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  1. Article ; Online: Determinants of long-term outcomes in patients with COVID-19 supported with ECMO.

    Guervilly, Christophe / Giani, Marco / Nesseler, Nicolas / Schmidt, Matthieu / Hraiech, Sami

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 5, Page(s) e41

    MeSH term(s) Humans ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation ; Respiratory Insufficiency ; Time Factors ; Retrospective Studies
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00010-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Assessment of Airway Closure and Expiratory Airflow Limitation to Set Positive End-Expiratory Pressure in Morbidly Obese Patients with Acute Respiratory Distress Syndrome.

    Mezidi, Mehdi / Esnault, Pierre / Hraiech, Sami / Guervilly, Christophe

    American journal of respiratory and critical care medicine

    2022  Volume 203, Issue 3, Page(s) 391–392

    MeSH term(s) Hemodynamics ; Humans ; Obesity, Morbid/complications ; Positive-Pressure Respiration ; Pulmonary Ventilation ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202009-3477LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Outcomes of Severe ARDS COVID-19 Patients Denied for Venovenous ECMO Support: A Prospective Observational Comparative Study.

    Sylvestre, Aude / Forel, Jean-Marie / Textoris, Laura / Gragueb-Chatti, Ines / Daviet, Florence / Salmi, Saida / Adda, Mélanie / Roch, Antoine / Papazian, Laurent / Hraiech, Sami / Guervilly, Christophe

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051493
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  4. Article: Neuromuscular blockade in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Ho, An Thi Nhat / Patolia, Setu / Guervilly, Christophe

    Journal of intensive care

    2020  Volume 8, Page(s) 12

    Abstract: Background: Neuromuscular blocking agent (NMBA) has been proposed by medical guidelines for early severe acute respiratory distress syndrome (ARDS) because of its survival benefits. However, new studies have provided evidence contradicting these results. ...

    Abstract Background: Neuromuscular blocking agent (NMBA) has been proposed by medical guidelines for early severe acute respiratory distress syndrome (ARDS) because of its survival benefits. However, new studies have provided evidence contradicting these results.
    Method: A search was performed of the Pubmed, Scopus, Clinicaltrials.gov, and Virtual Health Library databases for randomized controlled trials (RCT) evaluating 28-day mortality in ARDS patients treated with NMBA within 48 h. An English language restriction was applied. Relevant data were extracted and pooled into risk ratios (RR), mean differences (MD), and corresponding 95% confidence intervals (CI) using random-effect model. Sensitivity and meta-regression analysis were performed.
    Results: From 2675 studies, we included five RCTs in the analysis, for a total of 1461 patients with a mean PaO
    Conclusion: NMBA improves oxygenation only after 48 h in moderate, severe ARDS patients and has a lower barotrauma risk without affecting ICU weakness. However, NMBA does not reduce ventilator-free days, duration of mechanical ventilation or, most importantly, the mortality risk regardless of the severity of ARDS.
    Keywords covid19
    Language English
    Publishing date 2020-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-020-0431-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute respiratory distress syndrome phenotyping and latent class analysis, first steps toward precision medicine in critical care illness?

    Guervilly, Christophe / Parzy, Gabriel / Papazian, Laurent

    Journal of thoracic disease

    2019  Volume 11, Issue Suppl 3, Page(s) S303–S306

    Language English
    Publishing date 2019-04-09
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2019.01.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Faisabilité et place du décubitus ventral chez le patient non intubé de réanimation. Non intubated prone in intensive care, feasibility and indications

    Perez, Yonatan / Pasquet, Augustin / Thepenier, Mathieu / Guervilly, Christophe / Ehrmann, Stephan

    Médecine intensive réanimation

    2022  Volume 31, Issue 4, Page(s) 273

    Language French
    Document type Article
    ZDB-ID 2870987-1
    ISSN 2496-6142
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4839: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Beyond current treatment of Fanconi Anemia: What do advances in cell and gene-based approaches offer?

