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Article ; Online: Editorial: "Peptides in biomaterials science: New trends and applications".

Mas-Moruno, Carlos

Journal of peptide science : an official publication of the European Peptide Society

2021 Volume 28, Issue 1, Page(s) e3379

Language	English
Publishing date	2021-11-10
Publishing country	England
Document type	Editorial
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/psc.3379
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Article ; Online: New trends in the development of multifunctional peptides to functionalize biomaterials.

Oliver-Cervelló, Lluís / Martin-Gómez, Helena / Mas-Moruno, Carlos

Journal of peptide science : an official publication of the European Peptide Society

2021 Volume 28, Issue 1, Page(s) e3335

Abstract: Improving cell-material interactions is a major goal in tissue engineering. In this regard, functionalization of biomaterials with cell instructive molecules from the extracellular matrix stands out as a powerful strategy to enhance their bioactivity and ...

Abstract	Improving cell-material interactions is a major goal in tissue engineering. In this regard, functionalization of biomaterials with cell instructive molecules from the extracellular matrix stands out as a powerful strategy to enhance their bioactivity and achieve optimal tissue integration. However, current functionalization strategies, like the use of native full-length proteins, are associated with drawbacks, thus urging the need of developing new methodologies. In this regard, the use of synthetic peptides encompassing specific bioactive regions of proteins represents a promising alternative. In particular, the combination of peptide sequences with complementary or synergistic effects makes it possible to address more than one biological target at the biomaterial surface. In this review, an overview of the main strategies using peptides to install multifunctionality on biomaterials is presented, mostly focusing on the combination of the RGD motif with other peptides sequences. The evolution of these approaches, starting from simple methods, like using peptide mixtures, to more advanced systems of peptide presentation, with very well defined chemical properties, are explained. For each system of peptide's presentation, three main aspects of multifunctionality-improving receptor selectivity, mimicking the extracellular matrix and preventing bacterial colonization while improving cell adhesion-are highlighted.
MeSH term(s)	Biocompatible Materials ; Cell Adhesion ; Peptides
Chemical Substances	Biocompatible Materials ; Peptides
Language	English
Publishing date	2021-05-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/psc.3335
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Article ; Online: Functionalization of 3D printed polymeric bioresorbable stents with a dual cell-adhesive peptidic platform combining RGDS and YIGSR sequences.

Chausse, Victor / Mas-Moruno, Carlos / Martin-Gómez, Helena / Pino, Marc / Díaz-Ricart, Maribel / Escolar, Ginés / Ginebra, Maria-Pau / Pegueroles, Marta

Biomaterials science

2023 Volume 11, Issue 13, Page(s) 4602–4615

Abstract: Biomimetic surface modification with cell-adhesive peptides is a promising approach to improve endothelialization of current bioresorbable stents (BRS). Among them, RGDS and YIGSR sequences have been reported to mediate adhesion and migration of ... ...

Abstract	Biomimetic surface modification with cell-adhesive peptides is a promising approach to improve endothelialization of current bioresorbable stents (BRS). Among them, RGDS and YIGSR sequences have been reported to mediate adhesion and migration of endothelial cells (ECs) while preventing platelet activation. This work presents the functionalization of novel 3D-printed poly-L-lactic acid (PLLA) and poly(L-lactic-
MeSH term(s)	Endothelial Cells ; Absorbable Implants ; Peptides/chemistry ; Stents ; Polymers/chemistry ; Cell Adhesion ; Printing, Three-Dimensional
Chemical Substances	tyrosyl-isoleucyl-glycyl-seryl-arginine (110590-64-2) ; Peptides ; Polymers
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00458a
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Article: Protease-degradable hydrogels with multifunctional biomimetic peptides for bone tissue engineering.

Oliver-Cervelló, Lluís / Martin-Gómez, Helena / Gonzalez-Garcia, Cristina / Salmeron-Sanchez, Manuel / Ginebra, Maria-Pau / Mas-Moruno, Carlos

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1192436

Abstract: Mimicking bone extracellular matrix (ECM) is paramount to develop novel biomaterials for bone tissue engineering. In this regard, the combination of integrin-binding ligands together with osteogenic peptides represents a powerful approach to recapitulate ...

