Article ; Online: Progress in novel cellular therapy options for chronic lymphocytic leukemia: the M D Anderson perspective.
Clinical lymphoma, myeloma & leukemia
2014 Volume 14 Suppl, Page(s) S18–22
Abstract: Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made ... ...
Abstract | Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made these modalities more available to a broader range of patients. Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity. This brief review discusses recent cutting-edge experience with chimeric antigen receptor T cells as well as developing cellular therapy products at the authors' institution. |
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MeSH term(s) | Adoptive Transfer ; Cell- and Tissue-Based Therapy/methods ; Humans ; Immunotherapy/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy ; Receptors, Antigen, T-Cell/genetics ; Recombinant Fusion Proteins/genetics ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism |
Chemical Substances | Receptors, Antigen, T-Cell ; Recombinant Fusion Proteins |
Language | English |
Publishing date | 2014-09 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 2540992-X |
ISSN | 2152-2669 ; 2152-2650 |
ISSN (online) | 2152-2669 |
ISSN | 2152-2650 |
DOI | 10.1016/j.clml.2014.06.013 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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