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  1. Article ; Online: Assessment of the Impact of Preanalytical DNA Integrity on the Genome Data Quality.

    Shim, Sung-Mi / Lee, Meehee / Jeon, Jae-Pil

    Biopreservation and biobanking

    2024  

    Abstract: Many molecular approaches have been employed for the quality control (QC) of biobanked DNA samples. Since 2003, the National Biobank of Korea (NBK) has provided various studies with over half a million quality-controlled genomic DNA samples using ... ...

    Abstract Many molecular approaches have been employed for the quality control (QC) of biobanked DNA samples. Since 2003, the National Biobank of Korea (NBK) has provided various studies with over half a million quality-controlled genomic DNA samples using conventional agarose gel electrophoresis and spectrophotometry. We assessed the postanalytical genomic data quality of DNA samples (
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2023.0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inter-crystal scattering event identification using a novel silicon photomultiplier signal multiplexing method.

    Shim, Hyeong Seok / Bae, Sangjin / Lee, Seungeun / Lee, Jae Sung

    Physics in medicine and biology

    2023  Volume 68, Issue 11

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Positron-Emission Tomography/methods ; Neural Networks, Computer ; Gamma Rays
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acd163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Novel MFSD7-ATP5I fusion promotes migration and invasion of human sarcoma.

    Shim, Jae Woo / Choi, Ji-Yoon / Shim, Da Mi / Seo, Sung Wook

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    2023  Volume 42, Issue 2, Page(s) 443–452

    Abstract: Fusion genes have been implicated in the development and progression of several types of sarcomas, serving as valuable diagnostic and prognostic markers, as well as potential therapeutic targets. We discovered a novel major facilitator superfamily domain- ...

    Abstract Fusion genes have been implicated in the development and progression of several types of sarcomas, serving as valuable diagnostic and prognostic markers, as well as potential therapeutic targets. We discovered a novel major facilitator superfamily domain-containing 7 (MFSD7) and adenosine triphosphate 5I (ATP5I) gene fusion from sarcomas. In this study, the MFSD7-ATP5I fusion transcript was screened using RNA sequencing in 55 sarcoma samples and sixteen normal samples. The MFSD7-ATP5I fusion transcript was detected in 58% of sarcoma samples. The correlation between the expression of MFSD7-ATP5I fusion transcript and clinicopathological information was analyzed, and MFSD7-ATP5I expression is associated with marked pleomorphism and lower tumor necrosis. Cell migration and invasion was significantly reduced by knock-down of MFSD7-ATP5I. Cell migration and invasion was increased by overexpression of MFSD7-ATP5I. A phosphokinase assay demonstrated that MFSD7-ATP5I is involved in the GSK-3 pathway. The current study found that MFSD7-ATP5I is associated with increasing pleomorphism and decreasing necrosis of tumors. And our gain and loss of function experiments prove that MFSD7-ATP5I promotes the invasiveness of tumor cells.
    MeSH term(s) Humans ; Glycogen Synthase Kinase 3 ; Sarcoma/genetics ; Soft Tissue Neoplasms ; Cell Movement ; Necrosis
    Chemical Substances Glycogen Synthase Kinase 3 (EC 2.7.11.26)
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605542-4
    ISSN 1554-527X ; 0736-0266
    ISSN (online) 1554-527X
    ISSN 0736-0266
    DOI 10.1002/jor.25689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Dose Optimization Using a Deep Learning Tool in Various CT Protocols for Urolithiasis: A Physical Human Phantom Study.

    Shim, Jae Hun / Choi, Se Young / Chang, In Ho / Park, Sung Bin

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Deep Learning ; Urolithiasis/diagnostic imaging ; Mental Processes ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Effects of dexmedetomidine on renal function after cardiac surgery for infective endocarditis: An interim analysis of a randomized controlled trial.

    Ham, Sung Yeon / Shim, Jae-Kwang / Lee, Sak / Ko, Seo Hee / Soh, Sarah / Kwak, Young-Lan

    Asian journal of surgery

    2024  

    Abstract: Background: Patients undergoing cardiac surgery for infective endocarditis (IE) are at a high risk of postoperative acute kidney injury (AKI) owing to heightened systemic inflammation. Therefore, we aimed to investigate the effect of dexmedetomidine on ... ...

    Abstract Background: Patients undergoing cardiac surgery for infective endocarditis (IE) are at a high risk of postoperative acute kidney injury (AKI) owing to heightened systemic inflammation. Therefore, we aimed to investigate the effect of dexmedetomidine on postoperative AKI in patients who underwent cardiac surgery for IE.
    Methods: A total of 63 patients who underwent cardiac surgery for IE were randomly assigned to receive either intravenous dexmedetomidine infusion of 0.4 μg kg
    Results: This trial was early terminated according to the results of interim analysis performed when 60 % of the pre-set number of patients have been collected. The incidence of AKI was significantly lower in the DEX group than in the control group (32.3 % vs. 9.4 %, p = 0.025). Patients in the DEX group had significantly lower epinephrine levels than those in the control group, whereas norepinephrine and interleukin-6 levels were similar. Perioperative mean arterial pressure or heart rate did not differ between the groups.
    Conclusions: Dexmedetomidine administration for 24 h starting from induction of anesthesia significantly reduced the incidence of postoperative AKI after cardiac surgery for IE (by 29 % vs. control) without hemodynamic side effects. This was accompanied by a significant attenuation of postoperative increase in serum epinephrine levels.
    Language English
    Publishing date 2024-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Correction to "Adjusted Bulk and Interfacial Properties in Highly Stable Semitransparent Perovskite Solar Cells Fabricated by Thermocompression Bonding between Perovskite Layers".