    Martínez-Balsalobre, Elena / Guervilly, Jean-Hugues / van Asbeck-van der Wijst, Jenny / Pérez-Oliva, Ana Belén / Lachaud, Christophe

    Blood reviews

    2023  Volume 60, Page(s) 101094

    Abstract: Fanconi anemia (FA) is a rare inherited disorder that mainly affects the bone marrow. This condition causes decreased production of all types of blood cells. FA is caused by a defective repair of DNA interstrand crosslinks and to date, mutations in over ... ...

    Abstract Fanconi anemia (FA) is a rare inherited disorder that mainly affects the bone marrow. This condition causes decreased production of all types of blood cells. FA is caused by a defective repair of DNA interstrand crosslinks and to date, mutations in over 20 genes have been linked to the disease. Advances in science and molecular biology have provided new insight between FA gene mutations and the severity of clinical manifestations. Here, we will highlight the current and promising therapeutic options for this rare disease. The current standard treatment for FA patients is hematopoietic stem cell transplantation, a treatment associated to exposure to radiation or chemotherapy, immunological complications, plus opportunistic infections from prolonged immune incompetence or increased risk of morbidity. New arising treatments include gene addition therapy, genome editing using CRISPR-Cas9 nuclease, and hematopoietic stem cell generation from induced pluripotent stem cells. Finally, we will also discuss the revolutionary developments in mRNA therapeutics as an opportunity for this disease.
    MeSH term(s) Humans ; Fanconi Anemia/diagnosis ; Fanconi Anemia/genetics ; Fanconi Anemia/therapy ; Bone Marrow/metabolism ; Genetic Therapy ; Hematopoietic Stem Cells/metabolism ; DNA Damage
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Using an Impella device to reverse refractory cardiac arrest and enable efficient coronary revascularisation.

    Persico, Nicolas / Guervilly, Christophe / Verhamme, Baptiste / Bonello, Laurent

    BMJ case reports

    2019  Volume 12, Issue 8

    Abstract: We report the case of a 54-year-old man who suffered from refractory cardiac arrest secondary to acute myocardial infarction. As veno-arterial extracorporeal membrane oxygenation was unavailable, mechanical chest compression was performed and an Impella ... ...

    Abstract We report the case of a 54-year-old man who suffered from refractory cardiac arrest secondary to acute myocardial infarction. As veno-arterial extracorporeal membrane oxygenation was unavailable, mechanical chest compression was performed and an Impella device was used that immediately delivered at 3.2 l/min flow to reach the optimal mean arterial pressure. Within 1 min, return of spontaneous circulation was achieved and a 40% left ventricular ejection fraction was measured on echography. Then, the right coronary artery could be revascularised. Despite 62 min low flow, the patient was discharged home on day 19 without neurological sequelae. During refractory cardiac arrest, the European Resuscitation Guidelines indicate that veno-arterial extracorporeal membrane oxygenation should be considered as rescue therapy. Other mechanical circulatory supports such as an Impella device (left ventricular assist device propelling blood in the ascending aorta) can be a promising treatment in select patients; however, insufficient data in humans are available.
    MeSH term(s) Advanced Cardiac Life Support/methods ; Coronary Angiography/methods ; Electric Countershock ; Heart Arrest/therapy ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Stents
    Language English
    Publishing date 2019-08-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Extracorporeal membrane oxygenation in acute respiratory distress syndrome: why is the EOLIA trial important?

    Persico, Nicolas / Guervilly, Christophe / Roch, Antoine / Papazian, Laurent

    Annals of translational medicine

    2017  Volume 6, Issue Suppl 1, Page(s) S20

    Language English
    Publishing date 2017-11-21
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.09.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Respiratory rate and peak inspiratory pressure, new targets from the LUNG SAFE study analysis or physiopathological artifacts?

    Guervilly, Christophe / Forel, Jean Marie / Papazian, Laurent

    Journal of thoracic disease

    2017  Volume 9, Issue 2, Page(s) 225–227

    Language English
    Publishing date 2017-01-01
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.02.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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