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  1. Book: Kurt Wolff

    Ermarth, Michael / Schneider, Deborah Lucas / Wolff, Kurt

    a portrait in essays & letters

    1991  

    Author's details ed. with a forew. by Michael Ermarth. Transl. by Deborah Lucas Schneider
    Language English
    Size XXVIII, 223 S., Ill.
    Publisher Univ. of Chicago Press
    Publishing place Chicago u.a.
    Document type Book
    Note Bibliogr. K. Wolff S. 199 - 200
    ISBN 0226905519 ; 9780226905518
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article: Biotechnological production of omega-3 fatty acids: current status and future perspectives.

    Qin, Jiansong / Kurt, Elif / LBassi, Tyler / Sa, Lucas / Xie, Dongming

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1280296

    Abstract: Omega-3 fatty acids, including alpha-linolenic acids (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have shown major health benefits, but the human body's inability to synthesize them has led to the necessity of dietary intake of the ...

    Abstract Omega-3 fatty acids, including alpha-linolenic acids (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have shown major health benefits, but the human body's inability to synthesize them has led to the necessity of dietary intake of the products. The omega-3 fatty acid market has grown significantly, with a global market from an estimated USD 2.10 billion in 2020 to a predicted nearly USD 3.61 billion in 2028. However, obtaining a sufficient supply of high-quality and stable omega-3 fatty acids can be challenging. Currently, fish oil serves as the primary source of omega-3 fatty acids in the market, but it has several drawbacks, including high cost, inconsistent product quality, and major uncertainties in its sustainability and ecological impact. Other significant sources of omega-3 fatty acids include plants and microalgae fermentation, but they face similar challenges in reducing manufacturing costs and improving product quality and sustainability. With the advances in synthetic biology, biotechnological production of omega-3 fatty acids via engineered microbial cell factories still offers the best solution to provide a more stable, sustainable, and affordable source of omega-3 fatty acids by overcoming the major issues associated with conventional sources. This review summarizes the current status, key challenges, and future perspectives for the biotechnological production of major omega-3 fatty acids.
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1280296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases.

    Lucas, Kurt / Fröhlich-Nowoisky, Janine / Oppitz, Nicole / Ackermann, Maximilian

    Frontiers in plant science

    2021  Volume 12, Page(s) 589783

    Language English
    Publishing date 2021-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.589783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Well-Defined Bifunctional Dendrimer Bearing 54 Nitric Oxide-Releasing Moieties and 54 Ursodeoxycholic Acid Groups Presenting High Anti-Inflammatory Activity.

    Garzón-Porras, Ana M / Bertuzzi, Diego L / Lucas, Kurt / Ornelas, Catia

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 12, Page(s) 5171–5187

    Abstract: Nitric oxide (NO) and ursodeoxycholic acid (UDCA) are endogenous molecules involved in physiological processes associated with inflammation. Since inflammatory processes are present in the mechanisms of many diseases, these molecules are important for ... ...

    Abstract Nitric oxide (NO) and ursodeoxycholic acid (UDCA) are endogenous molecules involved in physiological processes associated with inflammation. Since inflammatory processes are present in the mechanisms of many diseases, these molecules are important for the development of new drugs. Herein, we describe the synthesis of a well-defined bifunctional dendrimer with 108 termini bearing 54 NO-releasing groups and 54 UDCA units (Dendri-(NO/UDCA)
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c00713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Parents’/guardians’ experiences with their adolescents’ prolonged recovery from a sport-related concussion

    Shelley Lucas / Nicole D. Bolter / Laura J. Petranek / Kurt Nilsson / Kristi Pardue / Hilary Flint

    Journal of Concussion, Vol

    2023  Volume 7

    Abstract: Sport-related concussions (SRCs) occur at alarming rates among adolescents and evidence suggests that adolescents experience more severe and longer-lasting symptoms compared to other age groups. Developmentally, adolescence is a time when youth become ... ...

