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  1. Article ; Online: Yi-Qi-Huo-Xue decoction alleviates intracerebral hemorrhage injury through inhibiting neuronal autophagy of ipsilateral cortex via BDNF/TrkB pathway.

    Han, Dan / Chang, Xinyue / Xu, Dan / Shen, Jizhong / Fan, Ali / Wang, Meihua / Li, Dingran / Chen, Xiangkai / Wang, Cheng / Wu, Yi / Yang, Zhaocong / Li, Jian / Wang, Siliang

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 128, Page(s) 155438

    Abstract: Background: Yi-Qi-Huo-Xue Decoction (YQHXD), a traditional Chinese medicine formula, has ...

    Abstract Background: Yi-Qi-Huo-Xue Decoction (YQHXD), a traditional Chinese medicine formula, has demonstrated efficacy in the clinical treatment of intracerebral hemorrhage (ICH) for over a decade. Nevertheless, the precise pharmacotherapeutic compounds of YQHXD capable of penetrating into cerebral tissue and the pharmacological underpinnings of YQHXD remain ambiguous.
    Methods: The active components of YQHXD in rat brains was analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. The potential targets, pathways and biological progresses of YQHXD ameliorating ICH induced injury was predicted by network pharmacology. Moreover, collagenase-induced ICH rat model, primary cortex neurons exposed to hemin and molecular docking were applied to validate the molecular mechanisms of YQHXD.
    Results: Eleven active components of YQHXD were identified within the brains. Employing the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases, our investigation concentrated on the roles of autophagy and the BDNF/TrkB signaling pathway in the pharmacological context. The pharmacological results revealed that YQHXD alleviated neurological dysfunction, brain water content, brain swelling, and pathological injury caused by ICH. Meanwhile, YQHXD inhibited autophagy influx and autophagosome in vivo, and regulated cortex neuronal autophagy and TrkB/BDNF pathway both in vivo and in vitro. Subsequently, N-acetyl serotonin (NAS), a selective TrkB agonist, was employed to corroborate the significance of the BDNF/TrkB pathway in this process. The combination of NAS and YQHXD did not further enhance the protective efficacy of YQHXD in ICH rats. Additionally, outcomes of molecular docking analysis revealed that nine compounds of YQHXD exhibited potential regulatory effects on TrkB.
    Conclusions: Ipsilateral neuronal autophagy and BDNF/TrkB pathway were activated 72 h after ICH. YQHXD effectively resisted injury induced by ICH, which was related with suppression of ipsilateral neuronal autophagy via BDNF/TrkB pathway. This study provides novel insights into the therapeutic mechanisms of traditional Chinese medicine in the context of ICH treatment.
    MeSH term(s) Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Autophagy/drug effects ; Male ; Rats, Sprague-Dawley ; Neurons/drug effects ; Molecular Docking Simulation ; Rats ; Signal Transduction/drug effects ; Receptor, trkB/metabolism ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Disease Models, Animal ; Neuroprotective Agents/pharmacology
    Chemical Substances Brain-Derived Neurotrophic Factor ; Drugs, Chinese Herbal ; Ntrk2 protein, rat (EC 2.7.10.1) ; Receptor, trkB (EC 2.7.10.1) ; Bdnf protein, rat ; Neuroprotective Agents
    Language English
    Publishing date 2024-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4115: Show issues Location:
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  2. Book: Yi

    Ouyang, Xiu / Xu, Wudang

    ji zhuan

    (Xin wu dai shi : 新五代史 ; / Ouyang Xiu zhuan; Xu Wudang zhu[...])

    1974  

    Series title Xin wu dai shi : 新五代史
    / Ouyang Xiu zhuan; Xu Wudang zhu[...]
    Language Chinese
    Size 11, 20, 346 p
    Edition Di 1 ban
    Publisher Zhonghua shu ju
    Publishing place Beijing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Yi

    Ouyang, Xiu / Xu, Wudang

    ji zhuan

    (Xin wu dai shi : 新五代史 ; / Ouyang Xiu zhuan; Xu Wudang zhu[...])

    1974  

    Series title Xin wu dai shi : 新五代史
    / Ouyang Xiu zhuan; Xu Wudang zhu[...]
    Language Chinese
    Size 11, 20, 346 p
    Edition Di 1 ban
    Publisher Zhonghua shu ju
    Publishing place Beijing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: [Yi Wan She--Huzhou medical association in the late Ming Dynasty].

