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Article ; Online: High-Intensity Focused Ultrasound Surgery for Tumor Ablation: A Review of Current Applications.

De Maio, Alessandro / Alfieri, Giulia / Mattone, Monica / Ghanouni, Pejman / Napoli, Alessandro

Radiology. Imaging cancer

2023 Volume 6, Issue 1, Page(s) e230074

Abstract: The management of cancer with alternative approaches is a matter of clinical interest worldwide. High-intensity focused ultrasound (HIFU) surgery is a noninvasive technique performed under US or MRI guidance. The most studied therapeutic uses of HIFU ... ...

Abstract	The management of cancer with alternative approaches is a matter of clinical interest worldwide. High-intensity focused ultrasound (HIFU) surgery is a noninvasive technique performed under US or MRI guidance. The most studied therapeutic uses of HIFU involve thermal tissue ablation, demonstrating both palliative and curative potential. However, concurrent mechanical bioeffects also provide opportunities in terms of augmented drug delivery and immunosensitization. The safety and efficacy of HIFU integration with current cancer treatment strategies are being actively investigated in managing primary and secondary tumors, including cancers of the breast, prostate, pancreas, liver, kidney, and bone. Current primary HIFU indications are pain palliation, complete ablation of localized earlystage tumors, or debulking of unresectable late-stage cancers. This review presents the latest HIFU applications, from investigational to clinically approved, in the field of tumor ablation.
MeSH term(s)	Male ; Humans ; Liver ; Drug Delivery Systems ; Hyperthermia, Induced ; Neoplasms/diagnostic imaging ; Neoplasms/surgery ; Ultrasonic Surgical Procedures
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2638-616X
ISSN (online)	2638-616X
DOI	10.1148/rycan.230074
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Article ; Online: Fecal Microbiota Transplantation in Amyotrophic Lateral Sclerosis: Clinical Protocol and Evaluation of Microbiota Immunity Axis.

Niccolai, Elena / Martinelli, Ilaria / Quaranta, Gianluca / Nannini, Giulia / Zucchi, Elisabetta / De Maio, Flavio / Gianferrari, Giulia / Bibbò, Stefano / Cammarota, Giovanni / Mandrioli, Jessica / Masucci, Luca / Amedei, Amedeo

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2761, Page(s) 373–396

Abstract: The fecal microbial transplantation (FMT) is a therapeutic transplant of fecal microbiota from healthy donors to patients. This practice is aimed at restoring eubiosis and rebalancing the enteric and systemic immune responses, and then eliminating ... ...

Abstract	The fecal microbial transplantation (FMT) is a therapeutic transplant of fecal microbiota from healthy donors to patients. This practice is aimed at restoring eubiosis and rebalancing the enteric and systemic immune responses, and then eliminating pathogenic triggers of multiple disease, including neurodegenerative diseases. Alterations of gut microbiota (GM) affect the central nervous system (CNS) health, impacting neuro-immune interactions, synaptic plasticity, myelination, and skeletal muscle function. T-regulatory lymphocytes (Treg) are among the most important players in the pathogenesis of amyotrophic lateral sclerosis (ALS), altering the disease course. Along with circulating neuropeptides, other immune cells, and the gut-brain axis, the GM influences immunological tolerance and controls Treg's number and suppressive functions. A double-blind, controlled, multicenter study on FMT in ALS patients has been designed to evaluate if FMT can modulate neuroinflammation, by restoring Treg number, thus modifying disease activity and progression.
MeSH term(s)	Humans ; Fecal Microbiota Transplantation ; Amyotrophic Lateral Sclerosis/therapy ; Microbiota ; Gastrointestinal Microbiome/physiology ; Clinical Protocols ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3662-6_27
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Article ; Online: In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing

Posteraro, Brunella / De Maio, Flavio / Motro, Yair / Menchinelli, Giulia / De Lorenzis, Desy / Marano, Roberto B M / Aljanazreh, Bessan / Errico, Federica Maria / Massaria, Giuseppe / Spanu, Teresa / Posteraro, Patrizia / Moran-Gilad, Jacob / Sanguinetti, Maurizio

Microbiology spectrum

2024 Volume 12, Issue 4, Page(s) e0330523

Abstract: Bloodstream infection (BSI) caused by carbapenem- ... ...

