LIVIVO - Search results -

Search results

Result 1 - 10 of total 13476

Search options

Article ; Online: Nano-metal diborides-supported anode catalyst with strongly coupled TaO

Wang, Yuannan / Zhang, Mingcheng / Kang, Zhenye / Shi, Lei / Shen, Yucheng / Tian, Boyuan / Zou, Yongcun / Chen, Hui / Zou, Xiaoxin

Nature communications

2023 Volume 14, Issue 1, Page(s) 5119

Abstract: The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE). Herein, we demonstrate high-surface-area nano- ... ...

Abstract	The sluggish kinetics of oxygen evolution reaction (OER) and high iridium loading in catalyst coated membrane (CCM) are the key challenges for practical proton exchange membrane water electrolyzer (PEMWE). Herein, we demonstrate high-surface-area nano-metal diborides as promising supports of iridium-based OER nanocatalysts for realizing efficient, low-iridium-loading PEMWE. Nano-metal diborides are prepared by a novel disulphide-to-diboride transition route, in which the entropy contribution to the Gibbs free energy by generation of gaseous sulfur-containing products plays a crucial role. The nano-metal diborides, TaB
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40912-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis.

Yang, Yinan / Zhou, Huijing / Huang, Xiawei / Wu, Chengfang / Zheng, Kewei / Deng, Jingrong / Zheng, Yonggang / Wang, Jiahui / Chi, Xiaofeng / Ma, Xianjue / Pan, Huimin / Shen, Rui / Pan, Duojia / Liu, Bo

Nature communications

2024 Volume 15, Issue 1, Page(s) 145

Abstract: ... signaling. Suppression of STRIPAK results in the activation of Hippo pathway through Tao-Hpo signaling ...

Abstract	The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully understood. Here, we identify a conserved signaling cascade that leads to Hippo pathway activation by innate immune/inflammatory signals. We show that Tak1, a key kinase in innate immune/inflammatory signaling, activates the Hippo pathway by inducing the lysosomal degradation of Cka, an essential subunit of the STRIPAK PP2A complex that suppresses Hippo signaling. Suppression of STRIPAK results in the activation of Hippo pathway through Tao-Hpo signaling. We further show that Tak1-mediated Hippo signaling is involved in processes ranging from cell death to phagocytosis and innate immune memory. Our findings thus reveal a molecular connection between innate immune/inflammatory signaling and the evolutionally conserved Hippo pathway, thus contributing to our understanding of infectious, inflammatory and malignant diseases.
MeSH term(s)	Protein Serine-Threonine Kinases/metabolism ; Hippo Signaling Pathway ; Signal Transduction ; Immunity, Innate
Chemical Substances	Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44542-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Yinan Yang / Huijing Zhou / Xiawei Huang / Chengfang Wu / Kewei Zheng / Jingrong Deng / Yonggang Zheng / Jiahui Wang / Xiaofeng Chi / Xianjue Ma / Huimin Pan / Rui Shen / Duojia Pan / Bo Liu

Nature Communications, Vol 15, Iss 1, Pp 1-

2024 Volume 17

Abstract: ... Hippo signaling. Suppression of STRIPAK results in the activation of Hippo pathway through Tao-Hpo ...

Abstract	Abstract The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully understood. Here, we identify a conserved signaling cascade that leads to Hippo pathway activation by innate immune/inflammatory signals. We show that Tak1, a key kinase in innate immune/inflammatory signaling, activates the Hippo pathway by inducing the lysosomal degradation of Cka, an essential subunit of the STRIPAK PP2A complex that suppresses Hippo signaling. Suppression of STRIPAK results in the activation of Hippo pathway through Tao-Hpo signaling. We further show that Tak1-mediated Hippo signaling is involved in processes ranging from cell death to phagocytosis and innate immune memory. Our findings thus reveal a molecular connection between innate immune/inflammatory signaling and the evolutionally conserved Hippo pathway, thus contributing to our understanding of infectious, inflammatory and malignant diseases.
Keywords	Science ; Q
Subject code	570
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Boosting performance of Co-free Li-rich cathode material through regulating the anionic activity by means of the strong TaO bonding.