    Yao, Y F / Xu, X C / Zheng, H

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2022  Volume 52, Issue 2, Page(s) 121–126

    Abstract: Yi Wan She, as a medical association in the Huzhou area, was organised by Lu Mingquan, Lu Shilong ... of local affairs. This was recorded in Yi Wan She Cao and Lu Shi San Shi Yi Yan. ...

    Abstract Yi Wan She, as a medical association in the Huzhou area, was organised by Lu Mingquan, Lu Shilong, Jin Desheng and other doctors in the late Ming Dynasty, developing daily medical theoretical discussions. It built up a hospital named Tian, paid deference to ancient medical doctors, and participated in activities to fight epidemics, organised by Hui Min Pharmacy, such as drug delivery, as an association of local affairs. This was recorded in Yi Wan She Cao and Lu Shi San Shi Yi Yan.
    MeSH term(s) China ; Humans ; Physicians
    Language Chinese
    Publishing date 2022-05-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.cn112155-20211229-00155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4688: Show issues Location:
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  5. Article ; Online: The Tibetan-Yi region is both a corridor and a barrier for human gene flow.

    Zhang, Zhe / Zhang, Yanlin / Wang, Yinan / Zhao, Zicheng / Yang, Melinda / Zhang, Lin / Zhou, Bin / Xu, Bingying / Zhang, Hongbo / Chen, Teng / Dai, Wenkui / Zhou, Yong / Shi, Shuo / Nielsen, Rasmus / Li, Shuai Cheng / Li, Shengbin

    Cell reports

    2022  Volume 39, Issue 4, Page(s) 110720

    Abstract: The Tibetan-Yi Corridor (TYC) region between Tibet and the rest of east Asia has served ...

    Abstract The Tibetan-Yi Corridor (TYC) region between Tibet and the rest of east Asia has served as a crossroads for human migrations for thousands of years. The lack of whole-genome sequencing data specific to the TYC populations has hindered the understanding of the fundamental patterns of migration and divergence between humans in east Asia and southeast Asia. Here, we provide 248 individual whole genomes from the 16 TYC and 3 outgroup populations to elucidate historical relationships. We find that the Tibetan plateau forms an important barrier to gene flow, with a more Tibetan-like ancestry in northern populations and a southern east Asian-related ancestry in south populations. An isolated population, Achang, shows a prolonged isolation and genetic drift compared to other TYC populations. We also note that previous claims regarding the history and structure of TYC populations inferred by linguistics are incompatible with the genetic evidence.
    MeSH term(s) Asians/genetics ; Ethnicity ; Gene Flow ; Genetics, Population ; Humans ; Tibet
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ecological and human health hazards of soil heavy metals after wildfire: A case study of Liangshan Yi autonomous prefecture, China.

    Rao, Lin / Zheng, Chao / Chen, Jian-Bin / Cai, Jun-Zhuo / Yang, Zhan-Biao / Xu, Xiao-Xun / Lv, Guo-Chun / Xu, Chang-Lian / Wang, Gui-Yin / Man, Yu-Bon / Wong, Ming-Hung / Cheng, Zhang

    Chemosphere

    2024  Volume 352, Page(s) 141506

    Abstract: Soil samples were collected in at different depths from the conflagration area in Liangshan Yi ...

    Abstract Soil samples were collected in at different depths from the conflagration area in Liangshan Yi Autonomous Region, China, to investigate the distribution characteristics and ecological and human health risks of heavy metals after a wildfire. The samples collected comprise wildfire ash (WA) above the soil surface, ash soil (AS) 0-5 cm, and plain soil (PS) 5-15 cm below the soil surface. Additionally, reference soil (RS) was collected from a nearby unburned area at the same latitude as the conflagration area. The results showed that the concentrations of zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd) in the WA and AS were significantly higher than in reference soil (RS) (p < 0.05). Concentrations of Pb in the PS were 2.52 times higher than that in RS (17.9 mg kg
    MeSH term(s) Humans ; Soil ; Environmental Monitoring ; Cadmium ; Lead ; Wildfires ; Risk Assessment ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; China ; Neoplasms
    Chemical Substances Soil ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2540: Show issues Location:
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  7. Article ; Online: Correlation between negative life events and suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture.

    Song, Xiaozhen / Zou, Shoukang / Li, Yangling / Chen, Liyu / Feng, Ping / Xu, Peiwei / Zhang, Hang / Deng, Fang / Xu, Hanmei / Tao, Yuanmei / Jin, Meijiang / Ran, Maojia / Zhang, Hong / Ma, Fanghua / Wang, Ying / Yin, Li

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1600

    Abstract: ... exercise, drug therapy and suicide attempts.: Methods: A total of 180 Yi adolescents aged 11-19 years ... that the incidence rate of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture was 13.9%. Negative ... of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture is high and should be considered ...

