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  1. Article ; Online: Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.

    Mangiafico, R A / Mangiafico, M

    Current medicinal chemistry

    2012  Volume 19, Issue 27, Page(s) 4688–4698

    Abstract: Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with an increased risk of stroke and systemic embolism. Oral anticoagulation with vitamin K antagonists (VKAs), such as warfarin, has historically been the mainstay of long-term ... ...

    Abstract Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with an increased risk of stroke and systemic embolism. Oral anticoagulation with vitamin K antagonists (VKAs), such as warfarin, has historically been the mainstay of long-term thromboprophylaxis in AF patients. However, although highly effective, VKAs have a number of limitations that make their use difficult and cumbersome in clinical practice. They have a slow onset and offset of action, narrow therapeutic window, marked dose-response variability, and multiple food and drug interactions, and require frequent coagulation monitoring and dose adjustments. To overcome VKA drawbacks, several new oral anticoagulants have been recently developed for use in AF, and three of them, the direct thrombin inhibitor dabigatran etexilate and the direct factor Xa inhibitors rivaroxaban and apixaban, have completed phase III trials. New agents have proven to be noninferior or superior to warfarin for AF-related stroke prevention, with similar or better safety profiles. These new drugs, with their predictable anticoagulant effect that allows for fixed dosing with no need for coagulation monitoring, have the potential to greatly simplify anticoagulation therapy for AF. Dabigatran etexilate and rivaroxaban are already approved in the United States and Europe for stroke prevention in nonvalvular AF, and dabigatran etexilate has entered current AF guidelines as an alternative to warfarin. However, some issues with new compounds are still unresolved, such as the lack of antidotes and standardized tests to measure drug activity. Active postmarketing monitoring surveillance of effectiveness and safety is required in the implementation of new anticoagulant therapies.
    MeSH term(s) Anticoagulants/chemistry ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Benzimidazoles/chemistry ; Benzimidazoles/therapeutic use ; Benzoates/chemistry ; Benzoates/therapeutic use ; Clinical Trials as Topic ; Coumarins/chemistry ; Coumarins/therapeutic use ; Dabigatran ; Factor Xa/metabolism ; Factor Xa Inhibitors ; Humans ; Morpholines/chemistry ; Morpholines/therapeutic use ; Pyrazoles/chemistry ; Pyrazoles/therapeutic use ; Pyridines/chemistry ; Pyridines/therapeutic use ; Pyridones/chemistry ; Pyridones/therapeutic use ; Rivaroxaban ; Thiophenes/chemistry ; Thiophenes/therapeutic use ; Thrombin/antagonists & inhibitors ; Thrombin/metabolism ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Benzimidazoles ; Benzoates ; Coumarins ; Factor Xa Inhibitors ; Morpholines ; Pyrazoles ; Pyridines ; Pyridones ; Thiophenes ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Thrombin (EC 3.4.21.5) ; Factor Xa (EC 3.4.21.6) ; Dabigatran (I0VM4M70GC) ; tecarfarin (WN1479YT50)
    Language English
    Publishing date 2012-07-16
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986712803306420
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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  2. Article ; Online: The Role of Heparin in COVID-19

    Marco Mangiafico / Andrea Caff / Luca Costanzo

    Journal of Clinical Medicine, Vol 11, Iss 3099, p

    An Update after Two Years of Pandemics

    2022  Volume 3099

    Abstract: Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial damage induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging as a crucial pathogenetic mechanism for the development of complications in an acute phase of the illness and for several postdischarge sequalae. Heparin has been shown to have a positive impact on COVID-19 due to its anticoagulant function. Moreover, several other biological actions of heparin were postulated: a potential anti-inflammatory and antiviral effect through the main protease (M pro ) and heparansulfate (HS) binding and a protection from the damage of vascular endothelial cells. In this paper, we reviewed available evidence on heparin treatment in COVID-19 acute illness and chronic sequalae, focusing on the difference between prophylactic and therapeutic dosage.
    Keywords COVID-19 ; heparin ; low molecular weight heparin ; coagulopathy ; thromboprophylaxis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Is the use of fully covered metal stents effective in the treatment of difficult lithiasis of the common bile duct?