Abstract	Mimicking bone extracellular matrix (ECM) is paramount to develop novel biomaterials for bone tissue engineering. In this regard, the combination of integrin-binding ligands together with osteogenic peptides represents a powerful approach to recapitulate the healing microenvironment of bone. In the present work, we designed polyethylene glycol (PEG)-based hydrogels functionalized with cell instructive multifunctional biomimetic peptides (either with cyclic RGD-DWIVA or cyclic RGD-cyclic DWIVA) and cross-linked with matrix metalloproteinases (MMPs)-degradable sequences to enable dynamic enzymatic biodegradation and cell spreading and differentiation. The analysis of the intrinsic properties of the hydrogel revealed relevant mechanical properties, porosity, swelling and degradability to engineer hydrogels for bone tissue engineering. Moreover, the engineered hydrogels were able to promote human mesenchymal stem cells (MSCs) spreading and significantly improve their osteogenic differentiation. Thus, these novel hydrogels could be a promising candidate for applications in bone tissue engineering, such as acellular systems to be implanted and regenerate bone or in stem cells therapy.
Language	English
Publishing date	2023-06-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1192436
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Article ; Online: Comparison of the Antibacterial Effect of Silver Nanoparticles and a Multifunctional Antimicrobial Peptide on Titanium Surface.

Moreno, Daniel / Buxadera-Palomero, Judit / Ginebra, Maria-Pau / Manero, José-María / Martin-Gómez, Helena / Mas-Moruno, Carlos / Rodríguez, Daniel

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Titanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two ... ...

Abstract	Titanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two antibacterial agents (silver nanoparticles and a multifunctional antimicrobial peptide) were used to coat titanium surfaces. The modulation of the nanoparticle (≈32.1 ± 9.4 nm) density on titanium could be optimized, and a sequential functionalization with both agents was achieved through a two-step functionalization method by means of surface silanization. The antibacterial character of the coating agents was assessed individually as well as combined. The results have shown that a reduction in bacteria after 4 h of incubation can be achieved on all the coated surfaces. After 24 h of incubation, however, the individual antimicrobial peptide coating was more effective than the silver nanoparticles or their combination against Staphylococcus aureus. All tested coatings were non-cytotoxic for eukaryotic cells.
MeSH term(s)	Titanium/pharmacology ; Silver/pharmacology ; Metal Nanoparticles ; Coated Materials, Biocompatible/pharmacology ; Anti-Bacterial Agents/pharmacology ; Staphylococcus aureus ; Surface Properties
Chemical Substances	Titanium (D1JT611TNE) ; Silver (3M4G523W1G) ; Coated Materials, Biocompatible ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119739
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Article ; Online: Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants.

Mas-Moruno, Carlos / Su, Bo / Dalby, Matthew J

Advanced healthcare materials

2018 Volume 8, Issue 1, Page(s) e1801103

Abstract: In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of ... ...

Abstract	In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can have devastating effects and reduce patient quality of life, representing an emerging concern in healthcare. Conversely, efforts toward inhibiting bacterial colonization may impair biomaterial-tissue integration. Therefore, to improve the long-term success of medical implants, biomaterial surfaces should ideally discourage the attachment of bacteria without affecting eukaryotic cell functions. However, most current strategies seldom investigate a combined goal. This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections. To this end, two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Biofouling ; Coated Materials, Biocompatible/pharmacology ; Humans ; Nanoparticles/chemistry ; Osteogenesis/drug effects ; Prostheses and Implants
Chemical Substances	Anti-Bacterial Agents ; Coated Materials, Biocompatible
Language	English
Publishing date	2018-11-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.201801103
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Article: Effectiveness of Direct Laser Interference Patterning and Peptide Immobilization on Endothelial Cell Migration for Cardio-Vascular Applications: An In Vitro Study.