    Abstract Sport-related concussions (SRCs) occur at alarming rates among adolescents and evidence suggests that adolescents experience more severe and longer-lasting symptoms compared to other age groups. Developmentally, adolescence is a time when youth become less reliant on their parents, establish their personal identity, and rely more on other social support networks (e.g., peers, teammates). However, previous studies show that parents play a prominent role in the recovery process from an SRC, especially in situations where recovery is prolonged. The purpose of this study was to examine the lived experiences of parents/guardians of teens who were recovering from a concussion and whose symptoms were persistent. Participants ( N = 12) were individually interviewed to better understand how they navigated and advocated for their teen during their prolonged recovery. An inductive content analysis revealed eight thematic categories that were interpreted with a developmental lens: (a) difficulties enforcing cognitive and physical rest, (b) concerns about depression and isolation, (c) observing struggles with athletic identity, (d) feelings of frustration, helplessness, and stress, (e) challenges of a hidden injury, (f) decisions about returning to sport, (g) being lied to about symptoms, and (h) offering strategies and practical advice. The themes illustrate how challenging and complicated the recovery process can be for parents of teenagers in particular, which is supported in previous concussion studies and the broader developmental literature. These results reinforce the idea that taking a biopsychosocial approach to care is best in order to adequately support parents/guardians and adolescents during the SRC recovery process.
    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Sports medicine ; RC1200-1245
    Subject code 150
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Identification of functional white matter networks in BOLD fMRI.

    Eby, Alexa L / Remedios, Lucas W / Kim, Michael E / Li, Muwei / Gao, Yurui / Gore, John C / Schilling, Kurt G / Landman, Bennett A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: White matter signals in resting state blood oxygen level dependent functional magnetic resonance (BOLD-fMRI) have been largely discounted, yet there is growing evidence that these signals are indicative of brain activity. Understanding how these white ... ...

    Abstract White matter signals in resting state blood oxygen level dependent functional magnetic resonance (BOLD-fMRI) have been largely discounted, yet there is growing evidence that these signals are indicative of brain activity. Understanding how these white matter signals capture function can provide insight into brain physiology. Moreover, functional signals could potentially be used as early markers for neurological changes, such as in Alzheimer's Disease. To investigate white matter brain networks, we leveraged the OASIS-3 dataset to extract white matter signals from resting state BOLD-FMRI data on 711 subjects. The imaging was longitudinal with a total of 2,026 images. Hierarchical clustering was performed to investigate clusters of voxel-level correlations on the timeseries data. The stability of clusters was measured with the average Dice coefficients on two different cross fold validations. The first validated the stability between scans, and the second validated the stability between subject populations. Functional clusters at hierarchical levels 4, 9, 13, 18, and 24 had local maximum stability, suggesting better clustered white matter. In comparison with JHU-DTI-SS Type-I Atlas defined regions, clusters at lower hierarchical levels identified well defined anatomical lobes. At higher hierarchical levels, functional clusters mapped motor and memory functional regions, identifying 50.00%, 20.00%, 27.27%, and 35.14% of the frontal, occipital, parietal, and temporal lobe regions respectively.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.08.556881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of posterior cruciate ligament tension on tibiofemoral and patellofemoral joint contact mechanics in cruciate-retaining total knee replacement: a combined musculoskeletal multibody and finite-element simulation.

    Sass, Jan-Oliver / Johnson, Kurt / Darques, Jean-Baptiste / Buerstenbinder, Lucas / Soodmand, Iman / Bader, Rainer / Kebbach, Maeruan

    Computer methods in biomechanics and biomedical engineering

    2024  , Page(s) 1–13

    Abstract: The influence of posterior cruciate ligament (PCL) tension on the clinical outcome of cruciate-retaining total knee replacement (CR-TKR) remains controversial. Various numerical approaches have been used to study this influence systematically, but the ... ...