    Grande, Giuseppe / Pigò, Flavia / Avallone, Luciana / Bertani, Helga / Mangiafico, Santi / Russo, Salvatore / Cocca, Silvia / Lupo, Marinella / Caruso, Angelo / Conigliaro, Rita

    Surgical endoscopy

    2022  Volume 36, Issue 8, Page(s) 5684–5691

    Abstract: Background: The management of difficult lithiasis of common bile duct (CBD) often requires a multimodal approach. Fully Covered Metal Stents (FCSEMS) could fragment the stones, dilate strictures of the CBD and progressively enlarge the papillary orifice. ...

    Abstract Background: The management of difficult lithiasis of common bile duct (CBD) often requires a multimodal approach. Fully Covered Metal Stents (FCSEMS) could fragment the stones, dilate strictures of the CBD and progressively enlarge the papillary orifice. The aim of the study was to evaluate the efficacy of FCSEMS in the treatment of difficult lithiasis of CBD.
    Methods: All consecutive cases of difficult lithiasis of CBD after an attempt of clearance with complete sphincterotomy were retrospectively considered from 2009 to 2019. Intrahepatic lithiasis cases were excluded. Multivariable analysis (stepwise logistic regression if p value < 0.1 at univariable analysis) was made to understand factors associated with efficacy of FCSEMS in difficult lithiasis of CBD.
    Results: 163 cases of difficult lithiasis over 1516 cases of lithiasis of CBD (incidence of 11%) were considered. Among eligible patients, 96 (mean age 78 ± 11.9 years, 43% males) placed a FCSEMS during the first ERCP. Mean diameter of stone was 17.5 ± 5.5 mm. An attempt of dilation during the same procedure was made in 18% cases. After removal of the stent, 52 (54%) patients had complete clearance of CBD at cholangiography. The rest of patients (44), subsequently underwent multimodal treatment (final success of 95%). After logistic regression, variables positively associated with clearance of CBD were sex male (OR 3.5) and stent permanence ≥ 30 days (OR 3.2). Diameter of the stone ≥ 2 cm was associated with failure (OR 0.2). 7 post-ERCP pancreatitis, 6 post-sphincterotomy bleeding and 3 cholangitis occurred.
    Conclusions: FCSEMS are useful in the approach of difficult lithiasis of CBD with no significant adverse events associated.
    MeSH term(s) Aged ; Aged, 80 and over ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Common Bile Duct/surgery ; Female ; Humans ; Lithiasis ; Male ; Retrospective Studies ; Stents ; Treatment Outcome
    Language English
    Publishing date 2022-01-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-021-08919-8
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    Zs.A 2214: Show issues Location:
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  4. Article ; Online: Catheter ablation of atrial fibrillation with a multi-electrode radiofrequency balloon; first and early two centre experience in Europe.

    Kanthasamy, Vijayabharathy / Breitenstein, Alexander / Schilling, Richard / Hofer, Daniel / Tiongco, Benny / Ang, Richard / Hunter, Ross / Earley, Mark / Ahsan, Syed / Mangiafico, Valentina / Honarbakhsh, Shohreh / Ahluwalia, Nikhil / Maclean, Edd / Creta, Antonio / Finlay, Malcolm

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 6, Page(s) 1350–1359

    Abstract: Introduction: The Heliostar™ ablation system is a novel RF balloon ablation technology with an integrated three-dimensional mapping system. Here, we describe our early experience and procedural outcomes using this technology for atrial fibrillation ... ...

    Abstract Introduction: The Heliostar™ ablation system is a novel RF balloon ablation technology with an integrated three-dimensional mapping system. Here, we describe our early experience and procedural outcomes using this technology for atrial fibrillation catheter ablation.
    Methods: We sought to comprehensively assess the first 60 consecutive patients undergoing pulmonary vein isolation using the novel HELISOTAR™ RF balloon technology including procedural outcomes. A comparison of the workflow between two different anaesthetic modalities (conscious sedation [CS] vs. general anaesthesia [GA]) was made. Procedural data were collected prospectively from two high-volume centers (Barts Heart Centre, UK and University Hospital of Zurich, Zurich). A standardized approach for catheter ablation was employed.
    Results: A total of 35 patients had the procedure under CS and the remaining under GA. Mean procedural and fluoroscopy times were 84 ± 33 min and 1.1 min. The median duration of RF energy application was 7 (5-9.8) mins per patient. All veins were successfully isolated, and the median isolation time was 10 (7-15) seconds. Our cohort's rate of procedural complications was low, with no mortality within 30 days postprocedure.
    Conclusion: Our early experience shows that catheter ablation using the Heliostar™ technology can be performed efficiently and safely; however, long-term data is yet to be established. Low fluoroscopy requirements, short learning curves and use of this technology with CS is possible, including the use of an oesophageal temperature probe.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Treatment Outcome ; Europe ; Electrodes ; Pulmonary Veins/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15799
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    Zs.A 2863: Show issues Location:
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  5. Article ; Online: Feasibility of double-blinded, placebo-controlled interventional study for assessing catheter ablation efficacy in persistent atrial fibrillation: Insights from the ORBITA AF feasibility study.