    Jung, Hee-Yun / Oh, Eun Sung / Kim, Dong Jun / Shim, Hongjae / Lee, Wonjong / Yoon, Soon-Gil / Lim, Jongchul / Yun, Jae Sung / Kim, Taek-Soo / Yang, Tae-Youl

    ACS applied materials & interfaces

    2024  Volume 16, Issue 8, Page(s) 11146

    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Published Erratum
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c01081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt-Jakob disease.

    Heo, Hwon / Park, Ho Young / Suh, Chong Hyun / Shim, Woo Hyun / Lim, Jae-Sung / Lee, Jae-Hong / Kim, Sang Joon

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4215

    Abstract: Quantification of diffusion restriction lesions in sporadic Creutzfeldt-Jakob disease (sCJD) may provide information of the disease burden. We aim to develop an automatic segmentation model for sCJD and to evaluate the volume of disease extent as a ... ...

    Abstract Quantification of diffusion restriction lesions in sporadic Creutzfeldt-Jakob disease (sCJD) may provide information of the disease burden. We aim to develop an automatic segmentation model for sCJD and to evaluate the volume of disease extent as a prognostic marker for overall survival. Fifty-six patients (mean age ± SD, 61.2 ± 9.9 years) were included from February 2000 to July 2020. A threshold-based segmentation was used to obtain abnormal signal intensity masks. Segmented volumes were compared with the visual grade. The Dice similarity coefficient was calculated to measure the similarity between the automatic vs. manual segmentation. Cox proportional hazards regression analysis was performed to evaluate the volume of disease extent as a prognostic marker. The automatic segmentation showed good correlation with the visual grading. The cortical lesion volumes significantly increased as the visual grade aggravated (extensive: 112.9 ± 73.2; moderate: 45.4 ± 30.4; minimal involvement: 29.6 ± 18.1 mm
    MeSH term(s) Humans ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Creutzfeldt-Jakob Syndrome/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Algorithms ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51927-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction: A combination of multiple autoantibodies is associated with the risk of Alzheimer's disease and cognitive impairment.

    Shim, Sung-Mi / Koh, Young Ho / Kim, Jong-Hoon / Jeon, Jae-Pil

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 2328

    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06478-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Genomic Evaluation of Six Selected Inbred Lines of the Naturalized Plants of Milk Thistle (

    Shim, Jeehyoung / Hong, Su Young / Han, Jae-Hyuk / Yu, Yeisoo / Yoo, Eunae / Sung, Jungsook / Chin, Joong Hyoun / Lee, O New

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 14

    Abstract: Milk thistle ( ...

    Abstract Milk thistle (
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12142702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current updates relating to treatment for interstitial cystitis/bladder pain syndrome: systematic review and network meta-analysis.

    Park, Jae Joon / Kim, Kwang Taek / Lee, Eun Ji / Chun, Joey / Lee, Serin / Shim, Sung Ryul / Kim, Jae Heon

    BMC urology

    2024  Volume 24, Issue 1, Page(s) 95

    Abstract: Background: Despite the publication of several meta-analyses regarding the efficacy of certain therapies in helping individuals with interstitial cystitis (IC) / bladder pain syndrome (BPS), these have not provided a comprehensive review of therapeutic ... ...

    Abstract Background: Despite the publication of several meta-analyses regarding the efficacy of certain therapies in helping individuals with interstitial cystitis (IC) / bladder pain syndrome (BPS), these have not provided a comprehensive review of therapeutic strategies. The study aimed to determine the efficacy of various therapies for IC/BPS and identify potential moderating factors using randomized controlled trials (RCTs).
    Methods: We queried the PubMed, Cochrane, and Embase databases to identify prospective RCTs using inclusion criteria: 1) patients diagnosed with IC, 2) interventions included relevant treatments, 3) comparisons were a specified control or placebo, 4) outcomes were mean differences for individual symptoms and structured questionnaires. The pairwise meta-analysis and network meta-analysis (NMA) were performed to compare the treatments used in IC/BPS. Hedges' g standardized mean differences (SMDs) were used for improvement in all outcomes using random-effects models. Efficacy outcomes included individual symptoms such as pain, frequency, urgency, and nocturia, as well as structured questionnaires measuring IC/BPS symptoms.
    Results: A comprehensive literature search was conducted which identified 70 RCTs with 3,651 patients. The analysis revealed that certain treatments, such as instillation and intravesical injection, showed statistically significant improvements in pain and urgency compared to control or placebo groups in traditional pairwise meta-analysis. However, no specific treatment demonstrated significant improvement in all outcomes measured in the NMA. The results of moderator analyses to explore influential variables indicated that increasing age was associated with increased nocturia, while longer follow-up periods were associated with decreased frequency.
    Conclusion: This systematic review and meta-analysis provide insights into the efficacy of various treatments for IC. Current research suggests that a combination of therapies may have a positive clinical outcome for patients with IC, despite the fact that treatment for this condition is not straightforward.
    Trial registration: PROSPERO CRD42022384024.
    MeSH term(s) Cystitis, Interstitial/therapy ; Humans ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Systematic Review ; Meta-Analysis
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-024-01485-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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