LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1287

Search options

  1. Article: Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients.

    Tang, Cha-Mei / Adams, Daniel L

    Biomedicines

    2022  Volume 10, Issue 3

    Abstract: The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has ... ...

    Abstract The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A recently identified type of circulating stromal cell, which appears to be more frequent than CTCs, was found engulfing tumor material at the tumor site and then entering the blood stream. These cells were defined as cancer-associated macrophage-like cells (CAMLs). Together, CTCs and CAMLs may be able to provide information for cancer detection and diagnosis, without the use of tissue. CTCs and CAMLs have many clinical applications, three of which are summarized in this review: for prognosis, as companion diagnostics, and for residual disease monitoring.
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10030587
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Pragmatism in manual therapy trials for knee osteoarthritis: a systematic review.

    Adams, Kyle R / Famuyide, Ayodeji O / Young, Jodi L / Maddox, C Daniel / Rhon, Daniel I

    Archives of physiotherapy

    2024  Volume 14, Page(s) 1–10

    Abstract: Introduction: Manual therapy is an often-utilized intervention for the management of knee osteoarthritis (OA). The interpretation of results presented by these trials can be affected by how well the study designs align applicability to real-world ... ...

    Abstract Introduction: Manual therapy is an often-utilized intervention for the management of knee osteoarthritis (OA). The interpretation of results presented by these trials can be affected by how well the study designs align applicability to real-world clinical settings.
    Aim: To examine the existing body of clinical trials investigating manual therapy for knee OA to determine where they fall on the efficacy-effectiveness spectrum.
    Methods: This systematic review has been guided and informed by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Randomized controlled trials that investigated manual therapy treatments for adults with knee OA were retrieved via searches of multiple databases to identify trials published prior to April 2023. The Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES) tool was used to objectively rate the efficacy-effectiveness nature of each trial design. The Cochrane Risk of Bias 2.0 assessment tool (RoB-2) was used to assess the risk of bias across five domains.
    Results: Of the 36 trials, a higher percentage of trials had a greater emphasis on efficacy within all four domains: participant characteristics (75.0%), trial setting (77.8%), flexibility of intervention (58.3%), and clinical relevance of experimental and comparison intervention (47.2%). In addition, 13.9% of the trials had low risk of bias, 41.7% had high risk of bias, and 44.4% had some concerns regarding bias.
    Conclusions: While many trials support manual therapy as effective for the management of knee OA, a greater focus on study designs with an emphasis on effectiveness would improve the applicability and generalizability of future trials.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2057-0082
    ISSN (online) 2057-0082
    DOI 10.33393/aop.2024.2916
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Solvent Suppression in Pure Shift NMR.

    Gates, Emma L / Bradley, Jonathan P / Berry, Daniel B G / Nilsson, Mathias / Morris, Gareth A / Adams, Ralph W / Castañar, Laura

    Analytical chemistry

    2024  Volume 96, Issue 9, Page(s) 3879–3885

    Abstract: Intense solvent signals ... ...

    Abstract Intense solvent signals in
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05379
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Cancer Associated Macrophage-like Cells Are Prognostic for Highly Aggressive Prostate Cancer in Both the Non-Metastatic and Metastatic Settings.

    Gironda, Daniel J / Bergan, Raymond C / Alpaugh, R Katherine / Danila, Daniel C / Chuang, Tuan L / Hurtado, Brenda Y / Ho, Thai / Adams, Daniel L

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Despite advancements in the early-stage detection and expansion of treatments for prostate cancer (PCa), patient mortality rates remain high in patients with aggressive disease and the overtreatment of indolent disease remains a major issue. Prostate- ... ...

    Abstract Despite advancements in the early-stage detection and expansion of treatments for prostate cancer (PCa), patient mortality rates remain high in patients with aggressive disease and the overtreatment of indolent disease remains a major issue. Prostate-specific antigen (PSA), a standard PCa blood biomarker, is limited in its ability to differentiate disease subtypes resulting in the overtreatment of non-aggressive indolent disease. Here we assess engorged cancer-associated macrophage-like cells (CAMLs), a ≥50 µm, cancer-specific, polynucleated circulating cell type found in the blood of patients with PCa as a potential companion biomarker to PSA for patient risk stratification. We found that rising PSA is positively correlated with increasing CAML size (r = 0.307,
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143725
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Intranodal Neurofibroma: A Case Report and Literature Review.

