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  1. Book ; Online ; Conference proceedings: Festschrift

    Lorenzen, Johan / Scharl, Michael

    aus Anlass der Verleihung des Georg Friedrich-Götz-Preises 2017

    2018  

    Event/congress Götz-Preisverleihung (2018, Zürich)
    Author's details Georg-Friedrich-Götz-Preis 2017
    Subject code 610
    Language German
    Size 1 Online-Ressource (58 Seiten), Illustrationen, Diagramme
    Publisher Georg-Friedrich-Götz-Stiftung, Medizinische Fakultät der Universität Zürich
    Publishing place Zürich
    Publishing country Switzerland
    Document type Book ; Online ; Conference proceedings
    Note Götz-Preisverleihung vom 5. April 2018
    HBZ-ID HT019657887
    DOI 10.4126/FRL01-006407764
    Database Repository for Life Sciences

    Full text online

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    Inter-library loan at ZB MED

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  2. Book ; Conference proceedings: Festschrift

    Lorenzen, Johan / Scharl, Michael

    aus Anlass der Verleihung des Georg Friedrich-Götz-Preises 2017

    2018  

    Title translation Festschrift
    Event/congress Götz-Preisverleihung (2018, Zürich)
    Author's details Georg-Friedrich-Götz-Preis 2017
    Subject code 610
    Language German
    Size 58 Seiten, Illustrationen, Diagramme
    Publisher Georg-Friedrich-Götz-Stiftung, Medizinische Fakultät der Universität Zürich
    Publishing place Zürich
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    Note Götz-Preisverleihung vom 5. April 2018
    HBZ-ID HT019657910
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 535 available for loan (reading room) Lesesaal EG

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  3. Book ; Thesis: In-vitro-Effekte von Arginase-Inhibitoren auf die glatte Muskulatur des humanen Corpus cavernosum penis

    Lorenzen, Johan Matthes

    2007  

    Author's details vorgelegt von Johan Matthes Lorenzen
    Subject code 616.6
    Language German
    Size 86 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2007
    HBZ-ID HT015472446
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 E 131 order for loan Magazin

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  4. Article: Circular RNAs as non-invasive urinary biomarker of kidney diseases.

    Kölling, Malte / Lorenzen, Johan M

    Annals of translational medicine

    2020  Volume 8, Issue 5, Page(s) 255

    Language English
    Publishing date 2020-03-30
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Diagnostic and Therapeutic Potential of microRNAs in Acute Kidney Injury.

    Brandenburger, Timo / Lorenzen, Johan M

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 657

    Abstract: During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers ...

    Abstract During hospital stay, about 20% of adult patients experience an episode of acute kidney injury (AKI), which is characterized by a rapid decrease in kidney function. Diagnostic tools regarding early diagnosis of kidney dysfunction prior to AKI and markers of renal recovery are not available. Additionally, there is no therapeutic option for the treatment of AKI. Thus, better and more specific diagnostic and therapeutic options are urgently needed in daily clinical practice. NoncodingRNAs (ncRNAs) have come into focus of research in the context of AKI in the last decade. The best characterized group of ncRNAs are microRNAs (miRNAs). An increasing body of literature has shown that miRNAs are involved in the pathogenesis of AKI and that they are promising future tools in the diagnosis and therapy of AKI. However, there are obstacles to be overcome before miRNAs can be transferred to patient care. This review will give an overview of our current knowledge of miRNA involvement in the context of AKI while critically evaluating their diagnostic and therapeutic potential.
    Language English
    Publishing date 2020-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.00657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Biogenesis and Function of Circular RNAs in Health and in Disease.

    Haddad, George / Lorenzen, Johan M

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 428

    Abstract: Circular RNAs (circRNAs) are a class of non-coding RNA that were previously thought to be insignificant byproducts of splicing errors. However, recent advances in RNA sequencing confirmed the presence of circRNAs in multiple cell lines and across ... ...

    Abstract Circular RNAs (circRNAs) are a class of non-coding RNA that were previously thought to be insignificant byproducts of splicing errors. However, recent advances in RNA sequencing confirmed the presence of circRNAs in multiple cell lines and across different species suggesting a functional role of this RNA species. CircRNAs arise from back-splicing events resulting in a circular RNA that is stable, specific and conserved. They can be generated from exons, exon-introns, or introns. CircRNAs have multifaceted functions. They are likely part of the competing endogenous RNA class. They can regulate gene expression by sponging microRNAs, binding proteins or they can be translated into a protein themselves. CircRNAs have been associated with health and disease, some with disease protective effects, some with disease promoting functions. The widespread expression and disease regulatory mechanisms endow circRNAs to be used as functional biomarkers and therapeutic targets for a variety of different disorders. In this concise article we provide an overview of the association of circRNAs with various diseases including cancer, cardiovascular and kidney disease as well as cellular senescence. We conclude with an assessment of the current status and future outlook of this new field of research that carries immense potential with respect to diagnostic and therapeutic approaches of a variety of diseases.
    Language English
    Publishing date 2019-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vascular and circulating microRNAs in renal ischaemia-reperfusion injury.

