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Article: Introduction and application of a metaverse platform used in Chosun University Hospital Metaverse.

Kim, Mi Ra / Noh, Hee Jeong / Choi, Ji Yun / Kim, Kyung Jong / Kim, Yoseup

Clinical and experimental emergency medicine

2024 Volume 11, Issue 1, Page(s) 106–114

Language	English
Publishing date	2024-01-11
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2383-4625
ISSN	2383-4625
DOI	10.15441/ceem.23.086
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mealtime shift delays conception in mice.

Park, Jihyun / Kim, Mi-Hee / Han, Dong-Hee / Noh, Jong-Yun / Ji, Eun-Sang / Lee, Sung-Ho / Kim, Chang-Ju / Cho, Sehyung

Reproduction (Cambridge, England)

2022 Volume 163, Issue 5, Page(s) 323–331

Abstract: The physiological processes of organisms in this rotating planet can adjust according to the time of day via built-in circadian clocks. However, more people are having different shift works, which can increase the risk of pathological conditions ... ...

Abstract	The physiological processes of organisms in this rotating planet can adjust according to the time of day via built-in circadian clocks. However, more people are having different shift works, which can increase the risk of pathological conditions including altered reproductive function. Thus, circadian rhythm disturbance has become prevalent in the modern society. Specifically, epidemiological evidence has shown that shift-working women are at high risk of spontaneous abortions, irregular menstrual cycles, and low-birth-weight babies. The current study aimed to investigate the effects of circadian rhythm disturbances on the reproductive function of mice caused by dietary time shift, which is common among night-shift workers. According to the schedule of restricted feeding, the mice were classified into the free feeding, daytime feeding, and night feeding groups. The fertility indices of each group were then evaluated. Activity monitoring was performed to determine whether pregnancy delay might be attributed to mealtime shift. Moreover, the estrous cycle of female mice and the reproductive phenotype of male mice were investigated. Results showed that a 12-h mealtime shift significantly delayed successful conception, which could be attributed to a disrupted estrous cycle, in adult female mice.
MeSH term(s)	Animals ; Circadian Rhythm ; Female ; Humans ; Male ; Meals ; Menstruation Disturbances ; Mice ; Pregnancy ; Reproduction ; Work Schedule Tolerance
Language	English
Publishing date	2022-04-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-21-0336
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Article ; Online: Alternating mealtimes during pregnancy and weaning triggers behavioral changes in adult offspring.

Kim, Mi-Hee / Park, Jihyun / Han, Dong-Hee / Noh, Jong-Yun / Ji, Eun-Sang / Lee, Sung-Ho / Kim, Chang-Ju / Cho, Sehyung

Reproduction (Cambridge, England)

2022 Volume 165, Issue 1, Page(s) 135–146

Abstract: In brief: Mealtime changes in pregnant mice revealed impaired neurobehavioral development in mouse offspring. This study is the basis for investigating diseases associated with neurobehavioral development of adult offspring of pregnant shift-working ... ...

Abstract	In brief: Mealtime changes in pregnant mice revealed impaired neurobehavioral development in mouse offspring. This study is the basis for investigating diseases associated with neurobehavioral development of adult offspring of pregnant shift-working women. Abstract: Most organisms on Earth have a biological clock, and their physiological processes are regulated by a 1-day cycle. In modern society, several factors can disturb these biological clocks in humans; in particular, individuals working in shifts are exposed to stark environmental changes that interfere with their biological clock. They have a high risk of various diseases. However, there are scarce experimental approaches to address the reproductive and health consequences of shift work in the offspring of exposed individuals. In this study, considering the fact that shift workers usually have their meals during their adjusted working time, we aimed to examine the effects of a 12-h shift with usual mealtime as a plausible night work model on the neurobehavioral development of adult mouse offspring. In these offspring, early exposure to this mealtime shift differentially affected circadian rhythmic variables and total locomotor activity depending on the timing and duration of restrictive feeding. Moreover, neurobehavioral alterations such as declined short-term memory and depressive-like behavior were observed in adulthood. These results have implications for the health concerns of shift-working women and their children.
MeSH term(s)	Humans ; Pregnancy ; Adult ; Child ; Animals ; Female ; Mice ; Adult Children ; Circadian Rhythm/physiology ; Weaning ; Behavior, Animal ; Reproduction
Language	English
Publishing date	2022-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-22-0164
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Article ; Online: Prognostic impact of muscle mass loss in elderly patients with oesophageal cancer receiving neoadjuvant chemoradiation therapy.