    Kanthasamy, Vijayabharathy / Schilling, Richard / Zongo, Olivier / Khan, Kamran / Earley, Mark / Monk, Vivienne / Hunter, Ross / Mangiafico, Valentina / Ang, Richard / Creta, Antonio / Aluwhalia, Nikhil / Honarbakhsh, Shohreh / Dhinoja, Mehul / Gupta, Dhiraj / Finlay, Malcolm

    American heart journal

    2023  Volume 269, Page(s) 56–71

    Abstract: Background: To date, there are no randomized, double-blinded clinical trials comparing catheter ablation to DC cardioversion (DCCV) with medical therapy in patients with persistent atrial fibrillation (PersAF). Conducting a large-scale trial to address ... ...

    Abstract Background: To date, there are no randomized, double-blinded clinical trials comparing catheter ablation to DC cardioversion (DCCV) with medical therapy in patients with persistent atrial fibrillation (PersAF). Conducting a large-scale trial to address this question presents considerable challenges, including recruitment, blinding, and implementation. We conducted a pilot study to evaluate the feasibility of conducting a definitive placebo-controlled trial.
    Methods: This prospective trial was carried out at Barts Heart Centre, United Kingdom, employing a randomized, double-blinded, placebo-controlled design. Twenty patients with PersAF (duration <2 years) were recruited, representing 10% of the proposed larger trial as determined by a power calculation. The patients were randomized in a 1:1 ratio to receive either PVI ± DCCV (PVI group) or DCCV + Placebo (DCCV group). The primary endpoint of this feasibility study was to evaluate patient blinding. Patients remained unaware of their treatment allocation until end of study.
    Results: During the study, 35% of patients experienced recurrence of PersAF prior to completion of 12 months follow-up. Blinding was successfully maintained amongst both patients and medical staff. The DCCV group had a trend to higher recurrence and repeat procedure rate compared to the PVI group (recurrence of PersAF 60% vs 30%; p = .07 and repeat procedure 70% vs 40%; p = .4). The quality of life experienced by individuals in the PVI group showed improvement, as evidenced by enhanced scores on the AF specific questionnaire (AF PROMS) (3 [±4] vs 21 [±8]) and SF-12 mental-component raw score (51.4 [±7] vs 43.24 [±15]) in patients who maintained sinus rhythm at 12 months.
    Conclusion: This feasibility study establishes the potential for conducting a blinded, placebo-controlled trial to evaluate the efficacy of PVI versus DCCV in patients with PersAF.
    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Atrial Fibrillation/drug therapy ; Feasibility Studies ; Quality of Life ; Prospective Studies ; Angina, Stable/surgery ; Pilot Projects ; Pulmonary Veins/surgery ; Percutaneous Coronary Intervention ; Catheter Ablation/methods ; Treatment Outcome ; Recurrence
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2023.12.007
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    Ui IV Zs.15: Show issues Location:
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  6. Article ; Online: Over-the-scope Technique for Partially Covered Self-expandable Metal Stent Placement to Treat Duodenal Perforation during EUS.

    Sbrozzzi-Vanni, Andrea / Galloro, Giuseppe / Piciucchi, Matteo / Castellani, Danilo / Germani, Ugo / Dell'Amico, Iginio / Zito, Francesco / Pallio, Socrate / Mangiafico, Santi / Zullo, Angelo / Manta, Raffaele

    Journal of gastrointestinal and liver diseases : JGLD

    2023  Volume 32, Issue 1, Page(s) 65–69

    Abstract: Background and aims: Although endoscopic ultrasound (EUS) is generally safe, duodenal perforation may occur during the procedure. When the iatrogenic break is wide, endoscopic positioning of a covered self- expandable metal stent is indicated to avoid a ...