    Lorenzen, Johan M

    The Journal of physiology

    2015  Volume 593, Issue 8, Page(s) 1777–1784

    Abstract: Ischaemia-reperfusion (I/R) injury of the kidney is a major cause of acute kidney injury. It may result in worsening or even loss of organ function. Transient occlusion of the renal vessel is followed by a reperfusion period, which induces further tissue ...

    Abstract Ischaemia-reperfusion (I/R) injury of the kidney is a major cause of acute kidney injury. It may result in worsening or even loss of organ function. Transient occlusion of the renal vessel is followed by a reperfusion period, which induces further tissue damage by release of reactive oxygen and nitrogen species. Ischaemia-reperfusion injury of the kidney may be associated with surgical interventions in native kidneys and is also a common and unavoidable phenomenon in kidney transplantation. MicroRNAs are fascinating modulators of gene expression. They are capable of post-transcriptional silencing of genetic information by targeting the 3'-untranslated region of mRNAs, culminating in a suppression of protein synthesis or an increase in mRNA degradation. They might therefore be useful diagnostic and therapeutic entities during renal I/R injury; for instance, miR-21 has been shown to be enriched in kidney tissue in mice and humans with acute kidney injury. Interestingly, most recent literature suggests that modulation of vascular microRNAs might result in the amelioration of kidney function during renal I/R injury. To that end, miR-126 and miR-24, which have been demonstrated to be highly enriched in endothelial cells, were therapeutically modulated and shown to ameliorate renal I/R injury in mice. MicroRNAs in plasma, urine or enriched in microvesicles have been shown to serve as non-invasive tools for disease monitoring and to have potential impact on downstream mechanisms in recipient cells. This review highlights the latest developments regarding the role of microRNAs in renal I/R injury.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Animals ; Disease Models, Animal ; Endothelium, Vascular/metabolism ; Humans ; Kidney/blood supply ; Kidney/metabolism ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Reperfusion Injury/complications ; Reperfusion Injury/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2015-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP270318
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Circular RNAs in kidney disease and cancer.

    van Zonneveld, Anton Jan / Kölling, Malte / Bijkerk, Roel / Lorenzen, Johan M

    Nature reviews. Nephrology

    2021  Volume 17, Issue 12, Page(s) 814–826

    Abstract: Circular RNAs (circRNAs) are a class of endogenously expressed regulatory RNAs with a single-stranded circular structure. They are generated by back splicing and their expression can be tightly regulated by RNA binding proteins. Cytoplasmic circRNAs can ... ...

    Abstract Circular RNAs (circRNAs) are a class of endogenously expressed regulatory RNAs with a single-stranded circular structure. They are generated by back splicing and their expression can be tightly regulated by RNA binding proteins. Cytoplasmic circRNAs can function as molecular sponges that inhibit microRNA-target interactions and protein function or as templates for the efficient generation of peptides via rolling circle amplification. They can also act as molecular scaffolds that enhance the reaction kinetics of enzyme-substrate interactions. In the nucleus, circRNAs might facilitate chromatin modifications and promote gene expression. CircRNAs are resistant to degradation and can be packaged in extracellular vesicles and transported in the circulation. Initial studies suggest that circRNAs have roles in kidney disease and associated cardiovascular complications. They have been implicated in hypertensive nephropathy, diabetic kidney disease, glomerular disease, acute kidney injury and kidney allograft rejection, as well as in microvascular and macrovascular complications of chronic kidney disease, including atherosclerotic vascular disease. In addition, several circRNAs have been reported to have oncogenic or tumour suppressor roles or to regulate drug resistance in kidney cancer. The available data suggest that circRNAs could be promising diagnostic and/or prognostic biomarkers and potential therapeutic targets for kidney disease, cardiovascular disease and kidney cancer.
    MeSH term(s) Cardiovascular Diseases ; Humans ; Kidney Neoplasms ; MicroRNAs/genetics ; RNA, Circular ; RNA-Binding Proteins
    Chemical Substances MicroRNAs ; RNA, Circular ; RNA-Binding Proteins
    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00465-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6334: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 107: Show issues

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  9. Article ; Online: The hypoxic kidney: pathogenesis and noncoding RNA-based therapeutic strategies.

