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Book ; Online: Bioinformatics and Machine Learning for Cancer Biology

Wan, Shibiao / Wan, Shibiao / Fan, Yiping / Jiang, Chunjie / Li, Shengli

2022

Keywords	Research & information: general ; Biology, life sciences ; tumor mutational burden ; DNA damage repair genes ; immunotherapy ; biomarker ; biomedical informatics ; breast cancer ; estrogen receptor alpha ; persistent organic pollutants ; drug-drug interaction networks ; molecular docking ; NGS ; ctDNA ; VAF ; liquid biopsy ; filtering ; variant calling ; DEGs ; diagnosis ; ovarian cancer ; PUS7 ; RMGs ; CPA4 ; bladder urothelial carcinoma ; immune cells ; T cell exhaustion ; checkpoint ; architectural distortion ; image processing ; depth-wise convolutional neural network ; mammography ; bladder cancer ; Annexin family ; survival analysis ; prognostic signature ; therapeutic target ; R Shiny application ; RNA-seq ; proteomics ; multi-omics analysis ; T-cell acute lymphoblastic leukemia ; CCLE ; sitagliptin ; thyroid cancer (THCA) ; papillary thyroid cancer (PTCa) ; thyroidectomy ; metastasis ; drug resistance ; n/a ; biomarker identification ; transcriptomics ; machine learning ; prediction ; variable selection ; major histocompatibility complex ; bidirectional long short-term memory neural network ; deep learning ; cancer ; incidence ; mortality ; modeling ; forecasting ; Google Trends ; Romania ; ARIMA ; TBATS ; NNAR
Language	English
Size	1 electronic resource (196 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030378719
ISBN	9783036548135 ; 3036548130
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: TIR enzymatic functions: signaling molecules and receptor mechanisms.

Wan, Li

aBIOTECH

2023 Volume 4, Issue 2, Page(s) 172–175

Abstract: The evolutionarily conserved Toll/Interleukin-1 Receptor (TIR) domains across kingdoms of prokaryotes, plants, and animals play critical roles in innate immunity. Recent studies have revealed the enzymatic functions of TIRs, the structural bases of TIRs ... ...

Abstract	The evolutionarily conserved Toll/Interleukin-1 Receptor (TIR) domains across kingdoms of prokaryotes, plants, and animals play critical roles in innate immunity. Recent studies have revealed the enzymatic functions of TIRs, the structural bases of TIRs as holoenzymes, and the identity of TIR-generated small signaling molecules and their receptors, which significantly advanced our understanding on TIR-mediated immune signaling pathways. We reviewed the most up-to-date findings in TIR enzymatic functions from the perspectives of signaling molecules and receptor mechanisms.
Language	English
Publishing date	2023-05-07
Publishing country	Singapore
Document type	Journal Article ; Review
ISSN	2662-1738
ISSN (online)	2662-1738
DOI	10.1007/s42994-023-00104-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cost-utility of sintilimab plus chemotherapy vs chemotherapy as first-line treatment of advanced gastric or gastroesophageal junction cancer in China.

Li, Wei / Wan, Li

Expert review of pharmacoeconomics & outcomes research

2024 , Page(s) 1–8

Abstract: Objectives: ORIENT-16, a phase III clinical trial conducted at 62 hospitals in China, reported that add-on sintilimab (Sin) to chemotherapy (Chemo) had favorable efficacy (: Methods: A three-state partitioned survival model was developed to simulate ... ...