    Abstract Objective: To investigate the incidence of suicide attempts among adolescents with HIV/AIDS in Liangshan Prefecture, Sichuan Province, as well as the correlation between negative life events, sleep, exercise, drug therapy and suicide attempts.
    Methods: A total of 180 Yi adolescents aged 11-19 years with HIV/AIDS in a county of Liangshan Prefecture, Sichuan Province, China, were investigated by census. The main outcome indicators included the incidence of suicide attempts and whether negative life events, sleep, exercise, drug therapy and other factors were related to suicide attempts.
    Results: We found that the incidence rate of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture was 13.9%. Negative life events were a risk factor for suicide attempts (OR = 1.047, p < 0.001, 95% CI 1.027-1.067). In the factors of negative life events, adaptation was a risk factor for suicide attempts (OR = 1.203, p = 0.026, 95% CI 1.022-1.416), and academic pressure showed a tendency to be a risk factor for suicide attempts (OR = 1.149, p = 0.077, 95% CI 0.985-1.339). However, the punishment factor, interpersonal stress factor and loss factor had no significant correlation with suicide attempts. There was no significant correlation between sleep, exercise, drug therapy and suicide attempts.
    Conclusion: The proportion of suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture is high and should be considered. Negative life events are independent risk factors for suicide attempts, and it is necessary to strengthen the screening and early intervention for suicide attempts in HIV/AIDS adolescents with definite negative life events.
    MeSH term(s) Humans ; Adolescent ; Suicide, Attempted ; Acclimatization ; Acquired Immunodeficiency Syndrome ; Censuses ; China/epidemiology
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-16377-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficacy and safety of Yi Shen Fang granules in elderly people with MCI

    Zhongwei Sha / Zhenghao Zhao / Nana Li / Shuyun Xiao / Ou Li / Jie Zhang / Zhimin Li / Jian Xu

    BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

    study protocol for a multicentre, randomized, double-blind, parallel-group, controlled trial

    2023  Volume 10

    Abstract: ... therefore, early intervention for MCI is important for delaying the occurrence and progression of dementia. Yi Shen Fang (YSF ...

    Abstract Abstract Background Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia. Most MCI patients will progress to dementia within 5 years; therefore, early intervention for MCI is important for delaying the occurrence and progression of dementia. Yi Shen Fang (YSF) granules are a promising traditional Chinese medicine (TCM) treatment that shows great neuroprotective potential against cognitive impairment, as evidenced in clinical and basic studies. This trial aims to systematically evaluate the efficacy and safety of YSF granules in elderly people with MCI. Methods This study is a multicentre, randomized, double-blind, parallel-group, controlled trial. Based on the results of previous clinical trials, 280 elderly patients with MCI will be randomly divided into a treatment group (n = 140) and control group (n = 140). The study will last 33 weeks, including 1 week of screening, 8 weeks of intervention, and 24 weeks of follow-up. The primary outcomes will be the changes in Montreal Cognitive Assessment (MoCA) and Memory and Executive Screening (MES) scores before and after the intervention. The secondary outcome measures will be homocysteine (HCY) levels, Functional Assessment Questionnaire (FAQ) scores and event-related potential (ERP) detection in typical cases. The TCM symptom scale is a combined measure of syndrome differentiation and treatment. During this study, the classifications and characteristics of adverse events, the times of occurrence and disappearance, the measures of treatment, their impact on the primary disease, and outcomes will be reported truthfully. Discussion This study will provide valuable clinical evidence that YSF can help to improve the cognitive function of elderly people with MCI, and the results will be disseminated via conferences and publications. Trial registration Chinese Clinical Trial Registry, ChiCTR2000036807. Registered on August 25, 2020.
    Keywords Traditional Chinese medicine ; Cognitive ; Mild cognitive impairment ; Clinical trial ; Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Change of moraine-dammed glacial lakes and simulation of glacial lake outburst flood in the Yi’ong Zangbo River basin

    Qi Wang / Hongyu Duan / Na Liu / Zhishui Du / Pan Wang / Bo Yi / Jun Xu / Jian Huang / Yuan Zhang / Xiaojun Yao

    Frontiers in Earth Science, Vol

    2022  Volume 10

    Abstract: ... property in downstream areas. In this study, moraine-dammed glacial lakes in the Yi’ong Zangbo River basin ...

