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  1. Article ; Online: Cibler la protéase majeure du SARS-CoV-2 pour fabriquer un médicament efficace contre ce coronavirus.

    Ladoux, Annie / Azoulay, Stéphane / Dani, Christian

    Medecine sciences : M/S

    2020  Volume 36, Issue 6-7, Page(s) 555–558

    Title translation SARS-CoV-2 protease: an excellent target to develop drugs against COVID-19.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/enzymology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; HIV Protease Inhibitors/therapeutic use ; Humans ; Pandemics/prevention & control ; Peptide Hydrolases/physiology ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Protease Inhibitors/therapeutic use ; SARS-CoV-2 ; Virus Replication
    Chemical Substances Antiviral Agents ; HIV Protease Inhibitors ; Protease Inhibitors ; Peptide Hydrolases (EC 3.4.-)
    Keywords covid19
    Language French
    Publishing date 2020-06-19
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Identification of Human Breast Adipose Tissue Progenitors Displaying Distinct Differentiation Potentials and Interactions with Cancer Cells.

    Peraldi, Pascal / Loubat, Agnès / Chignon-Sicard, Bérengère / Dani, Christian / Ladoux, Annie

    Biomedicines

    2022  Volume 10, Issue 8

    Abstract: Breast adipose tissue (AT) participates in the physiological evolution and remodeling of the mammary gland due to its high plasticity. It is also a favorable microenvironment for breast cancer progression. However, information on the properties of human ... ...

    Abstract Breast adipose tissue (AT) participates in the physiological evolution and remodeling of the mammary gland due to its high plasticity. It is also a favorable microenvironment for breast cancer progression. However, information on the properties of human breast adipose progenitor cells (APCs) involved in breast physiology or pathology is scant. We performed differential enzymatic dissociation of human breast AT lobules. We isolated and characterized two populations of APCs. Here we report that these distinct breast APC populations selectively expressed markers suitable for characterization. The population preferentially expressing
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications.

    Ladoux, Annie / Peraldi, Pascal / Chignon-Sicard, Bérengère / Dani, Christian

    Biomedicines

    2021  Volume 9, Issue 1

    Abstract: Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it must adapt to the metabolic demand and constraints. It exhibits ... ...

    Abstract Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it must adapt to the metabolic demand and constraints. It exhibits also endocrine functions important to regulate energy homeostasis. This complex organ is composed of depots able to produce opposite functions to monitor energy: the so called white adipose tissue acts to store energy as triglycerides preventing ectopic fat deposition while the brown adipose depots dissipate it. It is composed of many cell types. Different types of adipocytes constitute the mature cells specialized to store or burn energy. Immature adipose progenitors (AP) presenting stem cells properties contribute not only to the maintenance but also to the expansion of this tissue as observed in overweight or obese individuals. They display a high regeneration potential offering a great interest for cell therapy. In this review, we will depict the attributes of the distinct types of adipocytes and their contribution to the function and metabolic features of adipose tissue. We will examine the specific role and properties of distinct depots according to their location. We will consider their cellular heterogeneity to present an updated picture of this sophisticated tissue. We will also introduce new trends pointing out a rational targeting of adipose tissue for medical applications.
    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9010040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues

    Annie Ladoux / Pascal Peraldi / Bérengère Chignon-Sicard / Christian Dani

    Biomedicines, Vol 9, Iss 40, p

    From Their Origins to Their Relevance for Medical Applications

    2021  Volume 40

    Abstract: Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it must adapt to the metabolic demand and constraints. It exhibits ... ...

    Abstract Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it must adapt to the metabolic demand and constraints. It exhibits also endocrine functions important to regulate energy homeostasis. This complex organ is composed of depots able to produce opposite functions to monitor energy: the so called white adipose tissue acts to store energy as triglycerides preventing ectopic fat deposition while the brown adipose depots dissipate it. It is composed of many cell types. Different types of adipocytes constitute the mature cells specialized to store or burn energy. Immature adipose progenitors (AP) presenting stem cells properties contribute not only to the maintenance but also to the expansion of this tissue as observed in overweight or obese individuals. They display a high regeneration potential offering a great interest for cell therapy. In this review, we will depict the attributes of the distinct types of adipocytes and their contribution to the function and metabolic features of adipose tissue. We will examine the specific role and properties of distinct depots according to their location. We will consider their cellular heterogeneity to present an updated picture of this sophisticated tissue. We will also introduce new trends pointing out a rational targeting of adipose tissue for medical applications.
    Keywords adipocytes ; adipose progenitors ; white adipose tissue ; brown/beige adipose tissue ; breast adipose tissue ; epicardial adipose tissue ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro.

    Peraldi, Pascal / Ladoux, Annie / Giorgetti-Peraldi, Sophie / Dani, Christian

    Cells

    2020  Volume 9, Issue 10

    Abstract: Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs). We, and others, have shown that the primary cilium, an antenna-shaped ... ...