Wu, Chao / Li, Heng / Cao, Shuang / Li, Zhi / Zeng, Peng / Chen, Jiarui / Zhu, Xitong / Guo, Xiaowei / Chen, Gairong / Chang, Baobao / Shen, Yongqiang / Wang, Xianyou

Journal of colloid and interface science

2022 Volume 628, Issue Pt B, Page(s) 1031–1040

Abstract: Benefiting from the extra contribution of O redox, Co-free Li-rich layered oxides (LRNMO) can satisfy the requirement of high specific capacities. However, during the high-voltage charging process, lattice oxygen being oxidized to ... ...

Abstract	Benefiting from the extra contribution of O redox, Co-free Li-rich layered oxides (LRNMO) can satisfy the requirement of high specific capacities. However, during the high-voltage charging process, lattice oxygen being oxidized to O
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2022.08.135
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 71/707: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders.

Zhang, Xiaoping / Li, Zeng / Shen, Chuanpu / He, Jinzhi / Wang, Longfei / Di, Lei / Rui, Bin / Li, Ning / Liu, Zhicheng

Pharmaceutical biology

2022 Volume 60, Issue 1, Page(s) 1739–1750

Abstract: Context: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used ...

Abstract	Context: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD). Objective: To explore the effective targets of TSD on DD animal models. Materials and methods: Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC-MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed. Results: Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED Discussion and conclusions: TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Arginase/metabolism ; Arginase/pharmacology ; Brain Ischemia ; Brain-Derived Neurotrophic Factor/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Depression/drug therapy ; Depression/metabolism ; Drugs, Chinese Herbal ; Hippocampus ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological/drug therapy ; Stress, Psychological/metabolism ; Stroke
Chemical Substances	Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Cyclic AMP Response Element-Binding Protein ; Drugs, Chinese Herbal ; si-wu decoction ; Arginase (EC 3.5.3.1)
Language	English
Publishing date	2022-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2116460
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1300: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders

Xiaoping Zhang / Zeng Li / Chuanpu Shen / Jinzhi He / Longfei Wang / Lei Di / Bin Rui / Ning Li / Zhicheng Liu

Pharmaceutical Biology, Vol 60, Iss 1, Pp 1739-

2022 Volume 1750

Abstract: Context The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ...

Abstract	Context The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD).Objective To explore the effective targets of TSD on DD animal models.Materials and methods Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC–MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed.Results Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED50=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention.Discussion and conclusions TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
Keywords	Metabolomics ; GC–MS ; traditional Chinese medicine ; depressive disorder ; Therapeutics. Pharmacology ; RM1-950
Subject code	150
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders

Zhang, Xiaoping / Li, Zeng / Shen, Chuanpu / He, Jinzhi / Wang, Longfei / Di, Lei / Rui, Bin / Li, Ning / Liu, Zhicheng

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1739-1750

2022

Abstract: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ...

Abstract	The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD). To explore the effective targets of TSD on DD animal models. Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC–MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed. Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED₅₀=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention. TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
Keywords	Oriental traditional medicine ; animals ; antidepressants ; arginase ; blood serum ; body weight ; fluoxetine ; gas chromatography ; mass spectrometry ; mental depression ; metabolites ; metabolomics ; ornithine ; serotonin ; stroke ; urea ; GC–MS ; traditional Chinese medicine ; depressive disorder
Language	English
Dates of publication	2022-1231
Size	p. 1739-1750.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2116460
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.B 1300: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tao, Virtue, Benevolence, Righteousness and Propriety:On the Core Values of Shu School

Shu Dagang / Shen Shengchao

Contemporary Social Sciences (2017)

2017

Abstract: ... inherited the tradition of adhering to the Tao(natural order of the Universe) and valuing morality. Shu ... scholars have creatively built the core values of "the Tao, virtue, benevolence, righteousness and ...