Abstract	Objectives: ORIENT-16, a phase III clinical trial conducted at 62 hospitals in China, reported that add-on sintilimab (Sin) to chemotherapy (Chemo) had favorable efficacy ( Methods: A three-state partitioned survival model was developed to simulate the 10-year life expectancy and total healthcare costs for patients with advanced HER2-negative GC/GEJC. Primary measure outcomes were: cost, quality-adjusted life-years (QALYs), and incremental cost-utility ratios (ICURs). Sensitivity/scenario analyses were conducted to assess the model robustness. Results: In all patients, Sin+Chemo vs Chemo increased costs by $6,472, additionally providing 0.61 QALYs, resulting in an ICUR of $10,610/QALY. While, in PD-L1 combined positive score ≥ 5 cohort, the ICUR was $9,738/QALYs. The ICUR was most sensitive to the utility of progression-free survival. The probabilistic sensitivity analysis showed that add-on Sin had a 100% probability of being cost-effective at a willingness-to-pay threshold of $18,625/QALY gained. Conclusions: Sin+Chemo is a cost-effective first-line treatment option for advanced HER2-negative GC/GEJC in China. Clinical trial registration: ORIENT-16, www.clinicaltrials.gov, identifier is NCT03745170.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2208481-2
ISSN	1744-8379 ; 1473-7167
ISSN (online)	1744-8379
ISSN	1473-7167
DOI	10.1080/14737167.2024.2341859
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-Performance Piezoelectric Nanogenerator of BTO-PVDF Nanofibers for Wearable Sensing.

Jiang, Jiang / Wan, Lingyu / Li, Liuyan / Li, Ping

Macromolecular rapid communications

2024 Volume 45, Issue 6, Page(s) e2300619

Abstract: Piezoelectric nanogenerator (PENG) produces stable electrical signals in response to external mechanical stimuli and holds promise in the fields of flexible sensors and smart wearable devices. In practice, a high-performance PENG with a straightforward ... ...

Abstract	Piezoelectric nanogenerator (PENG) produces stable electrical signals in response to external mechanical stimuli and holds promise in the fields of flexible sensors and smart wearable devices. In practice, a high-performance PENG with a straightforward structure and exceptional reliability is deeply desired. This study optimally synthesizes piezoelectric composites comprising polyvinylidene fluoride (PVDF) incorporated with barium titanate (BTO) nanoparticles (NPs) and fabricated a PENG with heightened sensitivity by using the electrospinning technique. The polar β-phase content of the dual-optimized BTO-PVDF (barium titanate and polyvinylidene fluoride) electrospun fiber reaches up to 82.39%. In the bending mode, it achieves a remarkable maximum open-circuit voltage of 19.152 V, a transferred charge of 8.058 nC, and an output voltage per unit area of 2.128 V cm
MeSH term(s)	Humans ; Barium ; Nanofibers ; Reproducibility of Results ; Electricity ; Fluorocarbon Polymers ; Polyvinyls
Chemical Substances	polyvinylidene fluoride (24937-79-9) ; Barium (24GP945V5T) ; Fluorocarbon Polymers ; Polyvinyls
Language	English
Publishing date	2024-01-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.202300619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of epidemic infectious diseases on the relationship between subjective well-being and social class identity in older adults: The mediating role of Self-rated health.

Feng, Qianxi / Li, Yan / Wan, Miao / Li, Wei

PloS one

2024 Volume 19, Issue 3, Page(s) e0301289

Abstract: Background: The purpose of this paper is to explore the relationship between subjective well-being, social class identity, and Self-rated health among older persons,. Focusing on the mediating role of health and the impact of epidemic infectious ... ...

Abstract	Background: The purpose of this paper is to explore the relationship between subjective well-being, social class identity, and Self-rated health among older persons,. Focusing on the mediating role of health and the impact of epidemic infectious diseases on these relationships. Methods: Based on the 2018 and 2021 China General Social Survey (CGSS) databases, the data were screened, and processed. Using Stata17, we employed ordered probit regression to examine the relationships among variables and Bootstrap methods to assess mediation effects, and the CGSS data for 2018 and 2021 were compared and analyzed. Results: Our results revealed that factors such as social class identity, health status, and personal income significantly positively impact older persons' subjective well-being (P<0.01). Notably, there was a partial mediating effect of health status between the subjective well-being of the elderly and social class identity. And findings showed that when older adults were affected by epidemic diseases, their subjective well-being, social class identity, and Self-rated health remained significantly positively correlated. Subjective well-being, social class identity. What is more noteworthy is that when affected by epidemic infectious diseases, older adults' subjective well-being, social class identity, and Self-rated health remained significantly positively correlated. The mediating role of self-rated health in older adults' subjective well-being and social class identity increased from 9.6% to 12.4%. Conclusions: In the face of epidemic infectious diseases, we need to pay more attention to the Self-rated health of the elderly, and the Chinese government should take effective measures to improve their health level, which will in turn improve the subjective well-being of the elderly and realize the goal of healthy aging.
MeSH term(s)	Aged ; Aged, 80 and over ; Humans ; China ; Health Status ; Social Class ; Social Identification ; East Asian People
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301289
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Functional Biomaterials and Digital Technologies in Dentistry: From Bench to Bedside.

