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  1. Article ; Online: [No title information]

    Hillerdal, Gunnar

    Lakartidningen

    2019  Volume 116

    Title translation Intrabronkiella ventiler ger god effekt – hos rätt patient.
    MeSH term(s) Bronchoscopy ; Humans ; Patient Selection ; Pneumonectomy ; Pulmonary Emphysema/surgery
    Language Swedish
    Publishing date 2019-05-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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    Ua VI Zs.411: Show issues Location:
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  2. Article ; Online: Bilateral endoscopic volume reduction in a woman with severe emphysema.

    Hillerdal, Gunnar

    The clinical respiratory journal

    2017  Volume 11, Issue 6, Page(s) 1091–1094

    Abstract: In selected patients with severe heterogenous emphysema lung volume reduction can be performed by using endobronchial valves. So far, only unilateral procedures have been published. Here is described a patient where a right-sided closure of the right ... ...

    Abstract In selected patients with severe heterogenous emphysema lung volume reduction can be performed by using endobronchial valves. So far, only unilateral procedures have been published. Here is described a patient where a right-sided closure of the right upper lobe resulted in an increase of FEV1sec of more than 50%, and some years later the procedure was repeated on the left side with further considerable improvement. A tracheal bronchus to the apical segment of the right upper lobe made measuring the collateral flow at bronchoscopy impossible, but clearly visible fissures were used as a substitute. In conclusion, valve treatment in suitable patients can give substantial improvement in lung function and quality of life and can be repeated on the other side if warranted some years later.
    MeSH term(s) Aged ; Bronchoscopy/methods ; Dyspnea/diagnosis ; Female ; Forced Expiratory Volume/physiology ; Humans ; Lung/diagnostic imaging ; Lung/physiopathology ; Lung/surgery ; Pneumonectomy/instrumentation ; Pneumonectomy/methods ; Pulmonary Atelectasis/diagnostic imaging ; Pulmonary Atelectasis/physiopathology ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/physiopathology ; Pulmonary Emphysema/surgery ; Quality of Life ; Radiography/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.12441
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  3. Article ; Online: Evidens finns för ventilbehandling till patienter med gravt emfysem.

    Hillerdal, Gunnar

    Lakartidningen

    2016  Volume 113

    Title translation There is evidence for valve treatment in patients with severe emphysema.
    MeSH term(s) Evidence-Based Medicine ; Humans ; Prosthesis Implantation ; Pulmonary Emphysema/surgery
    Language Swedish
    Publishing date 2016-02-15
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  4. Article ; Online: Serodiagnosis of Lyme borreliosis-is IgM in serum more harmful than helpful?

    Hillerdal, Henrik / Henningsson, Anna J

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 6, Page(s) 1161–1168

    Abstract: Interpretation of serological findings in suspected Lyme borreliosis (LB) may be challenging and IgM reactivities in serum are often unspecific (false positive). There is a risk for overdiagnosis of LB, inadequate use of antibiotics, and potential delay ... ...

    Abstract Interpretation of serological findings in suspected Lyme borreliosis (LB) may be challenging and IgM reactivities in serum are often unspecific (false positive). There is a risk for overdiagnosis of LB, inadequate use of antibiotics, and potential delay of proper diagnosis. In this study, we evaluated the diagnostic value of IgM analysis in serum and IgM antibody index (AI) in LB diagnosis. This was a retrospective observational study regarding Borrelia-specific antibodies in serum and Borrelia-specific AI in LB investigations being made during 2017 in Jönköping County, Sweden. Medical records of 610 patients with detectable anti-Borrelia antibodies in serum (IgM and/or IgG) and 15 patients with elevated Borrelia-specific AI were retrospectively scrutinized, and the compliance to current European recommendations was assessed. Among the 610 patients, only 30% were tested according to the European recommendations. Within this group of tests taken correctly, 50% of the LB diagnoses in patients with isolated IgM reactivity in serum were retrospectively assessed as incorrect (LB unlikely). Three pediatric patients with clinical and laboratory findings suggestive of Lyme neuroborreliosis (LNB) had elevated IgM AI alone. Serological testing without distinct clinical signs/symptoms consistent with LB contributes to most misdiagnoses. Isolated IgM positivity in serum shows limited clinical value and needs further assessment before being reported by the laboratory. Detection of IgM in combination with IgG antibodies in serum shows no clinical enhancement for correct LB diagnosis compared to isolated IgG positivity. However, Borrelia-specific IgM AI may be important for sensitivity in early LNB.
    MeSH term(s) Antibodies, Bacterial/blood ; Borrelia/classification ; Borrelia/genetics ; Borrelia/immunology ; Borrelia/isolation & purification ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Lyme Disease/blood ; Lyme Disease/diagnosis ; Lyme Disease/microbiology ; Retrospective Studies ; Serologic Tests ; Sweden
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2021-01-07
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-020-04093-2
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    Zs.A 1732: Show issues Location:
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  5. Article: Intrabronchial stents in heterogenous emphysema: a highly selected material followed 5 years.

    Hillerdal, Gunnar / Koyi, Hirsh

    Journal of thoracic disease

    2020  Volume 12, Issue 7, Page(s) 3524–3528

    Abstract: Background: Endobronchial lung volume reduction (EBVR) with one-way valves introduced into the most diseased lobe of the lung is a non-invasive method to improve lung function in patients with severe heterogenous emphysema. The problem is to select the ... ...

    Abstract Background: Endobronchial lung volume reduction (EBVR) with one-way valves introduced into the most diseased lobe of the lung is a non-invasive method to improve lung function in patients with severe heterogenous emphysema. The problem is to select the right patients for the procedure. Furthermore, the long-term effects have not been reported in most studies.
    Methods: EBVR was performed in 35 patients with severely handicapping emphysema and with one radiologically clearly enlarged (at least 125%) target lung lobe and clearly visible and complete interlobar fissures on CT. Most of the successful survivors have then been followed for five years.
    Results: Five (14%) were primary failures (defined as less than 15% increase of FEV
    Conclusions: With careful selection of patients remarkably good results in lung function can be achieved, and these improvements will last for years though slowly decrease. In addition, the results indicate an improvement in survival with successful EBVR procedure.
    Language English
    Publishing date 2020-07-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-19-4082
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  6. Article ; Online: Mesothelin and osteopontin.

    Hillerdal, Gunnar

    The European respiratory journal

    2013  Volume 42, Issue 2, Page(s) 557

    MeSH term(s) Biomarkers, Tumor/metabolism ; GPI-Linked Proteins/metabolism ; Humans ; Mesothelioma/diagnosis ; Osteopontin/metabolism ; Pleural Neoplasms/metabolism
    Chemical Substances Biomarkers, Tumor ; GPI-Linked Proteins ; Osteopontin (106441-73-0)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00052213
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  7. Article ; Online: Mesothelioma in immigrants from Turkey: Genes have a minor role.

    Metintas, Selma / Metintas, Muzaffer / Ak, Guntulu / Hillerdal, Gunnar / Koyi, Hirsh

    Respiratory medicine

    2021  Volume 186, Page(s) 106527

    Abstract: Objective: To examine the incidence and epidemiology of malignant mesothelioma in immigrants from Karain where there is an extraordinarily high incidence of mesothelioma, Cappadocia, Turkey, to Stockholm, Sweden, and their children over 20 years of age ... ...