    Haddad, George / Kölling, Malte / Lorenzen, Johan M

    Swiss medical weekly

    2019  Volume 149, Page(s) w14703

    Abstract: Acute kidney injury (AKI) is a disease entity of major importance, affecting approximately 6% of all patients on the intensive care unit. The mortality rate exceeds 60%. AKI is related to several underlying conditions, including sepsis, nephrotoxicity or ...

    Abstract Acute kidney injury (AKI) is a disease entity of major importance, affecting approximately 6% of all patients on the intensive care unit. The mortality rate exceeds 60%. AKI is related to several underlying conditions, including sepsis, nephrotoxicity or major surgery. Ischaemia reperfusion injury or hypoxic conditions may lead to severe injury of the kidney and is associated with a steep decline in survival rates of patients. At present, AKI is diagnosed on the basis of creatinine levels and urine output. Novel markers and knowledge of their pathophysiological role is of major importance for targeted therapeutic interventions. Noncoding RNAs (ncRNAs) have recently been introduced and are the subject of intensive research initiatives. They are arbitrarily separated into small ncRNAs (≤200 nucleotides) and long ncRNAs (lncRNAs, ≥200 nucleotides). Whereas small ncRNAs such as microRNAs have been extensively studied over the past several years, investigations into the role of linear lncRNAs and circular RNAs (circRNAs) are largely lacking. The present review article therefore aims to elucidate in detail the role of microRNAs, lncRNAs and circRNAs in animal models as well as patients with ischaemic AKI and to describe their use as biomarkers as well as their potential use as therapeutics.
    MeSH term(s) Acute Kidney Injury/mortality ; Acute Kidney Injury/physiopathology ; Animals ; Biomarkers/blood ; Humans ; Hypoxia ; MicroRNAs/physiology ; RNA ; RNA, Long Noncoding/physiology ; Renal Replacement Therapy
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Long Noncoding ; RNA, circular ; RNA (63231-63-0)
    Language English
    Publishing date 2019-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2019.14703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Safety of Kidney Biopsy when Performed as an Outpatient Procedure.

    Bonani, Marco / Seeger, Harald / Weber, Nina / Lorenzen, Johan M / Wüthrich, Rudolf P / Kistler, Andreas D

    Kidney & blood pressure research

    2021  Volume 46, Issue 3, Page(s) 310–322

    Abstract: Introduction: Kidney biopsy remains the gold standard for the diagnosis of most renal diseases. A major obstacle to performing a biopsy is safety concerns. However, many safety measures are not evidence based and therefore vary widely between centers. ... ...

    Abstract Introduction: Kidney biopsy remains the gold standard for the diagnosis of most renal diseases. A major obstacle to performing a biopsy is safety concerns. However, many safety measures are not evidence based and therefore vary widely between centers. We sought to determine the rate and timing of kidney biopsy complications in our center, to compare the complication rate between native and transplant kidney biopsies, to evaluate the feasibility of performing kidney biopsies as an outpatient procedure and the value of a postbiopsy ultrasound before discharge, and to identify risk factors for complications.
    Methods: We performed a single-center, retrospective, observational study at the Division of Nephrology of the University Hospital Zurich including all patients who underwent renal biopsy between January 2005 and December 2017. Major bleeding (primary outcome) and any other bleeding or nonbleeding complications (secondary outcomes) were compared between native and transplant kidney biopsies and between inpatient and outpatient procedures and correlated with clinical factors possibly affecting bleeding risk.
    Results: Overall, 2,239 biopsies were performed in 1,468 patients, 732 as inpatient and 1,507 as outpatient procedures. Major bleeding was observed in 28 (3.8%) inpatient and in 15 (1.0%) outpatient procedures, totaling to 43 (1.9%) of all biopsies. Major bleeding requiring intervention amounted to 1.0% (0.5% of outpatient procedures). Rate of major bleeding was similar between native and transplant kidneys. 13/15 (87%) bleeding episodes in planned outpatient procedures were detected during the 4-h surveillance period. Risk factors for bleeding were aspirin use, low eGFR, anemia, cirrhosis, and amyloidosis. Routine postbiopsy ultrasound did not change management.
    Conclusions: Kidney biopsy is an overall safe procedure and can be performed as an outpatient procedure in most patients with an observation period as short as 4 h. The value of routine postbiopsy ultrasound is questionable.
    MeSH term(s) Adult ; Aged ; Biopsy/adverse effects ; Female ; Hemorrhage/etiology ; Humans ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/pathology ; Male ; Middle Aged ; Outpatients ; Retrospective Studies
    Language English
    Publishing date 2021-06-02
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 1326018-2
    ISSN 1423-0143 ; 1420-4096
    ISSN (online) 1423-0143
    ISSN 1420-4096
    DOI 10.1159/000515439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1458: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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