Li, Ping / Wan, Guojiang / Xu, Shulan / Li, An

Journal of functional biomaterials

2024 Volume 15, Issue 4

Abstract: This Special Issue, "Functional Biomaterials and Digital Technologies in Dentistry: From Bench to Bedside", highlights the integration of advanced materials science and digital technologies in dental and maxillofacial applications [ ... ]. ...

Abstract	This Special Issue, "Functional Biomaterials and Digital Technologies in Dentistry: From Bench to Bedside", highlights the integration of advanced materials science and digital technologies in dental and maxillofacial applications [...].
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb15040107
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A trial-based cost-utility analysis of sugemalimab vs. placebo as consolidation therapy for unresectable stage III NSCLC in China.

Li, Wei / Wan, Li

PloS one

2023 Volume 18, Issue 6, Page(s) e0286595

Abstract: Objective: The effectiveness of sugemalimab vs. placebo in post-chemoradiotherapy patients with locally advanced, unresectable stage III NSCLC has been demonstrated and approved by China National Medical Products Administration. The purpose of this ... ...

Abstract	Objective: The effectiveness of sugemalimab vs. placebo in post-chemoradiotherapy patients with locally advanced, unresectable stage III NSCLC has been demonstrated and approved by China National Medical Products Administration. The purpose of this study was to assess the cost-effectiveness of sugemalimab vs. placebo for consolidation treatment of stage III NSCLC from the perspective of the Chinese healthcare system. Methods: A 3-state Markov model with a 3-week cycle length was performed to appraise the incremental cost-utility ratio (ICUR) of sugemalimab consolidation therapy based on the GEMSTONE-301 clinical trial over a 10-year time horizon. Only direct medical costs, including costs of drug (maintenance and subsequent treatment), routine follow-up, best supportive care, and terminal care in end of life were considered in this model. Costs and health utilities were obtained from local databases and published articles. Sensitivity and scenario analyses were adopted to evaluate the model uncertainty. Internal and external data sources were used to justify the plausibility of the extrapolated portion of the survival model chosen. Results: In comparison with the placebo, sugemalimab consolidation therapy was not cost-effective as it yielded an ICUR value of $90,277 and $49,692 for the concurrent chemoradiotherapy (cCRT) and the sequential chemoradiotherapy (sCRT) population at the willingness-to-pay (WTP) threshold of $37,663/QALYs, respectively. When taking the sugemalimab patient assistance program (PAP) into consideration, sugemalimab consolidation therapy was cost-effective with an ICUR dramatic decreases below the WTP. Sensitivity analyses demonstrated that the ICUR was most sensitive to the discount rate and subsequent treatment. However, none of the sensitive parameters could affect the cost-effective conclusions without or with PAP. Scenario analyses revealed that the model was particularly affected by assumptions regarding discount in sugemalimab, time horizon, mean duration of sugemalimab maintenance treatment. Conclusions: From the perspective of Chinese healthcare system, sugemalimab consolidation therapy was not a cost-effective strategy in cCRT and sCRT patients with unresectable stage III NSCLC. Given that the sugemalimab PAP was available, sugemalimab consolidation therapy became a cost-effective option.
MeSH term(s)	Humans ; Cost-Benefit Analysis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Chemoradiotherapy ; Lung Neoplasms/drug therapy
Chemical Substances	sugemalimab
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0286595
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cost-effectiveness analysis of adding transarterial chemoembolisation to lenvatinib as first-line treatment for advanced hepatocellular carcinoma in China.