Abstract	The core concepts of Confucianism were developed over the change of the times by Confucian scholars after Zi Si and Mencius, and have formed their respective structures: The three great principles of "benevolence, wisdom and bravery," and the self-cultivation model of "benevolence, righteousness and propriety" by Confucius. Following Confucius, Zi Si vigorously advocated the five virtues of "benevolence, righteousness, propriety, wisdom and sage."Mencius initiated the four cardinal virtues of "benevolence, righteousness, propriety and wisdom."Xun Zi often constructed the collocation of "benevolence and righteousness, rites and music, and loyalty and trustworthiness."Dong Zhongshu finally developed the five constant virtues of "benevolence, righteousness, propriety, wisdom, and trustworthiness."In a simple, clear, practical and feasible way, the core values of Confucianism have won support among the people and have had an impact on Chinese society for more than two thousand years. Being open and inclusive, the connotation of Confucianism took advantage of the strengths of different schools of philosophy in ancient China, and adopted changes from philosophies with positive attitudes. The Bashu area, in the southwest of China, has inherited the tradition of adhering to the Tao(natural order of the Universe) and valuing morality. Shu scholars have creatively built the core values of "the Tao, virtue, benevolence, righteousness and propriety," and developed a characteristic branch of philosophy above and beyond the Confucian scholars of the Central Plains. This concept stems from Yan Junping of the Western Han Dynasty, promoted by Yang Xiong, developed by Zhao Rui of the Tang Dynasty, Zhang Shangying and Su Dongpo of the Song Dynasty, and Lai Zhide of the Ming Dynasty, then further developed by Liu Yuan and Duan Zhengyuan of the Qing Dynasty, and formed the persistent system of core values of the Shu School. Compared with the values of orthodox Confucianism, the core values of the Shu School have the functions of"a ...
Keywords	shu school ; core values ; five conducts ; five virtues ; tao ; virtue ; benevolence ; righteousness and propriety ; Social Sciences ; H
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	Editorial Department of Contemporary Social Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation.

Lin, Wei / Wang, Ying / Lin, Sisi / Li, Cuixian / Zhou, Chun / Wang, Shaogui / Huang, Heqing / Liu, Peiqing / Ye, Guan / Shen, Xiaoyan

European journal of medicinal chemistry

2012 Volume 47, Issue 1, Page(s) 214–220

Abstract: Sixteen carbazole alkaloids from Clausena vestita D. D. Tao were extracted, and their anti-tumor ...

Abstract	Sixteen carbazole alkaloids from Clausena vestita D. D. Tao were extracted, and their anti-tumor activities were evaluated. Among the extracts, Clauszoline-I exhibited an obvious growth inhibitory activity against several cancer cell lines through its ability to induce cell cycle arrest in the S and G2/M phases. A dramatic morphologic change with decreased F-actin staining and RhoA activity was found in Clauszoline-I treated HepG2 cells, in which the phosphorylation of PKCδ (Ser643) was inhibited. Our results indicated that induction cell cycle arrest by Clauszoline-I might be achieved by decreasing the RhoA activity via the inhibition of PKCδ phosphorylation.
MeSH term(s)	Alkaloids/chemistry ; Alkaloids/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carbazoles/chemistry ; Carbazoles/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Clausena/chemistry ; Hep G2 Cells ; Humans ; Phosphorylation/drug effects ; Protein Kinase C-delta/chemistry ; Protein Kinase C-delta/metabolism ; Serine/metabolism ; rhoA GTP-Binding Protein/metabolism
Chemical Substances	Alkaloids ; Antineoplastic Agents ; Carbazoles ; clauszoline-I ; Serine (452VLY9402) ; Protein Kinase C-delta (EC 2.7.11.13) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2012-01
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2011.10.047
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Tao hua wu nian hua zhi lü

Shen, Hong

xun zhao shi qu de nian hua

(Huigui chuantong ganshou gudian ; 回归传统感受古典)

2007

Author's details	Shen Hong
Series title	Huigui chuantong ganshou gudian 回归传统感受古典
Language	Chinese
Size	4, 233 p, Ill
Edition	Di 1 ban
Publisher	Jilin renmin chubanshe
Publishing place	Changchun
Document type	Book
ISBN	9787206051944 ; 7206051944
Database	Former special subject collection: coastal and deep sea fishing

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED