glucocorticoid receptor, which functions as a ligand-bound transcription factor inducing or repressing the expression of a large number of target genes. To achieve homeostasis, glucocorticoid signaling should have an optimal effect on all tissues. Indeed, any inappropriate glucocorticoid effect in terms of quantity or quality has been associated with pathologic conditions, which are characterized by short-term or long-lasting detrimental effects. Two such conditions, the primary generalized glucocorticoid resistance and hypersensitivity syndromes, are discussed in this review article. Undoubtedly, the tremendous progress of structural, molecular, and cellular biology, in association with the continued progress of biotechnology, has led to a better and more in-depth understanding of these rare endocrinologic conditions, as well as more effective therapeutic management.
MeSH term(s)	Animals ; Drug Hypersensitivity Syndrome/etiology ; Drug Hypersensitivity Syndrome/metabolism ; Drug Hypersensitivity Syndrome/pathology ; Drug Resistance/genetics ; Glucocorticoids/pharmacology ; Humans ; Metabolism, Inborn Errors/genetics ; Metabolism, Inborn Errors/pathology ; Receptors, Glucocorticoid/deficiency ; Receptors, Glucocorticoid/genetics
Chemical Substances	Glucocorticoids ; Receptors, Glucocorticoid
Language	English
Publishing date	2021-10-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221910839
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging: Data from Up-to-Date Experimental Studies.

Valtetsiotis, Konstantinos / Valsamakis, Georgios / Charmandari, Evangelia / Vlahos, Nikolaos F

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: Female infertility and reproduction is an ongoing and rising healthcare issue, resulting in delaying the decision to start a family. Therefore, in this review, we examine potential novel metabolic mechanisms involved in ovarian aging according to recent ... ...

Abstract	Female infertility and reproduction is an ongoing and rising healthcare issue, resulting in delaying the decision to start a family. Therefore, in this review, we examine potential novel metabolic mechanisms involved in ovarian aging according to recent data and how these mechanisms may be addressed through new potential medical treatments. We examine novel medical treatments currently available based mostly on experimental stem cell procedures as well as caloric restriction (CR), hyperbaric oxygen treatment and mitochondrial transfer. Understanding the connection between metabolic and reproductive pathways has the potential to offer a significant scientific breakthrough in preventing ovarian aging and prolonging female fertility. Overall, the field of ovarian aging is an emerging field that may expand the female fertility window and perhaps even reduce the need for artificial reproductive techniques.
MeSH term(s)	Female ; Humans ; Aging ; Ovary/metabolism ; Reproduction ; Infertility, Female/metabolism ; Reproductive Techniques ; Oocytes/metabolism
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24129828
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

Nicolas C. Nicolaides / Evangelia Charmandari

International Journal of Molecular Sciences, Vol 22, Iss 10839, p

A 2021 Update

2021 Volume 10839

Abstract: Glucocorticoids are the final products of the neuroendocrine hypothalamic–pituitary—adrenal axis, and play an important role in the stress response to re-establish homeostasis when it is threatened, or perceived as threatened. These steroid hormones have ...

Abstract	Glucocorticoids are the final products of the neuroendocrine hypothalamic–pituitary—adrenal axis, and play an important role in the stress response to re-establish homeostasis when it is threatened, or perceived as threatened. These steroid hormones have pleiotropic actions through binding to their cognate receptor, the human glucocorticoid receptor, which functions as a ligand-bound transcription factor inducing or repressing the expression of a large number of target genes. To achieve homeostasis, glucocorticoid signaling should have an optimal effect on all tissues. Indeed, any inappropriate glucocorticoid effect in terms of quantity or quality has been associated with pathologic conditions, which are characterized by short-term or long-lasting detrimental effects. Two such conditions, the primary generalized glucocorticoid resistance and hypersensitivity syndromes, are discussed in this review article. Undoubtedly, the tremendous progress of structural, molecular, and cellular biology, in association with the continued progress of biotechnology, has led to a better and more in-depth understanding of these rare endocrinologic conditions, as well as more effective therapeutic management.
Keywords	glucocorticoid hypersensitivity ; glucocorticoid receptor ; glucocorticoid resistance ; glucocorticoids ; NR3C1 gene mutations ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Do Children and Adolescents with Overweight or Obesity Adhere to the National Food-Based Dietary Guidelines in Greece?