Jang, Jeong Yun / Oh, Dongryul / Noh, Jae Myoung / Sun, Jong-Mu / Kim, Hong Kwan / Shim, Young Mog

Journal of cachexia, sarcopenia and muscle

2024

Abstract: Background: We aimed to identify the impact of muscle mass on locally advanced oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation therapy (NACRT).: Methods: We reviewed the medical records of 345 patients diagnosed ... ...

Abstract	Background: We aimed to identify the impact of muscle mass on locally advanced oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation therapy (NACRT). Methods: We reviewed the medical records of 345 patients diagnosed with LAEC who underwent NACRT and surgery. Physical variables, including height, weight, skeletal muscle mass, and laboratory values, were obtained before and after NACRT. Body mass index (BMI, kg/m Results: During a median follow-up of 32.8 months (range, 2.0-176.2), 192 patients died, with a median OS of 50.2 months. Elderly patients did not show inferior OS (young vs. elderly, 57.7% vs. 54.0% at 3 years, P = 0.247). 71.0% and 87.2% of all patients had low muscle mass before and after NACRT, respectively, which was not associated with OS (P = 0.270 and P = 0.509, respectively). Inflammatory (NLR and PLR) and nutritional index (PNI) values or their changes did not correlate with OS. However, the EML group had worse OS (41.6% vs. 63.2% at 3 years, P < 0.0001). In the multivariate analysis, EML was also a significant prognostic factor for OS. In the subgroup analysis by age, EML was a strong prognostic factor for OS in the elderly group. The 3-year OS was 36.8% in the EML group and 64.9% in the non-EML group (P < 0.0001) in elderly patients, and 47.4% and 62.1% (P = 0.063) in the young patients. In multivariate analysis of each subgroup, EML remained prognostic only in the elderly group (P = 0.008). Conclusions: EML may be strongly associated with a deteriorated OS in elderly patients undergoing NACRT, followed by surgery for LAEC. The strategies for decreasing muscle loss in these patients should be investigated.
Language	English
Publishing date	2024-04-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13462
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Article ; Online: Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease.

Noh, Myungkyung / Sim, Jeong Yeon / Kim, Jisung / Ahn, Jee Hwan / Min, Hye-Young / Lee, Jong-Uk / Park, Jong-Sook / Jeong, Ji Yun / Lee, Jae Young / Lee, Shin Yup / Lee, Hyo-Jong / Park, Choon-Sik / Lee, Ho-Young

Journal of hazardous materials

2023 Volume 464, Page(s) 132932

Abstract: Chronic obstructive pulmonary disease (COPD) is a group of illnesses associated with unresolved inflammation in response to toxic environmental stimuli. Persistent exposure to PM is a major risk factor for COPD, but the underlying mechanism remains ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a group of illnesses associated with unresolved inflammation in response to toxic environmental stimuli. Persistent exposure to PM is a major risk factor for COPD, but the underlying mechanism remains unclear. Using our established mouse model of PM-induced COPD, we find that repeated PM exposure provokes macrophage-centered chronic inflammation and COPD development. Mechanistically, chronic PM exposure induces transcriptional downregulation of HAAO, KMO, KYNU, and QPRT in macrophages, which are the enzymes of de novo NAD
MeSH term(s)	Animals ; Mice ; Humans ; Particulate Matter/toxicity ; Particulate Matter/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Sirtuin 1/pharmacology ; Histones/metabolism ; NAD/metabolism ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/genetics ; Macrophages ; Inflammation/metabolism ; Epigenesis, Genetic
Chemical Substances	Particulate Matter ; Sirtuin 1 (EC 3.5.1.-) ; Histones ; NAD (0U46U6E8UK)
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132932
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Article ; Online: Integrating biological ion exchange with biological activated carbon treatment for drinking water: A novel approach for NOM removal, trihalomethane formation potential, and biological stability.