Abstract	Bloodstream infection (BSI) caused by carbapenem-resistant
MeSH term(s)	Humans ; Klebsiella pneumoniae ; Colistin ; Phylogeny ; Klebsiella Infections/epidemiology ; Multilocus Sequence Typing ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Anti-Bacterial Agents/pharmacology ; Carbapenems ; Anti-Infective Agents ; Plasmids/genetics ; Italy ; Hospitals ; Microbial Sensitivity Tests
Chemical Substances	Colistin (Z67X93HJG1) ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; Anti-Bacterial Agents ; Carbapenems ; Anti-Infective Agents
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03305-23
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Article ; Online: Profiling the Urobiota in a Pediatric Population with Neurogenic Bladder Secondary to Spinal Dysraphism.

De Maio, Flavio / Grotti, Giacomo / Mariani, Francesco / Buonsenso, Danilo / Santarelli, Giulia / Bianco, Delia Mercedes / Posteraro, Brunella / Sanguinetti, Maurizio / Rendeli, Claudia

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development ... ...

Abstract	The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development of urinary tract disorders is now of great interest. Patients with spina bifida (SB) can be born with (or develop over time) neurological deficits due to damaged nerves that originate in the lower part of the spinal cord, including the neurogenic bladder. This condition represents a predisposing factor for urinary tract infections so that the most frequently used approach to treat patients with neurogenic bladder is based on clean intermittent catheterization (CIC). In this study, we analyzed the urobiota composition in a pediatric cohort of patients with SB compared to healthy controls, as well as the urobiota characteristics based on whether patients received CIC or not.
MeSH term(s)	Humans ; Child ; Urinary Bladder, Neurogenic/complications ; Urinary Bladder, Neurogenic/therapy ; Spinal Dysraphism/complications ; Intermittent Urethral Catheterization ; Urinary Tract Infections/complications ; Urinary Tract
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098261
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Article ; Online: Pilot study on cultural and metagenomic analysis of bile and biliary stentslead to unveiling the key players in stent occlusion.

Cacaci, Margherita / De Maio, Flavio / Matteo, Maria Valeria / Posteraro, Brunella / Di Vito, Maura / Menchinelli, Giulia / Tringali, Andrea / Monzo, Francesca Romana / Torelli, Riccardo / Costamagna, Guido / Spada, Cristiano / Bugli, Francesca / Sanguinetti, Maurizio / Boskoski, Ivo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3344

Abstract: Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically ... ...

Abstract	Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically arising from surgical interventions such as liver transplants and cholecystectomy, as well as chronic inflammatory conditions, present a common clinical challenge. The current gold standard for treating BBSs involves the periodic insertion of plastic stents at intervals of 3-4 months, spanning a course of approximately one year. Unfortunately, stent occlusion emerges as a prevalent issue within this treatment paradigm, leading to the recurrence of symptoms and necessitating repeated ERCPs. In response to this clinical concern, we initiated a pilot study, delving into the microbial composition present in bile and on the inner surfaces of plastic stents. This investigation encompassed 22 patients afflicted by BBSs who had previously undergone ERCP with plastic stent placement. Our preliminary findings offered promising insights into the microbial culprits behind stent occlusion, with Enterobacter and Lactobacillus spp. standing out as prominent bacterial species known for their biofilm-forming tendencies on stent surfaces. These revelations hold promise for potential interventions, including targeted antimicrobial therapies aimed at curtailing bacterial growth on stents and the development of advanced stent materials boasting anti-biofilm properties.
MeSH term(s)	Humans ; Bile ; Pilot Projects ; Treatment Outcome ; Cholestasis/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Biliary Tract ; Stents ; Retrospective Studies
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51480-2
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Article: Self-Completion Questionnaire on Sleep Evaluation in Patients Undergoing Oxaliplatin Therapy: An Observational Study.