Georgiou, Alexandra / Androutsos, Odysseas / Chouliaras, Giorgos / Charmandari, Evangelia

Children (Basel, Switzerland)

2022 Volume 9, Issue 2

Abstract: Childhood obesity increases the risk for metabolic disorders, but is also related to nutritional deficiencies, such as anemia and hypovitaminosis D. Although children/adolescents with overweight/obesity may have higher energy intake, their diet quality ... ...

Abstract	Childhood obesity increases the risk for metabolic disorders, but is also related to nutritional deficiencies, such as anemia and hypovitaminosis D. Although children/adolescents with overweight/obesity may have higher energy intake, their diet quality and diversity may be low. The present study aimed to evaluate the consumption of foods against the national food-based dietary guidelines in children and adolescents with overweight or obesity in Greece. Sociodemographic, anthropometric and lifestyle data were collected from a sample of 1467 children 2-18 years old (962 obese, 505 overweight, 51.2% females) in 2014-2017. The results of this study show that the consumption of dairy products, fruit, vegetables, legumes and fish by children/adolescents with overweight or obesity was lower than the national recommendations (ranging from a minimum of 39.5% for fish, to a maximum of 75.5% for cereal/potato/rice). Only the consumption of meat/poultry was found to exceed the national recommendation (estimated coverage of 131.3%). Moreover, a large proportion of participants regularly consumed various unhealthy foods/beverages. The present findings indicate that the majority of children/adolescents with overweight/obesity do not comply with the national food-based dietary guidelines in Greece. The implementation of new strategies to promote healthy diets among children/adolescents with overweight/obesity are urgently required.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9020256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between Telomere Length and Pediatric Obesity: A Systematic Review.

Raftopoulou, Christina / Paltoglou, George / Charmandari, Evangelia

Nutrients

2022 Volume 14, Issue 6

Abstract: Objective: Telomere length (TL) is a robust marker of biological aging, and increased telomere attrition is noted in adults with obesity. The primary objective of this systematic review was to summarize current knowledge on the effects of childhood ... ...

Abstract	Objective: Telomere length (TL) is a robust marker of biological aging, and increased telomere attrition is noted in adults with obesity. The primary objective of this systematic review was to summarize current knowledge on the effects of childhood obesity in TL. The secondary objective was to assess the effect of weight management interventions in TL. Methods: The following databases were searched: PubMed, Scopus, Web of Science and Heal-link.gr from inception to September 2021. The search was performed using the following combinations of terms: "telomer" [All Fields] AND ("length" [All Fields] OR "lengths" [All Fields]) AND "obes" [All Fields] AND ("child" [All Fields] OR "adolescen" [All Fields]). Results: A total of 16 original articles were included in this systematic review. Eleven of them were cross-sectional and five were lifestyle interventions. Conclusions: There was a tendency towards a negative association between childhood obesity and TL. Life-style interventions in children have been associated with increased TL peripherally, indicating a possible association of the redistribution of younger cells in the periphery with the favorable effect of these interventions. Further prospective studies with larger sample sizes that employ other markers of cell aging would potentially elucidate this important mechanistic relation.
MeSH term(s)	Adult ; Aging ; Child ; Humans ; Pediatric Obesity ; Prospective Studies ; Telomere ; Telomere Homeostasis
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14061244
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolic Mechanisms and Potential Therapeutic Targets for Prevention of Ovarian Aging

Konstantinos Valtetsiotis / Georgios Valsamakis / Evangelia Charmandari / Nikolaos F. Vlahos

International Journal of Molecular Sciences, Vol 24, Iss 9828, p

Data from Up-to-Date Experimental Studies

2023 Volume 9828

Abstract	Female infertility and reproduction is an ongoing and rising healthcare issue, resulting in delaying the decision to start a family. Therefore, in this review, we examine potential novel metabolic mechanisms involved in ovarian aging according to recent data and how these mechanisms may be addressed through new potential medical treatments. We examine novel medical treatments currently available based mostly on experimental stem cell procedures as well as caloric restriction (CR), hyperbaric oxygen treatment and mitochondrial transfer. Understanding the connection between metabolic and reproductive pathways has the potential to offer a significant scientific breakthrough in preventing ovarian aging and prolonging female fertility. Overall, the field of ovarian aging is an emerging field that may expand the female fertility window and perhaps even reduce the need for artificial reproductive techniques.
Keywords	longevity ; aging ; oocytes ; reproduction ; fertility ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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