Schieber, Romain / Mas-Moruno, Carlos / Lasserre, Federico / Roa, Joan Josep / Ginebra, Maria-Pau / Mücklich, Frank / Pegueroles, Marta

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 7

Abstract: Endothelial coverage of an exposed cardiovascular stent surface leads to the occurrence of restenosis and late-stent thrombosis several months after implantation. To overcome this difficulty, modification of stent surfaces with topographical or ... ...

Abstract	Endothelial coverage of an exposed cardiovascular stent surface leads to the occurrence of restenosis and late-stent thrombosis several months after implantation. To overcome this difficulty, modification of stent surfaces with topographical or biochemical features may be performed to increase endothelial cells' (ECs) adhesion and/or migration. This work combines both strategies on cobalt-chromium (CoCr) alloy and studies the potential synergistic effect of linear patterned surfaces that are obtained by direct laser interference patterning (DLIP), coupled with the use of Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) peptides. An extensive characterization of the modified surfaces was performed by using AFM, XPS, surface charge, electrochemical analysis and fluorescent methods. The biological response was studied in terms of EC adhesion, migration and proliferation assays. CoCr surfaces were successfully patterned with a periodicity of 10 µm and two different depths, D (≈79 and 762 nm). RGD and YIGSR were immobilized on the surfaces by CPTES silanization. Early EC adhesion was increased on the peptide-functionalized surfaces, especially for YIGSR compared to RGD. High-depth patterns generated 80% of ECs' alignment within the topographical lines and enhanced EC migration. It is noteworthy that the combined use of the two strategies synergistically accelerated the ECs' migration and proliferation, proving the potential of this strategy to enhance stent endothelialization.
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12071217
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Article ; Online: Comparison of the Antibacterial Effect of Silver Nanoparticles and a Multifunctional Antimicrobial Peptide on Titanium Surface

Daniel Moreno / Judit Buxadera-Palomero / Maria-Pau Ginebra / José-María Manero / Helena Martin-Gómez / Carlos Mas-Moruno / Daniel Rodríguez

International Journal of Molecular Sciences, Vol 24, Iss 9739, p

2023 Volume 9739

Abstract	Titanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two antibacterial agents (silver nanoparticles and a multifunctional antimicrobial peptide) were used to coat titanium surfaces. The modulation of the nanoparticle (≈32.1 ± 9.4 nm) density on titanium could be optimized, and a sequential functionalization with both agents was achieved through a two-step functionalization method by means of surface silanization. The antibacterial character of the coating agents was assessed individually as well as combined. The results have shown that a reduction in bacteria after 4 h of incubation can be achieved on all the coated surfaces. After 24 h of incubation, however, the individual antimicrobial peptide coating was more effective than the silver nanoparticles or their combination against Staphylococcus aureus. All tested coatings were non-cytotoxic for eukaryotic cells.
Keywords	titanium functionalization ; silver nanoparticles ; antimicrobial peptide ; Staphylococcus aureus ; silanization ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Titanium Boston keratoprosthesis with corneal cell adhesive and bactericidal dual coating.

Gómez, Silvia González / Guillem-Marti, Jordi / Martín-Gómez, Helena / Mas-Moruno, Carlos / Ginebra, Maria-Pau / Gil, Francisco Javier / Barraquer, Rafael Ignasi / Manero, José María

Biomaterials advances

2023 Volume 154, Page(s) 213654

Abstract: The Boston keratoprosthesis (BKPro) is a medical device used to restore vision in complicated cases of corneal blindness. This device is composed by a front plate of polymethylmethacrylate (PMMA) and a backplate usually made of titanium (Ti). Ti is an ... ...