    Abstract Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs). We, and others, have shown that the primary cilium, an antenna-shaped organelle, controls several aspects of APs' biology. We studied the conversion of human APs into CAFs by breast cancer cell lines (BCCs). Deletion of the cilium of APs by a pharmacological inhibitor, or by siRNA, allow us to demonstrate that the cilium is necessary for the differentiation of APs into CAFs. BCCs increase production of TGF-β1 by APs, which is a known inducer of CAFs. Pharmacological inhibition of TGF-β1 signaling in APs prevents their conversion into CAFs. Since we previously showed that deletion of the APs' cilium inhibits TGF-β1 signaling, we propose that BCCs induce TGF-β1 production in Aps, which binds to the primary cilium of Aps and leads to their differentiation into CAFs. Inhibition of APs conversion into CAFs induces a loss in some of the biological effects of CAFs since deletion of the cilium of APs decreases their effect on the migration of BCCs. This is the first observation of a function of the cilium of APs in their conversion into CAFs, and its consequences on BCCs.
    MeSH term(s) Adipose Tissue/metabolism ; Breast Neoplasms/metabolism ; Cancer-Associated Fibroblasts/metabolism ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/physiology ; Cell Proliferation/drug effects ; Cilia/metabolism ; Cilia/physiology ; Fibroblasts/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MCF-7 Cells ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/physiology ; Signal Transduction/drug effects ; Stem Cells/metabolism ; Stem Cells/physiology ; Transforming Growth Factor beta1/genetics ; Tumor Microenvironment/physiology
    Chemical Substances TGFB1 protein, human ; Transforming Growth Factor beta1
    Language English
    Publishing date 2020-10-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9102251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cibler la protéase majeure du SARS-CoV-2 pour fabriquer un médicament efficace contre ce coronavirus

    Ladoux, Annie / Azoulay, Stéphane / Dani, Christian

    ISSN: 0767-0974 ; EISSN: 1958-5381 ; médecine/sciences ; https://hal.archives-ouvertes.fr/hal-02903995 ; médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.555-558. ⟨10.1051/medsci/2020106⟩

    2020  

    Abstract: International audience ... No abstract ... ...

    Abstract International audience

    No abstract available
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Cibler la protéase majeure du SARS-CoV-2 pour fabriquer un médicament efficace contre ce coronavirus

    Ladoux, Annie / Azoulay, Stéphane / Dani, Christian

    ISSN: 0767-0974 ; EISSN: 1958-5381 ; médecine/sciences ; https://hal.archives-ouvertes.fr/hal-02903995 ; médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.555-558. ⟨10.1051/medsci/2020106⟩

    2020  

    Abstract: International audience ... No abstract ... ...

    Abstract International audience

    No abstract available
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Cibler la protéase majeure du SARS-CoV-2 pour fabriquer un médicament efficace contre ce coronavirus

    Ladoux, Annie / Azoulay, Stéphane / Dani, Christian

    ISSN: 0767-0974 ; EISSN: 1958-5381 ; médecine/sciences ; https://hal.archives-ouvertes.fr/hal-02903995 ; médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.555-558. ⟨10.1051/medsci/2020106⟩

    2020  

    Abstract: International audience ... No abstract ... ...

    Abstract International audience

    No abstract available
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Cibler la protéase majeure du SARS-CoV-2 pour fabriquer un médicament efficace contre ce coronavirus

    Ladoux, Annie / Azoulay, Stéphane / Dani, Christian

    ISSN: 0767-0974 ; EISSN: 1958-5381 ; médecine/sciences ; https://hal.archives-ouvertes.fr/hal-02903995 ; médecine/sciences, EDP Sciences, 2020, 36 (6-7), pp.555-558. ⟨10.1051/medsci/2020106⟩

    2020  

    Abstract: International audience ... No abstract ... ...

    Abstract International audience

    No abstract available
    Keywords [SDV]Life Sciences [q-bio] ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro

    Pascal Peraldi / Annie Ladoux / Sophie Giorgetti-Peraldi / Christian Dani

    Cells, Vol 9, Iss 2251, p

    2020  Volume 2251

    Abstract: Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs). We, and others, have shown that the primary cilium, an antenna-shaped ... ...

    Abstract Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs). We, and others, have shown that the primary cilium, an antenna-shaped organelle, controls several aspects of APs’ biology. We studied the conversion of human APs into CAFs by breast cancer cell lines (BCCs). Deletion of the cilium of APs by a pharmacological inhibitor, or by siRNA, allow us to demonstrate that the cilium is necessary for the differentiation of APs into CAFs. BCCs increase production of TGF-β1 by APs, which is a known inducer of CAFs. Pharmacological inhibition of TGF-β1 signaling in APs prevents their conversion into CAFs. Since we previously showed that deletion of the APs’ cilium inhibits TGF-β1 signaling, we propose that BCCs induce TGF-β1 production in Aps, which binds to the primary cilium of Aps and leads to their differentiation into CAFs. Inhibition of APs conversion into CAFs induces a loss in some of the biological effects of CAFs since deletion of the cilium of APs decreases their effect on the migration of BCCs. This is the first observation of a function of the cilium of APs in their conversion into CAFs, and its consequences on BCCs.
    Keywords adipose progenitor ; primary cilium ; cancer associated fibroblasts ; breast cancer cells ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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