    Abstract Glacial lake outburst floods (GLOFs) are a serious potential threat to the safety of life and property in downstream areas. In this study, moraine-dammed glacial lakes in the Yi’ong Zangbo River basin were recognized based on Landsat ETM+/TM/OLI images in 2000 and 2019. Also, GLOFs for the Jionglaco, the largest glacial lake in this basin, were simulated using the one-dimensional hydrodynamic model. The results show that the total number and area of moraine-dammed glacial lakes in this basin increased by 10 (10.52%) and 5.49 km2 (48.24%) from 2000 to 2019, respectively, in which the area of the Jionglaco increased by 3.22 km2. The peak discharge at the breach outlet for five scenarios with different combinations of breach width (80 and 120 m), depth (2.5 and 5 m), and flood time (1.5 and 3 h) are 489 , 1,327.43, 444.32, 617.47, and 1,570.61 m3/s. With the addition of baseflow in the river, the peak discharge at bridge site 15,138.93 km from Jionglaco, is 1,040.89, 1,724.00, 1,024.85, 1,162.25, and 1,990.52 m3/s. The combination of baseflow in river and the GLOF discharge results in an increasing peak discharge in the further downstream region. However, the arrival of peak discharge in downstream areas is delayed, which increases the chances of people escaping.
    Keywords glacial lake ; GLOF ; hydrodynamic modeling ; MIKE 11 ; Qinghai–Tibet Plateau ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Yi-shen-hua-shi granules modulate immune and inflammatory damage via the ALG3/PPARγ/NF-κB pathway in the treatment of immunoglobulin a nephropathy.

    Xu, Rongjia / Zhang, Jiajia / Hu, Xingge / Xu, Penghao / Huang, Shiqi / Cui, Shiyan / Guo, Yuxin / Yang, Hongtao / Chen, Xiangmei / Jiang, Chen

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 2, Page(s) 117204

    Abstract: ... Although supplementary treatment using Yi-Shen-Hua-Shi (YSHS) granules has distinct advantages with respect to improving ...

    Abstract Ethnopharmacological relevance: Controversy persists regarding the treatment of immunoglobulin A nephropathy (IgAN), thereby highlighting the demand for safer more effective therapeutic drugs. Although supplementary treatment using Yi-Shen-Hua-Shi (YSHS) granules has distinct advantages with respect to improving renal function in IgAN, a lack of clarity regarding the underlying mechanisms limits their clinical application.
    Aim of the study: In this study, we aimed to elucidate the therapeutic mechanisms underlying the efficacy of YSHS granules in the treatment of IgAN.
    Materials and methods: A rat model of IgAN was established based on lipopolysaccharide, carbon tetrachloride, and bovine serum albumin induction. In order to evaluate the effects of YSHS granules, we performed a range of techniques, including immunofluorescence assays, hematoxylin and eosin staining, and flow cytometry, to assess inflammation, immunity, and other relevant factors. Direct data-independent acquisition-mass spectrometry (DIA-MS) analysis and parallel reaction monitoring (PRM) were used for functional characterization and quantitative validation of differentially expressed proteins (DEPs), and Western blot analysis is used to identify downstream proteins associated with DEPs.
    Results: Compared with the model group, the levels of proteinuria, urine red blood cells, serum creatinine, blood urea nitrogen, low-density lipoprotein-cholesterol, triglycerides, and pathological kidney damage were reduced in the YSHS group. A high dose of YSHS granules was found to raise the levels of CD8 T cells and reduce the CD4/CD8 ratio in the peripheral serum. To examine the mechanisms underlying the therapeutic effects YSHS granules, we performed direct DIA-MS analysis to identify proteins that were differentially expressed among the model, YSHS, and control groups. A total of 29 proteins were identified as being commonly expressed in all three groups. Further KEGG and protein-protein interaction (PPI) network analysis revealed that YSHS granules can contribute to the regulation of N-glycosylation-associated proteins, such as ALG3 and STT3A, in rats with IgAN. Detected changes in the expression of ALG3 and STT3A were consistent with the PRM results. We also established that the administration of YSHS granules can contribute to regulation of the ALG3-associated PPAR-γ/NF-κB signaling pathway.
    Conclusions: Our findings in this study provide evidence to indicate the efficacy of YSHS granules in the treatment of IgAN, the putative underlying mechanisms of which involve the modulation of N-glycosylation, mediated via the PPAR-γ/NF-κB pathway.
    MeSH term(s) Rats ; Animals ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/pathology ; NF-kappa B/metabolism ; PPAR gamma ; Signal Transduction ; Proteinuria
    Chemical Substances NF-kappa B ; PPAR gamma
    Language English
    Publishing date 2023-09-25
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117204
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