Mussa, Maria Valentina / Allegra, Sarah / Armando, Tiziana / Storto, Silvana / Ghezzo, Beatrice / Soave, Giulia / Abbadessa, Giuliana / Chiara, Francesco / Di Maio, Massimo / Dagnoni, Fiammetta Maria / De Francia, Silvia

Cancers

2024 Volume 16, Issue 5

Abstract: Sleep is a fundamental human need; sleep disruption, in fact, causes an increase in the activity of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and pro-inflammatory ... ...

Abstract	Sleep is a fundamental human need; sleep disruption, in fact, causes an increase in the activity of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and pro-inflammatory responses. The scientific literature is finally starting to pay attention to the central role of sleep alterations in patients health. Oxaliplatin is extensively used for the treatment of gastrointestinal cancer and other malignancies, with an increased frequency of use in recent years. This study aims to understand the effects of sleep complaints on health and quality of life in cancer patients treated with oxaliplatin. A study has been conducted through the creation and distribution of questionnaires to patients to investigate their complaints about sleep quality. We observed significant differences between males and females in evaluating sleep hygiene scores, the Pittsburgh Sleep Quality Index, and previous difficulty sleeping. Moreover, in females, stress, worries, and anxiety seem to play a negative role in the sleep hygiene score. The obtained results could improve the interest of healthcare personnel and caregivers in sleep quality in patients undergoing chemotherapy.
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16050946
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Article ; Online: Lung microbiota composition, respiratory mechanics, and outcomes in COVID-19-related ARDS.

De Pascale, Gennaro / Posteraro, Brunella / De Maio, Flavio / Pafundi, Pia Clara / Tanzarella, Eloisa Sofia / Cutuli, Salvatore Lucio / Lombardi, Gianmarco / Grieco, Domenico Luca / Franchini, Emanuele / Santarelli, Giulia / Infante, Amato / Sanguinetti, Maurizio / Antonelli, Massimo

Microbiology spectrum

2024 Volume 12, Issue 4, Page(s) e0357423

Abstract: Few data are available on the lung microbiota composition of patients with coronavirus disease 2019-related acute respiratory distress syndrome (C-ARDS) receiving invasive mechanical ventilation (IMV). Moreover, it has never been investigated whether ... ...

Abstract	Few data are available on the lung microbiota composition of patients with coronavirus disease 2019-related acute respiratory distress syndrome (C-ARDS) receiving invasive mechanical ventilation (IMV). Moreover, it has never been investigated whether there is a potential correlation between lung microbiota communities and respiratory mechanics. We performed a prospective observational study in two intensive care units of a university hospital in Italy. Lung microbiota was investigated by bacterial 16S rRNA gene sequencing, performed on bronchoalveolar lavage fluid samples withdrawn after intubation. The lung bacterial communities were analyzed after stratification by respiratory system compliance/predicted body weight (Crs) and ventilatory ratio (VR). Weaning from IMV and hospital survival were assessed as secondary outcomes. In 70 C-ARDS patients requiring IMV from 1 April through 31 December 2020, the lung microbiota composition (phylum taxonomic level, permutational multivariate analysis of variance test) significantly differed between who had low Crs vs those with high Crs ( Importance: Lung microbiota characteristics were demonstrated to predict ventilator-free days and weaning from mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). In this study, we observed that in severe coronavirus disease 2019 patients with ARDS who require invasive mechanical ventilation, lung microbiota characteristics were associated with respiratory mechanics. Specifically, the lung microbiota of patients with low respiratory system compliance and low ventilatory ratio was characterized by Proteobacteria dominance. Moreover, after multivariable regression analysis, we also found an association between patients' microbiota diversity and a higher possibility of being weaned from mechanical ventilation and discharged alive from the hospital. For these reasons, lung microbiota characterization may help to stratify patient characteristics and orient the delivery of target interventions. (This study has been registered at ClinicalTrials.gov on 17 February 2020 under identifier NCT04271345.). Registered at ClinicalTrials.gov, 17 February 2020 (NCT0427135).
MeSH term(s)	Humans ; COVID-19/therapy ; RNA, Ribosomal, 16S/genetics ; Lung ; Respiratory Distress Syndrome/therapy ; Respiratory Mechanics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03574-23
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Article ; Online: Individual variations in motives for nicotine self-administration in male rats: evidence in support for a precision psychopharmacology.