    Abstract The influence of posterior cruciate ligament (PCL) tension on the clinical outcome of cruciate-retaining total knee replacement (CR-TKR) remains controversial. Various numerical approaches have been used to study this influence systematically, but the models used are limited by certain assumptions and simplifications. Therefore, the objective of this computational study was to develop a combined musculoskeletal multibody and finite-element simulation during a squat motion to 90° knee flexion with a CR-TKR design to overcome previous limitations regarding model inputs. In addition, different PCL tensions (tight, lax, resected) were modeled and the influence on tibiofemoral and resurfaced patellofemoral joint dynamics and contact stresses was evaluated. The effect of the PCL on knee joint dynamics and contact stresses was more pronounced at higher flexion angles. Tibiofemoral joint dynamics were influenced and a tight PCL induced increased posterior femoral translation during flexion. The maximum contact stress in the tibial insert increased from 20.6 MPa to 22.5 MPa for the resected and tightest PCL at 90° knee flexion. Patellofemoral joint dynamics were only slightly affected by PCL tension. However, the maximum contact stress in the patellar component decreased from 58.0 MPa to 53.7 MPa for the resected and tightest PCL at 90° knee flexion. The combination of musculoskeletal multibody and finite-element simulation is a sufficient method to comprehensively investigate knee joint dynamics and contact stresses in CR-TKR. The PCL tension after CR-TKR affects joint dynamics and contact stresses at the articulating implant surfaces.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071764-7
    ISSN 1476-8259 ; 1025-5842
    ISSN (online) 1476-8259
    ISSN 1025-5842
    DOI 10.1080/10255842.2024.2329946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6374: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Molecular hydrogen (H

    Lucas, Kurt / Rosch, Moritz / Langguth, Peter

    Archiv der Pharmazie

    2020  Volume 354, Issue 4, Page(s) e2000378

    Abstract: Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or ... ...

    Abstract Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID-19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms of fatigue, and antioxidant treatments have been shown to be effective in alleviating the symptoms of fatigue. In this study, we review the role of reactive oxygen and nitrogen species in fatigue and the antioxidant effects of the intake of molecular hydrogen. We propose that molecular hydrogen is well suited for the treatment of temporary and chronic forms of oxidative stress-associated fatigue.
    MeSH term(s) Antioxidants/metabolism ; Antioxidants/pharmacology ; COVID-19/metabolism ; COVID-19/physiopathology ; Fatigue/etiology ; Fatigue/metabolism ; Fatigue/therapy ; Humans ; Hydrogen/metabolism ; Hydrogen/pharmacology ; Nitrogen ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Quantitative Structure-Activity Relationship ; Reactive Oxygen Species ; SARS-CoV-2
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Hydrogen (7YNJ3PO35Z) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2020-12-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202000378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.4: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet.

    Rosch, Moritz / Lucas, Kurt / Al-Gousous, Jozef / Pöschl, Ulrich / Langguth, Peter

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 12

    Abstract: Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets ... ...

    Abstract Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.
    Language English
    Publishing date 2021-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14121327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chemical modification by peroxynitrite enhances TLR4 activation of the grass pollen allergen Phl p 5.

    Reinmuth-Selzle, Kathrin / Bellinghausen, Iris / Leifke, Anna Lena / Backes, Anna T / Bothen, Nadine / Ziegler, Kira / Weller, Michael G / Saloga, Joachim / Schuppan, Detlef / Lucas, Kurt / Pöschl, Ulrich / Fröhlich-Nowoisky, Janine

    Frontiers in allergy

    2023  Volume 4, Page(s) 1066392

    Abstract: The chemical modification of aeroallergens by reactive oxygen and nitrogen species (ROS/RNS) may contribute to the growing prevalence of respiratory allergies in industrialized countries. Post-translational modifications can alter the immunological ... ...

    Abstract The chemical modification of aeroallergens by reactive oxygen and nitrogen species (ROS/RNS) may contribute to the growing prevalence of respiratory allergies in industrialized countries. Post-translational modifications can alter the immunological properties of proteins, but the underlying mechanisms and effects are not well understood. In this study, we investigate the Toll-like receptor 4 (TLR4) activation of the major birch and grass pollen allergens Bet v 1 and Phl p 5, and how the physiological oxidant peroxynitrite (ONOO
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2023.1066392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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