    Adams, Steven H / Huston, Tara L / Lozeau, Daniel

    The American Journal of dermatopathology

    2022  Volume 44, Issue 4, Page(s) 306–311

    Abstract: Purpose: To report a case of neurofibroma involving the lymph nodes and to perform a literature review on this topic.: Observations: A 72-year-old woman with a history of neurofibromatosis and biopsy-proven malignant melanoma of the left forearm ... ...

    Abstract Purpose: To report a case of neurofibroma involving the lymph nodes and to perform a literature review on this topic.
    Observations: A 72-year-old woman with a history of neurofibromatosis and biopsy-proven malignant melanoma of the left forearm underwent wide local excision of the malignant lesion along with sentinel axillary lymph node biopsy. Histological examination of axillary nodes revealed diffuse neurofibromatosis within 2 lymph node capsules. A thorough review of the English literature pertaining to intranodal neurofibroma was performed by querying Google Scholar and PubMed. Only 5 cases of intranodal neurofibroma have been described until now.
    Conclusions and importance: Neurofibroma involving the lymph nodes is rare and this is the first reported case that is shown to diffusely involve the intracapsular space. Furthermore, intranodal neurofibroma can represent a diagnostic pitfall in the evaluation of sentinel lymph nodes for metastatic melanoma.
    MeSH term(s) Aged ; Axilla ; Diagnosis, Differential ; Fatal Outcome ; Female ; Forearm ; Humans ; Melanoma/complications ; Melanoma/diagnosis ; Melanoma/secondary ; Neoplasms, Multiple Primary/complications ; Neoplasms, Multiple Primary/diagnosis ; Neoplasms, Multiple Primary/pathology ; Neurofibroma/complications ; Neurofibroma/diagnosis ; Neurofibroma/pathology ; Neurofibromatoses ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/complications ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002137
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1518: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Using Photovoice to Explore the Lived Environment and Experience of Older Adults with Frailty on their Kidney Transplant Journey.

    Hladek, Melissa deCardi / Wilson, Deborah / Krasnansky, Katie / McDaniel, Kennedy / Shanbhag, Meera / McAdams-DeMarco, Mara / Crews, Deidra C / Brennan, Daniel C / Taylor, Janiece / Segev, Dorry / Walston, Jeremy / Xue, Qian-Li / Szanton, Sarah L

    Kidney360

    2024  Volume 5, Issue 4, Page(s) 589–598

    MeSH term(s) Humans ; Kidney Transplantation ; Aged ; Frailty/psychology ; Female ; Male ; Photography ; Frail Elderly/psychology ; Aged, 80 and over
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000380
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients

    Cha-Mei Tang / Daniel L. Adams

    Biomedicines, Vol 10, Iss 587, p

    2022  Volume 587

    Abstract: The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has ... ...

    Abstract The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A recently identified type of circulating stromal cell, which appears to be more frequent than CTCs, was found engulfing tumor material at the tumor site and then entering the blood stream. These cells were defined as cancer-associated macrophage-like cells (CAMLs). Together, CTCs and CAMLs may be able to provide information for cancer detection and diagnosis, without the use of tissue. CTCs and CAMLs have many clinical applications, three of which are summarized in this review: for prognosis, as companion diagnostics, and for residual disease monitoring.
    Keywords cancer-associated macrophage-like cells CAMLs ; CTCs ; circulating tumor cells ; immunotherapy ; PD-L1 ; residual disease ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Fish assemblage shifts in an Ozark river over 80 years amidst a mosaic of forest regeneration and persistent pasture

    Morrill, Daniel P. / Connolly, Matthew H. / Adams, Ginny L. / Adams, Steven Reid

    Ecology of Freshwater Fish. 2023 Apr., v. 32, no. 2 p.257-269

    2023  

    Abstract: Fish assemblages are useful in evaluating the health of aquatic ecosystems. Over time, fish assemblages will respond to anthropogenic disturbances but may also simultaneously respond to conservation efforts in a watershed, shifting the taxonomic and ... ...