Abstract	The Boston keratoprosthesis (BKPro) is a medical device used to restore vision in complicated cases of corneal blindness. This device is composed by a front plate of polymethylmethacrylate (PMMA) and a backplate usually made of titanium (Ti). Ti is an excellent biomaterial with numerous applications, although there are not many studies that address its interaction with ocular cells. In this regard, despite the good retention rates of the BKPro, two main complications compromise patients' vision and the viability of the prosthesis: imperfect adhesion of the corneal tissue to the upside of the backplate and infections. Thus, in this work, two topographies (smooth and rough) were generated on Ti samples and tested with or without functionalization with a dual peptide platform. This molecule consists of a branched structure that links two peptide moieties to address the main complications associated with BKPro: the well-known RGD peptide in its cyclic version (cRGD) as cell pro-adherent motif and the first 11 residues of lactoferrin (LF1-11) as antibacterial motif. Samples were physicochemically characterized, and their biological response was evaluated in vitro with human corneal keratocytes (HCKs) and against the gram-negative bacterial strain Pseudomonas aeruginosa. The physicochemical characterization allowed to verify the functionalization in a qualitative and quantitative manner. A higher amount of peptide was anchored to the rough surfaces. The studies performed using HCKs showed increased long-term proliferation on the functionalized samples. Gene expression was affected by topography and peptide functionalization. Roughness promoted α-smooth muscle actin (α-SMA) overexpression, and the coating notably increased the expression of extracellular matrix components (ECM). Such changes may favour the development of unwanted fibrosis, and thus, corneal haze. In contrast, the combination of the coating with a rough topography decreased the expression of α-SMA and ECM components, which would be desirable for the long-term success of the prosthesis. Regarding the antibacterial activity, the functionalized smooth and rough surfaces promoted the death of bacteria, as well as a perturbation in their wall definition and cellular morphology. Bacterial killing values were 58 % for smooth functionalised and 68 % for rough functionalised samples. In summary, this study suggests that the use of the dual peptide platform with cRGD and LF1-11 could be a good strategy to improve the in vitro and in vivo performance of the rough topography used in the commercial BKPro.
MeSH term(s)	Humans ; Cornea/surgery ; Titanium/pharmacology ; Corneal Diseases/surgery ; Prostheses and Implants ; Peptides ; Anti-Bacterial Agents
Chemical Substances	Titanium (D1JT611TNE) ; Peptides ; Anti-Bacterial Agents
Language	English
Publishing date	2023-10-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2023.213654
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Article ; Online: Antimicrobial Peptides: Powerful Biorecognition Elements to Detect Bacteria in Biosensing Technologies.

Hoyos-Nogués, Mireia / Gil, F J / Mas-Moruno, Carlos

Molecules (Basel, Switzerland)

2018 Volume 23, Issue 7

Abstract: Bacterial infections represent a serious threat in modern medicine. In particular, biofilm treatment in clinical settings is challenging, as biofilms are very resistant to conventional antibiotic therapy and may spread infecting other tissues. To address ...

Abstract	Bacterial infections represent a serious threat in modern medicine. In particular, biofilm treatment in clinical settings is challenging, as biofilms are very resistant to conventional antibiotic therapy and may spread infecting other tissues. To address this problem, biosensing technologies are emerging as a powerful solution to detect and identify bacterial pathogens at the very early stages of the infection, thus allowing rapid and effective treatments before biofilms are formed. Biosensors typically consist of two main parts, a biorecognition moiety that interacts with the target (i.e., bacteria) and a platform that transduces such interaction into a measurable signal. This review will focus on the development of impedimetric biosensors using antimicrobial peptides (AMPs) as biorecognition elements. AMPs belong to the innate immune system of living organisms and are very effective in interacting with bacterial membranes. They offer unique advantages compared to other classical bioreceptor molecules such as enzymes or antibodies. Moreover, impedance-based sensors allow the development of label-free, rapid, sensitive, specific and cost-effective sensing platforms. In summary, AMPs and impedimetric transducers combine excellent properties to produce robust biosensors for the early detection of bacterial infections.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Biosensing Techniques/methods ; Peptides/pharmacology ; Peptides/therapeutic use
Chemical Substances	Anti-Infective Agents ; Peptides
Language	English
Publishing date	2018-07-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules23071683
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