    Abstract Background and aims: Although endoscopic ultrasound (EUS) is generally safe, duodenal perforation may occur during the procedure. When the iatrogenic break is wide, endoscopic positioning of a covered self- expandable metal stent is indicated to avoid a more invasive surgical approach. We evaluated the efficacy of the 'over-the-scope stenting' (OTSS) technique to treat iatrogenic duodenal perforations occurred during EUS.
    Methods: Data of patients with large iatrogenic duodenal perforations treated with OTSS procedure were collected in 5 centers. Technical success was defined as a correct stent placement on the perforation site, and clinical success as complete healing of the duodenal leak at stent removal 3 weeks later.
    Results: A total of 15 (7 males; median age: 78 years, range 47-91) patients were included in this series. A correct stent positioning was achieved in all cases (technical success: 100%), and the perforation was healed in all, apart from one patient at stent removal (clinical success: 93%). This patient was successfully treated with a novel stent placement. No immediate post-procedural adverse events occurred, and no need for emergency surgery was recorded. In one (6.7%) patient, stent migration occurred 10 days after positioning, and it was spontaneously expulsed with stool movement without complications two days later.
    Conclusions: Our data showed that the OTTS technique for partially covered self-expandable metal stent placement is feasible, safe and effective to tread large iatrogenic duodenal perforation occuring during EUS.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Retrospective Studies ; Treatment Outcome ; Self Expandable Metallic Stents ; Stents ; Iatrogenic Disease
    Language English
    Publishing date 2023-04-01
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-4625
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    Zs.A 3825: Show issues Location:
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  7. Article ; Online: Endoscopic full-thickness resection in a recurrent perianastomotic esophagojejunal cancer followed by fully covered metal stent placement for lumen occlusion.

    Caruso, Angelo / Russo, Salvatore / Grande, Giuseppe / Pigò, Flavia / Mangiafico, Santi / Bertani, Helga / Conigliaro, Rita

    Endoscopy

    2020  Volume 52, Issue 9, Page(s) E337–E338

    MeSH term(s) Endosonography ; Humans ; Metals ; Neoplasms ; Stents
    Chemical Substances Metals
    Language English
    Publishing date 2020-03-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1113-7001
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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  8. Article ; Conference proceedings: OVERSTITCH SUTURE OF PARIETAL DEFECTS AFTER ESD AND EFTR IS FEASIBLE, SAFE AND REDUCE THE NEED FOR HOSPITALIZATION

    Grande, G. / Bertani, H. / Cocca, S. / Lupo, M. / Mangiafico, S. / Pigò, F. / Russo, S. / Caruso, A. / Conigliaro, R.

    Endoscopy

    2022  Volume 54, Issue S 01

    Event/congress ESGE Days 2022, Prague, Czech Republic, 2022-04-28
    Language English
    Publishing date 2022-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0042-1744884
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  9. Article ; Online: Mechanical thrombectomy for in-hospital stroke: data from the Italian Registry of Endovascular Treatment in Acute Stroke.

    Naldi, Andrea / Pracucci, Giovanni / Cavallo, Roberto / Saia, Valentina / Boghi, Andrea / Lochner, Piergiorgio / Casetta, Ilaria / Sallustio, Fabrizio / Zini, Andrea / Fainardi, Enrico / Cappellari, Manuel / Tassi, Rossana / Bracco, Sandra / Bigliardi, Guido / Vallone, Stefano / Nencini, Patrizia / Bergui, Mauro / Mangiafico, Salvatore / Toni, Danilo

    Journal of neurointerventional surgery

    2023  Volume 15, Issue e3, Page(s) e426–e432

    Abstract: Background: The benefit, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) are unclear. We sought to evaluate the outcomes and treatment times for IHS patients compared with out-of-hospital stroke (OHS) ...