Lee, Yun / Noh, Jin-Hyung / Park, Ji-Won / Yoon, Seon-Won / Kim, Sang-Yeob / Son, Hee Jong / Lee, Woorim / Maeng, Sung Kyu

Water research

2023 Volume 245, Page(s) 120598

Abstract: Ion exchange resins (IEX) are used in drinking water utilities to remove natural organic matter (NOM) from surface water; however, the disposal of used brine can be a major drawback. Recently, biological ion exchange (BIEX) has been proposed as an ... ...

Abstract	Ion exchange resins (IEX) are used in drinking water utilities to remove natural organic matter (NOM) from surface water; however, the disposal of used brine can be a major drawback. Recently, biological ion exchange (BIEX) has been proposed as an alternative to biological activated carbon (BAC) for removing natural organic matter (NOM). The present study is, to the best of our knowledge, the first attempt to use a hybrid BIEX and BAC (BIEX+BAC) system for drinking water treatment. The removal of NOM, assimilable organic carbon, and trihalomethane formation potential was investigated by operating four columns comprising IEX, BIEX, BAC, and BIEX+BAC with 18,000 bed volumes. The BIEX+BAC system was the most effective at removing dissolved organic carbon (59.9%). Based on fluorescence excitation-emission matrix spectroscopy, the BIEX+BAC column showed the maximum removal rates in all peak regions of T1, T2, and A. Using liquid chromatography-organic carbon detection, resin-containing columns were found to effectively remove humic substances, which are the principal precursors of trihalomethanes. The lowest potential for trihalomethane formation was observed in BIEX+BAC. BIEX+BAC also had the highest assimilable organic carbon removal efficiency (61.2%) followed by BIEX (52.3%), BAC (49.5%), and IEX (47.1%). The BIEX+BAC hybrid was found to be the most effective method for removing NOM fractions and reducing the formation of disinfection byproducts.
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.120598
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Article ; Online: Quantification of diffuse parenchymal lung disease in non-small cell lung cancer patients with definitive concurrent chemoradiation therapy for predicting radiation pneumonitis.

An, Ye Chan / Kim, Jong Hoon / Noh, Jae Myung / Yang, Kyung Mi / Oh, You Jin / Park, Sung Goo / Pyo, Hong Ryul / Lee, Ho Yun

Thoracic cancer

2023 Volume 14, Issue 36, Page(s) 3530–3539

Abstract: Background: We sought to quantify diffuse parenchymal lung disease (DPLD) extent using quantitative computed tomography (CT) analysis and to investigate its association with radiation pneumonitis (RP) development in non-small cell lung cancer (NSCLC) ... ...

Abstract	Background: We sought to quantify diffuse parenchymal lung disease (DPLD) extent using quantitative computed tomography (CT) analysis and to investigate its association with radiation pneumonitis (RP) development in non-small cell lung cancer (NSCLC) patients receiving definitive concurrent chemoradiation therapy (CCRT). Methods: A total of 82 NSCLC patients undergoing definitive CCRT were included in this prospective cohort study. Pretreatment CT scans were analyzed using quantitative CT analysis software. Low-attenuation area (LAA) features based on lung density and texture features reflecting interstitial lung disease (ILD) were extracted from the whole lung. Clinical and dosimetric factors were also evaluated. RP development was assessed using the Common Terminology Criteria for Adverse Events version 5.0. Univariable and multivariable logistic regression analyses were performed to identify independent risk factors for grade ≥3 (≥GR3) RP. Results: RP was identified in 68 patients (73.9%), with nine patients (10.9%) experiencing ≥GR3 RP. Univariable logistic regression analysis identified excess kurtosis and high-attenuation area (HAA)_volume (cc) as significantly associated with ≥GR3 RP. Multivariable logistic regression analysis showed that the combined use of imaging features and clinical factors (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], and CHEMO regimen) demonstrated the best performance (area under the receiver operating characteristic curve = 0.924) in predicting ≥GR3 RP. Conclusion: Quantified imaging features of DPLD obtained from pretreatment CT scans would predict the occurrence of RP in NSCLC patients undergoing definitive CCRT. Combining imaging features with clinical factors could improve the accuracy of the predictive model for severe RP.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Radiation Pneumonitis/etiology ; Radiation Pneumonitis/epidemiology ; Lung Neoplasms/drug therapy ; Prospective Studies ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Retrospective Studies
Language	English
Publishing date	2023-11-12
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15156
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Article ; Online: Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment

Hyemin Jang / Jong-Yun Park / Young Kyoung Jang / Hee Jin Kim / Jin San Lee / Duk L. Na / Young Noh / Samuel N. Lockhart / Joon-Kyung Seong / Sang Won Seo

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 8

Abstract: Abstract Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments ...

Abstract	Abstract Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments (SVCI) patients can be classified by the underlying pathobiologies. A total of 45 11 C-Pittsburgh compound B PET positive (PiB(+)) SVCI patients were included in this study. They were classified using a new cluster analysis method which adopted the Louvain method, which finds optimal decomposition of the participants based on similarity of relative Aβ deposition pattern. We measured atherosclerotic cerebral small vessel disease (CSVD) markers and cerebral amyloid angiopathy (CAA) markers. Forty-five PiB(+) SVCI patients were classified into two groups: 17 patients with the characteristic Alzheimer’s disease like Aβ uptake with sparing of occipital region (OccSp) and 28 patients with occipital predominant Aβ uptake (OccP). Compared to OccSp group, OccP group had more postive association of atherosclerotic CSVD score (p for interaction = 0.044), but not CAA score with occipital/global ratio of PiB uptake. Our findings suggested that Aβ positive SVCI patients might consist of heterogeneous groups with combined CSVD and Aβ resulting from various pathobiologies. Furthermore, atherosclerotic CSVD might explain increased occipital Aβ uptakes.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment.

Jang, Hyemin / Park, Jong-Yun / Jang, Young Kyoung / Kim, Hee Jin / Lee, Jin San / Na, Duk L / Noh, Young / Lockhart, Samuel N / Seong, Joon-Kyung / Seo, Sang Won

Scientific reports

2018 Volume 8, Issue 1, Page(s) 16178

Abstract: Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments (SVCI) ... ...

Abstract	Amyloid-β (Aβ) and cerebral small vessel disease (CSVD) commonly coexist. They can occur independently by chance, or may interact with each other. We aimed to determine whether the distribution of Aβ in subcortical vascular cognitive impairments (SVCI) patients can be classified by the underlying pathobiologies. A total of 45
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Amyloid/metabolism ; Amyloidogenic Proteins/metabolism ; Aniline Compounds/therapeutic use ; Cerebral Small Vessel Diseases/diagnostic imaging ; Cerebral Small Vessel Diseases/metabolism ; Cerebral Small Vessel Diseases/physiopathology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Occipital Lobe/diagnostic imaging ; Occipital Lobe/physiopathology ; Positron-Emission Tomography ; Thiazoles/therapeutic use
Chemical Substances	2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole ; Amyloid ; Amyloidogenic Proteins ; Aniline Compounds ; Thiazoles
Language	English
Publishing date	2018-11-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-34032-3
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Article ; Online: A TiO

Kim, Moon-Ju / Park, Jong-Min / Yun, Tae Gyeong / Noh, Joo-Yoon / Kang, Min-Jung / Pyun, Jae-Chul

Chemical communications (Cambridge, England)

2020 Volume 56, Issue 32, Page(s) 4420–4423

Abstract: It has been challenging to detect small analytes in both positive and negative ion modes using organic matrices in conventional matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Herein, ... ...

Abstract	It has been challenging to detect small analytes in both positive and negative ion modes using organic matrices in conventional matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Herein, TiO
Language	English
Publishing date	2020-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d0cc00866d
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