    Abstract Fish assemblages are useful in evaluating the health of aquatic ecosystems. Over time, fish assemblages will respond to anthropogenic disturbances but may also simultaneously respond to conservation efforts in a watershed, shifting the taxonomic and functional structure of the assemblage. We quantified temporal changes in taxonomic and functional structure of fish assemblages in the Current River, Missouri, over an 80‐year time span and related these changes to forest regeneration and persistent pasture land use within the watershed. We found shifts in taxonomic and functional assemblage structure in two time‐steps from the 1940s to 2020 related to land use within the watershed. Reforested reaches exhibited increases in benthic species, rheophilic species and invertivorous feeding guilds. Higher pasture reaches exhibited decreases in benthic species and native centrarchid species while generalist centrarchid species increased. Ultimately, fish assemblage structure in the Current River appears to be shifting to an alternative state (i.e. increased presence/abundance of benthic species) in response to forest regeneration and persistent pasture land use.
    Keywords benthic organisms ; ecology ; forest regeneration ; freshwater fish ; land use ; pastures ; rheophilic species ; rivers ; watersheds ; Missouri
    Language English
    Dates of publication 2023-04
    Size p. 257-269.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 913011-1
    ISSN 0906-6691
    ISSN 0906-6691
    DOI 10.1111/eff.12683
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5359: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Broadly conserved FlgV controls flagellar assembly and

    Zamba-Campero, Maxime / Soliman, Daniel / Yu, Huaxin / Lasseter, Amanda G / Chang, Yuen-Yan / Liu, Jun / Aravind, L / Jewett, Mollie W / Storz, Gisela / Adams, Philip P

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Flagella propel pathogens through their environments yet are expensive to synthesize and are immunogenic. Thus, complex hierarchical regulatory networks control flagellar gene expression. Spirochetes are highly motile bacteria, but peculiarly in the Lyme ...

    Abstract Flagella propel pathogens through their environments yet are expensive to synthesize and are immunogenic. Thus, complex hierarchical regulatory networks control flagellar gene expression. Spirochetes are highly motile bacteria, but peculiarly in the Lyme spirochete
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.09.574855
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Cancer associated macrophage-like cells in metastatic renal cell carcinoma predicts for poor prognosis and tracks treatment response in real time.

    Ali, Amama / Adams, Daniel L / Kasabwala, Dimpal M / Tang, Cha-Mei / Ho, Thai H

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10544

    Abstract: Renal Cell Carcinoma (RCC) is a fatal urological cancer, with one third of patients diagnosed with metastasis, resulting in a 5-year survival of only 12%. Recent advancements in therapies have increased survival in mRCC, but lack efficacy in subtypes, ... ...

    Abstract Renal Cell Carcinoma (RCC) is a fatal urological cancer, with one third of patients diagnosed with metastasis, resulting in a 5-year survival of only 12%. Recent advancements in therapies have increased survival in mRCC, but lack efficacy in subtypes, due to treatment resistance and toxic side effects. Currently, white blood cells, hemoglobin, and platelets are limitedly used as blood based biomarkers to help determine RCC prognosis. Cancer associated macrophage-like cells (CAMLs) are a potential mRCC biomarker which have been identified in peripheral blood of patients with malignant tumors and have been shown to predict poor clinical patient outcomes based on their number and size. In this study, blood samples from 40 RCC patients were obtained to evaluate the clinical utility of CAMLs. CAML changes were monitored during treatment regimens to evaluate their ability to predict treatment efficacy. It was observed that patients with smaller CAMLs had better progression free survival (HR = 2.84, 95% CI 1.22-6.60, p = 0.0273) and overall survival (HR = 3.95, 95% CI 1.45-10.78, p = 0.0154) versus patients with larger CAMLs. These findings suggest that CAMLs can be used as a diagnostic, prognostic, and predictive biomarker for patients with RCC which may help improve management of advanced RCC.
    MeSH term(s) Humans ; Carcinoma, Renal Cell ; Kidney Neoplasms ; Blood Platelets ; Drug-Related Side Effects and Adverse Reactions ; Macrophages
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37671-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top