    Abstract Background: The benefit, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) are unclear. We sought to evaluate the outcomes and treatment times for IHS patients compared with out-of-hospital stroke (OHS) patients receiving MT.
    Methods: We analyzed data from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) between 2015 and 2019. We compared the functional outcomes (modified Rankin Scale (mRS) scores) at 3 months, recanalization rates, and symptomatic intracranial hemorrhage (sICH) after MT. Time intervals from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were recorded for both groups, as were door-to-imaging and door-to-groin for OHS. A multivariate analysis was performed.
    Results: Of 5619 patients, 406 (7.2%) had IHS. At 3 months, IHS patients had a lower rate of mRS 0-2 (39% vs 48%, P<0.001) and higher mortality (30.1% vs 19.6%, P<0.001). Recanalization rates and sICH were similar. Time intervals (min, median (IQR)) from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were favorable for IHS (60 (34-106) vs 123 (89-188.5); 150 (105-220) vs 220 (168-294); 227 (164-303) vs 293 (230-370); all P<0.001), whereas OHS had lower door-to-imaging and door-to-groin times compared with stroke onset-to-imaging and onset-to-groin for IHS (29 (20-44) vs 60 (34-106), P<0.001; 113 (84-151) vs 150 (105-220); P<0.001). After adjustment, IHS was associated with higher mortality (aOR 1.77, 95% CI 1.33 to 2.35, P<0.001) and a shift towards worse functional outcomes in the ordinal analysis (aOR 1.32, 95% CI 1.06 to 1.66, P=0.015).
    Conclusion: Despite favorable time intervals for MT, IHS patients had worse functional outcomes than OHS patients. Delays in IHS management were detected.
    MeSH term(s) Humans ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Intracranial Hemorrhages/etiology ; Hospitals ; Thrombectomy/methods ; Registries ; Italy/epidemiology ; Endovascular Procedures/methods ; Brain Ischemia/therapy ; Retrospective Studies
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2022-019939
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    Zs.A 6845: Show issues Location:
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  10. Article ; Online: Outcomes with Endovascular Treatment of Patients with M2 Segment MCA Occlusion in the Late Time Window.

    Bala, F / Kim, B J / Najm, M / Thornton, J / Fainardi, E / Michel, P / Alpay, K / Herlihy, D / Goyal, M / Casetta, I / Nannoni, S / Ylikotila, P / Power, S / Saia, V / Hegarty, A / Pracucci, G / Rautio, R / Ademola, A / Demchuk, A /
    Mangiafico, S / Boyle, K / Hill, M D / Toni, D / Murphy, S / Menon, B K / Almekhlafi, M A

    AJNR. American journal of neuroradiology

    2023  Volume 44, Issue 4, Page(s) 447–452

    Abstract: Background and purpose: Randomized trials in the late window have demonstrated the efficacy and safety of endovascular thrombectomy in large-vessel occlusions. Patients with M2-segment MCA occlusions were excluded from these trials. We compared outcomes ...

    Abstract Background and purpose: Randomized trials in the late window have demonstrated the efficacy and safety of endovascular thrombectomy in large-vessel occlusions. Patients with M2-segment MCA occlusions were excluded from these trials. We compared outcomes with endovascular thrombectomy in patients with M2-versus-M1 occlusions presenting 6-24 hours after symptom onset.
    Materials and methods: Analyses were on pooled data from studies enrolling patients with stroke treated with endovascular thrombectomy 6-24 hours after symptom onset. We compared 90-day functional independence (mRS ≤ 2), mortality, symptomatic intracranial hemorrhage, and successful reperfusion (expanded TICI = 2b-3) between patients with M2 and M1 occlusions. The benefit of successful reperfusion was then assessed among patients with M2 occlusion.
    Results: Of 461 patients, 367 (79.6%) had M1 occlusions and 94 (20.4%) had M2 occlusions. Patients with M2 occlusions were older and had lower median baseline NIHSS scores. Patients with M2 occlusion were more likely to achieve 90-day functional independence than those with M1 occlusion (adjusted OR = 2.13; 95% CI, 1.25-3.65). There were no significant differences in the proportion of successful reperfusion (82.9% versus 81.1%) or mortality (11.2% versus 17.2%). Symptomatic intracranial hemorrhage risk was lower in patients with M2-versus-M1 occlusions (4.3% versus 12.2%,
    Conclusions: In the late time window, patients with M2 occlusions treated with endovascular thrombectomy achieved better clinical outcomes, similar reperfusion, and lower symptomatic intracranial hemorrhage rates compared with patients with M1 occlusion. These results support the safety and benefit of endovascular thrombectomy in patients with M2 occlusions in the late window.
    MeSH term(s) Humans ; Treatment Outcome ; Stroke/etiology ; Thrombectomy/methods ; Intracranial Hemorrhages/surgery ; Intracranial Hemorrhages/etiology ; Endovascular Procedures/methods ; Brain Ischemia/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A7833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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