    Abstract Objective: To examine the incidence and epidemiology of malignant mesothelioma in immigrants from Karain where there is an extraordinarily high incidence of mesothelioma, Cappadocia, Turkey, to Stockholm, Sweden, and their children over 20 years of age born in Stockholm, i.e. two genetically similar populations with and without erionite exposure.
    Methods: This survey was conducted as a retrospective cohort study. Standardized average annual mesothelioma incidence rates (AAMIRs) and mesothelioma standardized incidence ratio (mSIR) were calculated. Cox regression analysis was used to determine the importance of different factors related to mesothelioma risk.
    Results: The cohort consisted of 337 people, 203 of whom were born and/or lived in Karain before immigrating to Sweden (erionite-exposed), and 134 who were born in Stockholm (erionite-unexposed). There were 69 deaths, 42 (61%) due to mesothelioma, and two patients with the disease who were still alive. Of these 44 patients, 22 were men. All mesothelioma patients were in the erionite-exposed group. In the age group 30-49 years, mesothelioma developed in 11 of 38 (29%) with erionite exposure, while there were no cases among 86 persons in the non-exposed group. For men, the AAMIR was 253.9 per 100,000 persons in the whole cohort, and for women, it was 350.9. The mSIR was 71.9 for men and 393.1 for women. Exposure to erionite exceeding 20 years and age over 40 years were associated with increased mesothelioma risk.
    Conclusion: Exposure to erionite is the leading cause of mesothelioma in Karain villagers, and genetic factors are probably of minor importance.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Emigrants and Immigrants/statistics & numerical data ; Environmental Exposure/adverse effects ; Female ; Gene-Environment Interaction ; Humans ; Incidence ; Male ; Mesothelioma/epidemiology ; Mesothelioma/etiology ; Mesothelioma/genetics ; Middle Aged ; Retrospective Studies ; Sex Factors ; Sweden/epidemiology ; Turkey/epidemiology ; Young Adult ; Zeolites/adverse effects
    Chemical Substances erionite (12510-42-8) ; Zeolites (1318-02-1)
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2021.106527
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    Ui III Zs.19: Show issues Location:
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  8. Article: Antibiotikaresistenta bakterier och feminiserade fiskar. Läkare som miljömarodörer.

    Hillerdal, Gunnar

    Lakartidningen

    2010  Volume 107, Issue 39, Page(s) 2301

    Title translation Antibiotic-resistant bacteria and feminized fishes. Physicians as environmental marauders.
    MeSH term(s) Animals ; Drug Industry ; Drug Prescriptions ; Drug Resistance, Multiple, Bacterial ; Feminization/chemically induced ; Fishes ; Humans ; Male ; Practice Patterns, Physicians' ; Water Pollutants, Chemical/adverse effects
    Chemical Substances Water Pollutants, Chemical
    Language Swedish
    Publishing date 2010-09
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  9. Article ; Online: Torakal aktinomykos – allvarlig sjukdom och en diagnostisk svår utmaning - Men med rätt behandling är prognosen god.

    Palm, Andreas / Isaksson, Johan / Brandén, Eva / Hillerdal, Gunnar

    Lakartidningen

    2019  Volume 116

    Abstract: Actinomycotic infection of the chest structures is rare but can be serious. Diagnosis is difficult, since both culture of the bacterium and pathological investigation require special methods. Investigations therefore usually take many months before the ... ...

    Title translation Thoracal actinomycosis - a diagnostic challenge.
    Abstract Actinomycotic infection of the chest structures is rare but can be serious. Diagnosis is difficult, since both culture of the bacterium and pathological investigation require special methods. Investigations therefore usually take many months before the correct treatment can be started. The most common differential diagnosis is a chest malignancy. Treatment is long-term antibiotics. We here present three cases which illustrate the clinical and radiological findings and the diagnostic difficulties.
    MeSH term(s) Actinomyces/isolation & purification ; Actinomycosis/diagnosis ; Actinomycosis/diagnostic imaging ; Actinomycosis/drug therapy ; Actinomycosis/pathology ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Radiography ; Tomography, X-Ray Computed
    Chemical Substances Anti-Bacterial Agents
    Language Swedish
    Publishing date 2019-12-03
    Publishing country Sweden
    Document type Case Reports
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  10. Book ; Thesis: PLEURAL PLAQUE

    Hillerdal, Gunnar

    OCCURRENCE, EXPOSURE TO ASBESTOS, AND CLINICAL IMPORTANCE

    (ABSTRACTS OF UPPSALA DISSERTATIONS FROM THE FACULTY OF MEDICINE ; 363 ; ACTA UNIVERSITATIS UPSALIENSIS)

    1980  

    Title variant PLEURAL PLAQUES
    Series title ABSTRACTS OF UPPSALA DISSERTATIONS FROM THE FACULTY OF MEDICINE ; 363
    ACTA UNIVERSITATIS UPSALIENSIS
    Acta Universitatis Upsaliensis
    Collection Acta Universitatis Upsaliensis
    Size 227 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis UPPSALA, UNIV., DISS., 1980
    HBZ-ID HT002265243
    ISBN 91-554-1039-1 ; 978-91-554-1039-1
    Database Catalogue ZB MED Medicine, Health

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    84 E 1570 order for loan Magazin

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