Garcia-Rivas, Vernon / Fiancette, Jean-François / Tostain, Jessica / de Maio, Giulia / Ceau, Matias / Wiart, Jean-François / Gaulier, Jean-Michel / Deroche-Gamonet, Véronique

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 85

Abstract: The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved smoking cessation therapies, supports the presence of individual variations in the mechanisms underlying smoking. This emphasizes the need ...

Abstract	The significant heterogeneity in smoking behavior among smokers, coupled with the inconsistent efficacy of approved smoking cessation therapies, supports the presence of individual variations in the mechanisms underlying smoking. This emphasizes the need to shift from standardized to personalized smoking cessation therapies. However, informed precision medicine demands precision fundamental research. Tobacco smoking is influenced and sustained by diverse psychopharmacological interactions between nicotine and environmental stimuli. In the classical experimental rodent model for studying tobacco dependence, namely intravenous self-administration of nicotine, seeking behavior is reinforced by the combined delivery of nicotine and a discrete cue (nicotine+cue). Whether self-administration behavior is driven by the same psychopharmacological mechanisms across individual rats remains unknown and unexplored. To address this, we employed behavioral pharmacology and unbiased cluster analysis to investigate individual differences in the mechanisms supporting classical intravenous nicotine self-administration (0.04 mg/kg/infusion) in male outbred Sprague-Dawley rats. Our analysis identified two clusters: one subset of rats sought nicotine primarily for its reinforcing effects, while the second subset sought nicotine to enhance the reinforcing effects of the discrete cue. Varenicline (1 mg/kg i.p.) reduced seeking behavior in the former group, whereas it tended to increase in the latter group. Crucially, despite this fundamental qualitative difference revealed by behavioral manipulation, the two clusters exhibited quantitatively identical nicotine+cue self-administration behavior. The traditional application of rodent models to study the reinforcing and addictive effects of nicotine may mask individual variability in the underlying motivational mechanisms. Accounting for this variability could significantly enhance the predictive validity of translational research.
MeSH term(s)	Rats ; Male ; Animals ; Nicotine/pharmacology ; Psychopharmacology ; Rats, Sprague-Dawley ; Motivation ; Tobacco Use Disorder/drug therapy ; Self Administration ; Cues
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-024-02774-6
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Article: Evaluation of Everolimus Activity against

Bianco, Delia Mercedes / De Maio, Flavio / Santarelli, Giulia / Palucci, Ivana / Salustri, Alessandro / Bianchetti, Giada / Maulucci, Giuseppe / Citterio, Franco / Sanguinetti, Maurizio / Tamburrini, Enrica / Sali, Michela / Delogu, Giovanni

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 1

Abstract: Even though Everolimus has been investigated in a phase II randomized trial as a host-directed therapy (HDT) to treat tuberculosis (TB), an oncological patient treated with Everolimus for a neuroendocrine pancreatic neoplasia developed active TB twice ... ...

Abstract	Even though Everolimus has been investigated in a phase II randomized trial as a host-directed therapy (HDT) to treat tuberculosis (TB), an oncological patient treated with Everolimus for a neuroendocrine pancreatic neoplasia developed active TB twice and a non-tuberculous mycobacterial (NTM) infection in a year and a half time span. To investigate this interesting case, we isolated and genotypically characterized the
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12010171
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Article: Photo-Protective Mechanisms and the Role of Poly (ADP-Ribose) Polymerase Activity in a Facultative CAM Plant Exposed to Long-Term Water Deprivation.

Vitale, Luca / Vitale, Ermenegilda / Costanzo, Giulia / De Maio, Anna / Arena, Carmen

Plants (Basel, Switzerland)

2020 Volume 9, Issue 9

Abstract: The Crassulacean acid metabolism (CAM) pathway helps plants to alleviate the oxidative stress under drought, but the shift to CAM-idling may expose plants to the overproduction of reactive oxygen species causing cell damages. The facultative CAM ... ...

Abstract	The Crassulacean acid metabolism (CAM) pathway helps plants to alleviate the oxidative stress under drought, but the shift to CAM-idling may expose plants to the overproduction of reactive oxygen species causing cell damages. The facultative CAM species
Language	English
Publishing date	2020-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants9091192
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