Li, Wei / Wan, Li

BMJ open

2023 Volume 13, Issue 9, Page(s) e074245

Abstract: Objective: The objective of this study was to evaluate the comparative cost-effectiveness of lenvatinib (LEN) plus transarterial chemoembolisation (TACE) (LEN-TACE) and LEN alone to treat advanced hepatocellular carcinoma (HCC) from the perspective of ... ...

Abstract	Objective: The objective of this study was to evaluate the comparative cost-effectiveness of lenvatinib (LEN) plus transarterial chemoembolisation (TACE) (LEN-TACE) and LEN alone to treat advanced hepatocellular carcinoma (HCC) from the perspective of the Chinese healthcare system. Design: A three-state partitioned survival model using clinical survival data from a phase III LAUNCH trial, a 5-year time horizon for costs and quality-adjusted life years (QALYs) was constructed to analyse the cost-effectiveness of LEN-TACE. Clinical inputs were extracted from the LAUNCH trial, with outcomes extrapolated using standard and flexible parametric survival models. Costs and utilities derived from published literature were discounted at an annual rate of 5%. Sensitivity analyses and scenario analyses were conducted to test the robustness of the model. Setting: The Chinese healthcare system perspective. Participants: A hypothetical Chinese cohort of patients with advanced HCC. Interventions: TACE plus LEN versus LEN. Primary outcome measure: Costs, QALYs, incremental cost-effectiveness ratio (ICER). Results: Base-case analysis revealed that LEN-TACE would be cost-effective in China at the willingness-to-pay (WTP) threshold of $37 663 per QALYs, with improved effectiveness of 0.382 QALYs and additional cost of $12 151 (ICER: $31 808 per QALY). The probabilistic sensitivity analysis suggested that LEN-TACE had a 93.5% probability of cost-effectiveness at WTP threshold of three times gross domestic product per capital ($37 663). One-way deterministic sensitivity analysis indicated that the duration of LEN treatment in both two arms, utility of progression-free survival and the cost of TACE had a greater impact on the stability of ICER values. Scenario analyses results were in line with base-case analysis. Conclusions: LEN-TACE might be a cost-effective strategy compared with LEN for the first-line treatment of patients with advanced HCC in China.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Cost-Effectiveness Analysis ; Liver Neoplasms/therapy ; Cost-Benefit Analysis
Chemical Substances	lenvatinib (EE083865G2)
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-074245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Colletotrichum nanjingense

Li, Hui / Wan, Yu / Li, De-Wei / Zhu, Li-Hua

Plant disease

2024 Volume 108, Issue 1, Page(s) 82–93

Abstract: ... ...

Abstract	Jasminum
MeSH term(s)	Colletotrichum ; Jasminum/genetics ; Phylogeny ; Plant Diseases ; DNA, Fungal/genetics ; China ; Plant Leaves
Chemical Substances	DNA, Fungal
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-04-23-0693-RE
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Excitations of atomic vibrations in amorphous solids.

Wan, Li

Journal of physics. Condensed matter : an Institute of Physics journal

2021 Volume 33, Issue 15

Abstract: We study excitations of atomic vibrations in the reciprocal space for amorphous solids. There are two kinds of excitations we obtained, collective excitation and local excitation. The collective excitation is the collective vibration of atoms in the ... ...

Abstract	We study excitations of atomic vibrations in the reciprocal space for amorphous solids. There are two kinds of excitations we obtained, collective excitation and local excitation. The collective excitation is the collective vibration of atoms in the amorphous solids while the local excitation is stimulated locally by a single atom vibrating in the solids. We introduce a continuous wave vector for the study and transform the equations of atomic vibrations from the real space to the reciprocal space. We take the amorphous silicon as an example and calculate the structures of the excitations in the reciprocal space. Results show that an excitation is a wave packet composed of a collection of plane waves. We also find a periodical structure in the reciprocal space for the collective excitation with longitudinal vibrations, which is originated from the local order of the structure in the real space of the amorphous solid. For the local excitation, the wave vector is complex. The imaginary part of the wave vector is inversed to evaluate the decaying length of the local excitation. It is found that the decaying length is larger for the local excitation with a higher vibration frequency.
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/abdd61
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